Yonsei Medical Journal最新文献

{"title":"Joint Effect of Inflammatory Dietary Patterns and Physical Activity on the Risk of Depressive Symptoms: A Nation-Wide Cross-Sectional Study.","authors":"Kim Thai Thien Nguyen, Juyeon Ko, Jaelim Cho","doi":"10.3349/ymj.2024.0172","DOIUrl":"10.3349/ymj.2024.0172","url":null,"abstract":"<p><strong>Purpose: </strong>Depression is a major global public health concern. Diet and physical activity are major modifiable lifestyle factors associated with depression; however, their joint effects have not been fully addressed. This cross-sectional study aimed to quantitatively examine the interaction between physical activity and inflammatory nutrients in depression and utilized Bayesian kernel machine regression (BKMR) models to compare the effects of inflammatory nutrients on depression in individuals with and without physical activity.</p><p><strong>Materials and methods: </strong>The inflammatory diet was assessed using the dietary inflammatory index (DII), while physical activity levels were measured using the Global Physical Activity Questionnaire, with sufficient physical activity defined as achieving 600 metabolic equivalent task minutes per week. Depression was defined as a 9-item Patient Health Questionnaire score of ≥10. We used multiple logistic regression and BKMR models to investigate the associations between the DII and depression, with all models adjusted for covariates.</p><p><strong>Results: </strong>A total of 4110 participants from the 2020 Korea National Health and Nutrition Examination Survey were included in this study. Notably, participants with higher total DII scores were more likely to have depressive symptoms, and the additive interaction between insufficient physical activity and inflammatory nutrients was attributed to a 36% risk of depression. Moreover, BKMR analyses showed that individuals with insufficient physical activity exhibited a greater risk of depression posed by pro-inflammatory dietary patterns and did not benefit from anti-inflammatory dietary patterns with regard to the risk of depression.</p><p><strong>Conclusion: </strong>Comprehensive plans for diet control and increased physical activity are essential to help prevent depression.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 7","pages":"446-455"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopausal Hormone Therapy and the Risk of Stroke: A Nationwide Cohort Study.","authors":"Sung Pil Choo, Hyunji Park, Hyemin Park, Inha Lee, Sihyun Cho, Changsoo Kim, Kyung-Yul Lee, Jae Hoon Lee, Jong-Youn Kim","doi":"10.3349/ymj.2024.0053","DOIUrl":"10.3349/ymj.2024.0053","url":null,"abstract":"<p><strong>Purpose: </strong>Most studies have reported that the risk of coronary heart disease decreases when menopausal hormone therapy (MHT) is initiated before the age of 60 years or within 10 years of menopause. However, the findings regarding stroke risk remain conflicting. This study investigated the association between the risk of ischemic stroke and MHT, categorized by the type of MHT.</p><p><strong>Materials and methods: </strong>This population-based, retrospective cohort study was based on the Korean National Health Insurance Service-National Sample Cohort (2004-2015). Participants were aged 45-60 years with no cardiovascular disease or preexisting stroke, classified as never, past, and current users of MHT.</p><p><strong>Results: </strong>Among the study participants, 16915 (88.77%) women had never undergone MHT, 1437 (7.54%) had previously undergone MHT, and 703 (3.69%) were currently using MHT. During the study period, with a mean follow-up of 11.23±2.13 years, the risk of ischemic events was significantly higher among current users [hazard ratio (HR): 2.98, 95% confidence interval (CI): 1.95-4.57, <i>p</i><0.001], particularly in those using estrogen-only MHT (HR: 3.49, 95% CI: 1.12-10.90, <i>p</i>=0.032) and tibolone (HR: 3.52, 95% CI: 2.05-6.03, <i>p</i><0.001), compared to never users. Meanwhile, no significant difference in the risk of ischemic events was observed between past users and never users, even after analyses accounting for estrogen type and progestin co-administration.</p><p><strong>Conclusion: </strong>Women currently receiving MHT without underlying cardiovascular disease exhibited an increased risk of ischemic stroke, particularly those treated with E-only MHT or tibolone. However, this increased risk returned to baseline after discontinuing MHT, indicating that past use of MHT was not associated with an increased risk of ischemic stroke.