Zeitschrift fur Geburtshilfe und Neonatologie最新文献

{"title":"The Immunohistochemical and Bioinformatics Analysis of the Placental Expressions of Vascular Cell Adhesion Protein 1 (VCAM-1) and High Mobility Group Box 1 (HMGB1) Proteins in Gestational Diabetic Mothers.","authors":"Süleyman Cemil Oğlak, Fırat Aşır, Emine Zeynep Yılmaz, Gökhan Bolluk, Tuğcan Korak, Elif Ağaçayak","doi":"10.1055/a-2451-2223","DOIUrl":"10.1055/a-2451-2223","url":null,"abstract":"<p><strong>Objective: </strong>  We aimed to examine both the expression levels of high mobility group box 1 (HMGB1) and vascular cell adhesion molecule-1 (VCAM-1) proteins in the placentas of pregnant women with gestational diabetes mellitus (GDM) and control groups by immunohistochemical (IHC) method.</p><p><strong>Material and methods: </strong>  An experimental case-control study was conducted, including 40 pregnant women complicated with GDM and 40 healthy pregnant women. Placental tissues obtained following cesarean delivery were subjected to routine tissue monitoring. The placental sections were stained with VCAM-1 and HMGB1 immunostains and subjected to IHC examination under a light microscope. H-score (HS) was used to evaluate the results of IHC staining by semi-quantitative analysis. Pathway analysis in Cytoscape software identified GDM-associated proteins within HMGB1 and VCAM-1 interaction networks, followed by GO analysis to explore associated biological processes.</p><p><strong>Results: </strong>  Placental HGMB1 expression was significantly increased in the GDM group compared to the control group (p<0.001). However, placental VCAM-1 expression was found to be statistically similar in GDM and control groups (p=0.584). The shared 19 proteins were identified between HMGB1 and GDM, and 13 between VCAM-1 and GDM, with notable GO biological process terms such as immune system activation for HMGB1 and interleukin-6 regulation for VCAM-1 associated with GDM.</p><p><strong>Conclusion: </strong>  We consider that GDM-related inflammation and oxidative stress may contribute to tissue damage and inflammation by increasing placental HMGB1 expression. The blockade of HMGB1 and its receptors might represent a promising therapeutic approach to control inflammation in GDM. Understanding the distinct roles of HMGB1 and VCAM-1 may provide valuable insights for the development of targeted therapies aimed at mitigating the inflammatory processes associated with GDM and improving maternal and fetal outcomes.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"90-98"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geburtshilfliches Prozedere und postpartale Mutter-Kind-Interaktion.","authors":"Dominique Singer","doi":"10.1055/a-2533-3408","DOIUrl":"https://doi.org/10.1055/a-2533-3408","url":null,"abstract":"","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":"229 2","pages":"81"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Episiotomy Applied in Vaginal Delivery on Breastfeeding Self-Efficacy and Mother-Infant Attachment in the Postpartum Period.","authors":"Tuğba Yılmaz Esencan, Ayça Demir Yıldırım, Mehtap Yıldız","doi":"10.1055/a-2532-3897","DOIUrl":"10.1055/a-2532-3897","url":null,"abstract":"<p><p>The aim of this study was to examine the effect of episiotomy applied in vaginal delivery on breastfeeding self-efficacy and mother-infant attachment in the postpartum period.This descriptive study includes 110 puerperal women who were registered in 3 family health centers in a district in Istanbul between July and December 2022 and had a vaginal delivery. Data was collected using a descriptive information form, maternal bonding scale and postpartum breastfeeding self-efficacy scale.The mean age of the participants was 30.04±5.13 years. 61.9% of the puerperal women were multiparous, the mean gestational age at delivery was 39±1.21 weeks, and 72.7% had an episiotomy at delivery. There was a statistically significant correlation between the number of deliveries, having problems during labor, and episiotomy application (p=0.005, p=0.044). There was no statistically significant difference between the maternal bonding scale scores and postpartumbreastfeeding self-efficacy scale scores of women who underwent episiotomy at delivery and women who did not.Episiotomy alone had no effect on maternal bonding and postpartum breastfeeding self-efficacy, and episiotomy-induced pain was found to be an effective factor in the postpartum period.