World Journal of Gastrointestinal Oncology最新文献

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Effects of student standardized patients combined with situational simulation on teaching outcomes of acute and severe gastrointestinal tumors. 学生标准化病人结合情境模拟对急重度胃肠道肿瘤教学效果的影响。
IF 2.5 4区 医学
World Journal of Gastrointestinal Oncology Pub Date : 2025-07-15 DOI: 10.4251/wjgo.v17.i7.104773
Jian Guo, Hai-Tao Mao
{"title":"Effects of student standardized patients combined with situational simulation on teaching outcomes of acute and severe gastrointestinal tumors.","authors":"Jian Guo, Hai-Tao Mao","doi":"10.4251/wjgo.v17.i7.104773","DOIUrl":"10.4251/wjgo.v17.i7.104773","url":null,"abstract":"<p><strong>Background: </strong>Student standardized patients (SSPs) can serve as valuable tools in teaching acute and severe gastrointestinal tumors.</p><p><strong>Aim: </strong>To explore the effect of SSP on scenario simulation teaching and its impact on teaching outcomes.</p><p><strong>Methods: </strong>From July 2021 to June 2024, 200 nursing interns were taught about severe gastrointestinal tumor disease. In July 2022 the SSP scenario simulation teaching method was introduced to an observation group of 100 students. A control group of 100 students was taught using traditional methods from July 2021 to June 2022. The traditional teaching included classroom theoretical instruction, laboratory practical teaching, and course assessments. During the practical laboratory sessions, students performed operations using simulation mannequins, and course assessments were based on theoretical test scores combined with practical assessments using the mannequins. The teaching effects of both groups were compared in terms of comprehensive quality and student satisfaction.</p><p><strong>Results: </strong>The observation group exhibited significantly higher theoretical and operational scores (<i>P</i> < 0.05), a notably livelier classroom atmosphere (<i>P</i> < 0.05), and a higher learning satisfaction than the control group (98.00% <i>vs</i> 91.00%) (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>SSP combined with scenario simulation teaching enhanced the effectiveness of acute and severe gastrointestinal tumor disease education, improved students' overall quality, and increased their learning satisfaction, making it a valuable approach for wider adoption.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 7","pages":"104773"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional risk index in hepatitis B virus-related liver cancer: Infection prediction and prognosis. 乙型肝炎病毒相关性肝癌的营养风险指数:感染预测与预后。
IF 2.5 4区 医学
World Journal of Gastrointestinal Oncology Pub Date : 2025-07-15 DOI: 10.4251/wjgo.v17.i7.105286
Xue-Zhen Zhai, Meng-Yun Dong, Yi-Fan Ding, Ting-Ting Luo
{"title":"Nutritional risk index in hepatitis B virus-related liver cancer: Infection prediction and prognosis.","authors":"Xue-Zhen Zhai, Meng-Yun Dong, Yi-Fan Ding, Ting-Ting Luo","doi":"10.4251/wjgo.v17.i7.105286","DOIUrl":"10.4251/wjgo.v17.i7.105286","url":null,"abstract":"<p><strong>Background: </strong>Surgical treatment for primary liver cancer can effectively reduce infection risks. Accurate prediction is crucial for timely intervention, particularly to reduce the risk of infection.</p><p><strong>Aim: </strong>To explore the predictive and prognostic value of the nutritional risk index (NRI) in hepatitis B virus (HBV)-related liver cancer.</p><p><strong>Methods: </strong>Ninety-six patients with HBV-related primary liver cancer who underwent surgery at our hospital between May 2022 and May 2024 were included. Patients were classified into infection and non-infection groups, and the NRI was compared. The infection group was further divided into mild and severe infection groups and then into survival and deceased groups, and the NRI was compared. Postoperative follow-up lasted 6 months. The predictive value of NRI for surgical site infections (SSIs), severity of infections, and prognostic assessment was analyzed.