Zeitschrift fur Geburtshilfe und Neonatologie最新文献

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Full trisomy 14 in one of bichorionic biamniotic twins. 双绒毛膜双胎中的一胎出现完全的 14 三体综合征。
IF 0.7 4区 医学
Zeitschrift fur Geburtshilfe und Neonatologie Pub Date : 2024-04-01 Epub Date: 2024-01-09 DOI: 10.1055/a-2215-6984
Dubravko Habek, Anis Cerovac
{"title":"Full trisomy 14 in one of bichorionic biamniotic twins.","authors":"Dubravko Habek, Anis Cerovac","doi":"10.1055/a-2215-6984","DOIUrl":"10.1055/a-2215-6984","url":null,"abstract":"<p><p>We describe the case of the lethal full trisomy (T) 14 in a fetus from bichorionic biamniotic (BCBA) twin pregnancy. This is a case of a 28-year-old primigravida, with an unremarkable personal and family history, who just like her 30-year-old husband, was without consanguinity between spouses. She conceived spontaneously, without a burdened gynecological-obstetric history. By the 12th week of pregnancy, she had hyperemesis gravidarum and one episode of bleeding due to which progesterone supplementation was prescribed. Due to asymptomatic bacteriuria, she took cefuroxime axetil in the 13th week of pregnancy and azithromycin in the 15th week due to cervicitis with ureaplasma urealyticum.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"196-197"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139404614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the "Neonatal Sequential Organ Failure Assessment" to Predict Mortality in Late-Onset Sepsis in Very Preterm Infants. 评估 "新生儿序贯器官衰竭评估 "以预测极早产儿晚期败血症的死亡率。
IF 0.7 4区 医学
Zeitschrift fur Geburtshilfe und Neonatologie Pub Date : 2024-04-01 Epub Date: 2023-12-11 DOI: 10.1055/a-2165-8307
Elvis Kraja, Ferhan Demirtas, Yasemin Ezgi Kostekci, Nazmiye Turker, Emel Okulu, Ömer Erdeve, Begum Atasay, Saadet Arsan
{"title":"Evaluation of the \"Neonatal Sequential Organ Failure Assessment\" to Predict Mortality in Late-Onset Sepsis in Very Preterm Infants.","authors":"Elvis Kraja, Ferhan Demirtas, Yasemin Ezgi Kostekci, Nazmiye Turker, Emel Okulu, Ömer Erdeve, Begum Atasay, Saadet Arsan","doi":"10.1055/a-2165-8307","DOIUrl":"10.1055/a-2165-8307","url":null,"abstract":"<p><strong>Introduction: </strong>We aimed to evaluate the use of \"Neonatal Sequential Organ Failure Assessment\" (nSOFA) scoring in predicting mortality, to compare the accuracy of nSOFA scores at different time points in very preterm infants with late-onset sepsis (LOS), and to investigate other possible parameters that would improve the prediction.</p><p><strong>Methods: </strong>This single-center, retrospective study included preterm infants born atS<32 weeks' gestation with culture-proven LOS. The nSOFA scores of non-fatal and fatal episodes were compared at nine time points.</p><p><strong>Results: </strong>Of 120 culture-proven LOS episodes in 106 infants, 90 (75%) episodes were non-fatal and 30 (25%) episodes were fatal. The mean birth weight (BW) of the infants who died was lower than that of survivors (p=0.038). In the fatal LOS episodes, median nSOFA scores were higher at all time points measured before sepsis evaluation, at the time of evaluation, and at all time points measured after the evaluation (p<0.001). nSOFA scores before death and at 48 hours were higher in the fatal episodes (p<0.001). At the time of sepsis assessment, nSOFA score>4 was associated with a 7- to 16-fold increased risk of mortality. Adjustment for BW, lymphocyte and monocyte counts increased the risk to 9- to 18-fold.</p><p><strong>Conclusion: </strong>This study demonstrated that the use of nSOFA to predict mortality and morbidity in extremely preterm infants seems feasible. The scoring system could be improved by evaluating the other parameters.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"174-180"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138803934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Characteristics and Outcome of Neonates With Postnatally Diagnosed Congenital Diaphragmatic Hernia]. [产后确诊先天性膈疝新生儿的特征和预后]。
IF 0.7 4区 医学
Zeitschrift fur Geburtshilfe und Neonatologie Pub Date : 2024-04-01 Epub Date: 2023-12-15 DOI: 10.1055/a-2198-8950
Bartolomeo B L Bo, Lotte Lemloh, Lennart Hale, Andreas Heydweiller, Brigitte Strizek, Charlotte Bendixen, Lukas Schroeder, Andreas Mueller, Florian Kipfmueller