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 7","pages":"429-437"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Pluripotent Stem Cell-Based Therapies for Parkinson's Disease: Challenges and Potential Solutions.","authors":"Mi-Yoon Chang, Sang-Hun Lee","doi":"10.3349/ymj.2024.0447","DOIUrl":"10.3349/ymj.2024.0447","url":null,"abstract":"<p><p>Over 20 years of research on human pluripotent stem cell (hPSC)-based therapies for Parkinson's disease (PD) has recently culminated in clinical trials. The first clinical report on autologous transplantation of patient-derived hPSCs showed significant motor symptom improvement, validating the therapeutic promise of this approach. However, critical challenges remain, notably the limited engraftment and survival of donor cells. Cellular stress incurred during in vitro differentiation of hPSCs into midbrain dopaminergic progenitors and neurons contributes to the reduced survival of grafted mDA neurons. Additionally, the host brain environment at the injection sites becomes hostile to transplanted cells due to needle trauma, immune rejection, and alpha-synuclein pathology present in the brains of PD patients. This review discusses potential strategies to address both intrinsic donor cell stress and hostile host brain environment, aiming to enhance the long-term efficacy and engraftment of hPSC-based cell therapies for PD.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 7","pages":"395-404"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Detection of Seroreactivity to Lyme Borreliosis in Agricultural Workers from a Non-Endemic Region of South Korea.","authors":"Jeong Rae Yoo, Miyeon Kim, Wooseong Jeong, Sung Wook Song","doi":"10.3349/ymj.2024.0376","DOIUrl":"10.3349/ymj.2024.0376","url":null,"abstract":"","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 7","pages":"456-458"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Large Language Models for Answering Cancer-Related Questions in Korean.","authors":"Hyun Chang, Jin-Woo Jung, Yongho Kim","doi":"10.3349/ymj.2024.0200","DOIUrl":"10.3349/ymj.2024.0200","url":null,"abstract":"<p><strong>Purpose: </strong>Large language models (LLMs) have shown potential in medicine, transforming patient education, clinical decision support, and medical research. However, the effectiveness of LLMs in providing accurate medical information, particularly in non-English languages, remains underexplored. This study aimed to compare the quality of responses generated by ChatGPT and Naver's CLOVA X to cancer-related questions posed in Korean.</p><p><strong>Materials and methods: </strong>The study involved selecting cancer-related questions from the National Cancer Institute and Korean National Cancer Information Center websites. Responses were generated using ChatGPT and CLOVA X, and three oncologists assessed their quality using the Global Quality Score (GQS). The readability of the responses generated by ChatGPT and CLOVA X was calculated using KReaD, an artificial intelligence-based tool designed to objectively assess the complexity of Korean texts and reader comprehension.</p><p><strong>Results: </strong>The Wilcoxon test for the GQS score of answers using ChatGPT and CLOVA X showed that there is no statistically significant difference in quality between the two LLMs (<i>p</i>>0.05). The chi-square statistic for the variables \"Good rating\" and \"Poor rating\" showed no significant difference in the quality of responses between the two LLMs (<i>p</i>>0.05). KReaD scores were higher for CLOVA X than for ChatGPT (<i>p</i>=0.036). The categorical data analysis for the variables \"Easy to read\" and \"Hard to read\" revealed no significant difference (<i>p</i>>0.05).</p><p><strong>Conclusion: </strong>Both ChatGPT and CLOVA X answered Korean-language cancer-related questions with no significant difference in overall quality.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 7","pages":"405-411"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undertriage of Severe Geriatric Trauma Patients: Who Are We Missing?","authors":"Jiye Park, Yo Huh, Seoyoung Song, Sora Kim, Jayoung Yoo, Kyoungwon Jung, Donghwan Choi","doi":"10.3349/ymj.2024.0215","DOIUrl":"10.3349/ymj.2024.0215","url":null,"abstract":"<p><strong>Purpose: </strong>Geriatric trauma patients have unique risk factors for being undertriaged, which differ from those in young trauma patients. This study aimed to identify these risk factors and their implications for public health stakeholders and trauma surgeons to improve prehospital triage of geriatric trauma patients.</p><p><strong>Materials and methods: </strong>Data were retrospectively reviewed from single level-1 trauma center database in patients aged ≥65 years, with Injury Severity Score (ISS) >15 between 2016 and 2020. Pre-hospital and hospital factors were compared between correctly triaged and undertriaged patients. The probabilities of survival and outcomes for correct and undertriage were calculated using the Trauma and Injury Severity Score (TRISS), observed (O):expected (E) ratio, z-score, and w-score.