Yonsei Medical Journal最新文献_第4页

Feasibility of a Machine Learning Classifier for Predicting Post-Induction Hypotension in Non-Cardiac Surgery. 机器学习分类器预测非心脏手术诱导后低血压的可行性。

IF 2.6 4区医学

Yonsei Medical Journal Pub Date : 2025-03-01 DOI: 10.3349/ymj.2024.0020

Insun Park, Jae Hyon Park, Young Hyun Koo, Chang-Hoon Koo, Bon-Wook Koo, Jin-Hee Kim, Ah-Young Oh

{"title":"Feasibility of a Machine Learning Classifier for Predicting Post-Induction Hypotension in Non-Cardiac Surgery.","authors":"Insun Park, Jae Hyon Park, Young Hyun Koo, Chang-Hoon Koo, Bon-Wook Koo, Jin-Hee Kim, Ah-Young Oh","doi":"10.3349/ymj.2024.0020","DOIUrl":"10.3349/ymj.2024.0020","url":null,"abstract":"Purpose: To develop a machine learning (ML) classifier for predicting post-induction hypotension (PIH) in non-cardiac surgeries.Materials and methods: Preoperative data and early vital signs were obtained from 3669 cases in the VitalDB database, an open-source registry. PIH was defined as sustained mean arterial pressure (MAP) <65 mm Hg within 20 minutes since induction or from induction to incision. Six different ML algorithms were used to create binary classifiers to predict PIH. The primary outcome was the area under the receiver operating characteristic curve (AUROC) of ML classifiers.Results: A total of 2321 (63.3%) cases exhibited PIH. Among ML classifiers, the random forest regressor and extremely gradient boosting regressor showed the highest AUROC, both recording a value of 0.772. Excluding these models, the light gradient boosting machine regressor showed the second highest AUROC [0.769; 95% confidence interval (CI), 0.767-0.771], followed by the gradient boosting regressor (0.768; 95% CI, 0.763-0.772), AdaBoost regressor (0.752; 95% CI, 0.743-0.761), and automatic relevance determination regression (0.685; 95% CI, 0.669-0.701). The top three important features were mean diastolic blood pressure (DBP), minimum MAP, and minimum DBP from anesthetic induction to tracheal intubation, and these features were lower in cases with PIH (all p<0.001).Conclusion: ML classifiers exhibited moderate performance in predicting PIH, and have the potential for real-time prediction.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 3","pages":"160-171"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D Attenuates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obesity Murine Model. 维生素D减轻高脂肪饮食诱导的肥胖小鼠模型中的非酒精性脂肪性肝病

IF 2.6 4区医学

Yonsei Medical Journal Pub Date : 2025-02-01 DOI: 10.3349/ymj.2024.0038

Sook In Chung, Lin Liang, Heejae Han, Kyung Hee Park, Jae-Hyun Lee, Jung-Won Park

{"title":"Vitamin D Attenuates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obesity Murine Model.","authors":"Sook In Chung, Lin Liang, Heejae Han, Kyung Hee Park, Jae-Hyun Lee, Jung-Won Park","doi":"10.3349/ymj.2024.0038","DOIUrl":"10.3349/ymj.2024.0038","url":null,"abstract":"Purpose: Obesity and metabolic syndrome are acknowledged as key factors contributing to the development of non-alcoholic fatty liver disease (NAFLD). Vitamin D (VitD) is a multifaceted secosteroid hormone known for its anti-fibrotic and anti-inflammatory properties, with its deficiency often linked to obesity. Our study aimed to investigate whether VitD supplementation could mitigate the liver pathology associated with NAFLD.Materials and methods: The NAFLD model was developed by subjecting male C57BL/6 mice to a high-fat diet (HFD) for 14 weeks. These mice were supplemented with VitD through intraperitoneal injection at a dosage of 7 µg/kg, administered three times per week for 7 weeks.Results: HFD resulted in VitD deficiency, insulin resistance, and increased liver weight. It elevated serum levels of liver aminotransferases and triglyceride, ultimately leading to steatohepatitis with fibrosis. This model exhibited increased levels of transforming growth factor (TGF)-β1, pro-inflammatory cytokines, HNF4α transcription factors, reactive oxygen species (ROS), renin-angiotensin system activity, and epithelial-mesenchymal transitions (EMT) within the liver. Supplementation with VitD resulted in the recovery of liver weight, improvement in histologic features associated with steatohepatitis, and reduction in alanine aminotransferases and triglyceride levels induced by the HFD. Additionally, it mitigated the HFD-induced over-expressions of TGF-β1 and fibrosis-related genes, along with pro-inflammatory cytokines and ROS. Notably, no adverse effect was found due to VitD supplementation in this model.Conclusion: VitD ameliorates steatohepatitis within obesity-induced NAFLD through its multifaceted pathways. VitD supplementation emerges as a potentially safe, cost-effective, and direct treatment approach for NAFLD patients dealing with obesity or metabolic dysfunction.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 2","pages":"75-86"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence-Based Early Prediction of Acute Respiratory Failure in the Emergency Department Using Biosignal and Clinical Data. 基于生物信号和临床数据的急诊急性呼吸衰竭人工智能早期预测

