Wiener Klinische Wochenschrift最新文献

{"title":"Predicting late failure in cartilage repair: the need for structural and biochemical monitoring in long-term ACI follow-up.","authors":"Piotr Bramora","doi":"10.1007/s00508-026-02834-5","DOIUrl":"https://doi.org/10.1007/s00508-026-02834-5","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum cholinesterase as a prognostic marker in respiratory critical illness: a narrative review.","authors":"Andreas Fazekas, Erwin Grasmuk-Siegl, Daniel Moser","doi":"10.1007/s00508-026-02827-4","DOIUrl":"https://doi.org/10.1007/s00508-026-02827-4","url":null,"abstract":"<p><p>Prognostication in respiratory critical care rests largely on composite severity scores derived from mixed medical, surgical or sepsis populations. Serum butyrylcholinesterase (pseudocholinesterase) is a liver-synthesized plasma enzyme, a negative acute-phase reactant and an established index of hepatic synthesis and nutrition, and has re-emerged as a candidate prognostic biomarker in critical illness. A direct cytokine-driven mechanism is inferred, not demonstrated, and whether the circulating enzyme modulates the cholinergic anti-inflammatory axis is unproven. This narrative review synthesizes the evidence across community-acquired pneumonia, acute exacerbation of chronic obstructive pulmonary disease and acute respiratory failure including coronavirus disease 2019 (COVID-19). A reproducible inverse association between enzyme activity and mortality or disease severity emerges, but it rests on small, mostly retrospective single-center studies with heterogeneous assays and data-derived thresholds. The review therefore asks one decisive question, almost never addressed in respiratory cohorts: whether the enzyme adds information beyond albumin and established severity scores, judged by incremental discrimination and reclassification. On that test it is a consistent signal in search of methodological rigour rather than an established independent marker. Prospective, setting-specific and adequately adjusted validation is required before clinical adoption, capturing the activity nadir and the slope of any recovery, whose prognostic role is untested. Mislabelling could influence decisions on escalation and limitation of treatment.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between thyroid hormone levels and cognitive dysfunction in older patients with subclinical hypothyroidism : A matched groups retrospective study.","authors":"Haiyan Zheng, Min Si, Qian Wang","doi":"10.1007/s00508-026-02729-5","DOIUrl":"10.1007/s00508-026-02729-5","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation between thyroid hormone levels and cognitive dysfunction in older patients with subclinical hypothyroidism (SCH).</p><p><strong>Methods: </strong>A retrospective matched case-control study (1:2 ratio) was conducted, enrolling 420 participants aged ≥ 60 years (140 SCH cases, 280 euthyroid controls) matched by gender, age (± 5 years) and education level. Thyroid function parameters, including thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb), and cognitive performance assessed via the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), Auditory Verbal Learning Test (AVLT), Trail Making Test (TMT), and Stroop Color and Word Test (Stroop Test) were measured.</p><p><strong>Results: </strong>The SCH patients had TSH levels consistent with the grouping criteria (TSH > 4.2 mIU/L), higher thyroid autoantibody positivity, and poorer cognitive performance across all domains (all P < 0.001). A dose-response relationship was observed between increasing TSH levels and worsening cognitive function. Multivariate logistic regression identified TSH (odds ratio, OR = 1.19), FT3 (OR = 0.68), age, education and APOE ε4 carrier status as independent predictors of cognitive impairment (ROC AUC = 0.786). Stratified analyses showed stronger associations in females and those aged < 75 years, whereas the significance of the correlation between TSH and cognitive impairment was lost in patients aged ≥ 75 years. Sensitivity analyses confirmed the robustness of the findings.</p><p><strong>Conclusion: </strong>The SCH is independently associated with cognitive dysfunction in older people, with thyroid hormones playing a critical role. The findings suggest potential clinical implications for thyroid function monitoring and cognitive protection in this population.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"623-631"},"PeriodicalIF":2.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"50. Jahrestagung der Österreichischen Gesellschaft für Pneumologie & 10. Jahrestagung der Österreichischen Gesellschaft für Thoraxchirurgie.","authors":"","doi":"10.1007/s00508-026-02836-3","DOIUrl":"10.1007/s00508-026-02836-3","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"871-921"},"PeriodicalIF":2.