Wiener Klinische Wochenschrift最新文献

{"title":"Self-administration of aspirin for acute chest pain-Does it prevent premature cardiovascular mortality?","authors":"Gudrun Lamm","doi":"10.1007/s00508-024-02471-w","DOIUrl":"10.1007/s00508-024-02471-w","url":null,"abstract":"<p><p>Aspirin as a class I guideline recommended medical treatment for acute coronary syndrome has been established for decades [1]. As early intake of aspirin is crucial, self-administration of aspirin in acute chest pain might be beneficial when weighing up the potential harm including a slightly elevated bleeding risk in patients with chest pain of another origin than myocardial infarction against the benefit in patients with coronary ischemia.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"291-296"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fake smoke, real fire: a retrospective single-center analysis of the underestimated risk of e-cigarette explosions and the typical burn patterns.","authors":"Christian Freystätter, Clement Staud, Anna Fast, Philipp Tratnig-Frankl, Gerald Ihra, Christine Radtke","doi":"10.1007/s00508-025-02520-y","DOIUrl":"https://doi.org/10.1007/s00508-025-02520-y","url":null,"abstract":"<p><p>Parallel to the increasing dissemination of electronic cigarettes (E-cigarette) in the population, increasing numbers of burn injuries caused by explosions of the devices or the rechargeable lithium-ion batteries have been observed worldwide. Several cases of E‑cigarette-related explosions have already resulted in fatalities. We report a series of 7 patients who were treated at our department between 2016 and 2022. Of the seven patients two required treatment in the intensive care unit (ICU), two further patients required normal ward and three patients could be treated as outpatients. The median age of the patients was 43 years and the female to male ratio 2:5. Most of the patients had superficial to full thickness burn injuries on their thighs and (dominant) hands; however, injuries to the genitals were also observed. The patients' burns had a median total body surface area of 4.5%. Of these patients 4 had to stay in hospital for a median of 12.5 days, 2 of them required surgical treatment and intensive care. No patient died during hospitalization. Explosions of E‑cigarettes often happen in public while the devices or rechargeable lithium-ion batteries are being carried in trouser pockets, as shown in our study. This often ignites the victim's clothing. In a crowd or on public transport, this fire could spread quickly and endanger surrounding persons. It is therefore in the public interest to raise awareness of this potential danger from E‑cigarettes.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One night with Venus, a lifetime with mercury : Analyses of heavy metals in Franz Schubert's hair are consistent with syphilis treatment.","authors":"Lisa Fischer, Stephan Hann, Christina Amory, Walther Parson, Farkas Pintér, Christian Reiter","doi":"10.1007/s00508-025-02524-8","DOIUrl":"https://doi.org/10.1007/s00508-025-02524-8","url":null,"abstract":"<p><p>Samples from three strands of Franz Schubert's hair, which are very likely to be authentic due to their well-documented origin and the chain of custody that is still valid today, were analyzed in terms of molecular biology and heavy metal content. The two hair samples presumably taken from the deceased's head showed matching molecular biological parameters, while the sample taken 35 years after his burial did not contain any usable DNA. Heavy metal analyses along the hair samples using LA-ICP-MS (laser ablation inductively coupled plasma mass spectrometry) with a temporal resolution of 4-5 h revealed significantly increased mercury and lead concentrations in all samples with a decreasing tendency towards the time of death. Taking the different storage conditions into account, the patterns of metal concentrations in the samples match well, suggesting that all three samples came from the same individual. The results of our research support the suggestion, often made in the literature, that Franz Schubert underwent cutaneous treatment with mercury for syphilitic illness many months before his death.