IF 2.6 4区医学

Yonsei Medical Journal Pub Date : 2025-02-01 DOI: 10.3349/ymj.2024.0126

Changho Han, Yun Jung Jung, Ji Eun Park, Wou Young Chung, Dukyong Yoon

{"title":"Artificial Intelligence-Based Early Prediction of Acute Respiratory Failure in the Emergency Department Using Biosignal and Clinical Data.","authors":"Changho Han, Yun Jung Jung, Ji Eun Park, Wou Young Chung, Dukyong Yoon","doi":"10.3349/ymj.2024.0126","DOIUrl":"10.3349/ymj.2024.0126","url":null,"abstract":"Purpose: Early identification of patients at risk for acute respiratory failure (ARF) could help clinicians devise preventive strategies. Analyzing biosignals with artificial intelligence (AI) can uncover hidden information and variability within time series. We aimed to develop and validate AI models to predict ARF within 72 h after emergency department admission, primarily using high-resolution biosignals collected within 4 h of arrival.Materials and methods: Our AI model, built on convolutional recurrent neural networks, combines biosignal feature extraction and sequence modeling. The model was developed and internally validated with data from 5284 admissions [1085 (20.5%) positive for ARF], and externally validated using data from 144 admissions [7 (4.9%) positive for ARF] from another institution. We defined ARF as the application of advanced respiratory support devices.Results: Our AI model performed well in predicting ARF, achieving area under the receiver operating characteristic curve (AUROC) of 0.840 and 0.743 in internal and external validations, respectively. It outperformed the Modified Early Warning Score (MEWS) and XGBoost models built only with clinical variables. High predictive ability for mortality was observed, with AUROC up to 0.809. A 10% increase in AI prediction scores was associated with 1.44-fold and 1.42-fold increases in ARF risk and mortality risk, respectively, even after adjusting for MEWS and demographic variables.Conclusion: Our AI model demonstrates high predictive accuracy and significant associations with clinical outcomes. Our AI model has the potential to promptly aid in triage decisions. Our study shows that using AI to analyze biosignals advances disease detection and prediction.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 2","pages":"121-130"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Elderly Patients with Chronic Kidney Disease. 老年慢性肾病患者的管理。

