World Journal of Gastrointestinal Oncology最新文献

{"title":"Cystic artery embolism after transarterial chemoembolization for hepatocellular carcinoma: A case report and review of the literature.","authors":"Yi-Fan Chen, Zhen-Yi Lin, Lin-Tao Chen, Yu Zhang, Zhao-Qing Du","doi":"10.4251/wjgo.v17.i3.99129","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.99129","url":null,"abstract":"<p><strong>Background: </strong>Acute cholecystitis due to unintended cystic artery embolism is an uncommon and mostly self-limiting complication after transarterial chemoembolization procedure for treatment of hepatocellular carcinoma. Usually, conservative management is sufficient for complete recovery of patients who develop this complication. If conservative treatment is ineffective, urgent surgical intervention may be required to prevent the progression of complications.</p><p><strong>Case summary: </strong>This article reports a rare and serious case of acute cholecystitis complicated by gallbladder necrosis and biliary peritonitis, which was initially treated conservatively but eventually necessitated emergency laparotomy. The patient initially presented with equivocal symptoms of fever and upper abdominal pain and distention, which worsened at the two weeks mark along with emergence of signs of peritonitis. This was managed by emergency laparotomy and cholecystostomy, allowing rapid symptom relief. The patient ultimately discharged and succumbed to advanced liver cancer 11 months after diagnosis.</p><p><strong>Conclusion: </strong>After cholecystostomy, the patient showed symptom relief and was discharged, surviving 11 months post-stage IIIB liver cancer diagnosis.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"99129"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New scoring system for the evaluation obstructive degrees based on computed tomography for obstructive colorectal cancer.","authors":"Xin-Chang Shang-Guan, Jun-Rong Zhang, Chao-Nan Lin, Shuai Chen, Yong Wei, Wen-Xuan Chen, Lin Pan, Li-Qin Huang, Shao-Hua Zheng, Xian-Qiang Chen","doi":"10.4251/wjgo.v17.i3.102728","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.102728","url":null,"abstract":"<p><strong>Background: </strong>The degree of obstruction plays an important role in decision-making for obstructive colorectal cancer (OCRC). The existing assessment still relies on the colorectal obstruction scoring system (CROSS) which is based on a comprehensive analysis of patients' complaints and eating conditions. The data collection relies on subjective descriptions and lacks objective parameters. Therefore, a scoring system for the evaluation of computed tomography-based obstructive degree (CTOD) is urgently required for OCRC.</p><p><strong>Aim: </strong>To explore the relationship between CTOD and CROSS and to determine whether CTOD could affect the short-term and long-term prognosis.</p><p><strong>Methods: </strong>Of 173 patients were enrolled. CTOD was obtained using k-means, the ratio of proximal to distal obstruction, and the proportion of nonparenchymal areas at the site of obstruction. CTOD was integrated with the CROSS to analyze the effect of emergency intervention on complications. Short-term and long-term outcomes were compared between the groups.</p><p><strong>Results: </strong>CTOD severe obstruction (CTOD grade 3) was an independent risk factor [odds ratio (OR) = 3.390, 95% confidence interval (CI): 1.340-8.570, <i>P</i> = 0.010] <i>via</i> multivariate analysis of short-term outcomes, while CROSS grade was not. In the CTOD-CROSS grade system, for the non-severe obstructive (CTOD 1-2 to CROSS 1-4) group, the complication rate of emergency interventions was significantly higher than that of non-emergency interventions (71.4% <i>vs</i> 41.8%, <i>P</i> = 0.040). The postoperative pneumonia rate was higher in the emergency intervention group than in the non-severe obstructive group (35.7% <i>vs</i> 8.9%, <i>P</i> = 0.020). However, CTOD grade was not an independent risk factor of overall survival and progression-free survival.</p><p><strong>Conclusion: </strong>CTOD was useful in preoperative decision-making to avoid unnecessary emergency interventions and complications.