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thelazia callipaeda infestation in an 8-month-old male infant in Hubei, China.","authors":"Xiaomei Wang, Changzhen Li","doi":"10.1007/s00508-025-02533-7","DOIUrl":"https://doi.org/10.1007/s00508-025-02533-7","url":null,"abstract":"<p><p>Thelazia callipaeda, a zoonotic nematode, primarily infests the ocular tissues of mammals, occasionally humans. Infestations in infants under 1 year of age are rarely reported. This case describes an 8‑month-old male infant diagnosed with ocular T. callipaeda infestation in Hubei, China. The infant was brought to the hospital by his mother, who reported that he had been rubbing his right eye for 3 days, accompanied by increased ocular discharge and mild tearing. Upon examination, a whitish, motile, thread-like worm was observed in the conjunctival sac of the right eye. During ophthalmological surgical exploration, a total of 10 worms were removed from the right eye, with 8 sent for identification. All 8 adult nematodes collected were morphologically identified as T. callipaeda, consisting of 4 females and 4 males. Following the removal of the nematodes, the infant's ocular symptoms rapidly resolved, with no recurrence noted during a 2-month follow-up.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized controlled pilot study investigating adherence to blood pressure diaries with personal pictures in stroke follow-up care.","authors":"Clemens V Farr, Johanna Ebner, Marie Beatrice Lang, Sonja Zehetmayer, Katharina Trawnicek, Stefan Greisenegger, Wolfgang Serles, Thomas Berger, Patrick Altmann","doi":"10.1007/s00508-025-02530-w","DOIUrl":"https://doi.org/10.1007/s00508-025-02530-w","url":null,"abstract":"<p><strong>Introduction: </strong>Blood pressure (BP) management is essential in secondary stroke prevention. Strategies to ensure continuous home BP monitoring are needed. Few studies investigated factors influencing adherence to home BP management. Therefore, we designed a pilot study to investigate the feasibility of keeping BP diaries (BPDs) with personal images.</p><p><strong>Methods: </strong>In this prospective trial, we randomized persons with a diagnosis of stroke or transient ischemic attack into two groups: (i) 10 patients received a personalized BPD with pictures of their choosing and (ii) 10 patients received a BPD without photographs. We instructed participants in both groups to document their BP at home twice daily over 28 days. Adherence was defined as the number of BP measurements performed relative to the maximum number of recommended measurements. We assessed patient reported outcomes as exploratory endpoints.</p><p><strong>Results: </strong>We found no statistically significant difference in mean adherence between the control group (64%) and the intervention group (69%). The BP was within the recommended range and precision of documentation was high in both groups, without statistically significant differences. Patient reported outcomes such as depression scores did not differ significantly between study groups.</p><p><strong>Conclusion: </strong>Our findings underline the relevance to investigate aspects of adherence to home BP management suggesting the inclusion of patient-provided pictures to be feasible.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of endothelin receptor antagonists in non-diabetic kidney nephropathy : A systematic review and meta-analysis.","authors":"Jiamei Xu, Congyuan Ma, Xuanwei Li, Meng Zhang, Ping Zhu","doi":"10.1007/s00508-025-02528-4","DOIUrl":"https://doi.org/10.1007/s00508-025-02528-4","url":null,"abstract":"<p><strong>Background: </strong>Recent evidence increasingly confirms the therapeutic potential of endothelin receptor antagonists (ERA) in treating non-diabetic kidney nephropathy. However, clinical data in this area remain limited. Therefore, we conducted this meta-analysis to investigate the efficacy and safety of ERAs in the treatment of non-diabetic kidney nephropathy.</p><p><strong>Methods: </strong>Randomized controlled trials were identified through PubMed, WOS, Embase, Cochrane Library and Google scholar. The initial participant characteristics and primary outcome measures were gathered, followed by the calculation of risk ratios (RR) and 95% confidence intervals (CI). Additionally, subgroup analyses were conducted to investigate the sources of heterogeneity.</p><p><strong>Result: </strong>In this study, seven randomized, controlled trials (RCT) were included. The results indicated that patients in the ERAs group exhibited a greater mean reduction in the urinary protein to creatinine ratio (UPCR) (standardized mean difference, MD -28.08, 95% CI -33.59 to -22.57, p < 0.001). The number of patients experiencing either complete or partial remission from proteinuria notably increased when treated with ERAs (complete remission: odds ratio, OR = 3.14, 95% CI 2.23-4.42, p < 0.001; partial remission: OR = 3.03, 95% CI 2.33-3.96, p < 0.001). Furthermore, ERAs delayed the decline in the estimated glomerular filtration rate (eGFR, MD = 3.81, 95% CI 1.71-5.90, p < 0.001). However, the incidence of edema events slightly increased in the ERA group (OR = 1.42, 95% CI 1.04-1.93, p = 0.03).