World Journal of Gastrointestinal Oncology最新文献

{"title":"Downregulation of uncoupling protein 1 by hypermethylation in gastric cancer activates <i>Rap1</i> signaling.","authors":"Yi-Jia Chen, Cheng Peng, Li-Wei Wang, Jia-Xin Chai, Jian-Dong Wang, Qi-Bin He","doi":"10.4251/wjgo.v17.i9.108760","DOIUrl":"10.4251/wjgo.v17.i9.108760","url":null,"abstract":"<p><strong>Background: </strong>Uncoupling protein 1 (<i>UCP1</i>) plays a pivotal role in modulating energy expenditure and maintaining metabolic homeostasis within brown and beige adipocytes. It has also been implicated in tumorigenesis.</p><p><strong>Aim: </strong>To investigate the expression and function of UCP1 in gastric cancer (GC).</p><p><strong>Methods: </strong>UCP1 protein expression in 211 GC tissues was examined using immunohistochemistry. Bisulfite sequencing PCR (BSP) was used to detect the methylation status of the <i>UCP1</i> promoter in GC cell lines and tissues. The relationship between UCP1 expression and clinicopathological parameters was analyzed. CCK8, scratch, transwell, and flow cytometry assays were carried out to analyze the proliferation, migration, invasion, and apoptosis of GC cell lines after knockdown or overexpression of UCP1 <i>in vitro</i>. A nude mouse tumor xenograft model was used to investigate the function of <i>UCP1 in vivo</i>. RNA sequencing, Kyoto Encyclopedia of Genes and Genomes analysis, and Rap1 pull-down assays were performed to identify the pathway associated with <i>UCP1</i>.</p><p><strong>Results: </strong>Loss of UCP1 was significantly associated with gender, poor differentiation, and advanced TNM stage of GC. Hypermethylation of <i>UCP1</i> was confirmed in GC cells and tumor tissues by BSP. Overexpression of UCP1 suppressed GC cell proliferation, migration, and invasion, and it promoted apoptosis <i>in vitro</i>. UCP1 overexpression also suppressed GC tumor growth <i>in vivo</i>. Moreover, overexpression of UCP1 in GC cells resulted in a significant decrease in active Rap1 protein levels, whereas downregulation of UCP1 markedly enhanced Rap1 activity.</p><p><strong>Conclusion: </strong>UCP1 downregulation in GC through promoter hypermethylation is related to the progression of GC, indicating that <i>UCP1</i> plays a role as a tumor suppressor in GC. It regulates <i>Rap1</i> signaling and may be a potential therapeutic target in GC.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 9","pages":"108760"},"PeriodicalIF":2.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic management of pancreatic cystic neoplasms.","authors":"Yan Zeng, Jun-Wen Zhang, Jian Yang","doi":"10.4251/wjgo.v17.i9.110376","DOIUrl":"10.4251/wjgo.v17.i9.110376","url":null,"abstract":"<p><p>Pancreatic cystic neoplasms (PCNs) represent a spectrum of heterogeneous lesions with diverse biological behaviors and malignant potential. This category encompasses relatively common subtypes, such as intraductal papillary mucinous neoplasms, serous cystic neoplasms, and mucinous cystic neoplasms, alongside relatively rarer entities, including cystic degeneration of solid pancreatic tumors. The widespread use of cross-sectional imaging has led to increased incidental detection of PCNs, subsequently driving a surge in PCN-related medical consultations and interventions; thus, standardized management of PCNs demands heightened attention. Continuous advancements in endoscopic technologies, particularly endoscopic ultrasound (EUS) and EUS-guided procedures, now offer diversified diagnostic and therapeutic options, establishing EUS as a pivotal tool for diagnosing, surveillance, and treating PCNs. This review synthesizes current evidence and evolving clinical practices in the endoscopic management of PCNs, emphasizing optimizing preoperative diagnostic accuracy, standardizing endoscopic protocols, implementing subtype-specific risk stratification, promoting multidisciplinary team approaches, and addressing challenges in emerging technologies.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 9","pages":"110376"},"PeriodicalIF":2.