World Journal of Gastrointestinal Oncology最新文献_第2页

Balancing early detection and over-screening: Evaluating colonoscopy's role in shaping colorectal cancer trends in Korea. 平衡早期发现和过度筛查：评估结肠镜检查在塑造韩国结直肠癌趋势中的作用。

IF 2.5 4区医学

World Journal of Gastrointestinal Oncology Pub Date : 2025-03-15 DOI: 10.4251/wjgo.v17.i3.102858

Di-Ping Luo, Bo-Tao Xu, Hui Zhang, Tie-Fei He

引用次数: 0

Metastasizing to the colon from triple-negative breast cancer: A case report and review of literature. 三阴性乳腺癌转移至结肠：一例报告及文献回顾。

IF 2.5 4区医学

World Journal of Gastrointestinal Oncology Pub Date : 2025-03-15 DOI: 10.4251/wjgo.v17.i3.103328

Ben-Quan Wang, Xing-Gui Fang, Ben-Hong Xiang, Xiao-Jiao Wang, Ming Cao, Cheng-Le Zhuang, Zhong-Chen Liu, Zheng Wang

引用次数: 0

Retrospective analysis of factors influencing the self-healing of patients with enterocutaneous fistulas receiving conservative treatment. 影响肠皮瘘保守治疗患者自愈的因素回顾性分析。

IF 2.5 4区医学

World Journal of Gastrointestinal Oncology Pub Date : 2025-03-15 DOI: 10.4251/wjgo.v17.i3.101076

Zhuo-Nan Zhuang, Rui Zhao, Yuan-Xin Li

{"title":"Retrospective analysis of factors influencing the self-healing of patients with enterocutaneous fistulas receiving conservative treatment.","authors":"Zhuo-Nan Zhuang, Rui Zhao, Yuan-Xin Li","doi":"10.4251/wjgo.v17.i3.101076","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.101076","url":null,"abstract":"Background: Enterocutaneous (EC) fistula incidence has been increasing in China, along with increases in the volume and complexity of surgeries. The conservative treatment strategy has been analyzed to improve the treatment outcomes for patients with EC fistulas and reduce the need for reoperation.Aim: To analyze the clinical data of patients undergoing conservative treatment for EC fistulas and identify the factors that promote self-healing. These findings provide a reference for improving the clinical cure rate of EC fistulas with conservative treatment.Methods: The clinical data of 91 patients with EC fistulas who underwent conservative treatment were collected. The relationships between the cure rate and characteristics such as age, sex, body mass index, albumin level, primary disease, cause of the fistula, location of the fistula, number of fistulas, nature of the fistula, infection status, diagnostic methods, nutritional support methods, somatostatin therapy, growth hormone therapy, and fibrin glue therapy were analyzed.Results: A comparison of the basic patient characteristics between the two groups revealed statistically significant differences in primary disease (P = 0.044), location of the fistula (P = 0.006), number of fistulas (P = 0.007), and use of adhesive sealing (χ 2 = 12.194, P < 0.001) between the uncured and cured groups. The use of fibrin glue was a significant factor associated with a cure for fistulas (odds ratio = 5.459, 95%CI: 1.958-15.219, P = 0.01).Conclusion: The cure rate of patients with a single EC fistula can be effectively improved via conservative treatment combined with the use of biological fibrin glue to seal the fistula.","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"101076"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current research status and future directions of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma. 晚期肝癌肝动脉灌注化疗的研究现状及未来发展方向。

IF 2.5 4区医学

World Journal of Gastrointestinal Oncology Pub Date : 2025-03-15 DOI: 10.4251/wjgo.v17.i3.99068

