World Journal of Gastrointestinal Oncology最新文献

{"title":"Complete response of gallbladder cancer treated with gemcitabine and cisplatin chemotherapy combined with durvalumab: A case report and review of literature.","authors":"Kai Chen, Xu Feng, Yuan Shi, Xin-Lin Li, Zheng-Rong Shi, Xiang Lan","doi":"10.4251/wjgo.v17.i1.98433","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i1.98433","url":null,"abstract":"<p><strong>Background: </strong>Gallbladder cancer (GBC) is the most common and aggressive subtype of biliary tract cancer (BTC) and has a poor prognosis. A newly developed regimen of gemcitabine, cisplatin, and durvalumab shows promise for the treatment of advanced BTC. However, the efficacy of this treatment for GBC remains unclear.</p><p><strong>Case summary: </strong>In this report, we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC, thus leading to a long-term survival benefit. A 68-year-old man was diagnosed with locally advanced GBC, which rendered him ineligible for curative surgery. Following three cycles of therapy, a partial response was observed. After one year of combined therapy, a clinical complete response was successfully achieved. Subsequent maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the patient. The patient experienced tolerable toxicities of reversible grade 2 nausea and fatigue. Tolerable adverse events were observed in the patient throughout the entirety of the treatment.</p><p><strong>Conclusion: </strong>The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC, with manageable adverse events. Further research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 1","pages":"98433"},"PeriodicalIF":2.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma.","authors":"Radu Cristian Poenaru, Elena Milanesi, Andrei Marian Niculae, Anastasia-Maria Dobre, Catalina Vladut, Mihai Ciocîrlan, Daniel Vasile Balaban, Vlad Herlea, Maria Dobre, Mihail Eugen Hinescu","doi":"10.4251/wjgo.v17.i1.98409","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i1.98409","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic ductal adenocarcinoma (PDAC) is an aggressive lethal malignancy with limited options for treatment and a 5-year survival rate of 11% in the United States. As for other types of tumors, such as colorectal cancer, aberrant <i>de novo</i> lipid synthesis and reprogrammed lipid metabolism have been suggested to be associated with PDAC development and progression.</p><p><strong>Aim: </strong>To identify the possible involvement of lipid metabolism in PDAC by analyzing in tumoral and non-tumoral tissues the expression level of the most relevant genes involved in the long-chain fatty acid (FA) import into cell.</p><p><strong>Methods: </strong>A gene expression analysis of <i>FASN</i>, <i>CD36</i>, <i>SLC27A1</i>, <i>SLC27A2</i>, <i>SLC27A3</i>, <i>SLC27A4</i>, <i>SLC27A5</i>, <i>ACSL1</i>, and <i>ACSL3</i> was performed by qRT-PCR in 24 tumoral PDAC tissues and 11 samples from non-tumoral pancreatic tissues obtained <i>via</i> fine needle aspiration or <i>via</i> surgical resection. The genes were considered significantly dysregulated between the groups when the p value was < 0.05 and the fold change (FC) was ≤ 0.5 and ≥ 2.</p><p><strong>Results: </strong>We found that three FA transporters and two long-chain acyl-CoA synthetases genes were significantly upregulated in the PDAC tissue compared to the non-tumoral tissue: <i>SLC27A2</i> (FC = 5.66; <i>P</i> = 0.033), <i>SLC27A3</i> (FC = 2.68; <i>P</i> = 0.040), <i>SLC27A4</i> (FC = 3.13; <i>P</i> = 0.033), <i>ACSL1</i> (FC = 4.10; <i>P</i> < 0.001), and <i>ACSL3</i> (FC = 2.67; <i>P</i> = 0.012). We further investigated any possible association between the levels of the analyzed mRNAs and the specific characteristics of the tumors, including the anatomic location, the lymph node involvement, and the presence of metastasis. A significant difference in the expression of <i>SLC27A3</i> (FC = 3.28; <i>P</i> = 0.040) was found comparing patients with and without lymph nodes involvement with an overexpression of this transcript in 17 patients presenting tumoral cells in the lymph nodes.</p><p><strong>Conclusion: </strong>Despite the low number of patients analyzed, these preliminary results seem to be promising. Addressing lipid metabolism through a broad strategy could be a beneficial way to treat this malignancy. Future <i>in vitro</i> and <i>in vivo</i> studies on these genes may offer important insights into the mechanisms linking PDAC with the long-chain FA import pathway.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 1","pages":"98409"},"PeriodicalIF":2.