World Journal of Gastroenterology最新文献

{"title":"Endoscopic resection of oesophageal gastrointestinal stromal tumours: Promise, pitfalls and the path forward.","authors":"Ashwin Krishnamoorthy, Ewen A Griffiths","doi":"10.3748/wjg.v31.i34.110448","DOIUrl":"10.3748/wjg.v31.i34.110448","url":null,"abstract":"<p><p>Oesophageal gastrointestinal stromal tumours are rare, anatomically challenging lesions with higher surgical morbidity than their gastric counterparts. Emerging endoscopic resection techniques such as endoscopic submucosal dissection and submucosal tunnelling endoscopic resection show much promise for the management of patients who are not fit for, or wish to avoid the morbidity of, major surgical resection. These techniques require careful patient selection and advanced technical skills. We build on the recent review of such techniques by Vogli <i>et al</i>. Current evidence is limited to small case series with heterogeneity in patient selection, tumor size, and outcomes. Notably, long-term oncological data remain sparse, and complications such as bleeding or perforation may be life-threatening in patients unfit for surgical rescue. Nonetheless, endoscopic approaches have many potential advantages to offer such as preserved quality of life and definitive management of unfit patients.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 34","pages":"110448"},"PeriodicalIF":5.4,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiparametric magnetic resonance imaging of deep learning-based super-resolution reconstruction for predicting histopathologic grade in hepatocellular carcinoma.","authors":"Zi-Zheng Wang, Shao-Ming Song, Gong Zhang, Rui-Qiu Chen, Zhuo-Chao Zhang, Rong Liu","doi":"10.3748/wjg.v31.i34.111541","DOIUrl":"10.3748/wjg.v31.i34.111541","url":null,"abstract":"<p><strong>Background: </strong>Deep learning-based super-resolution (SR) reconstruction can obtain high-quality images with more detailed information.</p><p><strong>Aim: </strong>To compare multiparametric normal-resolution (NR) and SR magnetic resonance imaging (MRI) in predicting the histopathologic grade in hepatocellular carcinoma.</p><p><strong>Methods: </strong>We retrospectively analyzed a total of 826 patients from two medical centers (training 459; validation 196; test 171). T2-weighted imaging, diffusion-weighted imaging, and portal venous phases were collected. Tumor segmentations were conducted automatically by 3D U-Net. Based on generative adversarial network, we utilized 3D SR reconstruction to produce SR MRI. Radiomics models were developed and validated by XGBoost and Catboost. The predictive efficiency was demonstrated by calibration curves, decision curve analysis, area under the curve (AUC) and net reclassification index (NRI).</p><p><strong>Results: </strong>We extracted 3045 radiomic features from both NR and SR MRI, retaining 29 and 28 features, respectively. For XGBoost models, SR MRI yielded higher AUC value than NR MRI in the validation and test cohorts (0.83 <i>vs</i> 0.79; 0.80 <i>vs</i> 0.78), respectively. Consistent trends were seen in CatBoost models: SR MRI achieved AUCs of 0.89 and 0.80 compared to NR MRI's 0.81 and 0.76. NRI indicated that the SR MRI models could improve the prediction accuracy by -1.6% to 20.9% compared to the NR MRI models.</p><p><strong>Conclusion: </strong>Deep learning-based SR MRI could improve the predictive performance of histopathologic grade in HCC. It may be a powerful tool for better stratification management for patients with operable HCC.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 34","pages":"111541"},"PeriodicalIF":5.4,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural killer cell-based immunotherapies for colorectal cancer: Current strategies, challenges, and future perspectives.","authors":"Xiao-Jun Zhang, Yan Yu, Jing-Yu Li, Yu-Zhu Yan, Sha-Sha Jiang, Yi Zhang, Qin Fei, Yi-Ran Zhang, Yong-Xin Zhao, Lei Guo, Jing Lv, He-Ping Zhao","doi":"10.3748/wjg.v31.i34.110051","DOIUrl":"10.3748/wjg.v31.i34.110051","url":null,"abstract":"<p><p>Natural killer (NK) cells have emerged as promising therapeutic agents for treating colorectal cancer because of their innate ability to recognize and eliminate tumor cells without prior sensitization. In this review, NK cell-based immunotherapeutic approaches, including cytokine therapy, immune checkpoint inhibition, antibody-dependent cellular cytotoxicity, and adoptive cell transfer, are comprehensively examined, and their respective clinical potential and limitations are highlighted. We discuss critical challenges in NK cell expansion, genetic engineering (particularly chimeric antigen receptor-NK development), and tumor microenvironment-mediated immunosuppression. Furthermore, we explore innovative strategies such as combination therapies, nanotechnology-enhanced delivery, and personalized medicine approaches that aim to overcome the current barriers. The review concludes with future directions emphasizing the need for standardized manufacturing protocols, new strategies to improve NK cell persistence, and clinical validation of emerging technologies, positioning NK cell immunotherapy as a transformative modality for colorectal cancer treatment.