Meer M Chisthi

{"title":"Current research status and future directions of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma.","authors":"Meer M Chisthi","doi":"10.4251/wjgo.v17.i3.99068","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.99068","url":null,"abstract":"The rapid evolution of systemic therapies for hepatocellular carcinoma (HCC), one of the most common types of liver cancer, has attracted significant attention especially to hepatic arterial infusion chemotherapy (HAIC) as a highly promising treatment approach. This method, which delivers chemotherapy directly into the liver's arterial supply, is designed to maximize the concentration of anti-cancer drugs at the tumor site while minimizing systemic side effects. Despite the potential and the encouraging results observed in various studies, HAIC has not yet achieved widespread acceptance and utilization. Sorafenib is a widely used systemic therapy that targets multiple pathways involved in tumor growth and angiogenesis, while transarterial chemoembolization (TACE) is a locoregional therapy that combines arterial embolization with chemotherapy. These treatments have been the mainstay of HCC management, yet they have limitations that HAIC may potentially overcome. This article specifically comments on the network meta-analysis that examined the current research status of HAIC, highlighting its effectiveness and safety profile in comparison to established standard treatments such as Sorafenib and TACE. Through an extensive review of existing studies, the authors conclude that patients receiving HAIC often experience better survival rates and longer periods without disease progression compared to those receiving Sorafenib or TACE.","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"99068"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.5 4区医学

World Journal of Gastrointestinal Oncology Pub Date : 2025-03-15 DOI: 10.4251/wjgo.v17.i3.102604

Nan Chen, Jie Zhang, Lin Wang, Qian Yang, Ai-Wen Wu

{"title":"Stoma related complications: A registry study based on a prospective registration system.","authors":"Nan Chen, Jie Zhang, Lin Wang, Qian Yang, Ai-Wen Wu","doi":"10.4251/wjgo.v17.i3.102604","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.102604","url":null,"abstract":"Background: Stoma creation is a common procedure in colorectal cancer surgery, however, stoma-related complications remain a significant concern.Aim: To investigate the incidence, types, and risk factors of stoma-related complications in colorectal cancer patients who underwent stoma creation.Methods: Patients with stoma was prospectively recorded in the established stoma system. Data was collected from this stoma management system from November 2021 through May 2024. The rates of stoma-related complications were assessed, and potential risk factors were analyzed using univariate and multivariate logistic regression models.Results: A total of 734 patients were included in the analysis. The results showed that 12.3% of patients experienced stoma-related complications, with mucocutaneous separation, edema, and skin excoriation being the most common complications. The majority (90%) of complications were classified as grade 2 according to the Clavien-Dindo classification. Surgical factors, such as blood loss volume greater than 500 mL and open surgery, were significantly associated with stoma complications. Additionally, stoma features like location, shape, color, height, and edema were important factors in the association with complications. Body mass index over 30 kg/m² was also found to be a significant risk factor.Conclusion: These findings highlight the need for a holistic approach to preventing and managing stoma complications, considering both patient-related and surgical factors.","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"102604"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterochronic gastric adenosquamous carcinoma combined with colonic adenoma: A case report. 异慢性胃腺鳞癌合并结肠腺瘤1例。

IF 2.5 4区医学

World Journal of Gastrointestinal Oncology Pub Date : 2025-03-15 DOI: 10.4251/wjgo.v17.i3.101734

Gui-Jiang Liu, Xiao-Yi Long, Fei Zhang, Tao Ren, Xun Xia

{"title":"Heterochronic gastric adenosquamous carcinoma combined with colonic adenoma: A case report.","authors":"Gui-Jiang Liu, Xiao-Yi Long, Fei Zhang, Tao Ren, Xun Xia","doi":"10.4251/wjgo.v17.i3.101734","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.101734","url":null,"abstract":"Background: Metachronous gastric cancer usually refers to a tumor that occurs in the stomach more than half a year after esophageal cancer surgery, and metastasis of primary esophageal cancer should be excluded. There are few reports of metachronous gastric adenosquamous carcinoma with signet ring cell carcinoma combined with early tubular adenoma of the colon after esophageal cancer surgery, which has a high degree of malignancy. This is also the reason for the poor treatment results.Case summary: A 54-year-old male patient was admitted to the hospital with \"dysphagia obstruction\". Seven years ago, the patient was diagnosed with well-differentiated squamous cell carcinoma in the middle esophagus (T4N1M0 stage) and left gastric lymph node metastasis. In the final resection of the esophageal cancer, no residual cancer tissue was found in the esophageal and gastric stump. The patient's medical history 7 years ago (preoperative gastroscopy and other examinations) revealed no gastric tumor. Combined with the patient's history, the diagnosis of recurrent esophageal cancer was made on this admission. The final pathological results were surprising: Metachronous gastric adenosquamous carcinoma with signet ring cell carcinoma combined with early tubular adenoma of the colon. Considering the high malignancy of the tumor, the complexity of the second operation, and many complications, the patient received chemotherapy.Conclusion: He had a history of esophageal cancer resection. Gastroenteroscopy should be performed simultaneously to avoid missed diagnosis and misdiagnosis.","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"101734"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current impact in the treatment of advanced hepatocellular carcinoma: The challenge remains. 晚期肝细胞癌治疗的当前影响：挑战依然存在。