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"102728"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solid pseudopapillary neoplasm of the pancreas in an adolescent: A case report and review of the literature.","authors":"Aakriti Sapkota, Rajesh Paudel, Sandip Pandey, Navin Bhatt","doi":"10.4251/wjgo.v17.i3.101859","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.101859","url":null,"abstract":"<p><strong>Background: </strong>Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare epithelial tumor that primarily affects young women. Since the condition is often asymptomatic or presents with non-specific symptoms, its diagnosis can be difficult.</p><p><strong>Case summary: </strong>This report details the case of a 15-year-old girl who presented with a 2-year history of abdominal pain, with no significant findings during physical examination. Abdominal ultrasound revealed a well-defined heterogeneous solid-cystic mass in the epigastric region, likely originating from the tail of the pancreas. A subsequent contrast-enhanced computed tomography scan indicated a well-defined cystic lesion with an enhancing solid component and capsule in the tail of the pancreas, suggestive of a cystic neoplasm. The patient underwent an open distal pancreatectomy with splenectomy, and histopathological analysis confirmed the diagnosis of SPN of the pancreas.</p><p><strong>Conclusion: </strong>This case highlights the risk of SPN in adolescent girls and the necessity of early diagnosis and intervention for better outcomes.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"101859"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>DNMT1</i> promotes the proliferation and migration of gastric cancer cells by inducing microRNA-125a-5p methylation to promote SERPINE1 protein.","authors":"Hui Xie, Hui Wang, Ru-Hong Li, Yue-Wen Zhang, Xi-Rui Fan, Xiao-Xue He, Ao-Ran Guan","doi":"10.4251/wjgo.v17.i3.98703","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.98703","url":null,"abstract":"<p><strong>Background: </strong>Gastric cancer (GC) is a malignant tumor originating from gastric mucosal epithelial cells that has high morbidity and mortality. microRNAs (miR) are important diagnostic markers and therapeutic targets in this disease.</p><p><strong>Aim: </strong>To explore the mechanism of miR-125a-5p in the pathogenesis of GC.</p><p><strong>Methods: </strong>The expression levels of miR-125a-5p, <i>SERPINE1</i> and <i>DNMT1</i> in GC cells and tissues were detected by real-time polymerase chain reaction (PCR) and Western blotting. Methylation-specific PCR was used to detect the level of miR-125a-5p methylation. A cell counting kit 8 assay, scratch test, and a Transwell assay were performed to detect the proliferation, migration, and invasiveness of HGC27 cells, respectively. The expression of the epithelial mesenchymal transition (EMT)-related proteins E-cadherin, N-cadherin and vimentin in HGC27 cells was detected by Western blotting, while the expression of vimentin was detected by immunofluorescence.</p><p><strong>Results: </strong>This study revealed that miR-125a-5p was expressed at low levels in GC clinical samples and cells and that miR-125a-5p overexpression inhibited the proliferation, migration, invasiveness and EMT of GC cells. Mechanistically, miR-125a-5p can reduce GC cell proliferation, promote E-cadherin expression, inhibit N-cadherin and vimentin expression, and reduce the EMT of GC cells, thus constraining GC cells to a certain extent. Moreover, <i>DNMT1</i> inhibited miR-125a-5p expression by increasing the methylation of the miR-125a-5p promoter, thereby promoting the expression of <i>SERPINE1</i>, which acts together with miR-125a-5p to exert antagonistic effects on GC.</p><p><strong>Conclusion: </strong>Our study revealed that <i>DNMT1</i> promoted SERPINE1 protein expression by inducing miR-125a-5p methylation, which led to the proliferation, migration and occurrence of EMT in GC cells.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"98703"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological role of <i>Herba Patriniae</i> and <i>Coix</i> seed in colorectal cancer.","authors":"Yu-Xin Zhang, Hui Wan, Guan-Yue Shan, Jun-Ya Cheng, Yi-Ying Liu, Wen-Na Shi, Hai-Jun Li","doi":"10.4251/wjgo.v17.i3.99673","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.99673","url":null,"abstract":"<p><p>Colorectal cancer (CRC) is the most prevalent cancer globally, and its traditional treatment modalities commonly encompass radiation therapy, chemotherapy, surgery and the administration of cytotoxic drugs. Currently, novel chemotherapy drugs that combine traditional Chinese medicine (TCM) with herbal extracts exhibit superior comprehensive benefits. Herein, we delved into an article authored by Wang <i>et al</i>, focusing specifically on the pharmacological effects of \"<i>Herba Patriniae</i> and <i>Coix</i> seed (HC)\" and their targeted mechanisms in combating CRC. From the perspective of TCM philosophy, damp-heat stagnation and toxicity are the cardinal pathogenic factors underlying CRC. HC, renowned for their abilities to antipyretic and enhance diuresis, have demonstrated promising efficacy in preliminary studies for the treatment of CRC. These findings offer potential insights in favor of fostering anti-cancer medications.