{"title":"[Characteristics and Outcome of Neonates With Postnatally Diagnosed Congenital Diaphragmatic Hernia].","authors":"Bartolomeo B L Bo, Lotte Lemloh, Lennart Hale, Andreas Heydweiller, Brigitte Strizek, Charlotte Bendixen, Lukas Schroeder, Andreas Mueller, Florian Kipfmueller","doi":"10.1055/a-2198-8950","DOIUrl":"10.1055/a-2198-8950","url":null,"abstract":"<p><strong>Introduction: </strong>Congenital diaphragmatic hernia (CDH) is one of the most severe neonatal malformations with a mortality of 20-35%. Currently, the rate of prenatally recognized CDHs is 60-80%. This study investigated the characteristics and outcome data of children with prenatally unrecognized CDH.</p><p><strong>Methods: </strong>Postnatally diagnosed CDH newborns treated at the University Hospital Bonn between 2012 and 2021 were included. Treatment and outcome data were compared according to type of maternity hospital, Apgar values, and between prenatally and postnatally diagnosed CDH.</p><p><strong>Results: </strong>Of 244 CDH newborns, 22 were included. Comparison for birth in a facility with vs. without pediatric care showed for mortality: 9% vs. 27%, p=0.478; ECMO rate: 9% vs. 36%, p=0.300; age at diagnosis: 84 vs. 129 min, p=0.049; time between intubation and diagnosis: 20 vs. 86 min, p=0.019. Newborns in the second group showed significantly worse values for pH and pCO2. Furthermore, there was a tendency for higher mortality and ECMO rates in children with an Apgar score<7 vs.≥7. Children diagnosed postnatally were significantly more likely to have moderate or severe PH and tended to have cardiac dysfunction more often than those diagnosed prenatally.</p><p><strong>Discussion: </strong>In our cohort, ca. one in 10 newborns received a postnatal CDH diagnosis. Birth in a facility without pediatric care is associated with later diagnosis, which may favor hypercapnia/acidosis and more severe pulm.</p><p><strong>Hypertension: </strong></p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"181-187"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138803911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First-trimester neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and systemic immune-response index (SIRI) as predictors of composite adverse outcomes in pregnant women with Familial Mediterranean fever. 中性粒细胞与淋巴细胞比率(NLR)、全身免疫炎症指数(SII)和全身免疫反应指数(SIRI)作为家族性地中海热孕妇综合不良后果的预测指标。
IF 0.7 4区 医学
Zeitschrift fur Geburtshilfe und Neonatologie Pub Date : 2024-04-01 Epub Date: 2023-08-17 DOI: 10.1055/a-2125-0973
Refaettin Sahin, Atakan Tanacan, Hakki Serbetci, Busra Karagoz, Zahid Agaoglu, Ozgur Kara, Dilek Sahin
{"title":"First-trimester neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and systemic immune-response index (SIRI) as predictors of composite adverse outcomes in pregnant women with Familial Mediterranean fever.","authors":"Refaettin Sahin, Atakan Tanacan, Hakki Serbetci, Busra Karagoz, Zahid Agaoglu, Ozgur Kara, Dilek Sahin","doi":"10.1055/a-2125-0973","DOIUrl":"10.1055/a-2125-0973","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the utility of the neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and systemic immune-response index (SIRI) in the prediction of adverse pregnancy outcomes in pregnant women with Familial Mediterranean fever (FMF) MATERIAL AND METHODS: This retrospective case-control study was conducted between 2019-2023. First-trimester NLR, SII (NLR X platelet count), and SIRI (NLR X monocyte count) values were compared between pregnant women with FMF (n=85) and without FMF (n=105). Thereafter, pregnant women with FMF were divided into two groups: 1) FMF with perinatal complications (n=30), and 2) FMF without perinatal complications (n=55). NLR, SII, and SIRI values were compared between the two subgroups. Finally, an ROC analysis was performed to determine optimal cut-off values for NLR, SII, and SIRI in the prediction of composite adverse pregnancy outcomes.</p><p><strong>Results: </strong>The FMF group had significantly higher first-trimester NLR, SII, and SIRI values compared to the controls. The FMF with perinatal complications group had significantly higher NLR, SII, and SIRI values than the FMF group without perinatal complications (p<0.05). Optimal cut-off values were 4.89 (80% sensitivity, 78.2% specificity), 1180.6 (76.7% sensitivity, 72.7% specificity), and 1.9 (83.3% sensitivity,72.7% specificity) for NLR, SII, and SIRI, respectively.</p><p><strong>Conclusion: </strong>SII, SIRI, and NLR may be used to predict adverse pregnancy outcomes in pregnant women with FMF.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"156-160"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10021519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extraperitoneal Cesarean Section after two Medial Laparotomies, Anus Prater, and Surgical Treatment of the Rectovaginal Fistula in a Patient with Crohn's Disease: A Case Report. 克罗恩病患者腹膜外剖宫产术后两次内腹手术,肛门吻合术和直肠阴道瘘手术治疗:1例报告。