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"116-123"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of enhanced recovery in women undergoing cesarean delivery improves breastfeeding and maternal perioperative outcomes.","authors":"Duygu Yıldız Birden, Alper Başbuğ, Engin Yurtcu, İbrahim Kale","doi":"10.1055/a-2529-5424","DOIUrl":"10.1055/a-2529-5424","url":null,"abstract":"<p><p>The study aimed to evaluate delivery outcomes after implementation of the Enhanced Recovery After Surgery (ERAS) protocol in patients delivered by cesarean section (CD).This randomized controlled prospective study was conducted on 78 pregnant women who underwent CD with the ERAS protocol and 78 pregnant women who under went standard perioperative care. We compared the time to first flatus, visual pain score (VAS), the success of breastfeeding, time to initiation of breastfeeding, time to return to daily activities, hemoglobin values, the incidence of postoperative nausea and vomiting, hospital readmission rates, postoperative wound infection rates, incidence of postpartum blues, and the need for blood transfusion between two groups.Time to first flatus, VAS score, time to initiation of breastfeeding, and time to return to activities of daily living were significantly lower in the ERAS group (p<0.001 for all). The rate of successful breastfeeding was significantly higher in the ERAS group (p<0.001). Both groups were similar in terms of other parameters.Implementation of ERAS after CD shortens the breastfeeding initiation time and increases rates of successful breastfeeding. ERAS protocols implemented in CD improve perioperative outcomes such as visual pain score and time to resume daily activities.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"124-130"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Diagnosis of a Bucket Handle Imperforate Anus.","authors":"Christelle Destinval, Jean-Louis Lemelle","doi":"10.1055/a-2481-5464","DOIUrl":"https://doi.org/10.1055/a-2481-5464","url":null,"abstract":"","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":"229 2","pages":"148-149"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal Gastroschisis: Maternal Epidemiologic Profile and Influence of Possible Risk Factors on Neonatal Outcomes.","authors":"Thalita Diógenes Muniz, Liliam Cristine Rolo, Edward Araujo Júnior","doi":"10.1055/a-2442-7557","DOIUrl":"10.1055/a-2442-7557","url":null,"abstract":"<p><strong>Objective: </strong>  The aim of this study was to evaluate the maternal epidemiological profile for gastroschisis as well as to assess whether the presence of meconium at birth was associated with adverse neonatal outcomes.</p><p><strong>Methods: </strong>  This was a retrospective observational cohort study that included 52 neonates with gastroschisis whose mothers had delivery at our service. The variables observed were the following: 1) socio-demographic data, 2) ultrasonographic data, 3) birth data, and 4) neonatal outcomes. Simple (univariate) and multiple (multivariate) logistic regression models were used to examine the influence of meconium on neonatal outcomes.</p><p><strong>Results: </strong>  Mean maternal age and body mass index (BMI) of the pregnant women were 21.9 years and 23.3 kg/m2, respectively. There was a similarity between mixed (50%) and white (48.1%) races, and 27.7% (13) reported to use an oral contraceptive (OC). Mean birth weight was 2,386.9 grams, and 24 of the neonates (46.2%) were premature (<37 weeks). The majority of neonates had neonatal sepsis (40.4%) and 39 were admitted to the neonatal intensive care unit with a median length of stay of 31 days. Forty neonates required mechanical ventilation, with a median duration of 5 days. Primary closure was achieved in 50% (26) of cases. Although not significant and with low precision, the point estimate suggested that the presence of meconium at birth, on average, reduced the chance of primary closure (OR=0.26, CI 95% [0.06; 1.16], p=0.077).</p><p><strong>Conclusion: </strong>  Pregnant women with gastroschisis fetuses were more likely to be young, primigravida, with a normal BMI, white or mixed, and with a history of OC use. There was no evidence of an association between the presence of meconium at birth and adverse perinatal outcomes.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"108-115"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Primary and secondary cerclage in high-risk pregnant women: Influence on prolongation of pregnancy and preterm birth].","authors":"Filiz Markfeld-Erol, Julia Meschede, Maximilian Klar, Ingolf Juhasz-Böss, Mirjam Kunze","doi":"10.1055/a-2467-8698","DOIUrl":"10.1055/a-2467-8698","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to evaluate the effectiveness of cerclage in women with previous late miscarriages or premature births. The primary aim was to prolong pregnancy and achieve a term delivery. Secondarily, it was investigated whether an intervention after an early pathological 75-g-oGTT result influences these endpoints.</p><p><strong>Methods: </strong>A total of 133 cases were analyzed retrospectively. 80 women underwent primary cerclage between the 14th and 16th week of pregnancy; 53 women underwent secondary cerclage after cervical shortening of less than 25 mm. This group was further subdivided into therapeutic and emergency cerclage groups. Women with early pathologic 75-g-oGTT were treated diabetologically.</p><p><strong>Results: </strong>Primary cerclage prolonged pregnancy by 20.6 weeks and led to a term delivery in 51 women (63.8%). In the group with secondary cerclage, 25 women (47.2%) had a term delivery with a prolongation of 20.1 weeks. For amniotic sac prolapse, the prolongation was 7.9 weeks. Pathological 75-g-oGTT results were found in 63 women. Early intervention had no significant effect on prolongation and term delivery.