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"99673"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of 1,25-dihydroxyvitamin D₃ in alleviating hepatic steatosis: Targeting M1 macrophage polarization in non-alcoholic fatty liver disease.","authors":"Jin-Wei Zhang","doi":"10.4251/wjgo.v17.i3.102424","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.102424","url":null,"abstract":"<p><p>Non-alcoholic fatty liver disease (NAFLD), a critical global health concern, continues to challenge medical researchers with limited treatment options. This letter examines on the study by Luo <i>et al</i>, demonstrating that vitamin D 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] improves hepatic steatosis in NAFLD by inhibiting M1 macrophage polarization <i>via</i> the vitamin D receptor-peroxisome proliferator-activated receptor gamma signaling pathway. This letter critically appraises these findings, comparing them to similar studies, and discusses their potential implications for treating NAFLD. Furthermore, we highlight future directions, including dose optimization and mechanistic studies.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"102424"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression significance of biomarker MORC4 in colorectal cancer patients and its relationship with pathological features and prognosis.","authors":"Li Wei, Liang Wang, Ya-Gang Liu, Li-Fei Gao","doi":"10.4251/wjgo.v17.i3.102434","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.102434","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) is one of the most common malignant gastrointestinal tumors worldwide, with high incidence and mortality rates.</p><p><strong>Aim: </strong>To investigate the expression significance of the chromatin-remodeling protein MORC family CW-type zinc finger 4 (MORC4) as a biomarker in CRC patients, and to explore its relationship with pathological features and prognosis.</p><p><strong>Methods: </strong>A total of 143 CRC specimens and 57 adjacent tissue specimens, surgically removed from our hospital between January 2020 and January 2021, were collected. MORC4 protein expression was assessed using immunohistochemistry after paraffin embedding. The relationship between MORC4 protein expression and clinicopathological characteristics of patients was analyzed. Kaplan-Meier survival curves were plotted to analyze the relationship between MORC4 protein expression and prognosis in CRC patients.</p><p><strong>Results: </strong>Compared with adjacent tissues, the expression rate of MORC4 protein in CRC tissues was significantly higher (<i>P</i> < 0.05). No significant difference was observed in the high expression rate of MORC4 protein in CRC tissues among patients of different gender, age, tumor location, tumor diameter, and primary tumor status (<i>P</i> > 0.05). However, significant differences were found in the high expression rate of MORC4 protein in patients with different degrees of differentiation, lymph node metastasis, distant metastasis, tumor-lymph node-metastasis stage, and serum carcinoembryonic antigen levels (<i>P</i> < 0.05). Compared with patients with low MORC4 expression, patients with high MORC4 expression had a worse prognosis (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The upregulation of MORC4 expression in CRC patients is closely related to disease severity and prognosis, suggesting its potential as an evaluation biomarker, which warrants further investigation.