IF 0.7 4区 医学
Zeitschrift fur Geburtshilfe und Neonatologie Pub Date : 2024-04-01 Epub Date: 2023-12-06 DOI: 10.1055/a-2200-9504
Boris Bačić, Zlatko Hrgović, Anis Cerovac, Ognjen Barčot, Jelena Sabljić, Stipe Dumančić, Blagoja Markoski, Mateo Leskur
{"title":"Extraperitoneal Cesarean Section after two Medial Laparotomies, Anus Prater, and Surgical Treatment of the Rectovaginal Fistula in a Patient with Crohn's Disease: A Case Report.","authors":"Boris Bačić, Zlatko Hrgović, Anis Cerovac, Ognjen Barčot, Jelena Sabljić, Stipe Dumančić, Blagoja Markoski, Mateo Leskur","doi":"10.1055/a-2200-9504","DOIUrl":"10.1055/a-2200-9504","url":null,"abstract":"<p><p>The aim of this case report is to show the advantages of the extraperitoneal cesarean section (ECS) approach in a pregnant patient with multiple previous abdominal transperitoneal colon surgeries and Crohn's disease. A pregnant nulliparous woman with Crohn's disease was admitted for delivery. After delivery, a large rupture and lesion of the rectum was observed. Suturing of the vagina, rectum and sphincter was performed by an abdominal surgeon. Because of a very large and irregularly shaped rectum rupture, the patient underwent infraumbilical medial laparotomy and sigmoidostomy. After 18 months, the patient started to experience vaginal discharge and Y-shaped rectovaginal fistula was confirmed. Surgical reconstruction was performed. The patient's second pregnancy began one year later. At 38 weeks of pregnancy, elective extraperitoneal cesarean section was performed. A healthy newborn was delivered. Follow-up showed full and fast recovery after the ECS. In cases of pregnant women who have had multiple colon surgeries, gynecology surgeons can choose to perform an ECS to avoid transperitoneal entrance into the abdomen. ECS avoids lysis of postoperative adhesions after repetitive gastrointestinal surgeries, the formation of new adhesions by lysis of the old adhesions, and most importantly, the possibility of colon or small intestine lesions during lysis of dense or firm adhesions.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"192-195"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138499570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Perinatal Networks: Ensuring Regional Care of Pregnant Woman and Newborns]. [围产期网络:确保为孕妇和新生儿提供区域护理]。
IF 0.7 4区 医学
Zeitschrift fur Geburtshilfe und Neonatologie Pub Date : 2024-04-01 Epub Date: 2024-02-16 DOI: 10.1055/a-2211-7018
Mario Rüdiger, Jörg Reichert, Jochen Schmitt, Cahit Birdir
{"title":"[Perinatal Networks: Ensuring Regional Care of Pregnant Woman and Newborns].","authors":"Mario Rüdiger, Jörg Reichert, Jochen Schmitt, Cahit Birdir","doi":"10.1055/a-2211-7018","DOIUrl":"10.1055/a-2211-7018","url":null,"abstract":"<p><p>Health care of pregnant women and their newborns is facing major challenges due to the decline in birth rate and shortage of specialists. In the current discussion about future concepts, the centralization associated with minimum quantities and the necessary safeguarding of care in the area are often construed as conflicting goals. Instead, concepts are needed to guarantee that pregnant women and their children will continue to receive care close to home. The example of the saxony center for feto/neonatal health is used to show how partners in a region can jointly ensure care during pregnancy, birth and the neonatal period on a supra-local and cross-hospital basis. The close cooperation of maximum care providers with regional partners enables comprehensive health care. At the same time, this cooperation enables hospitals to remain attractive employers in structurally weak regions and to provide comprehensive care for young families in need of medical services related to pregnancy and birth through good family and social integration close to home and work. The overriding goals of the saxony center for feto/neonatal health are optimal, guideline-based, interdisciplinary and intersectoral care of pregnant women and premature or sick newborns in the region.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"127-134"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11014747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139747532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Legal Compliance of Medical Information in the Case of a Relatively Indicated Secondary Caesarean Section in Obstetric Clinics in Germany - Part I: Status Quo-Survey]. [德国产科诊所相对指示性的二次剖腹产手术中医疗信息的法律合规性——第一部分:现状调查]。