IF 2.6 4区医学

Yonsei Medical Journal Pub Date : 2025-02-01 DOI: 10.3349/ymj.2024.0178

Yohan Park, Won Min Hwang

{"title":"Management of Elderly Patients with Chronic Kidney Disease.","authors":"Yohan Park, Won Min Hwang","doi":"10.3349/ymj.2024.0178","DOIUrl":"10.3349/ymj.2024.0178","url":null,"abstract":"Chronic kidney disease (CKD) is highly prevalent among elderly patients, and as the global population ages, the number of elderly patients with CKD is increasing. Elderly patients require additional considerations beyond those required for their younger counterparts, such as comorbidities, frailty, and geriatric syndromes. In this review, we primarily focus on these additional considerations specific to elderly patients and discuss the assessment of CKD and its management strategies, including blood pressure and glycemic control; dyslipidemia, anemia, and electrolyte and metabolic acidosis management; and medication dosage, among others, as well as polypharmacy and nonpharmacological management. Furthermore, the concept of conservative kidney management and the practical recommendations of the Korean Society of Geriatric Nephrology for elderly patients with end-stage kidney disease requiring dialysis therapy are discussed. In particular, the aging rate in Korea is exceptionally high; therefore, it is crucial to pay more attention to the increase in elderly patients with CKD. A more palliative approach, rather than intensive treatment strategies, may be necessary for these patients. In a world with an abundance of information, shared decision-making with patients is of great importance, and it is essential to keep in mind that this holds true for elderly patients as well.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 2","pages":"63-74"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conventional versus Instillation Negative-Pressure Wound Therapy for Severe Soft Tissue Injury in Open Pelvic Fractures: A Retrospective Review. 传统负压创面与灌注负压创面治疗开放性骨盆骨折严重软组织损伤的回顾性分析。

IF 2.6 4区医学

Yonsei Medical Journal Pub Date : 2025-02-01 DOI: 10.3349/ymj.2023.0473

Donghwan Choi, Won Tae Cho, Hyung Keun Song, Junsik Kwon, Byung Hee Kang, Hohyung Jung, Min Ji Kim, Kyoungwon Jung

{"title":"Conventional versus Instillation Negative-Pressure Wound Therapy for Severe Soft Tissue Injury in Open Pelvic Fractures: A Retrospective Review.","authors":"Donghwan Choi, Won Tae Cho, Hyung Keun Song, Junsik Kwon, Byung Hee Kang, Hohyung Jung, Min Ji Kim, Kyoungwon Jung","doi":"10.3349/ymj.2023.0473","DOIUrl":"10.3349/ymj.2023.0473","url":null,"abstract":"Purpose: We investigated the clinical features, current negative-pressure wound therapy (NPWT) management strategies, and outcomes of pelvic-perineal soft tissue infection after open pelvic fractures.Materials and methods: We analyzed the data of patients admitted to our trauma center with pelvic-perineal soft tissue after open pelvic fractures over a 7-year period. We investigated the injury severity score (ISS), medical costs, number of NPWTs, time required to reach definite wound coverage, complications, fracture classifications, transfusion requirements, interventions, length of stay (LOS) in hospital and intensive care unit (ICU), and prognosis.Results: Twenty patients with open pelvic fractures were treated with NPWT, and one patient who underwent NPWT died of pelvic sepsis during ICU treatment. The median LOS in hospital and medical costs were 98 [56-164] days and 106400 [65600-171100] USD, respectively. Patients treated with instillation NPWT (iNPWT, n=10) had a shorter NPWT duration (24 [13-39] vs. 46 [42-91] days, p=0.023), time to definite wound coverage (30 [21-43] vs. 49 [42-93] days, p=0.026), and hospital LOS (56 [43-72] vs. 158 [101-192] days, p=0.001), as well as lower medical costs (67800 [42500-102500] vs. 144200 [110400-236000] USD, p=0.009) compared to those treated with conventional NPWT.Conclusion: NPWT is a feasible method for treating pelvic soft tissue infections in patients with open pelvic fractures. iNPWT can reduce the duration of NPWT, hospital LOS, and medical costs.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 2","pages":"94-102"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Distal Fusion Level on Sacroiliac Joint Degenerative Change Following Adolescent Idiopathic Scoliosis Surgery. 远端融合水平对青少年特发性脊柱侧凸手术后骶髂关节退行性改变的影响。

IF 2.6 4区医学

Yonsei Medical Journal Pub Date : 2025-02-01 DOI: 10.3349/ymj.2023.0634

Sang-Ho Kim, Jae-Won Shin, Seong-Hwan Moon, Kyung-Soo Suk, Si-Young Park, Byung-Ho Lee, Ji-Won Kwon, Joong Won Ha, Yung Park, Hak-Sun Kim