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"102434"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penile metastasis from colon cancer with <i>BRAF</i> ^V600E mutation treated with BRAF/MEK-targeted therapy plus cetuximab: A case report.","authors":"Jun-Chen Wu, Hua-Xi Cheng, Qiu-Sheng Lan, He-Yang Xu, Yu-Jie Zeng, Wei Lai, Zhong-Hua Chu","doi":"10.4251/wjgo.v17.i3.100152","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.100152","url":null,"abstract":"<p><strong>Background: </strong>The incidence of colon cancer has been progressively increasing over time, whereas penile metastasis of colon cancer has remained exceedingly uncommon. Since the prognosis for colon cancer with <i>BRAF</i> ^V600E mutation is relatively unfavorable, further exploration and investigation are still required to develop treatment strategies for such rare cases.</p><p><strong>Case summary: </strong>About one year after surgery and chemotherapy, a 50-year-old patient with sigmoid colon cancer developed a mass at the base of the patient's penis, accompanied by severe tenderness and pain during urination. With disease progression, multiple metastatic nodules also emerged in other regions of the penis, including the coronal sulcus. The nodules located in the coronal sulcus were excised for histopathological examination. The histopathological findings revealed that the nodules were metastases originating from the sigmoid colon cancer, with a <i>BRAF</i> ^V600E mutation detected. This prompted a modification of the therapy regimen of cetuximab, dabrafenib and trametinib, which effectively held back the progression of penile metastasis in the patient.</p><p><strong>Conclusion: </strong>Combining the BRAF/MEK-targeted therapy with cetuximab demonstrates a favorable therapeutic response in <i>BRAF</i> ^V600E-mutated colon cancer with penile metastasis.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"100152"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential role of coagulation markers in early detection of bone metastasis in gastric cancer: A critical review.","authors":"Qing-Nan Lin, Qian Wu, Chong Lv, Jun Tang, Ling-Yun Zhao, Ke-Yang Xu","doi":"10.4251/wjgo.v17.i3.100292","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.100292","url":null,"abstract":"<p><p>This letter to the editor involves the article published in the <i>World Journal of Gastrointestinal Oncology</i>. Bone metastasis (BM) in gastric cancer (GC) is uncommon but can be prevalent in autopsy studies. BM significantly impairs quality of life and is frequently underdiagnosed, as sensitive diagnostic tests are only performed after symptoms occur. Imaging is crucial for the diagnosis of BM but is not routinely used for screening and is expensive. Examining laboratory risk factors for BM in GC patients using multivariate analysis could be a more effective approach.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"100292"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple pseudoprogressions during ongoing immunotherapy-based treatment of advanced gastric neuroendocrine carcinoma: A case report and review of literature.","authors":"Yan-Hua Mou, Juan Zhang, Hui Shen, Jing Yu, Lan Han, Hui Li, Qing-Feng Li","doi":"10.4251/wjgo.v17.i3.102804","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.102804","url":null,"abstract":"<p><strong>Background: </strong>Gastric neuroendocrine carcinomas (NECs) exhibit aggressive features, such as rapid growth, higher rate of metastasis, and a generally unfavorable prognosis compared to gastric adenocarcinoma. As a result, therapeutic options for NECs remain limited, contributing to the poor prognosis of patients. Immunotherapy has emerged as a promising treatment strategy and demonstrated the potential to partially improve the survival and prognosis of patients with NECs. Nevertheless, the unique clinical response termed pseudoprogression (PsP) has garnered considerable attention in the context of immunotherapy.</p><p><strong>Case summary: </strong>Presented here is a case of NEC recurrence five and a half months after radical gastric surgery. The 45-year-old male patient underwent combination treatment involving a PD-1 blocker and tyrosine kinase inhibitors and encountered two instances of PsP during treatment. The patient ultimately achieved a durable treatment response without altering his treatment regimens, resulting in a substantial therapeutic benefit.</p><p><strong>Conclusion: </strong>This case report aimed to provide the authors' experience with the diagnosis of PsP and treatment strategies for PsP in ongoing immunotherapy.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"102804"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}