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin in gastric cancer treatment: A commentary on mechanistic insights and future directions.","authors":"Xin-Yue Wei, Wen-Bo Cao, Sai-Jun Mo, Zhi-Yan Sun","doi":"10.4251/wjgo.v17.i1.100369","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i1.100369","url":null,"abstract":"<p><p>The study by Yang <i>et al</i> presents a comprehensive investigation into the therapeutic potential of curcumin for gastric cancer (GC). Using network pharmacology, the researchers identified 48 curcumin-related genes, 31 of which overlap with GC targets. Key genes, including <i>ESR1</i>, <i>EGFR</i>, <i>CYP3A4</i>, <i>MAPK14</i>, <i>CYP1A2</i>, and <i>CYP2B6</i>, are linked to poor survival in GC patients. Molecular docking confirmed strong binding affinity of curcumin to these genes. <i>In vitro</i> experiments demonstrated that curcumin effectively inhibits the growth and proliferation of <i>BGC-823</i>, suggesting its therapeutic potential in GC through multiple targets and pathways.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 1","pages":"100369"},"PeriodicalIF":2.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer.","authors":"Yi-Qing Shen, Qiu-Wan Wei, Yi-Ren Tian, Yun-Zhi Ling, Min Zhang","doi":"10.4251/wjgo.v17.i1.98725","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i1.98725","url":null,"abstract":"<p><strong>Background: </strong>Gastric cancer (GC) is a prevalent malignancy with a substantial health burden and high mortality rate, despite advances in prevention, early detection, and treatment. Compared with the global average, Asia, notably China, reports disproportionately high GC incidences. The disease often progresses asymptomatically in the early stages, leading to delayed diagnosis and compromised outcomes. Thus, it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce mortality.</p><p><strong>Aim: </strong>To investigate coagulation and fibrinogen products in GC tumor-node-metastasis (TNM) stage and metastasis correlation.</p><p><strong>Methods: </strong>Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai Hospital between December 2022 and December 2023. The associations of coagulation indices - partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen, fibrinogen degradation products (FDP), fasting blood glucose, and D-dimer (D-D) with TNM stage and distant metastasis were examined.</p><p><strong>Results: </strong>Prolongation of APTT, PT, and TT was significantly correlated with the GC TNM stage. Hence, abnormal coagulation system activation was closely related to disease progression. Elevated FDP and D-D were significantly associated with distant metastasis in GC (<i>P</i> < 0.05), suggesting that increased fibrinolytic activity contributes to increased metastatic risk.</p><p><strong>Conclusion: </strong>Our Results reveal coagulation indices, FDPs as GC biomarkers, reflecting abnormal coagulation/fibrinolysis, aiding disease progression, metastasis prediction, and helping clinicians assess thrombotic risk for early intervention and personalized treatment plans.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 1","pages":"98725"},"PeriodicalIF":2.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between autoimmune gastritis and gastric polyps: Clinical characteristics and risk factors.","authors":"Jing-Zheng Jin, Xiao Liang, Shu-Peng Liu, Rui-Lan Wang, Qing-Wei Zhang, Yu-Feng Shen, Xiao-Bo Li","doi":"10.4251/wjgo.v17.i1.92908","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i1.92908","url":null,"abstract":"<p><strong>Background: </strong>The relationship between autoimmune gastritis (AIG) and gastric polyps (GPs) is not well understood.</p><p><strong>Aim: </strong>To explore the clinical characteristics and risk factors of AIG with GPs in patients.</p><p><strong>Methods: </strong>This double center retrospective study included 530 patients diagnosed with AIG from July 2019 to July 2023. We collected clinical, biochemical, serological, and demographic data were of each patient. Logistic regression analyses, both multivariate and univariate, were conducted to pinpoint independent risk factors for GPs in patients with AIG patients. Receiver operating characteristic curves were utilized to establish the optimal cutoff values, sensitivity, and specificity of these risk factors for predicting GPs in patients with AIG.</p><p><strong>Results: </strong>Patients with GPs had a higher median age than those without GPs [61 (52.25-69) years <i>vs</i> 58 (47-66) years, <i>P</i> = 0.006]. The gastrin-17 levels were significantly elevated in patients with GPs compared with those without GPs [91.9 (34.2-138.9) pmol/mL <i>vs</i> 60.9 (12.6-98.4) pmol/mL, <i>P</i> < 0.001]. Additionally, the positive rate of parietal cell antibody (PCA) antibody was higher in these patients than in those without GPs (88.6% <i>vs</i> 73.6%, <i>P</i> < 0.001). Multivariate and univariate analyses revealed that PCA positivity [odds ratio (OR) = 2.003, <i>P</i> = 0.017], pepsinogen II (OR = 1.053, <i>P</i> = 0.015), and enterochromaffin like cells hyperplasia (OR = 3.116, <i>P</i> < 0.001) were significant risk factors for GPs, while pepsinogen I was identified as a protective factor.</p><p><strong>Conclusion: </strong>PCA positivity and enterochromaffin like cells hyperplasia are significant risk factor for the development of GPs in patients with AIG. Elevated gastrin-17 levels may also play a role in this process. These findings suggest potential targets for further research and therapeutic intervention in managing GPs in patients with AIG.