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of combined detection of IgG/IgM/IgA vs. separate IgG and IgM antibodies to Anaplasma phagocytophilum in culture and PCR-confirmed patients with human granulocytic anaplasmosis.","authors":"Gary P Wormser, Lois Zentmaier, Dionysios Liveris, Ira Schwartz, Lindsey Schneider, Maria E Aguero-Rosenfeld","doi":"10.1007/s00508-026-02830-9","DOIUrl":"https://doi.org/10.1007/s00508-026-02830-9","url":null,"abstract":"<p><p>Sera from 26 patients from New York State with culture and PCR confirmed human granulocytic anaplasmosis (HGA) were used to assess the performance of three different immunofluorescence assays (IFA), combined IgG/IgA/IgM and separate IgM and IgG to detect acute and/or convalescent antibodies to Anaplasma phagocytophilum. Convalescent samples were obtained within 6 weeks of the acute sample. An IFA titer ≥ 80 was considered positive. Overall, 22 acute and 21 convalescent samples were tested by all 3 IFA assays.On the acute phase serum sample, 14/22 (63.6%) were positive using the combined IgG/IgA/IgM assay, 10/22 (45.5%) by IgM, 12/22 (54.5%) by IgG and 13/22 (59.1%) by either IgM or IgG assays. Only 1 of 8 (12.5%) samples testing negative by the combined IgG/IgA/IgM assay was positive by an individual IFA testing (IgM IFA only). Of the 21 cases with a convalescent phase sample, 100% tested positive on the combined IgG/IgA/IgM, 20 (95.2%) on the IgG and 20 (95.2%) on the IgM IFA individual assays; all 21 (100%) tested positive by either the IgM or the IgG individual IFA assays.Titers ≥ 640 were found in the acute phase in 58.3-80%, and in the convalescent phase for 85%-95.2% of the positive samples for the 3 IFA assays assessed.In conclusion, the 3 IFA methods tested had comparable sensitivity on acute and convalescent phase serum samples of patients with HGA when using a cut-off of ≥ 80. Further studies should be conducted to determine the IFA cut-off values that offer the best sensitivity and specificity.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avoidance of air pollution by home-based high tone therapy in cancer patients.","authors":"Robert Wakolbinger-Habel, Christof Pabinger, Harald Lothaller, Klaus Hohenstein, Richard Crevenna, Tatjana Paternostro-Sluga","doi":"10.1007/s00508-026-02727-7","DOIUrl":"10.1007/s00508-026-02727-7","url":null,"abstract":"<p><strong>Background: </strong>Home-based treatments are highly relevant for cancer patients due to their limited access to rehabilitation resources. Therefore, home-based treatments offer several advantages in the oncologic setting. In addition, there is potential to decrease the environmental footprints. No previous study has addressed the co-benefits of home-based electrotherapy. Therefore, the aim of this study was to evaluate the reductions in CO₂, NOx and particulate emissions using home-based high tone therapy.</p><p><strong>Methods: </strong>This study was conducted at two supraregional clinics in Vienna, Austria. A total of 65 cancer patients treated for chemotherapy-induced polyneuropathy via home-based high tone therapy over a period of 3 weeks were evaluated. Basic data as well as the distance from the patients' home to the respective clinic, means of transportation, and treatment adherence were analyzed. Based on this information, the total saved km and emissions of CO₂, NOx and particulates were calculated.</p><p><strong>Results: </strong>All patients performed the treatment on at least 15 out of 21 days and 59 patients (91%) even daily. No adverse events were reported and 60% of the patients would have travelled by car and 40% would have used public transport. On average, 129 travel km were saved per patient per treatment week. This corresponds to a saving of 15 kg of CO₂, 8 g of NOx and 0.4 g of particulates. Assuming an average of 1-3 treatments/week, 1341-4023 km would be saved annually per patient corresponding to a saving of 155-465 kg of CO2, 81-243 g of NOx and 4-13 g of particulates.</p><p><strong>Conclusion: </strong>Home-based high tone therapy was highly accepted with a high number of treatment sessions among all patient groups. Additionally, strong reductions of emissions of CO₂, NOx and particulates were demonstrated. It is shown that in Austria alone, home-based therapy could save as many emissions as 77 ha (190 acres) of forest can absorb. Therefore, the home-based treatment may be a promising approach to decrease our environmental footprint.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"632-637"},"PeriodicalIF":2.