Zeitschrift fur Geburtshilfe und Neonatologie最新文献

{"title":"[Evaluation of a tertiary perinatal center's preterm birth rate before and after a changed therapy management].","authors":"Tobias Florian Poeplau, Johanna Katharina Weide, Lara Ilona Becker, Siegmund Köhler, Matthias Kalder","doi":"10.1055/a-2869-2148","DOIUrl":"10.1055/a-2869-2148","url":null,"abstract":"<p><strong>Introduction: </strong>Preterm birth is a major adverse event during pregnancy. It is the leading cause of neonatal death and neonatal morbidity and produces a significant socioeconomic burden. Therefore, prevention of preterm birth must be a primary objective in obstetrics.</p><p><strong>Introduction: </strong>The aim of this publication is to evaluate the preterm birth rate at a tertiary care perinatal center before and after a change in treatment protocol.</p><p><strong>Material and methods: </strong>We conducted a retrospective analysis of the birth statistics between the federal average and a tertiary care perinatal center from 2003 to 2008 (3,931,833 children born including 358,059 preterm; 7,638 children born including 1,370 preterm) and 2016 to 2021 (4,614,669 children born including 383,675 preterm; 11,363 children born including 1,439 preterm).</p><p><strong>Results: </strong>The preterm birth rate at the examined university hospital has been decreasing further than the nationwide comparison (18.0% to 12.9% vs. 9.1% to 8.3%; p<0.05). The absolute and relative reductions show the same result (5.1%, 28.1% vs. 0.8%, 8.67%; p<0.05).</p><p><strong>Conclusion: </strong>Since the implementation of probiotics, cerclage pessaries, and PAMG-1-tests, a significant reduction of the examined center's preterm birth rate has been observed.</p><p><strong>Conclusion: </strong>So far, prevention of preterm birth has not been included in the quality indicators of perinatal centers; the authors suggest reconsidering this aspect.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"425-431"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory, Immuno-Nutritional, and Composite Stress Indices in Previable Preterm Premature Rupture of Membranes.","authors":"Ilayda Gercik Arzik, Hale Ankara Aktas, Zubeyde Emiralioglu Cakir, Ilknur Toka, Burak Bayraktar, Raziye Torun, Ceren Saglam Purut, Emre Bayram, Esra Bozcelik, Hakan Golbasi","doi":"10.1055/a-2824-1036","DOIUrl":"10.1055/a-2824-1036","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate inflammatory, immuno-nutritional, and composite stress indices derived from routine laboratory parameters in pregnancies complicated by previable preterm premature rupture of membranes (PPROM) and compare these with gestational age-matched healthy controls.</p><p><strong>Methods: </strong>This retrospective cohort included 50 women with previable PPROM before 22 weeks and 50 gestational age-matched controls. Hematological and biochemical parameters obtained within 24 hours of admission were used to calculate neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), systemic immune-inflammation index (SII), white blood cell-to-albumin ratio (WAR), neutrophil-to-albumin ratio (NAR), neutrophil-to-lymphocyte-to-albumin ratio (NLAR), lymphocyte-to-albumin ratio (LAR), platelet-to-albumin ratio (PAR), platelet-to-lymphocyte ratio (PLR), and hemoglobin-to-albumin ratio (HAR). In addition, a novel hemato-immuno-nutritional impairment index (HINI) and newly proposed composite stress-reserve indices-composite stress index (CSI), inflammation-over-reserve index (IORI), thrombo-hemoglobin composite index (THCI), and global composite systemic index (GCSI)-were evaluated. Statistical comparisons, age-adjusted logistic regression, and receiver operating characteristic analysis were performed.</p><p><strong>Results: </strong>In age-adjusted logistic regression analyses, only NLR, dNLR, SII, WAR, NAR, NLAR, CSI, IORI, and GCSI remained independently associated with PPROM, whereas other evaluated indices did not retain statistical significance. Receiver operating characteristic analysis demonstrated the strongest discriminatory performance for NAR, NLAR, and IORI.</p><p><strong>Conclusion: </strong>Previable PPROM is characterized by acute neutrophil-dominant inflammation. Combined indices integrating inflammatory activity with physiological reserve, especially NAR, NLAR, and IORI, may improve early identification of affected pregnancies.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"411-418"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Late termination of pregnancy beyond 14+0 weeks of gestation: indication, methodology and complications, a retrospective analysis from 2008-2024].","authors":"Paula Hintz, Ivonne Bedei, Felix Zöllner, Johanna Schenk, Cindy Degenhardt, Aline Wolter, Ellydda Widriani, Roland Axt-Fliedner, Anita Windhorst","doi":"10.1055/a-2773-3034","DOIUrl":"10.1055/a-2773-3034","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study is to present the medical indications, diagnostic procedures, fetal pathologies, and timing of abortions for medical reasons after the 12+0 week of pregnancy (p.c.) as well as to examine the influence of the introduction of NIPT on the timing and pattern of indications.</p><p><strong>Methods: </strong>Retrospective analysis of 561 abortions from the 12+0 week of pregnancy at a university hospital between 2008 and 2024. Diagnoses are based on ultrasound examinations, invasive prenatal diagnostic procedures, and molecular genetic analyses. Statistical evaluations were performed descriptively and inferentially.</p><p><strong>Results: </strong>The most common indications were chromosomal abnormalities (38.1%), followed by malformations of the CNS (22.4%) and multiple malformations (17.0%). Terminations of pregnancy before the 24+0 week of gestation occurred significantly earlier and more frequently in cases of chromosomal abnormalities, while malformations of the CNS dominated after the 24+0 week of gestation. Complications in the mother were rare overall (4%), no maternal deaths. The introduction of NIPT led to an earlier diagnosis of chromosomal abnormalities.