</p><p><strong>Results: </strong>Compared with patients with mild infection, those with severe infections had a significantly lower NRI (<i>P</i> < 0.05). Compared with patients with mild infections, those with severe infections had a significantly higher NRI (<i>P</i> < 0.05). The NRI was significantly lower in the good prognosis group than in the poor prognosis group (<i>P</i> < 0.05). Receiver operating characteristic curve analysis showed that the areas under the curve for NRI in predicting SSIs, infection severity, and patient prognosis were 0.984, 0.986, and 0.949, respectively.</p><p><strong>Conclusion: </strong>The NRI can accurately predict postoperative SSIs in patients with HBV-related primary liver cancer and plays a role in predicting the severity of infections and in prognostic assessment.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 7","pages":"105286"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pan-cancer analysis of UDP-glucose 6-dehydrogenase in human tumors and its function in hepatocellular carcinoma. 人肿瘤中udp -葡萄糖6-脱氢酶的泛癌分析及其在肝癌中的作用。
IF 2.5 4区 医学
World Journal of Gastrointestinal Oncology Pub Date : 2025-07-15 DOI: 10.4251/wjgo.v17.i7.105981
Xu Cao, Shi-Hao Zheng, Jiu-Mei Shen, Si-Ze Li, Li Hou, Jia-Xin Zhang, Xiao-Ke Li, Hong-Bo Du, Li-Ping Zhang, Yong-An Ye, Xiao-Bin Zao
{"title":"Pan-cancer analysis of UDP-glucose 6-dehydrogenase in human tumors and its function in hepatocellular carcinoma.","authors":"Xu Cao, Shi-Hao Zheng, Jiu-Mei Shen, Si-Ze Li, Li Hou, Jia-Xin Zhang, Xiao-Ke Li, Hong-Bo Du, Li-Ping Zhang, Yong-An Ye, Xiao-Bin Zao","doi":"10.4251/wjgo.v17.i7.105981","DOIUrl":"10.4251/wjgo.v17.i7.105981","url":null,"abstract":"<p><strong>Background: </strong>UDP-glucose 6-dehydrogenase (UGDH) is a key enzyme in glucuronic acid metabolism and acts as a key mediator in several cancer developmental signaling pathways.</p><p><strong>Aim: </strong>To offer a more systematic and comprehensive elucidation of the involvement of UGDH in the onset and progression of various malignancies.</p><p><strong>Methods: </strong>The role of UGDH in cancer was investigated <i>via</i> public databases. The data were analyzed <i>via</i> various R packages and websites, including TISIDB, cBioPortal, STRING, Cytoscape, GSCALite, and CancerSEA. A rat hepatocellular carcinoma (HCC) model was established <i>via</i> the intraperitoneal injection of diethylnitrosamine. Hematoxylin-eosin staining, Masson staining, Ki67 and UGDH immunohistochemical staining, and ARG1 immunofluorescence staining of liver tissues were performed. Real-time quantitative PCR and Western blotting were used to detect UGDH expression. The UGDH gene was knocked down in Huh7 cells, and CCK8 and nude mouse tumor xenograft assays were performed.</p><p><strong>Results: </strong>High UGDH expression is associated with poor clinical outcomes in HCC, lung adenocarcinoma, lung squamous cell carcinoma, and sarcoma patients and is differentially expressed across molecular and immune subtypes. UGDH is primarily involved in the pentose and glucuronate interconversion pathway. Its expression is positively correlated with T helper, Tcm, and Th2 cells in most cancers. Moreover, experimental results demonstrated that UGDH expression is elevated in HCC tissues and that its downregulation inhibits HCC cell proliferation.</p><p><strong>Conclusion: </strong>Our study revealed that UGDH could be a valuable prognostic biomarker and potential therapeutic target in many cancers, especially liver and lung cancer. UGDH could promote HCC cell proliferation, potentially by modulating the pentose and glucuronate interconversion pathways.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 7","pages":"105981"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting SHP2: Dual breakthroughs in colorectal cancer therapy-from signaling pathway modulation to immune microenvironment remodeling. 靶向SHP2:结直肠癌治疗的双重突破——从信号通路调节到免疫微环境重塑。
IF 2.5 4区 医学