IF 2.5 4区医学

World Journal of Gastrointestinal Oncology Pub Date : 2025-03-15 DOI: 10.4251/wjgo.v17.i3.102932

Angelo A de Mattos, Cristiane V Tovo, Isadora Z Bombassaro, Luis F Ferreira

{"title":"Current impact in the treatment of advanced hepatocellular carcinoma: The challenge remains.","authors":"Angelo A de Mattos, Cristiane V Tovo, Isadora Z Bombassaro, Luis F Ferreira","doi":"10.4251/wjgo.v17.i3.102932","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.102932","url":null,"abstract":"Hepatocellular carcinoma remains a significant cause of mortality worldwide, particularly among patients with liver cirrhosis. In most cases, surveillance in cirrhotic patients is neglected, leading to a diagnosis when the neoplasm is at an advanced stage. Within this context, Zhou et al carried out a network meta-analysis to demonstrate the effectiveness of hepatic arterial infusion chemotherapy, concluding that it is a superior approach compared to sorafenib and transarterial chemoembolization in the treatment of advanced hepatocellular carcinoma. Unfortunately, the meta-analysis in question lacks methodological rigor, preventing the authors from making more definitive assertions. Additionally, we understand that transarterial chemoembolization, when properly indicated, is a highly effective therapeutic option, and that sorafenib, given the results of new therapies based on immune checkpoint inhibitors, is no longer the recommended drug for the treatment of these patients. Therefore, we believe the use of hepatic arterial infusion chemotherapy is increasingly limited and lacks strong scientific support.","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"102932"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased risk of colorectal cancer in young males with higher cardiovascular risk: A nationwide population-based cohort study. 心血管风险较高的年轻男性结直肠癌风险增加：一项基于全国人群的队列研究

IF 2.5 4区医学

World Journal of Gastrointestinal Oncology Pub Date : 2025-03-15 DOI: 10.4251/wjgo.v17.i3.101260

Ji Hyun Song, Su-Yeon Choi, Young Sun Kim, Sun Young Yang, Kyung-Do Han

{"title":"Increased risk of colorectal cancer in young males with higher cardiovascular risk: A nationwide population-based cohort study.","authors":"Ji Hyun Song, Su-Yeon Choi, Young Sun Kim, Sun Young Yang, Kyung-Do Han","doi":"10.4251/wjgo.v17.i3.101260","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.101260","url":null,"abstract":"Background: Although the link between cardiovascular disease (CVD) and various cancers is well-established, the relationship between CVD risk and colorectal cancer (CRC) remains underexplored.Aim: To elucidate the relationship between CVD risk scores and CRC incidence.Methods: In this population-based cohort study, participants from the 2009 National Health Checkup were followed-up until 2020. The cardiovascular (CV) risk score was calculated as the sum of risk factors (age, family history of coronary artery disease, hypertension, smoking status, and high-density lipoprotein levels) with high-density lipoprotein (≥ 60 mg/dL) reducing the risk score by one. The primary outcome was incidence of newly diagnosed CRC.Results: Among 2526628 individuals, 30329 developed CRC during a mean follow-up of 10.1 years. Categorized by CV risk scores (0, 1, 2, and ≥ 3). CRC risk increased with higher CV risk scores after adjusting for covariates [(hazard ratio = 1.155, 95% confidence interval: 1.107-1.205) in risk score ≥ 3, P < 0.001]. This association was exclusively observed in males, most notably in the younger cohort (< 50 years) and was more pronounced in individuals not using statins. Moreover, even in participants without diabetes, a higher CV risk was associated with an increased CRC risk.Conclusion: Increased CV risk scores were significantly associated with higher CRC risk, especially among males, younger populations, and non-statin users. Thus, males with a higher CV risk score, even at a younger age, are recommended to control their risk factors and undergo individualized CRC screening.","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"101260"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastric cancer diagnosis and prevention: Detecting precancerous at community level. 胃癌诊断与预防：在社区一级检测癌前病变。