</p><p><strong>Conclusion: </strong>The use of ERAs is more effective than regimens without ERAs in slowing the progression of non-diabetic nephropathy.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunophenotyping of bronchoalveolar lavage and functional impairment in post-COVID syndrome : Insights from a prospective cohort trial.","authors":"Maximilian Robert Gysan, Antje Lehmann, Dominik Bernitzky, Andreas Zech, Jonas Brugger, Helmut Prosch, Marco Idzko, Daniela Gompelmann","doi":"10.1007/s00508-025-02531-9","DOIUrl":"https://doi.org/10.1007/s00508-025-02531-9","url":null,"abstract":"<p><strong>Objective: </strong>Following recovery from COVID-19, there is evidence for pulmonary sequelae and functional impairment. Data regarding the immunopathological mechanisms are limited. This study aimed to investigate the relationship between bronchoalveolar lavage fluid (BALF) cellularity, lung function impairment and high-resolution computed tomography (HRCT) changes in post-COVID syndrome patients.</p><p><strong>Methods: </strong>Patients with post-COVID syndrome were enrolled in this Austrian single-center prospective observational cohort study. All patients underwent a pulmonary function test (PFT) and chest HRCT. Those with pathological HRCT findings underwent bronchoscopy with BALF sampling for differential cell count and fluorescence-activated cell sorting analysis.</p><p><strong>Results: </strong>In this study 26 patients with post-COVID syndrome underwent bronchoscopy with BAL. The HRCT showed ground-glass opacifications (69.2%), organizing pneumonia (7.7%) or both (11.5%). The PFT revealed restrictive lung disease in 38.5% and reduced diffusion capacity in 68%, 19.2% showed a pathological BAL cell pattern predominantly consisting of CD4⁺ T‑cells. The BALF lymphocyte count was associated with reduced forced vital capacity (p = 0.016) and an elevated alveolar-arterial oxygen gradient (p = 0.04).</p><p><strong>Conclusion: </strong>A notable percentage of patients with post-COVID syndrome with persistent HRCT changes showed T‑helper lymphocytic inflammation in the lungs. The degree of alveolar lymphocytosis was associated with lung function impairment. This could suggest that a prolonged inflammatory response in the alveolar compartment contributes to the pathogenesis of post-COVID syndrome.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Markers for the angiogenic potential of fat grafts.","authors":"Maryana Teufelsbauer, Sandra Stickler, Marie-Therese Eggerstorfer, Dennis C Hammond, Clemens Lang, Gerhard Hamilton","doi":"10.1007/s00508-025-02532-8","DOIUrl":"https://doi.org/10.1007/s00508-025-02532-8","url":null,"abstract":"<p><strong>Background: </strong>Fat grafting is widely utilized in reconstructive and esthetic plastic surgery, typically with minimal complications. Nevertheless, the occurrence of fat necrosis is dependent on the technique used for fat extraction, tissue processing and the volume of the graft. The longevity of the graft critically depends on the presence of adipose-derived stromal cells (ADSC) and their promotion of a reconstituted vascular supply.</p><p><strong>Objective: </strong>This study seeks to determine whether there are differences in 13 angiogenesis-related adipokines based on their grouping by vascular endothelial growth factor (VEGF) expression levels.</p><p><strong>Methods: </strong>The expression of 14 adipokines related to angiogenesis in 12 cultured ADSCs was evaluated using Human Adipokine Profiler kits, which simultaneously detect 58 mediators. Adipokines of the high and low VEGF expression groups were evaluated for their expression of the remaining 13 angiogenic proteins.</p><p><strong>Results: </strong>We were able to show that there are significant differences in VEGF^low and VEGF^high ADSCs regarding fibroblast growth factor 19 (p = 0.043) and insulin like growth factor binding protein 3 (p = 0.028). Furthermore, ADSCs with differentially highly expressed VEGF show a different pattern in the amount of protein levels regarding the 13 other adipokines observed.</p><p><strong>Conclusion: </strong>The VEGF has been described as a key angiogenic factor in fat grafts that may be linked to successful grafting; however, two of the fat samples analyzed exhibited high expression of VEGF but lacked significant co-expression of a range of other angiogenic factors. Thus, the assessment of the expression of predisposing mediators for graft angiogenesis for wound healing or contouring should include further angiogenesis promoters aside VEGF as parameters.