</p><p><strong>Results: </strong>A total of 512 patients were included in the study; 401 (78%) were correctly triaged and 111 (22%) were undertriaged. Correct triage group presented significant z-score (correct triage: 4.29 vs. undertriage: -0.11), w-score (correct triage: 7.79 vs. undertriage: 4.29), and O:E ratio of mortality (correct triage: 0.73 vs. undertriage: 1.66). Undertriaged patients were older (77 [72-82] vs. 73 [68-80], <i>p</i><0.001), had a higher women proportion (53% vs. 34%, <i>p</i><0.001), had lower ISS (25 [17-25] vs. 27 [19-38], <i>p</i><0.001), and had more head and neck injuries (89% vs. 65%, <i>p</i><0.001). On multivariable logistic regression, female sex (odds ratio 2.55, 95% confidence interval [1.07-6.09], <i>p</i>=0.034), ground fall injury (5.82 [1.89-17.91], <i>p</i>=0.002), prehospital systolic blood pressure <110 mm Hg (0.13 [0.03-0.67], <i>p</i>=0.003), and presence of cerebrovascular disease (5.53 [1.35-22.68], <i>p</i>=0.018) were significantly associated with undertriage.</p><p><strong>Conclusion: </strong>Geriatric trauma patients were undertriaged when they were women, sustained ground-level fall injuries, the more alert in the scene, and had cerebrovascular disease. Trauma surgeons and fire agency stakeholders should collaborate to create geriatric-specific triage guidelines and educate paramedics about these risk factors to prevent undertriage in this patient population.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 7","pages":"438-445"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of COX-2 Selectivity in Pain Medication Use with Endometriosis Incidence: Retrospective Cohort Study.","authors":"Jongchan Park, Hye Jin Chang, Kyung Joo Hwang, Sun Hyung Yum, Chang Eun Park, Joo Hee Kim, Miran Kim","doi":"10.3349/ymj.2024.0255","DOIUrl":"10.3349/ymj.2024.0255","url":null,"abstract":"<p><strong>Purpose: </strong>This retrospective cohort study aimed to investigate the association between the use of pain medications with varying cyclooxygenase-2 (COX-2) selectivity and the incidence of endometriosis (EMS) in women.</p><p><strong>Materials and methods: </strong>Medical records from January 1, 1994, to December 31, 2022, were retrospectively analyzed. The cohort included 33406 patients diagnosed with any pain-related condition who were prescribed either selective COX-2 inhibitors or nonsteroidal anti-inflammatory drugs (NSAIDs). Patients were followed for up to 5 years from the cohort entry date. The incidence of EMS was compared between the two medication groups using Cox proportional hazards models, adjusting for confounding factors such as age, past drug use, and prior diagnosis.</p><p><strong>Results: </strong>The incidence rates of EMS were 3.00 per 1000 person-years in the COX-2 inhibitor group and 3.97 per 1000 person-years in the NSAIDs group. After adjustment for confounders, the hazard ratio for EMS incidence in the COX-2 inhibitor group compared to the NSAIDs group was 0.77 [95% confidence interval (CI), 0.63 to 0.93; <i>p</i><0.01], indicating a significantly lower risk in the COX-2 inhibitor group. Subgroup analysis revealed that this association was particularly significant in younger women aged 20-44 years, with a hazard ratio of 0.71 (95% CI, 0.54 to 0.95; <i>p</i><0.05) in this age group.</p><p><strong>Conclusion: </strong>The findings suggest that COX-2 inhibitors may reduce the incidence of EMS compared to traditional NSAIDs, highlighting their potential as a strategic option for managing EMS, particularly among younger women. Further prospective studies are needed to confirm these findings.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 6","pages":"374-382"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient with Behçet Syndrome with Subaortic Pseudoaneurysm Who Underwent the Bentall Operation Showed Improvement after Medical Treatment.","authors":"Hanbyul Lee, Chang Sin Kim, Jo Won Jung, Han Ki Park, Jong Gyun Ahn","doi":"10.3349/ymj.2023.0186","DOIUrl":"10.3349/ymj.2023.0186","url":null,"abstract":"<p><p>Aortic regurgitation (AR) in children is usually caused by congenital valve anomalies, and Behçet syndrome (BS) can be suspected in cases of isolated AR. Patients with BS undergoing aortic valve surgery due to aortic valve invasion have a high risk of complications, such as leakage around the valve and dehiscence. Cardiovascular involvement occurs in 7%-46% of adult patients with BS and is the main cause of mortality; however, its prevalence is unclear and rare in children. A 12-year-old boy was diagnosed with severe AR associated with BS. A progressive subaortic pseudoaneurysm was observed after aortic valve replacement. The periaortic intracardiac pouch was at risk of rupture; therefore, the patient underwent a Bentall operation. After the Bentall procedure, a newly developed subaortic pseudoaneurysm was detected below the prosthetic valve. However, the risk of rupture reduced as the subaortic pseudoaneurysm regressed with anti-inflammatory drugs alone without reoperation. Repeated surgery is inevitable in patients with BS undergoing aortic valve surgery due to the progressive chronic inflammatory reactions that present with a pseudoaneurysm. Here, we report an 8-year follow-up of a pediatric case of BS with subaortic pseudoaneurysm, highlighting the importance of close follow-up, medical management, and early diagnosis in treating this condition.