IF 0.7 4区 医学
Zeitschrift fur Geburtshilfe und Neonatologie Pub Date : 2024-04-01 Epub Date: 2023-10-18 DOI: 10.1055/a-2183-8841
Alexandra Marina Jaster, Peter Wolfgang Gaidzik, Sven Schiermeier
{"title":"[Legal Compliance of Medical Information in the Case of a Relatively Indicated Secondary Caesarean Section in Obstetric Clinics in Germany - Part I: Status Quo-Survey].","authors":"Alexandra Marina Jaster, Peter Wolfgang Gaidzik, Sven Schiermeier","doi":"10.1055/a-2183-8841","DOIUrl":"10.1055/a-2183-8841","url":null,"abstract":"<p><strong>Introduction: </strong>In order to guarantee the patient's right to self-determination, in the case of a relative indication for a secondary caesarean section the Supreme Court expects early information about this real treatment alternative and the patient's option to choose the delivery method. The aim of this study throughout Germany was to survey the status quo of legal compliance of the practice of providing information at all German obstetric clinics and a further comparison based on the clinic format.</p><p><strong>Methods: </strong>All obstetric clinics in Germany were emailed within the context of an anonymous online study using a questionnaire developed on the basis of the BGH judgment of August 28, 2018 (AZ: VI ZR 509/17). Three questions had to be answered cumulatively with \"yes\" to affirm legal compliance. The responding clinics were divided into six groups based on their format (status as university hospital / other hospitals stratified by number of births per year).</p><p><strong>Results: </strong>93 questionnaires were analyzed. 14 clinics (15.05%) met the requirements. Clinics with an annual number of births of 1,000-1,499 perform best in comparison.</p><p><strong>Conclusion: </strong>There is an urgent need for a secure, legally compliant information concept for everyday birth practice in German clinics.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"151-155"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49682946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minimally Invasive Cesarean Section - Extraperitoneal Cesarean Section. The Outcomes of Applying to the Same Patient More than Once. Case Series. 微创剖腹产 - 腹膜外剖腹产。对同一患者多次应用的结果。病例系列。
IF 0.7 4区 医学
Zeitschrift fur Geburtshilfe und Neonatologie Pub Date : 2024-04-01 Epub Date: 2023-12-14 DOI: 10.1055/a-2215-3145
Aytaj Jafarzade
{"title":"Minimally Invasive Cesarean Section - Extraperitoneal Cesarean Section. The Outcomes of Applying to the Same Patient More than Once. Case Series.","authors":"Aytaj Jafarzade","doi":"10.1055/a-2215-3145","DOIUrl":"10.1055/a-2215-3145","url":null,"abstract":"<p><strong>Background: </strong>Extraperitoneal caesarean section (EPCS) provides intraoperative and postoperative advantages to patients compared to transperitoneal (TPCS). Nevertheless, it is less preferred.</p><p><strong>Methods: </strong>Extraperitoneal caesarean section (EPCS) is a type of caesarean section performed without entering the peritoneal cavity.</p><p><strong>Results: </strong>In this study, EPCS was successfully performed again in patients who had previously undergone EPCS.</p><p><strong>Conclusion: </strong>This method, which reduces maternal mortality and health expenditures, can be performed more than once.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"188-191"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Influence of Fetomaternal Risk Factors on Mortality and Morbidity in Extremely Preterm Infants]. [孕产妇风险因素对极早产儿死亡率和发病率的影响]。
IF 0.7 4区 医学
Zeitschrift fur Geburtshilfe und Neonatologie Pub Date : 2024-04-01 Epub Date: 2023-12-11 DOI: 10.1055/a-2198-9124
Paula Winkler, Eva Cloppenburg, Axel Heep, Eduard Malik, Dörte Lüdders, Matthias Lange