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High lymphocyte count and bleeding risk in patients with chronic lymphocytic leukemia treated with Bruton's tyrosine kinase inhibitors.","authors":"Ivan Krečak, Bruna Kvinta, Marina Paladin, Aron Grubešić, Marija Stanić Damić, Neven Franjić, Josipa Budimir, Josipa Antonija Bačić, Davor Galušić, Zinaida Perić, Marko Skelin","doi":"10.1007/s00508-025-02529-3","DOIUrl":"https://doi.org/10.1007/s00508-025-02529-3","url":null,"abstract":"<p><p>Bruton's tyrosine kinase inhibitors (BTKi) are being increasingly used to treat patients with chronic lymphocytic leukemia (CLL). Pathological bleeding is a well-known side effect of BTKi but identifying its predictors remains a challenge. This retrospective multicenter study analyzed whether baseline absolute lymphocyte count (ALC) may be associated with bleeding risk in CLL patients treated with BTKi. Time to bleeding (TTB) was the primary outcome of interest. A total of 108 CLL patients treated with BTKi (ibrutinib, n = 86, acalabrutinib, n = 22) were included. The median age was 70 years (range 41-88 years) and 48 (44.4%) were female. The median follow-up time was 32 months (range 1-108 months) and 17 (15.7%) bleeding events occurred during this time. Receiver operating curve analysis set the optimal cut-off value of the ALC at > 77.4 × 10⁹/L. Patients with higher ALC presented with higher total white blood cell count (p < 0.001), lower hemoglobin (p = 0.012), higher Rai stages (p = 0.037) and higher total tumor mass (p < 0.001). Univariately, patients with higher ALC had an inferior TTB when compared to those with lower ALC (hazard ratio, HR 3.27, p = 0.016); this effect persisted in the multivariate Cox regression analysis where higher ALC (HR 4.59, p = 0.032), higher Cumulative Illness Rating Scale (CIRS, HR 4.21, p = 0.040) and the use of antiplatelets/anticoagulants (HR 3.96, p = 0.046) remained independently of each other associated with an inferior TTB. This study provides an important signal regarding the higher risk of bleeding in CLL patients treated with BTKi who present with higher ALC and higher CIRS. Further studies are needed to validate our findings and to unravel the exact pathophysiological mechanisms behind this interesting observation.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone transport nails for reconstruction of lower limb diaphyseal defects in patients with bone sarcomas : A case series.","authors":"Maria Anna Smolle, Silvia Zötsch, Dimosthenis Andreou, Marisa Valentini, Andreas Leithner, Philipp Lanz","doi":"10.1007/s00508-025-02527-5","DOIUrl":"https://doi.org/10.1007/s00508-025-02527-5","url":null,"abstract":"<p><strong>Purpose: </strong>Bone transport nails (BTN) are increasingly being used for defect reconstruction in orthopedic surgery, including orthopedic oncology. Herein, we report on preliminary outcomes in three adult sarcoma patients undergoing bone defect reconstruction of the lower limbs with a BTN.</p><p><strong>Methods: </strong>In this study three patients were retrospectively included; ID1 male, 18 years, Ewing's sarcoma of the right tibial diaphysis; ID2 female, 30 years, G2 periosteal osteosarcoma of the left femoral diaphysis; ID3 female, 28 years, epithelioid malignant peripheral nerve sheath tumor (MPNST) originating from the right proximal tibial metaphysis. All patients had been treated at a university hospital for primary sarcomas of the lower limbs and underwent defect reconstruction with a BTN (Precice® System, NuVasive GmbH, Globus Medical, Audubon, PA, USA).</p><p><strong>Results: </strong>Bone defect lengths were 8.5 cm, 14.1 cm and 14.4 cm, respectively. Bone transport time amounted to 5.3 months, 9.1 months and 10.3 months, and time to bony consolidation to 9.1 months, 12.3 months and 14.7 months, respectively (in ID1 and ID3 partially). Patient ID1 required revision surgery for a wire breakage (used for two-level transport) and one screw avulsion. Patient ID2 developed a peri-implant infection that was successfully treated with prolonged antibiotics. In ID3, an occult intraoperative distal femoral fracture was initially treated conservatively. A consecutive varus/flexion deformity and residual ipsilateral limb length discrepancy was addressed via distal femoral osteotomy and retrograde femoral growing nail implantation.</p><p><strong>Conclusion: </strong>The Precice® BTN can be used for reconstruction of diaphyseal long bone defects in patients with primary malignant tumors; however, candidate patients have to be thoroughly counselled regarding the prolonged immobilization and partial weight-bearing period associated with the lengthening procedure as well as risk for complications and revision surgery.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}