{"title":"Impact of Distal Fusion Level on Sacroiliac Joint Degenerative Change Following Adolescent Idiopathic Scoliosis Surgery.","authors":"Sang-Ho Kim, Jae-Won Shin, Seong-Hwan Moon, Kyung-Soo Suk, Si-Young Park, Byung-Ho Lee, Ji-Won Kwon, Joong Won Ha, Yung Park, Hak-Sun Kim","doi":"10.3349/ymj.2023.0634","DOIUrl":"10.3349/ymj.2023.0634","url":null,"abstract":"Purpose: To evaluate the relationship between distal fusion level in correction and fusion surgery for adolescent idiopathic scoliosis (AIS) and radiologic changes in the sacroiliac (SI) joint.Materials and methods: This retrospective cohort study evaluated patients who underwent correction and fusion for AIS between 2005 and 2017 with at least 5 years of follow-up. We categorized patients into two groups: Group 1 (distal fusion above L2, 74 patients) and Group 2 (distal fusion at L3 and below, 52 patients). Radiologic parameters and SI joint changes were evaluated on plain radiographs obtained from preoperative to 5 years postoperatively. We also investigated other risk factors for SI joint change.Results: Analysis of demographic factors revealed no significant difference between the two groups. There was a significant difference in the incidence of SI joint change between Group 1 (5 patients, 6.75%) and Group 2 (18 patients, 34.61%), with Group 2 showing a faster increase in incidence according to the Kaplan-Meier method (p<0.0001). Preoperative lumbar lordosis (LL) and ΔLL had a significant relationship with SI joint changes [preoperative LL, hazard ratio (HR)=0.77, 95% confidence interval (CI)=0.64-0.93, p=0.008; ΔLL, HR=0.79, 95% CI=0.67-0.95, p=0.01).Conclusion: After AIS surgery, patients who had fusion to the lower lumbar vertebrae (L3 or L4) experienced a higher incidence and faster progression of degenerative changes in the SI joint. Low preoperative LL and inadequate correction of LL during the operation were also risk factors for SI joint degeneration.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 2","pages":"103-110"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound-Guided Nerve Hydrodissection for the Management of Carpal Tunnel Syndrome: A Systematic Review and Network Meta-Analysis. 超声引导下神经水解剖治疗腕管综合征：系统综述和网络荟萃分析。

IF 2.6 4区医学

Yonsei Medical Journal Pub Date : 2025-02-01 DOI: 10.3349/ymj.2024.0089

KunWook Lee, Jong Mi Park, Seo Yeon Yoon, Min Seo Kim, Yong Wook Kim, Jae Il Shin, Sang Chul Lee

{"title":"Ultrasound-Guided Nerve Hydrodissection for the Management of Carpal Tunnel Syndrome: A Systematic Review and Network Meta-Analysis.","authors":"KunWook Lee, Jong Mi Park, Seo Yeon Yoon, Min Seo Kim, Yong Wook Kim, Jae Il Shin, Sang Chul Lee","doi":"10.3349/ymj.2024.0089","DOIUrl":"10.3349/ymj.2024.0089","url":null,"abstract":"Purpose: Ultrasound-guided nerve hydrodissection has emerged as a potential non-surgical treatment for carpal tunnel syndrome (CTS). The objective of this research was to offer suggestions for optimizing injectables utilized in hydrodissection for the treatment of CTS through a systematic review and network meta-analysis.Materials and methods: PubMed, MEDLINE, EMBASE, Cochrane, Scopus, and Web of Science were searched through April 25, 2024. Effect sizes were quantified using standard mean differences within a random-effects model. Effectiveness ranking for each treatment was expressed as the surface under the cumulative ranking curve (SUCRA).Results: Nine studies with 458 patients with CTS were included. According to SUCRA, 5% dextrose (DW) was the most effective option for the Boston Carpal Tunnel Questionnaire (BCTQ) function at 99.9, 89.8, and 88.8 at 4, 12, and 24 weeks, respectively; for BCTQ symptoms, 5% DW was the most effective option at 99.9 at 4 weeks and platelet-rich plasma at 95.7 and 93.9 at 12 and 24 weeks, respectively. In terms of both BCTQ symptoms and BCTQ function, the 5 cc injection was the most effective, with SUCRA values of 99.5 for both categories. However, the effectiveness of the electrodiagnostic assessment and ultrasound variables was dependent on the type and dose of medication.Conclusion: Administration of 5% DW showed better results in terms of initial symptom relief and long-term functional recovery compared to other agents, while platelet-rich plasma showed greater long-term symptom improvement; an injection dose of 5 cc showed the greatest benefit. However, additional research is required to establish precise protocols based on disease severity.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 2","pages":"111-120"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic Surgery for Deeply Located Intracranial Cysts: Risk Factors for Re-Operation and Symptom Improvement. 内窥镜手术治疗深部颅内囊肿：再次手术的危险因素及症状改善。