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystic fibrosis care today-a narrative review based on views of experts, patients and the public.","authors":"Florian Singer, Anja Maria Schaffer, Michaela Auer, Jakob Auer, Jasmin Pansy, Vanessa Stadlbauer, Ernst Eber","doi":"10.1007/s00508-026-02739-3","DOIUrl":"10.1007/s00508-026-02739-3","url":null,"abstract":"<p><p>Cystic fibrosis (CF) is one of the most common rare, genetic diseases. Newly available, highly effective modulator therapy (HEMT) improves many domains of CF pathophysiology. Thereby, HEMT challenges current standards of care and prediction models of disease outcomes.We established a public patient involvement (PPI) group including experts and caregivers of children with CF and collated a narrative review on CF management. This review is based on the views of healthcare professionals and caregivers and summarizes important features of the disease, prevention and treatment which are currently considered relevant for caregivers and Austrian healthcare settings.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"612-622"},"PeriodicalIF":2.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Implementation of a national lung cancer screening in Austria : Position paper of the Austrian Radiological Society (ÖRG), the Austrian Society of Pneumology (ÖGP), the Austrian Society of General Practice and Family Medicine (ÖGAM) and the Austrian Society of Thoracic Surgery (ÖGTC)].","authors":"Romana Wass, Gerlig Widmann, Herbert Bachler, Thomas Klikovits, Judith Löffler-Ragg, Martin Uggowitzer, Peter Kowatsch, Florian Augustin, Arschang Valipour, Klaus Wicke, Florian Tomaselli, Marie-Kathrin Breyer, Stefan Watzka, Maximilian Hochmair, Eveline Kink, Marcel Rowhani, Bernd Lamprecht, Helmut Prosch","doi":"10.1007/s00508-026-02813-w","DOIUrl":"10.1007/s00508-026-02813-w","url":null,"abstract":"<p><strong>Background: </strong>Lung cancer is one of the leading causes of cancer-related mortality in Austria and is frequently diagnosed at an advanced stage. International studies have demonstrated that structured screening using low-dose computed tomography reduces lung cancer mortality and increases the detection of early-stage, potentially curable disease. The aim of this position paper is to provide an evidence-based framework for the implementation of a national lung cancer screening program in Austria.</p><p><strong>Methods: </strong>This position paper is based on the available international evidence, current European guidelines and recommendations as well as Austrian epidemiological and health economic data. Representatives of the Austrian Radiological Society, the Austrian Society of Pneumology, the Austrian Society of General Practice and Family Medicine and the Austrian Society of Thoracic Surgery jointly developed recommendations regarding the target population, program organization, quality assurance and implementation of a national lung cancer screening program.</p><p><strong>Results: </strong>The position paper defines the target population, inclusion and exclusion criteria and the requirements for diagnostics, quality assurance, program organization and multidisciplinary care within a national screening program. The participating scientific societies jointly endorse the implementation of a quality-assured, risk-adapted national lung cancer screening program in Austria.</p><p><strong>Conclusion: </strong>The available evidence supports the implementation of a national quality-assured lung cancer screening program in Austria. Such a program has the potential to sustainably reduce lung cancer mortality, increase the detection of tumors at curable stages and improve the long-term care of individuals at high risk for lung cancer. This position paper provides a scientifically sound basis for the health policy implementation of a national lung cancer screening program in Austria.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"859-870"},"PeriodicalIF":2.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MUW researcher of the month: Dr.in Julia Maria Ressler.","authors":"","doi":"10.1007/s00508-026-02839-0","DOIUrl":"https://doi.org/10.1007/s00508-026-02839-0","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":"138 19-20","pages":"647-648"},"PeriodicalIF":2.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Masked pressure lesion on the tip of the toe, a diagnostic challenge : Case report.","authors":"Regina Fink-Puches, Linda Irmler, Maximilian Zarfl","doi":"10.1007/s00508-026-02732-w","DOIUrl":"10.1007/s00508-026-02732-w","url":null,"abstract":"<p><p>Amelanotic acral melanoma is an uncommon melanoma subtype often associated with delayed diagnosis due to its nonpigmented and clinically inconspicuous presentation. We report the case of a 61-year-old man presenting with a painful erythematous nodule on the plantar aspect of the second toe persisting for 1 year and initially presumed benign. Histopathological evaluation confirmed acral amelanotic melanoma (pT3a) with micrometastatic sentinel lymph node involvement. The patient underwent partial toe amputation followed by adjuvant immunotherapy with nivolumab. This case underscores the importance of early biopsy of persistent acral lesions to reduce diagnostic delay and improve outcomes.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"642-644"},"PeriodicalIF":2.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}