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations among healthcare insurance, tumor-node-metastasis stage and cancer survival: More to be understood.","authors":"Zhuo-Yu Li, Rui Wang, Xin-Zu Chen","doi":"10.4251/wjgo.v17.i9.106116","DOIUrl":"10.4251/wjgo.v17.i9.106116","url":null,"abstract":"<p><p>Cancers remain a major health burden with a high mortality rate in China. Basic medical insurance, is the most important element in the financial support system of healthcare resources in both urban and rural areas, and requires further understanding to improve health policy. For instance, a single hospital-based prospective cohort study found that esophageal cancer survival outcomes were associated with different healthcare payment patterns and situations. Comparing the extracted literature-data between urban employee basic medical insurance and urban and rural resident basic medical insurance, the proportions of tumor-node-metastasis (TNM) stage I-II were 27.1% and 34.6%, while those of TNM stage IV were 35.0% and 26.1%, respectively. Additionally, high out-of-pocket rate (> 60%) of hospitalization was associated with a higher proportion of TNM stage I-II (40.3% <i>vs</i> 26.9%) and a lower proportion of TNM stage IV (22.7% <i>vs</i> 32.8%). In addition, healthcare payment simultaneously influenced or was influenced by the proportions of early and advanced esophageal cancers. The critical difficulty in improving survival of esophageal cancer in populations should be a low proportion of early disease. A more comprehensive and robust public healthcare insurance system is desired to support cancer prevention and control in particular, in order to increase the proportion of early cancers and consequently improve patient survival. Additionally, commercial medical insurance and social charities hope to be fully introduced and encouraged to achieve these goals as active supplement.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 9","pages":"106116"},"PeriodicalIF":2.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative impact of antiviral therapies on postoperative recurrence risk in patients with hepatitis B virus-related hepatocellular carcinoma.","authors":"Hua-Mei Liu, Xin Zhang, Hang-Ying Huang, Jia-Min Sun, Qing-Dong Tong","doi":"10.4251/wjgo.v17.i9.106297","DOIUrl":"10.4251/wjgo.v17.i9.106297","url":null,"abstract":"<p><strong>Background: </strong>Entecavir (ETV) and tenofovir fumarate (TDF) are recommended first-line agents for the treatment of chronic hepatitis B virus (HBV) infection. However, the effect of these 2 antiviral agents on the risk for recurrence of HBV-associated hepatocellular carcinoma (HCC) after radical hepatectomy remains controversial.</p><p><strong>Aim: </strong>To compare the effect of TDF <i>vs</i> ETV on the risk for HCC recurrence after radical surgery for HBV-related HCC.</p><p><strong>Methods: </strong>Data from consecutive patients, who received TDF or ETV after radical hepatectomy for HBV-related HCC and admitted to the Second Hospital of Longyan between December 2018 and December 2023, were retrospectively analyzed. Based on treatment method and propensity score matching (PSM), data from 100 patients were included, with 50 in each of the TDF and ETV groups, respectively. The baseline characteristics of the 2 groups were analyzed, and the risk for HCC recurrence was compared between the groups.</p><p><strong>Results: </strong>The median follow-up for 100 patients [median age, 61 years; 84 male (84%)] who underwent radical resection for HBV-related HCC - Barcelona Clinic Liver Cancer stage 0 [<i>n</i> = 16 (16%)], stage A [<i>n</i> = 61 (61%)] - was 29 months (range, 12-60 months); the median tumor size was 3.0 cm (range, 2.1-4.3 cm). Sixty-eight (68%) patients exhibited HBV-DNA levels > 1000 IU/mL. Twenty-two (22%) patients tested positive for hepatitis B e antigen, in whom the HCC recurrence rate was 59.1% (13/22). After PSM, HCC recurrence rates in the ETV and TDF groups after hepatectomy were 66% (<i>n =</i> 33) and 42% (<i>n =</i> 21), respectively (<i>P</i> = 0.016), and cumulative recurrence rates at 1, 3, and 5 years were 26%, 58%, and 66%, and 18%, 38%, and 42%, respectively (<i>P</i> = 0.045).</p><p><strong>Conclusion: </strong>TDF treatment is associated with a lower risk for HCC-related outcomes than that for ETV in patients with HBV-associated HCC after curative therapy.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 9","pages":"106297"},"PeriodicalIF":2.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Misdiagnosis of gastric oxyntic gland adenoma as hyperplastic polyp: A case report.","authors":"Rui-Xiang Xue, Xin-Yu Lu, Pei Deng, Lin-Heng Wang, Yi-Fei Yun","doi":"10.4251/wjgo.v17.i9.110505","DOIUrl":"10.4251/wjgo.v17.i9.110505","url":null,"abstract":"<p><strong>Background: </strong>Gastric oxyntic gland adenoma is a rare neoplasm often misdiagnosed as a hyperplastic or fundic gland polyp due to nonspecific endoscopic features and the limitations of superficial biopsies, leading to diagnostic delays.