</p><p><strong>Conclusion: </strong>Medically indicated abortions are safe and have a low complication rate in mothers. The most common indications relate to chromosomal abnormalities and malformations of the central nervous system. The introduction of NIPT tends to enable earlier diagnosis of fetal chromosomal abnormalities. Further long-term observations are necessary to fully assess the impact of NIPT.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"400-410"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Missed Target of Ocular Prophylaxis: Neonatal Chlamydia trachomatis.","authors":"Beritan Aplak, Döndü Nilay Penezoğlu, Ferhan Demirtas, Ahmet Erkantarcı, Zeynep Beyza Tağluk, Esra Şahlı, Halil Özdemir, Ömer Erdeve","doi":"10.1055/a-2798-9421","DOIUrl":"10.1055/a-2798-9421","url":null,"abstract":"","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"457-459"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Serum Periostin as a Potential Biomarker for Gestational Diabetes Mellitus and Adverse Perinatal Outcomes.","authors":"Semra Eroglu, Neset Gumusburun, Sebati Sinan Urkmez, Yeşim Civil Ürkmez, Samettin Çelik, Kübra Şahin","doi":"10.1055/a-2827-9333","DOIUrl":"10.1055/a-2827-9333","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether maternal serum periostin levels measured in the second trimester can serve as a biomarker for gestational diabetes mellitus (GDM) and predict perinatal outcomes.</p><p><strong>Methods: </strong>This prospective case-control study included 173 pregnant women (103 with GDM and 70 healthy controls). Serum periostin levels were measured between 15-20 weeks of gestation. GDM was diagnosed using a 75-g oral glucose tolerance test at 24-28 weeks. Receiver operating characteristic (ROC) analysis and logistic regression were used to evaluate diagnostic performance.</p><p><strong>Results: </strong>Serum periostin levels were significantly higher in the GDM group compared to controls (median: 50.7 vs. 33.7 ng/mL, p<0.001). Periostin showed moderate diagnostic accuracy for GDM (AUC: 0.752). Higher periostin levels were associated with cesarean delivery, neonatal intensive care unit admission, and meconium-stained amniotic fluid.</p><p><strong>Conclusion: </strong>Elevated maternal serum periostin levels in the second trimester are associated with gestational diabetes msellitus and adverse perinatal outcomes. Periostin may serve as a supplementary biomarker for early identification of GDM.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"419-424"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thanatophoric Dysplasia Type 1 with Severe Pulmonary Hypoplasia: Discharge after Tracheostomy.","authors":"Hasan Akduman, Canan Atak, Hüseyin Başkan, Abdülkerim Kolkıran, Firdevs Dinçsoy Bir, İsmail Bulut","doi":"10.1055/a-2866-9555","DOIUrl":"10.1055/a-2866-9555","url":null,"abstract":"","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"460-462"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148219922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Influence of Shift Timing on Mortality Rates in <32-Week Preterm Infants.","authors":"Mustafa Senol Akin, Ufuk Cakir","doi":"10.1055/a-2830-7916","DOIUrl":"10.1055/a-2830-7916","url":null,"abstract":"<p><strong>Introduction: </strong>Quality of continuous patient care is crucial in neonatal intensive care units (NICUs). Staff numbers and intervention timings may vary with working hours, potentially affecting clinical outcomes. However, the effect of on- and off-duty hours on neonatal mortality remains unclear. This study examined the clinical data of deceased premature infants during these hours and assessed mortality frequency over time.</p><p><strong>Materials and methods: </strong>A retrospective cohort analysis was performed at a single institution, focusing on deceased infants born at ≤ 32 weeks' gestation (WG). The study classified patients based on their time of death using two methods: on-duty versus off-duty periods and three consecutive eight-hour shifts across the day.</p><p><strong>Results: </strong>Overall, 256 deceased premature infants (on-duty group: 66 (25.8%); off-duty group: 190 (74.2%)) were enrolled. The off-duty period lasted approximately three times longer than the on-duty period, with a corresponding three-fold increase in the mortality rate. During off-duty hours, the number of medical doctors was 4.5 times fewer than that during on-duty hours. Nevertheless, mortality rates per unit time were comparable between the groups. Additionally, the clinical characteristics and morbidities of patients across the groups exhibited similar profiles.</p><p><strong>Conclusion: </strong>Despite a 4.5-fold decrease in physicians working during off-duty hours in our NICU, the mortality and morbidity rates for infants born at or before 32 WG remained unchanged.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"432-438"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amniotic Band Sequence Mimicking Genetic Limb Reduction Defects.","authors":"Akshay Mehta, Bhawna Malik","doi":"10.1055/a-2843-8333","DOIUrl":"10.1055/a-2843-8333","url":null,"abstract":"","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"455-456"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"„Guter Hoffnung“ – optimistisches Plädoyer oder euphemistisches Lippenbekenntnis inmitten medizinethischer Grenzbereiche.","authors":"Alexander Strauss","doi":"10.1055/a-2926-2027","DOIUrl":"https://doi.org/10.1055/a-2926-2027","url":null,"abstract":"","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":"230 5","pages":"369-370"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Pelvic Abscess After Cesarean Section Successfully Treated with Laparoscopic Excision: A case Report.","authors":"Irem Herguner, Melik Kaan Bengi, Taylan Onat","doi":"10.1055/a-2859-1125","DOIUrl":"10.1055/a-2859-1125","url":null,"abstract":"","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"452-454"},"PeriodicalIF":0.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}