World Journal of Gastrointestinal Oncology Pub Date : 2025-07-15 DOI: 10.4251/wjgo.v17.i7.107380
Pan Liu, Jia Chen
{"title":"Targeting SHP2: Dual breakthroughs in colorectal cancer therapy-from signaling pathway modulation to immune microenvironment remodeling.","authors":"Pan Liu, Jia Chen","doi":"10.4251/wjgo.v17.i7.107380","DOIUrl":"10.4251/wjgo.v17.i7.107380","url":null,"abstract":"<p><p>SHP2 is the first identified oncogenic tyrosine phosphatase that promotes colorectal cancer (CRC) progression, and it is consistently overexpressed in CRC. It facilitates CRC oncogenesis by mediating downstream signaling cascades of receptor tyrosine kinases, including the RAS/ERK, JAK/STAT, and PI3K/AKT pathways, which are clinically associated with poor prognosis. Furthermore, SHP2 orchestrates immunosuppressive signaling networks by impairing cytotoxic T cell infiltration and changing the phenotype of tumor-associated macrophages within the tumor microenvironment (TME). Targeting SHP2 represents a dual therapeutic strategy in CRC: It concurrently regulates RTK signaling and reprograms the immunosuppressive TME. SHP2 inhibitors, administered both as monotherapy and in combination regimens, have advanced into clinical trial phases. Consequently, SHP2 serves as both a molecular target for precision oncology and an immunomodulatory node, positioning it as a high-priority candidate for CRC treatment.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 7","pages":"107380"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond numbers: Public health insurance and oesophageal cancer mortality risk. 数字之外:公共健康保险和食道癌死亡风险。
IF 2.5 4区 医学
World Journal of Gastrointestinal Oncology Pub Date : 2025-07-15 DOI: 10.4251/wjgo.v17.i7.107460
Divya K Huilgol, Brandon Lucke-Wold
{"title":"Beyond numbers: Public health insurance and oesophageal cancer mortality risk.","authors":"Divya K Huilgol, Brandon Lucke-Wold","doi":"10.4251/wjgo.v17.i7.107460","DOIUrl":"10.4251/wjgo.v17.i7.107460","url":null,"abstract":"<p><p>In this article, we comment on the work put forth by Wu <i>et al</i> regarding the investigation of oesophageal cancer-specific mortality for a cohort of patients from Chongqing University Cancer Hospital. We specifically focused on the implications of public health plans such as Urban Employee Basic Medical Insurance (UEBMI) and Urban Resident Basic Medical Insurance as well as out-of-pocket ratios on patient treatment plans regarding whether they pursue surgical interventions or therapeutic treatments such as chemotherapy. While Wu <i>et al</i> put forth potential explanations for why patients with the UEBMI plan surprisingly had a 23.30% increased risk of oesophageal cancer-specific death, more analysis is needed to alleviate cancer burden within this group. Although it is likely that patients covered by Urban Resident Basic Medical Insurance and higher out-of-pocket ratios have stronger self-recovery awareness, more work must be done to improve outcomes for people with the UEBMI plan while simultaneously implementing international and domestic initiatives to better emphasize cancer prevention and early detection. Lastly, future research must explore the relationship between Serious Illness Medical Insurance as well as the New Rural Cooperative Medical System on the mortality rate of oesophageal cancer patients in rural China, where disease burden is significantly higher than urban areas. By unifying these public health insurance schemes, officials can significantly alleviate economic burden of treatment and better prognosis for patients with oesophageal cancer.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 7","pages":"107460"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SAC3 domain containing 1 intervention in energy metabolism reprogramming assists in the progression of hepatocellular carcinoma. 含1的SAC3结构域干预能量代谢重编程有助于肝细胞癌的进展。
IF 2.5 4区 医学
World Journal of Gastrointestinal Oncology Pub Date : 2025-07-15 DOI: 10.4251/wjgo.v17.i7.107971