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 34","pages":"110051"},"PeriodicalIF":5.4,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dark green urine following endoscopic ultrasound-guided hepaticogastrostomy: A case report.","authors":"Ke-Yi Zhang, Qi He, Yu Jin, Jun Liu, Rong Lin, Chao-Qun Han","doi":"10.3748/wjg.v31.i34.109900","DOIUrl":"10.3748/wjg.v31.i34.109900","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic ultrasound-guided biliary drainage, including endoscopic ultrasound-guided choledochoduodenostomy and endoscopic ultrasound-guided hepatogastrostomy (EUS-HGS), is an efficacious alternative to endoscopic retrograde cholangiopancreatography and its common complications are bile leak, infection, stent migration and bleeding. Here, we report an atypical case of a patient who developed unexplained dark green urine after receiving EUS-HGS, which we suspected to be caused by an abnormal biliary-vascular fistula.</p><p><strong>Case summary: </strong>A 76-year-old woman diagnosed with pancreatic adenocarcinoma received EUS-HGS for relieving jaundice. The patient reported abdominal pain and chest tightness after the operation, with difficulty in urinating. X-ray suggested right-sided pleural effusion and dark green pleural effusion was drained out. However, the patient also developed dark green urine, which appeared everyday afternoon and disappeared automatically after intravenous treatment. The previous pleural effusion disappeared after one week, but later the patient showed an increase of ascites, and the lesions were compartmentalized and encapsulated internally.</p><p><strong>Conclusion: </strong>Postoperative surveillance after EUS-HGS must be emphasized to check for in order to prevent severe and hidden complications.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 34","pages":"109900"},"PeriodicalIF":5.4,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Image analysis of cardiac hepatopathy secondary to heart failure: Machine learning <i>vs</i> gastroenterologists and radiologists.","authors":"Suguru Miida, Hiroteru Kamimura, Shinya Fujiki, Taichi Kobayashi, Saori Endo, Hiroki Maruyama, Tomoaki Yoshida, Yusuke Watanabe, Naruhiro Kimura, Hiroyuki Abe, Akira Sakamaki, Takeshi Yokoo, Masanori Tsukada, Fujito Numano, Takeshi Kashimura, Takayuki Inomata, Yuma Fuzawa, Tetsuhiro Hirata, Yosuke Horii, Hiroyuki Ishikawa, Hirofumi Nonaka, Kenya Kamimura, Shuji Terai","doi":"10.3748/wjg.v31.i34.108807","DOIUrl":"10.3748/wjg.v31.i34.108807","url":null,"abstract":"<p><strong>Background: </strong>Congestive hepatopathy, also known as nutmeg liver, is liver damage secondary to chronic heart failure (HF). Its morphological characteristics in terms of medical imaging are not defined and remain unclear.</p><p><strong>Aim: </strong>To leverage machine learning to capture imaging features of congestive hepatopathy using incidentally acquired computed tomography (CT) scans.</p><p><strong>Methods: </strong>We retrospectively analyzed 179 chronic HF patients who underwent echocardiography and CT within one year. Right HF severity was classified into three grades. Liver CT images at the paraumbilical vein level were used to develop a ResNet-based machine learning model to predict tricuspid regurgitation (TR) severity. Model accuracy was compared with that of six gastroenterology and four radiology experts.</p><p><strong>Results: </strong>In the included patients, 120 were male (mean age: 73.1 ± 14.4 years). The accuracy of the results predicting TR severity from a single CT image for the machine learning model was significantly higher than the average accuracy of the experts. The model was found to be exceptionally reliable for predicting severe TR.</p><p><strong>Conclusion: </strong>Deep learning models, particularly those using ResNet architectures, can help identify morphological changes associated with TR severity, aiding in early liver dysfunction detection in patients with HF, thereby improving outcomes.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 34","pages":"108807"},"PeriodicalIF":5.4,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided percutaneous thermal and non-thermal ablation of intrahepatic cholangiocarcinoma.","authors":"Antonio Giorgio, Emanuela Ciracì, Massimo De Luca, Giuseppe Stella, Valeria C Rollo, Luca Montesarchio, Valentina Giorgio","doi":"10.3748/wjg.v31.i34.108623","DOIUrl":"10.3748/wjg.v31.i34.108623","url":null,"abstract":"<p><p>Ultrasound-guided percutaneous thermal ablation has gained popularity as treatment for malignant hepatic tumors. It was first introduced as ablation therapy for hepatocellular carcinoma and cirrhosis comorbidity. Recently, this technique has also been used in the treatment of intrahepatic cholangiocarcinoma for patients who are not eligible for surgical resection. There are several types of thermal ablation techniques. Radiofrequency ablation and microwave ablation are two common methods that induce necrosis of the lesions. Irreversible electroporation is a relatively new non-thermal technique and is suitable in cases where thermal ablation would be ineffective or dangerous (<i>e.g.