</p><p><strong>Case summary: </strong>In 2020, a gastroscopy of a 47-year-old man revealed a 0.5 cm lesion that was diagnosed as a hyperplastic polyp by superficial biopsy. By 2022, the lesion had enlarged to 1.0 cm exhibiting firmness, bleeding tendency, and disrupted submucosal layers on endoscopic ultrasound. Repeat biopsies again suggested hyperplasia. Endoscopic submucosal dissection was performed, confirming the diagnosis of gastric oxyntic gland adenoma. Additional surgical resection confirmed negative margins, and no recurrence at the three-year postoperative follow-up. However, endoscopic ultrasound revealed localized thickening (1.2 mm) of the muscularis mucosae at the gastric lesser curvature, likely representing post-procedural fibrosis. The patient was clinically asymptomatic, and was advised to continue annual endoscopic monitoring.</p><p><strong>Conclusion: </strong>This case highlights the necessity of deep biopsy or complete resection for diagnosis. We recommend long-term endoscopic surveillance post-resection and heightened clinical vigilance to mitigate misdiagnosis risks.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 9","pages":"110505"},"PeriodicalIF":2.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing patterns of cholangiocarcinoma and gallbladder cancer: A regional perspective from Northeastern Italy.","authors":"Duygu Kirkik, Ayse Naz Ozabaci, Sevgi Kalkanli Tas","doi":"10.4251/wjgo.v17.i9.108578","DOIUrl":"10.4251/wjgo.v17.i9.108578","url":null,"abstract":"<p><p>Cholangiocarcinoma (CCA) is the second most common primary liver cancer worldwide, with a high mortality rate. Due to the lack of information regarding disease markers, characterization tools, and early detection methods, mortality continues to increase. The disease can be classified into two main groups: Intrahepatic CCA and extrahepatic CCA, the second of which is further subdivided into perihilar CCA and distal CCA. Certain regions are found to be at higher risk due to the presence of different contributing factors. These include hepatobiliary diseases, extrahepatic conditions, and environmental exposures. CCA shows a sex-related disparity, affecting men more than women, and its incidence rises progressively with age. These risk factors likely contribute to the rising incidence observed in certain regions, as each region is predominantly affected by distinct factors, resulting in wide geographical variations in CCA incidence. Epidemiological reports published before 2000 indicate a global increase in the incidence of intrahepatic CCA, whereas the incidence of extrahepatic CCA is reportedly decreasing. The present study offers an important epidemiological perspective by analyzing the incidence trends of gallbladder malignancies over a 17-year period in Northeastern Italy, analyzed according to sex and age groups.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 9","pages":"108578"},"PeriodicalIF":2.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors and efficacy of postoperative chemotherapy in patients with gastric cancer with positive peritoneal cytology after gastrectomy.","authors":"Yoichi Sugiyama, Kazuaki Tanabe, Senichiro Yanagawa, Hirofumi Tazawa, Kazuhiro Toyota, Mikihiro Kano, Toshihiro Misumi, Masayuki Shishida, Keisuke Okano, Ryuichi Hotta, Hiroshi Ota, Yasuhiro Imaoka, Toshikatsu Fukuda, Shinya Takahashi, Hideki Ohdan","doi":"10.4251/wjgo.v17.i9.110245","DOIUrl":"10.4251/wjgo.v17.i9.110245","url":null,"abstract":"<p><strong>Background: </strong>Peritoneal lavage cytology-positive (CY1) gastric cancer (stage IV) has a poor prognosis, though some cases fare better. Therefore, identifying prognostic factors and an optimal treatment strategy is crucial.</p><p><strong>Aim: </strong>To investigate prognostic factors in patients with gastric cancer who underwent gastrectomy with CY1, and to evaluate the optimal postoperative chemotherapy regimen.</p><p><strong>Methods: </strong>This multicenter retrospective cohort study analyzed prognostic factors and postoperative chemotherapy in patients with CY1 gastric cancer who underwent gastrectomy, excluding those with macroscopic peritoneal dissemination. Data from 13 institutions (2015-2019) were reviewed.