{"title":"[Influence of Fetomaternal Risk Factors on Mortality and Morbidity in Extremely Preterm Infants].","authors":"Paula Winkler, Eva Cloppenburg, Axel Heep, Eduard Malik, Dörte Lüdders, Matthias Lange","doi":"10.1055/a-2198-9124","DOIUrl":"10.1055/a-2198-9124","url":null,"abstract":"<p><strong>Introduction: </strong>The management of pregnant women at risk of preterm delivery poses a challenge to the interdisciplinary team. At the edge of viability, it is crucial to take into consideration maternal and fetal risk factors when determining individual counseling and therapeutic approaches.</p><p><strong>Methods: </strong>At a level 4 perinatal center, all preterm infants (PI) born in the years 2017 to 2020 who had a gestational age between 23<sup>0/7</sup> and 24<sup>6/7</sup> weeks and were cared for with a curative therapeutic approach were enrolled in a retrospective observational study. Divided into two groups (23<sup>0/7</sup>-23<sup>6/7</sup> and 24<sup>0/7</sup>-24<sup>6/7</sup> weeks of gestation), the PI were compared in terms of mortality and morbidity based on maternal and fetal risk factors. Thirteen risk factors and their prognostic relevance for survival were analyzed.</p><p><strong>Results: </strong>41 mothers with 48 PI were included. 9 neonates received primary palliative treatment and were excluded from the analyses. The survival rates between the two groups (n=21, n=27) showed no significant difference (66.7% versus 74.1%, p=0.750). A significantly higher mortality was observed in PI with an increased number of risk factors (p=0.004), the most severe of which were hypertensive disorders of pregnancy and preterm premature rupture of membranes. Data regarding morbidity showed no significant difference.</p><p><strong>Conclusion: </strong>Data regarding mortality correlate with national findings. Observed morbidity in the study population was recorded. The prediction of probability of survival is more precise when risk factors are taken into consideration.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"166-173"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19, Pregnancy, and Diabetes Mellitus. 新冠肺炎、妊娠和糖尿病。
IF 0.7 4区 医学
Zeitschrift fur Geburtshilfe und Neonatologie Pub Date : 2024-02-01 Epub Date: 2023-11-02 DOI: 10.1055/a-2180-7715
Helmut J Kleinwechter, Katharina S Weber, Tatjana P Liedtke, Ute Schäfer-Graf, Tanja Groten, Mario Rüdiger, Ulrich Pecks
{"title":"COVID-19, Pregnancy, and Diabetes Mellitus.","authors":"Helmut J Kleinwechter, Katharina S Weber, Tatjana P Liedtke, Ute Schäfer-Graf, Tanja Groten, Mario Rüdiger, Ulrich Pecks","doi":"10.1055/a-2180-7715","DOIUrl":"10.1055/a-2180-7715","url":null,"abstract":"<p><p>During the severe acute respiratory distress virus coronavirus type 2 (SARS-CoV-2) pandemic, many women were infected during their pregnancies. The SARS-CoV-2-induced coronavirus disease 19 (COVID-19) has an impact on maternal health and pregnancy outcomes; peripartum and perinatal morbidity and mortality are increased. Pregnancy is considered a risk factor for severe COVID-19 course. Additional risk factors during pregnancy are diabetes mellitus, gestational diabetes mellitus (GDM), and obesity. Systemic inflammation can lead to severe metabolic dysregulation with ketoacidosis. The endocrine pancreas is a target organ for SARS-CoV-2 and the fetal risk depends on inflammation of the placenta. Up to now there is no evidence that SARS-CoV-2 infection during pregnancy leads to permanent diabetes in mothers or their offspring via triggering autoimmunity or beta cell destruction. The frequently observed increased prevalence of GDM compared to the years before the pandemic is most likely due to changed lifestyle during lockdown. Furthermore, severe COVID-19 may be associated with the development of GDM due to worsening of glucose tolerance. Vaccination with a mRNA vaccine is safe and highly effective to prevent infection and to reduce hospitalization. Registries support offering evidence-based recommendations on vaccination for pregnant women. Even with the current omicron virus variant, there are increased risks for symptomatic and unvaccinated pregnant women.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"17-31"},"PeriodicalIF":0.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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