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 1","pages":"92908"},"PeriodicalIF":2.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gallbladder carcinoma in the era of artificial intelligence: Early diagnosis for better treatment.","authors":"Ismail As Burud, Sherreen Elhariri, Nabil Eid","doi":"10.4251/wjgo.v17.i1.99994","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i1.99994","url":null,"abstract":"<p><p>Gallbladder carcinoma (GBC) is the most common malignant tumor of biliary tract, with poor prognosis due to its aggressive nature and limited therapeutic options. Early detection of GBC is a major challenge, with most GBCs being detected accidentally during cholecystectomy procedures for gallbladder stones. This letter comments on the recent article by Deqing <i>et al</i> in the <i>World Journal of Gastrointestinal Oncology</i>, which summarized the various current methods used in early diagnosis of GBC, including endoscopic ultrasound (EUS) examination of the gallbladder for high-risk GBC patients, and the use of EUS-guided elastography, contrast-enhanced EUS, trans-papillary biopsy, natural orifice transluminal endoscopic surgery, magnifying endoscopy, choledochoscopy, and confocal laser endomicroscopy when necessary for early diagnosis of GBC. However, there is a need for novel methods for early GBC diagnosis, such as the use of artificial intelligence and non-coding RNA biomarkers for improved screening protocols. Additionally, the use of <i>in vitro</i> and animal models may provide critical insights for advancing early detection and treatment strategies of this aggressive tumor.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 1","pages":"99994"},"PeriodicalIF":2.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the landscape of pediatric pancreatic tumors: Insights from Japan.","authors":"Savvas Lampridis","doi":"10.4251/wjgo.v17.i1.101477","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i1.101477","url":null,"abstract":"<p><p>Pediatric pancreatic tumors, though rare, pose significant diagnostic and management challenges. The recent, 22-year nationwide survey on pediatric pancreatic tumors in Japan by Makita <i>et al</i> offers valuable insights into this uncommon entity, revealing striking geographical variations and questioning current treatment paradigms. This editorial commentary analyzes the study's key findings, including the predominance of solid pseudopapillary neoplasms and their younger age of onset, which contrast sharply with Western data. It explores the implications for clinical practice and research, emphasizing the need for population-specific approaches to diagnosis and treatment. The revealed limited institutional experience and surgical management patterns prompt a reevaluation of optimal care delivery for these complex cases, suggesting benefits of centralizing healthcare services. Furthermore, the commentary advocates for international collaborative studies to elucidate the genetic, environmental, and lifestyle factors influencing the development and progression of pediatric pancreatic tumors across diverse populations. It also outlines future directions, calling for advancements in precision medicine and innovative care delivery models to improve global patient outcomes. Unraveling Makita <i>et al</i>'s findings within the broader landscape of pediatric oncology can stimulate further research and clinical advancements in managing pancreatic and other rare tumors in children.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 1","pages":"101477"},"PeriodicalIF":2.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma: A case report.","authors":"Yun-Chuan Yang, Zhi-Tao Chen, Da-Long Wan, Hui Tang, Mu-Lin Liu","doi":"10.4251/wjgo.v17.i1.100757","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i1.100757","url":null,"abstract":"<p><strong>Background: </strong>Gallbladder neuroendocrine carcinoma (NEC) represents a subtype of gallbladder malignancies characterized by a low incidence, aggressive nature, and poor prognosis. Despite its clinical severity, the genetic alterations, mechanisms, and signaling pathways underlying gallbladder NEC remain unclear.</p><p><strong>Case summary: </strong>This case study presents a rare instance of primary gallbladder NEC in a 73-year-old female patient, who underwent a radical cholecystectomy with hepatic hilar lymphadenectomy and resection of liver segments IV-B and V. Targeted gene sequencing and bioinformatics analysis tools, including STRING, GeneMANIA, Metascape, TRRUST, Sangerbox, cBioPortal and GSCA, were used to analyze the biological functions and features of mutated genes in gallbladder NEC. Twelve mutations (<i>APC</i>, <i>ARID2</i>, <i>IFNA6</i>, <i>KEAP1</i>, <i>RB1</i>, <i>SMAD4</i>, <i>TP53</i>, <i>BTK</i>, <i>GATA1</i>, <i>GNAS</i>, and <i>PRDM3</i>) were identified, and the tumor mutation burden was determined to be 9.52 muts/Mb <i>via</i> targeted gene sequencing. A protein-protein interaction network showed significant interactions among the twelve mutated genes. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were used to assess mutation functions and pathways. The results revealed 40 tumor-related pathways. A key regulatory factor for gallbladder NEC-related genes was identified, and its biological functions and features were compared with those of gallbladder carcinoma.</p><p><strong>Conclusion: </strong>Gallbladder NEC requires standardized treatment. Comparisons with other gallbladder carcinomas revealed clinical phenotypes, molecular alterations, functional characteristics, and enriched pathways.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 1","pages":"100757"},"PeriodicalIF":2.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population.","authors":"Si-Yun Lin, Hou Huang, Jin-Jie Yu, Feng Su, Tian Jiang, Shao-Yuan Zhang, Lu Lv, Tao Long, Hui-Wen Pan, Jun-Qing Qi, Qiang Zhou, Wei-Feng Tang, Guo-Wen Ding, Li-Ming Wang, Li-Jie Tan, Jun Yin","doi":"10.4251/wjgo.v17.i1.96702","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i1.96702","url":null,"abstract":"<p><strong>Background: </strong>Transforming growth factor-β (TGF-β) superfamily plays an important role in tumor progression and metastasis. Activin A receptor type 1C (ACVR1C) is a TGF-β type I receptor that is involved in tumorigenesis through binding to different ligands.</p><p><strong>Aim: </strong>To evaluate the correlation between single nucleotide polymorphisms (SNPs) of ACVR1C and susceptibility to esophageal squamous cell carcinoma (ESCC) in Chinese Han population.</p><p><strong>Methods: </strong>In this hospital-based cohort study, 1043 ESCC patients and 1143 healthy controls were enrolled. Five SNPs (rs4664229, rs4556933, rs77886248, rs77263459, rs6734630) of ACVR1C were assessed by the ligation detection reaction method. Hardy-Weinberg equilibrium test, genetic model analysis, stratified analysis, linkage disequilibrium test, and haplotype analysis were conducted.</p><p><strong>Results: </strong>Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC, and those with rs77886248 TA mutant were related with higher risk, especially in older male smokers. In the haplotype analysis, ACVR1C T_rs4664229A_rs4556933T_rs77886248C_rs77263459A_rs6734630 increased risk of ESCC, while T_rs4664229G_rs4556933T_rs77886248C_rs77263459A_rs6734630 was associated with lower susceptibility to ESCC.</p><p><strong>Conclusion: </strong>ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC, which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 1","pages":"96702"},"PeriodicalIF":2.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Shenqi Xiangyi granules in advanced gastric cancer chemotherapy.","authors":"Xiao-Jing Shi, Yu Song, Xue-Xue Liang, Ting Chen, Huang-Yu Hao, Xue Han, Ya-Nan Chen","doi":"10.4251/wjgo.v17.i1.99272","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i1.99272","url":null,"abstract":"<p><strong>Background: </strong>Owing to the absence of specific symptoms in early-stage gastric cancer, most patients are diagnosed at intermediate or advanced stages. As a result, treatment often shifts from surgery to other therapies, with chemotherapy and targeted therapies being the primary options for advanced gastric cancer treatment.</p><p><strong>Aim: </strong>To investigate both treatment efficacy and immune modulation.</p><p><strong>Methods: </strong>A total of 116 patients with advanced gastric cancer, admitted from January 2021 to December 2023, were selected and divided into two groups of 58 each using the random number table method. The control group received FOLFOX4 chemotherapy (oxaliplatin + calcium + folinate + 5-fluorouracil) combined with intravenous sindilizumab. The observation group received the same treatment as the control group, supplemented by oral administration of Senqi Shiyiwei granules. Both groups underwent treatment cycles of 3 weeks, with a minimum of two cycles. The therapeutic efficacy, immune mechanisms, and treatment-related toxicity and side effects were compared between the groups.</p><p><strong>Results: </strong>The objective remission rate in the observation group (55.17%) was higher than that of the control group (36.21%) (<i>P</i> < 0.05). After two treatment cycle, CD3+, CD4+, and CD4+/CD8+ levels were higher in the observation group compared to the control group, while CD8+, regulatory T cells, and natural killer cells were lower (<i>P</i> < 0.05). Additionally, the incidence of leukopenia, nausea, and vomiting was lower in observed group (<i>P</i> < 0.05). No significant differences were observed in the incidence of other adverse reactions (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>Adjuvant therapy with Shenqixian granules may enhance the efficacy of simudizumab combined with FOLFOX4 chemotherapy in advanced gastric cancer and the immune function by increasing immune cell counts, making it a valuable option in clinical treatment.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 1","pages":"99272"},"PeriodicalIF":2.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}