</p><p><strong>Conclusion: </strong>Primary cerclage was more effective in achieving term delivery. Women with therapeutic cerclage without amniotic sac prolapse also benefited. With cervical shortening without prolapse, the prolongation was the same in both groups. The worst outcome was observed in emergency cerclage with amniotic sac prolapse. An early 75-g-oGTT is important in order to recognize and treat gestational diabetes in time.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"99-107"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Is the structure of perinatal care in Germany responsible for the less-than-optimal, merely average results in European comparison regarding rates for both infant and maternal mortality as well as rates of premature birth?]","authors":"Rainer Rossi","doi":"10.1055/a-2550-6215","DOIUrl":"https://doi.org/10.1055/a-2550-6215","url":null,"abstract":"<p><p>The outcomes of perinatal care in Germany in terms of infant mortality and prematurity rates remain only at the European average. Neither medical factors, such as maternal age, nor socioeconomic data sufficiently explain these differences. Perinatal care in Germany in characterized by a high number of obstetric units with relatively low annual deliveries; almost half of these units are not directly linked to a pediatric department. In contrast, Northern European countries have substantially larger obstectric units in terms of annual deliveries, and these are almost invariably integrated with pediatric departments. This structure of perinatal care is associated with significantly lower prematurity rates - particularly for gestational ages below 28 weeks - as well as reduced infant mortality rates, despite requiring longer travel distances. Consequently, these epidemiological differences should be considered in healthcare planning, and obstetric units should be exclusively organized in conjunction with pediatric departments to optimize outcomes.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram of the width, length, and area of the fetal optic chiasm according to gestational week.","authors":"Aytakin Mahammadaliyeva, Ayşegül Özel, İbrahim Kale","doi":"10.1055/a-2550-6724","DOIUrl":"10.1055/a-2550-6724","url":null,"abstract":"<p><p>Using transabdominal 2D ultrasonography, we aimed to establish nomograms for fetal optic chiasm (OC) width, length, and area between 16-37 weeks of gestation.OC measurements were performed by a resident and a perinatologist. An agreement was evaluated using intraclass correlation coefficients (ICCs) with 95% confidence intervals. Then, nomogram tables of OC width, length, and area measurements were derived using these measurements. A strong positive correlation was found between OC measurements and gestational week (GW) (r=0.873 for width, r=0.827 for length, r=0.863 for area; p<0.001). The regression equations obtained were: OC width=1.164+0.206×GW, OC length=0.072+0.180×GW, OC area =-25.226+2.228×GW. Interobserver agreement was high, with ICC values of 0.798 for width, 0.705 for length, and 0.758 for area, indicating consistent measurements between observers.This is the first study to establish normative data and nomograms for OC dimensions. Our findings confirm that OC width, length, and area increase linearly with advancing gestation. The high interobserver reliability suggests that these measurements can be reliably used in clinical practice and future research.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Correlation of Vitamin D Concentrations in Healthy Pregnant Women and Their Infants with Outcome Parameters.","authors":"Marjana Jerković Raguž, Tatjana Barišić, Ivanka Mikulić, Vinka Mikulic, Ivona Šušak, Vajdana Tomic","doi":"10.1055/a-2542-2818","DOIUrl":"https://doi.org/10.1055/a-2542-2818","url":null,"abstract":"<p><p>The objective of this prospective study was to assess the concentration and impact of maternal 25(OH)D status on neonatal vitamin D concentrations and early neonatal outcomes in the newborns of mothers who did not take vitamin D supplements during pregnancy. The study is a cohort prospective study of the correlation of VD concentrations in mothers and their newborns. The study included 100 pairs. Only 16 mothers had a VD concentration in the reference interval (75-100 nmol/L), while 84 mothers had values less than 75 nmol/L (p<0.001). A significant difference in maternal VD concentration was determined in relation to tobacco consumption habits during pregnancy and placental condition (p<0.001). 95% of the neonates (95/100) of older, obese multigravida, who had hypovitaminosis D and inadequate exposure to sunshine, had normal VD concentrations (the mean=49.27 nmol/L) on the first day of life. The majority of the mothers gave birth to full-termnewborns with normal vitality scores and CRP and bilirubin levels in the reference interval. The conclusion of this prospective study is that 84% of the healthy pregnant women had hypovitaminosis D. However 95% of their newborns were born full term, with normal anthropometric measurements, normal vitality scores, and normal VD concentrations. This study also confirmed that there is still no cause-and-effect association between hypovitaminosis D in pregnant women and their offspring with outcome parameters for both.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}