IF 2.5 4区医学

World Journal of Gastrointestinal Oncology Pub Date : 2025-03-15 DOI: 10.4251/wjgo.v17.i3.100521

Sergey M Kotelevets, Sergey Z Chukov

{"title":"Gastric cancer diagnosis and prevention: Detecting precancerous at community level.","authors":"Sergey M Kotelevets, Sergey Z Chukov","doi":"10.4251/wjgo.v17.i3.100521","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.100521","url":null,"abstract":"The problem of gastric cancer (GC) prevention remains relevant for a long time. Various methods of population serological screening of atrophic gastritis and precancerous changes in the gastric mucosa have been created at present. Modern endoscopic and morphological methods of verification of the diagnosis of precancerous diseases and changes in the gastric mucosa have been introduced into the practice of gastroenterologists and oncologists. GC risk stratification systems allow the formation of risk groups that require population screening. Practical hints for population serological screening of atrophic gastritis, endoscopic and morphological verification of precancerous changes and diseases of the stomach recommend using it: When developing state programs for the prevention of stomach cancer; when implementing preventive measures for stomach cancer by doctors of all specialties; the authors also offer the possibility of use by anyone over the age of 40, provided that they seek methodological help from their doctor; in the work of health schools in any medical and preventive institutions. The use of an assessment system of certain risk factor signatures with prognostic value would add significant assistance to preventive measures against GC.","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"100521"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL-22/IL-22R1 pathway enhances cholangiocarcinoma progression via ERK1/2 activation. IL-22/IL-22R1通路通过ERK1/2激活促进胆管癌进展。

IF 2.5 4区医学

World Journal of Gastrointestinal Oncology Pub Date : 2025-03-15 DOI: 10.4251/wjgo.v17.i3.102083

Jin Zhou, Jing-Rui Chen, Jin-Ming Li, Shuang-Qing Han, Xi-Yue Deng, Zhong-Min Li, Wen Tong, Chao Wang, Yi Bai, Ya-Min Zhang

{"title":"IL-22/IL-22R1 pathway enhances cholangiocarcinoma progression via ERK1/2 activation.","authors":"Jin Zhou, Jing-Rui Chen, Jin-Ming Li, Shuang-Qing Han, Xi-Yue Deng, Zhong-Min Li, Wen Tong, Chao Wang, Yi Bai, Ya-Min Zhang","doi":"10.4251/wjgo.v17.i3.102083","DOIUrl":"https://doi.org/10.4251/wjgo.v17.i3.102083","url":null,"abstract":"Background: IL-22 plays a pivotal role in the processes of inflammation and tissue healing., but its role in cholangiocarcinoma (CCA) remains unclear. our study explored the IL-22/IL-22R1 pathway and its impact on CCA progression through the ERK1/2 signaling cascade.Aim: To determine the mechanism of the IL-22/IL-22R1 pathway in CCA and provide new directions for its clinical treatment.Methods: IL-22R1 expression was assessed in human and rat CCA tissues utilizing immunohistochemical techniques, Western blot analysis, and quantitative reverse transcription PCR. The impact of IL-22 on CCA cells was assessed in vitro via tests for proliferation, migration, invasion, and apoptosis assays. The rat models of thioacetamide-induced CCA and subcutaneous xenografts in nude mice were used to assess the in vivo effects. ERK1/2 inhibitors were applied to elucidate the mechanistic role of the pathway.Results: IL-22R1 was overexpressed in CCA cell lines and tissues. IL-22 treatment increased the phosphorylation of ERK1/2, promoting tumor cell proliferation, migration, invasion, and resistance to apoptosis. ERK1/2 inhibition considerably reversed these effects both in vitro and in vivo.Conclusion: The IL-22/IL-22R1 axis promotes CCA progression by activating ERK1/2 signaling. Targeting this pathway with ERK1/2 inhibitors offers potential therapeutic strategies for CCA.","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 3","pages":"102083"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0