</i>, malignant tumors close to vascular or biliary structures). Irreversible electroporation can induce tumoral necrosis without damage to vascular and biliary structures. The aim of this minireview was to describe the safety, efficacy, and clinical indications of these techniques in the treatment of patients with intrahepatic cholangiocarcinoma who are ineligible for surgery.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 34","pages":"108623"},"PeriodicalIF":5.4,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum homocysteine-based traffic light triage colonoscopy screening in colorectal cancer at-risk patients: A prospective cohort study.","authors":"Francisco Xavier Cano, José María Duque, Lucia Seoane, Miguel Puga-Tejada, Alejandra Espinoza de Los Monteros, Pablo Bermeo, Eduardo Junquera, Daniel Pérez, Jimmy Martin-Delgado, Monica Santelli, Carla Pérez, Francisco Javier Pérez Rivera","doi":"10.3748/wjg.v31.i34.109718","DOIUrl":"10.3748/wjg.v31.i34.109718","url":null,"abstract":"<p><strong>Background: </strong>Elevated plasma homocysteine (Hcy) levels are associated with increased risk of colorectal cancer (CRC), particularly in patients with systemic inflammation or chronic conditions.</p><p><strong>Aim: </strong>To evaluate serum Hcy levels as a predictive marker of lesion risk and CRC to prioritize patients undergoing diagnostic colonoscopy.</p><p><strong>Methods: </strong>We conducted a prospective cohort study of 301 fecal occult blood test-positive patients at San Agustín University Hospital in Asturias, Spain. Plasma Hcy levels were measured prior to the colonoscopy and classified into three thresholds: ≤ 12, 12-15, and > 15 μmol/L. Colonoscopy and histopathology determined the presence of low-risk, high-risk polyps or adenocarcinoma. Predictive performance of serum Hcy to detect lesions was assessed using logistic regression and diagnostic accuracy measures, including models adjusted for age and sex.</p><p><strong>Results: </strong>Median Hcy levels rose progressively with lesion severity, reaching 15.3 μmol/L in adenocarcinoma (<i>P</i> < 0.001). Higher levels were also observed in men and individuals aged 65 or older. A threshold above 15 μmol/L showed good sensitivity (76.6%) and positive predictive value (87.2%) for detecting adenocarcinoma. When combined with age and sex, predictive accuracy improved (area under the receiver operating characteristic curve = 0.706). Based on these findings, we propose a three-tier triage system: Green (≤ 12 μmol/L in both sexes, colonoscopy within three months), Yellow (> 12-15 μmol/L in men, intervention within one month and red (≥ 15 in either sex or > 12 μmol/L in women, immediate colonoscopy).</p><p><strong>Conclusion: </strong>Serum Hcy is a clinically useful biomarker for identifying high-risk colorectal lesions and cancer, particularly when interpreted in combination with age and sex. This composite model improves predictive accuracy and enables a structured three-tiered triage system that supports faster colonoscopy scheduling for at-risk groups. The traffic light approach offers a low cost, scalable strategy to reduce delays and optimize resource use in CRC screening, especially in public health systems with limited endoscopic capacity.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 34","pages":"109718"},"PeriodicalIF":5.4,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dopamine receptor D1-mediated suppression of liver fibrosis <i>via</i> Hippo/Yes-associated protein 1 signaling in levodopa treatment.","authors":"Hai-Yan Wang, Man-Man Qi, Kai Zhang, Yu-Zhao Zhu, Jian Zhang","doi":"10.3748/wjg.v31.i34.108617","DOIUrl":"10.3748/wjg.v31.i34.108617","url":null,"abstract":"<p><strong>Background: </strong>Yes-associated protein 1 (YAP1), a downstream transcriptional coactivator regulated by the Hippo signaling pathway, has been shown to be involved in liver fibrosis. YAP activity is modulated by G-protein coupled receptors, including Gα s-coupled protein dopamine receptor D1 (DRD1). Levodopa, a dopamine precursor, activates DRD1 on cell surface, triggering its downstream signaling pathway.</p><p><strong>Aim: </strong>To investigate the therapeutic effect of levodopa and the downstream mechanism on carbon tetrachloride (CCl₄)-induced liver fibrosis, including liver DRD1 expression.</p><p><strong>Methods: </strong>SD rats were intraperitoneally injected with 40% CCl₄ for 8 weeks to induce liver fibrosis, followed by treatment with varying doses of levodopa for 2 weeks. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured, and liver pathology was assessed using hematoxylin and eosin and Masson's staining. Alpha-smooth muscle actin (α-SMA) content, along with the expressions of DRD1, YAP, and phosphorylated protein, was analyzed by Western blot, immunohistochemistry, and reverse transcription-quantitative real-time polymerase chain reaction.