</p><p><strong>Results: </strong>Overall, 82 patients met the inclusion criteria. The median overall survival was 22.8 months, and diffuse-type histology and the absence of postoperative chemotherapy were identified as independent poor prognostic factors. The 5-year survival rate was 82.4% for those receiving fluoropyrimidine plus docetaxel/oxaliplatin <i>vs</i> 21.8% for those with S-1 monotherapy or a cisplatin-based regimen. Median overall survival was not reached in the fluoropyrimidine + docetaxel/oxaliplatin group but was 22.9 months in the S-1/cisplatin group. Chemotherapy regimen was an independent prognostic factor (hazard ratio = 5.47, <i>P</i> = 0.004). The fluoropyrimidine plus docetaxel/oxaliplatin group had an average relative dose intensity of 82.1%, with significantly more patients achieving a relative dose intensity ≥ 80% than in the S-1 monotherapy or cisplatin-based group (<i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>Diffuse-type histology and the absence of postoperative chemotherapy influence the prognosis of patients with CY1 gastric cancer. Combination therapy with oxaliplatin or docetaxel may enhance the treatment intensity and improve survival outcomes after gastrectomy.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 9","pages":"110245"},"PeriodicalIF":2.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untargeted metabolomics analysis of metabolite changes in gastric cancer patients from plateau regions.","authors":"Ling-Hong Zhu, Zhao-Xin Jin, Yan-Qing Ma, Xiao Feng, Cai-Hong Ci, Yun-Song Zhou, Qiao-Ling Gu, Yong-Mei Lan, Zi-Long Zhang","doi":"10.4251/wjgo.v17.i9.109777","DOIUrl":"10.4251/wjgo.v17.i9.109777","url":null,"abstract":"<p><strong>Background: </strong>Metabolomics sequencing technology was used to investigate the changes of intestinal flora and metabolites in gastric cancer patients in plateau areas.</p><p><strong>Aim: </strong>To investigate changes in gut microbiota and their metabolites in patients with gastric cancer from plateau regions using untargeted metabolomic sequencing.</p><p><strong>Methods: </strong>Fresh morning fecal samples were collected from 30 gastric cancer patients diagnosed at a tertiary hospital in Qinghai Province and 30 healthy individuals (controls). Liquid chromatography-tandem mass spectrometry based untargeted metabolomic sequencing was used to analyze metabolite changes and predict metabolic function.</p><p><strong>Results: </strong>Metabolomic analysis identified 281 metabolites in samples from both groups. These metabolites were categorized into eight major classes, listed in descending order of abundance: Lipids and lipid-like molecules (35.443%); organic acids and derivatives (29.114%); organic oxygen compounds (15.19%); nucleosides, nucleotides, and analogs (13.924%); organoheterocyclic compounds (2.532%), amino acids and peptides (1.266%); benzenoids (1.266%); and fatty acids (1.266%). Compared with the control group, the top 10 metabolites elevated in the gastric cancer group included: Dethiobiotin, glycylproline, glycine, hydroxyisocaproic acid, tyramine, methionine sulfoxide, 5-aminopentanoic acid, citrulline, betonicine, and formiminoglutamic acid and the top 10 decreased were: Cytidine, 5'-methylthioadenosine, trehalose, melibiose, lotaustralin, adenosine, inosine, ribothymidine, raffinose, and galactinol. Functional prediction analysis revealed that these differential metabolites were primarily enriched in 12 metabolic pathways, including purine metabolism, cysteine and methionine metabolism, galactose metabolism, lysine degradation, glycine, serine, and threonine metabolism, biotin metabolism, pyrimidine metabolism, arginine and proline metabolism, histidine metabolism, primary bile acid biosynthesis, starch and sucrose metabolism, and tyrosine metabolism.</p><p><strong>Conclusion: </strong>Significant differences in intestinal microbial metabolites and associated metabolic pathways were observed between gastric cancer patients and healthy controls residing in plateau regions.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 9","pages":"109777"},"PeriodicalIF":2.