IF 2.6 4区医学

Yonsei Medical Journal Pub Date : 2025-02-01 DOI: 10.3349/ymj.2024.0037

Jun Kyu Hwang, Ju-Seong Kim, Eun Kyung Park, Kyu Won Shim, Dong-Seok Kim

{"title":"Endoscopic Surgery for Deeply Located Intracranial Cysts: Risk Factors for Re-Operation and Symptom Improvement.","authors":"Jun Kyu Hwang, Ju-Seong Kim, Eun Kyung Park, Kyu Won Shim, Dong-Seok Kim","doi":"10.3349/ymj.2024.0037","DOIUrl":"10.3349/ymj.2024.0037","url":null,"abstract":"Purpose: We investigated the results of endoscopic fenestration for deeply located intracranial cysts (DLICs), risk factors for re-operation, and symptom improvement.Materials and methods: We included 51 patients with DLICs who underwent endoscopic fenestration between November 2006 and October 2022. The median age was 5±20 years (6 days-67 years), and 36 (70.6%) patients were aged <20 years. The male-to-female ratio was 1.3:1. The ventriculoscope was used to fenestrate the cysts, which had diameters under 4.5 mm. The volume of DLICs was measured separately on serial magnetic resonance imaging, and the patients were followed up for 32±40 months.Results: The mean preoperative volume of DLICs was 63.5±87.4 cm³, which decreased to 23.7±56.2 cm³ postoperatively, with a 45.4%±32.1% decrease rate in 32 months. All DLICs were approached appropriately, avoiding the eloquent areas. Overall, 39 (76.5%) patients showed symptom improvement after a single operation, which was preserved without recurrence, whereas 12 (23.5%) underwent a second operation [shunting (17.6%) or repeating the endoscopic fenestration (5.9%)] owing to symptom aggravation and recurrent cysts. Patients aged <12 months showed 7.4 times more re-operation rate (p=0.046) and 7.4 times less symptom improvement (p=0.038) compared to those with older age. Females showed 6.5 times more re-operation rate (p=0.037) and 7.1 times less symptom improvement (p=0.027) than males. No patients experienced complications such as cerebrospinal fluid leakage, postoperative hemorrhage, or infection.Conclusion: Endoscopic surgery is feasible for the treatment of DLICs. Female sex and age <12 months are risk factors for re-operation and less symptom improvement.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 2","pages":"87-93"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Patients Who Were Not Evaluated and Lost to Follow-Up with Multidrug/Rifampin-Resistant Tuberculosis in South Korea. 韩国多药/利福平耐药结核病患者未评估和随访失败的比较

IF 2.6 4区医学

Yonsei Medical Journal Pub Date : 2025-01-01 DOI: 10.3349/ymj.2024.0048

Hongjo Choi, Jeongha Mok, Young Ae Kang, Dawoon Jeong, Hee-Yeon Kang, Hee Jin Kim, Hee-Sun Kim, Doosoo Jeon