Xue-Jing Lin, Er-Jiang Tang, Bin Sun, Ai-Li Wang, Ying Chen, Lei Chen, Yi-Yang Xue, A-Jian Li, Chun-Ying Liu
{"title":"SAC3 domain containing 1 intervention in energy metabolism reprogramming assists in the progression of hepatocellular carcinoma.","authors":"Xue-Jing Lin, Er-Jiang Tang, Bin Sun, Ai-Li Wang, Ying Chen, Lei Chen, Yi-Yang Xue, A-Jian Li, Chun-Ying Liu","doi":"10.4251/wjgo.v17.i7.107971","DOIUrl":"10.4251/wjgo.v17.i7.107971","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysregulation is considered a significant hallmark of hepatocellular carcinoma (HCC). SAC3 domain containing 1 (SAC3D1) functions in the cell cycle, and its expression is upregulated in various cancers. It is known that metabolic changes occur at different stages of the cell cycle to maintain the biosynthesis and replication of both normal and cancer cells. Based on the role of SAC3D1 in mitosis, we hypothesize that abnormal expression of SAC3D1 may affect cellular metabolism. However, it remains unclear whether SAC3D1 mediates the progression of HCC by regulating metabolic reprogramming.</p><p><strong>Aim: </strong>To comprehensively elucidate the impact and molecular mechanism of SAC3D1 on the progression of HCC by regulating the metabolic reprogramming.</p><p><strong>Methods: </strong>The constructed SAC3D1 overexpression and knockdown HCC cell lines were used for detecting cell proliferation, migration capabilities, as well as glycolysis and adenosine triphosphate (ATP) production rate assays. They were also employed for examining molecular markers associated with cell migration and glycolysis. The transcriptome sequencing data of cells have revealed the pathways potentially influenced by SAC3D1.The tail vein metastasis model and xenograft tumor experiments were utilized to demonstrate SAC3D1's tumor-promoting effects <i>in vivo</i>.</p><p><strong>Results: </strong>SAC3D1 expression was upregulated and associated with poor prognosis in HCC patients. SAC3D1 enhanced the proliferation and migration abilities and reduced the population dependence of HCC cells <i>in vitro</i> and <i>in vivo</i>. The upregulation of SAC3D1 enhanced cellular glycolysis and ATP production. The cell transcriptome sequencing data revealed that SAC3D1 activated Wnt signaling pathway. SAC3D1 did not modulate the transcription of <i>β-Catenin</i>, while might inhibit its degradation. Further investigations indicated that the increase of SAC3D1 leads to more β-Catenin accumulating in the nucleus, facilitating the expression of c-Myc, one of the upstream regulatory factors of glycolysis. The iCRT3, an antagonist of β-Catenin, could counteract the increase of c-Myc induced by SAC3D1, while also downregulating the expression of glycolysis-related proteins.</p><p><strong>Conclusion: </strong>This study found that SAC3D1 enhances HCC cell glycolysis and ATP production <i>via</i> the β-Catenin/c-Myc signaling axis, thereby promoting the progression of HCC.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 7","pages":"107971"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adoptive cell therapy in colorectal cancer: Advances in chimeric antigen receptor T cells. 结直肠癌的过继细胞治疗:嵌合抗原受体T细胞的研究进展。
IF 2.5 4区 医学
World Journal of Gastrointestinal Oncology Pub Date : 2025-07-15 DOI: 10.4251/wjgo.v17.i7.106723
Meng-Yan Chen, Chen Wang, Yu-Gang Wang, Min Shi
{"title":"Adoptive cell therapy in colorectal cancer: Advances in chimeric antigen receptor T cells.","authors":"Meng-Yan Chen, Chen Wang, Yu-Gang Wang, Min Shi","doi":"10.4251/wjgo.v17.i7.106723","DOIUrl":"10.4251/wjgo.v17.i7.106723","url":null,"abstract":"<p><p>Colorectal cancer (CRC) is the third most common cancer worldwide and remains a major treatment challenge, particularly in advanced and metastatic stages. Current standard treatments have limited efficacy, underscoring the urgent need for innovative strategies. Adoptive cell therapy (ACT), which involves <i>in vitro</i> expansion or genetic engineering of immune cells, is a promising approach to bolster anti-tumor