</p><p><strong>Results: </strong>Compared with the controls, levodopa-treated rats showed a decrease in the proportion of collagen in the liver and a recovery from liver fibrosis (<i>P</i> = 0.0007). Western blot and immunohistochemistry indicated that DRD1 was upregulated in the fibrotic liver of rats treated with levodopa, showing an increase in DRD1 Level (<i>P</i> < 0.0001). In addition, the upregulation of DRD1 activated the Hippo signaling pathway, manifested as increased YAP phosphorylation (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>This was the first study to demonstrate that levodopa attenuates CCl₄-induced liver fibrosis by inhibiting the Hippo/YAP signaling pathways.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 34","pages":"108617"},"PeriodicalIF":5.4,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging in perianal fistulising Crohn's disease: A practical guide for the gastroenterologist.","authors":"Habeeb Habeeb, Lynna Chen, Isabelle De Kock, Gauraang Bhatnagar, Numan Kutaiba, Abhinav Vasudevan, Ashish R Srinivasan","doi":"10.3748/wjg.v31.i34.110611","DOIUrl":"10.3748/wjg.v31.i34.110611","url":null,"abstract":"<p><p>Perianal fistulising Crohn's disease is a challenging complication that can affect up to 20% of patients with Crohn's disease and is associated with significant morbidity. Despite advances in medical therapies, particularly anti-tumor necrosis factor agents, the majority of patients still require surgical intervention. Accurate diagnosis and monitoring are essential to optimise outcomes and guide multidisciplinary management. Although clinical scoring systems such as the perianal disease activity index are widely used, their subjective application limits their reproducibility and reliability, underscoring the need for more objective methods of evaluating perianal fistulising Crohn's disease activity. Imaging has thus become central to the objective assessment of perianal fistulising Crohn's disease, with magnetic resonance imaging (MRI) recognised as the gold standard in view of its ability to provide clear, detailed images of the perianal region in a radiation-free manner. Guidelines also endorse the use of imaging modalities such as endoanal ultrasound and transperineal ultrasound as viable alternatives to MRI for the assessment of perianal fistulising Crohn's disease in centres with appropriate expertise. This article aims to evaluate and compare the diagnostic accuracy and clinical utility of MRI, endoanal ultrasound, and transperineal ultrasound in the assessment of perianal fistulising Crohn's disease, highlighting their respective strengths, limitations, and roles in clinical practice.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 34","pages":"110611"},"PeriodicalIF":5.4,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B cell CLL/lymphoma 10 promotes colorectal cancer cell proliferation and regulates cuproptosis sensitivity through the NF-κB signaling pathway.","authors":"Peng-Tuo Xiao, Chang-Feng Li, Yuan-Da Liu, Jing Zhong, Xi-Lun Cui, Chang Liu, Wei Yang","doi":"10.3748/wjg.v31.i34.109825","DOIUrl":"10.3748/wjg.v31.i34.109825","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) is a major global health burden. B cell CLL/lymphoma 10 (BCL10), a key component of the caspase recruitment domain protein-BCL10-mucosa-associated lymphoid tissue lymphoma paracaspase complexes, is upregulated in CRC and associated with poor patient prognosis, suggesting its potential role in CRC development and progression. Cuproptosis, a novel form of programmed cell death, has emerged as a promising therapeutic strategy for cancer.</p><p><strong>Aim: </strong>To explore the role of BCL10 in regulating the sensitivity of CRC cells to cuproptosis.</p><p><strong>Methods: </strong>A series of <i>in vitro</i> and <i>in vivo</i> experiments were conducted using CRC cell lines and CRC mouse models to evaluate the effects of BCL10 on CRC cell proliferation, migration, invasion, and sensitivity to copper-induced cell death. Mechanistic studies were performed to elucidate the underlying molecular pathways.</p><p><strong>Results: </strong>BCL10 promoted CRC cell proliferation, migration, and invasion, while its knockdown had the opposite effects. BCL10 also influenced the sensitivity of CRC cells to cuproptosis, with BCL10 overexpression enhancing resistance and its knockdown increasing sensitivity. The mechanism involved BCL10 modulating the expression of DLAT, a key protein in the copper-induced cell death pathway, through activation of the nuclear factor kappa-B (NF-κB) signaling pathway.</p><p><strong>Conclusion: </strong>BCL10 promotes CRC growth and regulates the sensitivity of CRC cells to cuproptosis by activating the NF-κB signaling pathway and modulating DLAT expression. These findings provide a molecular basis for developing BCL10-targeted therapies for CRC.</p>","PeriodicalId":23778,"journal":{"name":"World Journal of Gastroenterology","volume":"31 34","pages":"109825"},"PeriodicalIF":5.4,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}