{"title":"Comparison of Patients Who Were Not Evaluated and Lost to Follow-Up with Multidrug/Rifampin-Resistant Tuberculosis in South Korea.","authors":"Hongjo Choi, Jeongha Mok, Young Ae Kang, Dawoon Jeong, Hee-Yeon Kang, Hee Jin Kim, Hee-Sun Kim, Doosoo Jeon","doi":"10.3349/ymj.2024.0048","DOIUrl":"10.3349/ymj.2024.0048","url":null,"abstract":"Purpose: This study aimed to evaluate the prognosis of the not evaluated (NE) group by comparing it with the lost to follow-up (LTFU) group among patients with multidrug/rifampin-resistant tuberculosis (MDR/RR-TB).Materials and methods: This was a retrospective longitudinal follow-up study using an integrated database constructed by data linkage of the three national databases. This database included 7226 cases of MDR/RR-TB notified between 2011 and 2017 in South Korea.Results: Among the 7226 MDR/RR-TB cases, 730 (10.1%) were classified as LTFU group, and 353 (4.9%) as NE group. When comparing NE group with LTFU group, there were no significant differences in the all-cause mortality rate (18.1% vs. 13.8%, p=0.065), median time to death [404 days (interquartile range, IQR 46-850) vs. 443 days (IQR 185-1157), p=0.140], and retreatment rate (26.9% vs. 22.2%, p=0.090). After adjusting for potential confounders, the adjusted hazard ratio (aHR) for all-cause mortality (aHR 1.11; 95% confidence interval 0.80-1.53; p=0.531) in NE group was not significantly different than that in LTFU group. Among retreated cases, NE group had a higher treatment success rate (57.9% vs 43.8%, p=0.029) and a lower LTFU rate (11.6% vs 38.3%, p<0.001) compared to LTFU group.Conclusion: NE group had an unfavorable outcome comparable to LTFU group, suggesting undetected cases of LTFU or deaths during the referral process. Establishing an efficient patient referral system would contribute to reducing the incidence of NE cases.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 1","pages":"16-24"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of Devices for the Five Times Sit To Stand Test: Comparing Plantar Pressure and Head Motion Analysis with Manual Measurement. 五次坐立测试装置的验证：比较脚底压力和头运动分析与人工测量。

IF 2.6 4区医学

Yonsei Medical Journal Pub Date : 2025-01-01 DOI: 10.3349/ymj.2023.0525

Sanghyun Jee, Chan Woong Jang, Kyoungmin Park, Sanghoon Shin, Min-Chul Paek, Jung Hyun Park

{"title":"Validation of Devices for the Five Times Sit To Stand Test: Comparing Plantar Pressure and Head Motion Analysis with Manual Measurement.","authors":"Sanghyun Jee, Chan Woong Jang, Kyoungmin Park, Sanghoon Shin, Min-Chul Paek, Jung Hyun Park","doi":"10.3349/ymj.2023.0525","DOIUrl":"10.3349/ymj.2023.0525","url":null,"abstract":"Purpose: This study aims to evaluate a new method for the five times sit to stand test (FTSST), crucial for addressing frailty in an aging population. It utilizes a smart insole for plantar pressure analysis and a marker-less motion capture device for head height analysis.Materials and methods: Thirty-five participants aged 50 years or older underwent FTSST assessment using three methods: manual measurement with a stopwatch (FTSST-M), plantar pressure analysis with smart insoles (FTSST-P), and head height analysis with a marker-less motion capture device (FTSST-H). Simultaneous measurements using three methods were done. Correlation between results of these methods were analyzed using intraclass correlation coefficient (ICC) and κ coefficient. Comprehensive clinical examinations were conducted with ethical approval.Results: Participants' mean scores for FTSST-M, FTSST-P, and FTSST-H were 2.43±1.20, 2.43±1.29, and 2.37±1.31, respectively. Correlations of the times and corresponding scores between FTSST-P and FTSST-M, as well as FTSST-H and FTSST-M, exceeded 0.9 (ICC and κ coefficients, p<0.001). Using an FTSST score of 3 or less to indicate vulnerability, the κ value for vulnerability classification between two measurements was 0.886 (p<0.001).Conclusion: This study showed strong correlation between FTSST results using smart insoles and marker-less motion capture, compared to conventional methods. These findings highlight the potential of these technologies for precise FTSST measurements, offering convenience and cost-effectiveness. Simultaneous use of these devices enables diverse analyses, enhancing our understanding of frailty.","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 1","pages":"51-57"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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