immune responses. Key ACT modalities include chimeric antigen receptor (CAR) T cells, tumor-infiltrating lymphocytes (TILs), and T cell receptor (TCR)-engineered T cells. CAR-T cell therapy has shown success in hematological malignancies but faces significant challenges in solid tumors like CRC. These challenges include antigen heterogeneity, an immunosuppressive tumor microenvironment, on-target off-tumor toxicity, among other factors. To address these limitations, combinatorial approaches, such as immune checkpoint inhibitors, cytokines, and advanced gene-editing tools like CRISPR/Cas9, are being actively explored. These strategies aim to enhance CAR-T cell specificity, improve resistance to immunosuppressive signals, and optimize <i>in vivo</i> functionality. This review summarizes ACT approaches for CRC, with a focus on CAR-T therapy. It briefly introduces TILs and TCR-T cells, while emphasizing the major challenges faced by CAR-T therapy in solid tumors and discusses potential strategies to improve therapeutic outcomes.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 7","pages":"106723"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Prohibitin 1 inhibits cell proliferation and induces apoptosis via the p53-mediated mitochondrial pathway in vitro. 在体外通过p53介导的线粒体途径抑制细胞增殖和诱导细胞凋亡。
IF 2.5 4区 医学
World Journal of Gastrointestinal Oncology Pub Date : 2025-07-15 DOI: 10.4251/wjgo.v17.i7.110127
Juan-Juan Shi, Shuang-Suo Dang
{"title":"Correction to: Prohibitin 1 inhibits cell proliferation and induces apoptosis <i>via</i> the p53-mediated mitochondrial pathway <i>in vitro</i>.","authors":"Juan-Juan Shi, Shuang-Suo Dang","doi":"10.4251/wjgo.v17.i7.110127","DOIUrl":"10.4251/wjgo.v17.i7.110127","url":null,"abstract":"<p><p>[This corrects the article on p. 398 in vol. 16, PMID: 38425403.].</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 7","pages":"110127"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of radiotherapy on lymphocytes in patients with middle and lower esophageal cancer and its relationship with prognosis. 放疗对中下段食管癌患者淋巴细胞的影响及其与预后的关系。
IF 2.5 4区 医学
World Journal of Gastrointestinal Oncology Pub Date : 2025-07-15 DOI: 10.4251/wjgo.v17.i7.108205
Shu-Guang Li, Yang Liu, Xue-Yuan Zhang, You-Mei Li, Wen-Bin Shen, Shu-Chai Zhu
{"title":"Effects of radiotherapy on lymphocytes in patients with middle and lower esophageal cancer and its relationship with prognosis.","authors":"Shu-Guang Li, Yang Liu, Xue-Yuan Zhang, You-Mei Li, Wen-Bin Shen, Shu-Chai Zhu","doi":"10.4251/wjgo.v17.i7.108205","DOIUrl":"10.4251/wjgo.v17.i7.108205","url":null,"abstract":"<p><strong>Background: </strong>Definitive chemoradiotherapy is the standard treatment for unresectable, locally advanced esophageal cancer. However, radiotherapy (RT) often affects the immune system of patients. One of the possible mechanisms of lymphopenia after RT is that a large number of circulating lymphocytes in the systemic and pulmonary circulation will be killed by more sessions of low-dose radiation. The impact of dose-volume parameters of organs at risk (OARs) on absolute lymphocyte count (ALC) and the relationship between the extent of lymphocyte count reduction and survival prognosis in patients with middle and lower thoracic esophageal squamous cell carcinoma (ESCC) both remain difficult to determine.</p><p><strong>Aim: </strong>To determine the relationship between RT parameters, lymphocyte count and survival prognosis of esophageal cancer patients.</p><p><strong>Methods: </strong>The clinical data of 112 patients with stage I-III ESCC who received definitive RT were analyzed retrospectively. The ALC values before RT, weekly during RT, and within 1 month after RT were determined. Logistic regression was used to evaluate the correlation between the parameters of radiation OARs and the lowest point of the ALC. Kaplan-Meier and Cox regression analyses were used to evaluate the relationship between the lowest point of the ALC and patient survival during RT.