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 6","pages":"390-394"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of T Cell-Mediated Immune Signaling Network During Pathogenesis of Chronic Obstructive Pulmonary Disease.","authors":"Chae Min Lee, Andrew Sehoon Kim, Minki Kim, Jae Woong Jeong, Sugyeong Jo, Nahee Hwang, Sungsoon Fang","doi":"10.3349/ymj.2024.0227","DOIUrl":"10.3349/ymj.2024.0227","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic obstructive pulmonary disease (COPD) is characterized by alveolar destruction and increased inflammation, leading to respiratory symptoms. This study aimed to identify the traits for COPD progression from mild to severe stages. Additionally, we explored the correlation between coronavirus disease-2019 (COVID-19) and COPD to uncover overlapping respiratory patterns.</p><p><strong>Materials and methods: </strong>Bulk RNA sequencing was conducted on data from 43 healthy individuals and 39 COPD patients across one dataset (GSE239897) to distinguish COPD characteristics. Single-cell RNA analysis was then performed on samples from seven mild patients, seven moderate patients, and three severe patients from three datasets (GSE167295, GSE173896, and GSE227691) to analyze disease progression. Finally, single-nuclei RNA analysis was applied to data from seven healthy individuals and 20 COVID-19 patients from one dataset (GSE171524) to compare the two conditions.</p><p><strong>Results: </strong>Bulk RNA sequencing revealed enhanced inflammatory pathways in COPD patients, indicating increased inflammation. Single-cell RNA sequencing showed a stronger inflammatory response from mild to moderate COPD with a decrease from moderate to severe stages. COVID-19 displayed similar biological patterns to moderate COPD, suggesting that stage-specific COPD analysis could enhance COVID-19 management.</p><p><strong>Conclusion: </strong>The analysis found that immune responses increased from mild to moderate stages but declined in severe cases, marked by reduced pulmonary T cell activation. The overlap between moderate COPD and COVID-19 suggests shared therapeutic strategies, warranting further investigation.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 6","pages":"354-365"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjusted Global Antiphospholipid Syndrome Score Is Associated with End-Stage Kidney Disease in Patients with ANCA-Associated Vasculitis: A Single-Centre Pilot Study.","authors":"Pil Gyu Park, Hyun Joon Choi, Yong-Beom Park, Sang-Won Lee","doi":"10.3349/ymj.2024.0170","DOIUrl":"10.3349/ymj.2024.0170","url":null,"abstract":"<p><strong>Purpose: </strong>The adjusted Global Antiphospholipid Syndrome (APS) Score (aGAPSS) was developed for assessing the probability of thrombotic events in APS patients. This study investigated whether the aGAPSS at diagnosis was associated with poor outcomes during follow-up in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).</p><p><strong>Materials and methods: </strong>This study included 170 AAV patients who had the results of APS-related antibodies at diagnosis but were not diagnosed with APS. All-cause mortality, end-stage kidney disease (ESKD), cerebrovascular accident, and acute coronary syndrome were considered poor AAV outcomes. The aGAPSS comprises five items, with 5, 4, 4, 3, and 1 points assigned to anticardiolipin antibodies, anti-β2-glycoprotein 1 antibodies, lupus anticoagulants, hyperlipidaemia, and arterial hypertension at AAV diagnosis, respectively.</p><p><strong>Results: </strong>The median age of the 170 patients [93 microscopic polyangiitis (MPA), 44 granulomatosis with polyangiitis (GPA), and 33 eosinophilic GPA (EGPA)] was 63.0 years. The optimal cut-off of the aGAPSS at diagnosis for ESKD during follow-up was set as two using the receiver operating characteristic curve. AAV patients with an aGAPSS ≥2 at diagnosis exhibited a significantly reduced ESKD-free survival rate compared to those with an aGAPSS <2 at diagnosis (<i>p</i>=0.045). Additionally, MPA and GPA patients, excluding EGPA patients for whom the median aGAPSS at diagnosis was close to 0, also showed similar patterns to the results among the 170 patients with AAV (<i>p</i>=0.021).</p><p><strong>Conclusion: </strong>This study is the first to demonstrate that the aGAPSS at diagnosis was significantly associated with ESKD during follow-up in AAV patients without APS.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 6","pages":"337-345"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}