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginsenoside F4 inhibits colorectal cancer progression by boosting dendritic cell maturation and remodeling the tumor microenvironment.","authors":"Wei Xie, Xue-Jian Li, Yu-Sen Zhong, Jie Fang, Hui Qi, Meng Yang, Hua-Zhong Ying, Chen-Huan Yu","doi":"10.4251/wjgo.v17.i9.108892","DOIUrl":"10.4251/wjgo.v17.i9.108892","url":null,"abstract":"<p><strong>Background: </strong>Immunotherapy that employs dendritic cells (DCs) to activate the patient's immune system has emerged as a promising therapeutic strategy to combat cancer; however, effective targeting agents are still limited. Ginsenoside F4, as a rare ginsenoside found in <i>Panax ginseng</i>, exhibits stronger antitumor and immunomodulatory activities than primary ginsenosides. However, its therapeutic effects on various diseases remain limited.</p><p><strong>Aim: </strong>To investigate the antitumor effect of Ginsenoside F4 and mechanism on the maturation of DCs in colorectal cancer (CRC).</p><p><strong>Methods: </strong>The changes in mature DC markers and cytokines generated after DCs were exposed to F4 were assessed using flow cytometry and enzyme-linked immunosorbent assay, respectively. The viability of CRC CT26 cells co-cultured with T lymphocytes was monitored by cell counting kit-8 assay. Furthermore, the histopathological characteristics and immune cell infiltration in tumor tissues of CT26-bearing mice were analyzed by hematoxylin-eosin and immunofluorescent staining. The expressions of apoptosis-relative proteins were detected by western blot assay.</p><p><strong>Results: </strong>Treatment with F4 promoted the maturation of DCs, elevated the expressions of cluster of differentiation (CD) 83 and CD86, increased the secretion of interleukin (IL)-2, IL-10, and IL-12 p70, and upregulated the expressions of phosphorylated phosphoinositide 3-kinase, phosphorylated protein kinase B, and nuclear factor kappa-B (NF-κB) phosphorylated p65 in DCs, which enhanced antigen-specific CD8+ T-cell responses. However, these benefits could be reversed by the sphingosine-1-phosphate 1 (S1PR1) inhibitor fingolimod hydrochloride. Furthermore, oral administration with F4 inhibited tumor growth and increased DC and CD8+ T-cell infiltration in the tumor tissues of CT26-bearing mice.</p><p><strong>Conclusion: </strong>The results demonstrated that F4 inhibited the growth of CRC by maturing DCs through activating S1PR1-mediated phosphoinositide 3-kinase/protein kinase B and NF-κB pathways, which triggered the antitumor effects of CD8+ T cells. Therefore, F4 could serve as an antitumor immunomodulator for CRC treatment.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 9","pages":"108892"},"PeriodicalIF":2.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between perineural invasion and clinicopathological characteristics in pancreatic cancer.","authors":"Xiao-Liang Lu, Chuang Ge, Ruo-Chen Wang, Hong Zang","doi":"10.4251/wjgo.v17.i9.108277","DOIUrl":"10.4251/wjgo.v17.i9.108277","url":null,"abstract":"<p><strong>Background: </strong>Perineural invasion (PNI) is common in pancreatic cancer (PC) and is associated with poor prognosis.</p><p><strong>Aim: </strong>To investigate the correlation between PNI and clinical pathological features in PC.</p><p><strong>Methods: </strong>Patients were retrospectively divided into non-neural invasion and neural invasion groups based on PNI. Differences in tumor location, size, carbohydrate antigen 19-9 (CA19-9) level, overall survival, abdominal pain, pathological type, differentiation, and lymph node invasion were compared. Correlation and logistic regression analyses were performed, and a predictive model was constructed.</p><p><strong>Results: </strong>The neural invasion group had a higher proportion of tumors in the head, larger size, higher CA19-9 levels, lower survival rates, more abdominal pain, and more lymph node invasion. Pancreatic ductal adenocarcinoma and higher differentiation were more common in the neural invasion group. Tumor location, survival, and differentiation were negatively correlated, while size, CA19-9 level, abdominal pain, and lymph node invasion were positively correlated with neural invasion. Tumor location, size, CA19-9 level, abdominal pain, differentiation, and lymph node invasion were independent risk factors. The predictive model showed good consistency with actual occurrence rates.</p><p><strong>Conclusion: </strong>Tumor location, size, CA19-9 level, abdominal pain, differentiation, and lymph node invasion are important factors in neural invasion and tumor progression in PC.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 9","pages":"108277"},"PeriodicalIF":2.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}