</p><p><strong>Results: </strong>The median value of the ALC before treatment was 1.57 × 10<sup>9</sup> cells/L, and 32 patients (28.6%) showed grade 4 ALC reduction during RT. The reduction in G4 ALC during RT was significantly associated with poor overall survival (OS) and progression-free survival. Multivariate analysis showed that stage III tumors (<i>P</i> = 0.003), high heart V<sub>10</sub> (<i>P</i> = 0.046), high lung V<sub>5</sub> (<i>P</i> = 0.048), and high lung V<sub>20</sub> (<i>P</i> = 0.031) were associated with G4 ALC reduction during RT.</p><p><strong>Conclusion: </strong>The reduction in G4 ALC is related to OS. Joint evaluation of the tumor stage and dose volume parameters has predictive value for G4 ALC reduction and OS.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 7","pages":"108205"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive value of a nomogram model for treatment response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. 局部晚期直肠癌新辅助放化疗治疗反应的nomogram模型的预测价值。
IF 2.5 4区 医学
World Journal of Gastrointestinal Oncology Pub Date : 2025-07-15 DOI: 10.4251/wjgo.v17.i7.105403
Qiong-Ya Guo, Wei Zhang, Lin Fu, Shan-Shan Hu, Lin Li
{"title":"Predictive value of a nomogram model for treatment response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer.","authors":"Qiong-Ya Guo, Wei Zhang, Lin Fu, Shan-Shan Hu, Lin Li","doi":"10.4251/wjgo.v17.i7.105403","DOIUrl":"10.4251/wjgo.v17.i7.105403","url":null,"abstract":"<p><strong>Background: </strong>Locally advanced rectal cancer (LARC) carries a substantial risk of recurrence, prompting the use of neoadjuvant chemoradiotherapy (nCRT) to improve tumor resectability and long-term outcomes. However, individual treatment responses vary considerably, highlighting the need for robust predictive tools to guide clinical decision-making.</p><p><strong>Aim: </strong>To develop a nomogram model integrating clinical characteristics and biomarkers to predict the likelihood of poor response to nCRT in LARC.</p><p><strong>Methods: </strong>A retrospective analysis was performed on 178 patients with stage II-III LARC treated from January 2021 to December 2023. All patients underwent standardized nCRT followed by total mesorectal excision. Clinical data, inflammatory markers [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha], and tumor markers [carcinoembryonic antigen (CEA), carbohydrate antigen 19-9] were collected. Logistic regression was used to identify independent predictors of poor nCRT response. A nomogram was constructed using significant predictors and validated <i>via</i> concordance index (C-index), receiver operating characteristic curve, calibration plot, and decision curve analysis (DCA).</p><p><strong>Results: </strong>A total of 178 patients were enrolled, with 36 (20.2%) achieving a good response and 142 (79.8%) exhibiting a poor response to nCRT. Baseline factors, including age and comorbidities, showed no significant differences. However, poor responders more frequently had lymph node metastasis, advanced tumor node metastasis/T stage, larger tumor diameter, and elevated CRP, IL-6, and CEA levels. Logistic regression confirmed CRP, IL-6, and CEA as independent predictors of poor response. The nomogram demonstrated high accuracy (area under the curve = 0.928), good calibration (Hosmer-Lemeshow <i>P</i> = 0.928), and a sensitivity of 88.1% with 82.6% specificity. Internal validation <i>via</i> bootstrap resampling (<i>n</i> = 1000) yielded an adjusted C-index of 0.716, and DCA confirmed substantial clinical utility.</p><p><strong>Conclusion: </strong>A nomogram incorporating serum CRP, IL-6, and CEA accurately predicts poor nCRT response in patients with LARC. This model provides a valuable framework for individualized treatment planning, potentially improving clinical outcomes.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 7","pages":"105403"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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