Virulence最新文献_第7页

Comparative genomic and virulence analyses of a novel sequence type 420 Streptococcus equi subspecies zooepidemicus isolated from donkey. 驴源新序列420型马链球菌亚种的比较基因组学和毒力分析。

IF 5.4 1区农林科学

Virulence Pub Date : 2025-12-01 Epub Date: 2025-06-29 DOI: 10.1080/21505594.2025.2525964

Yuhui Tian, Yan Su, Xinyu Jiang, Lingling Su, Baojiang Zhang, Fenfen Lv

{"title":"Comparative genomic and virulence analyses of a novel sequence type 420 Streptococcus equi subspecies zooepidemicus isolated from donkey.","authors":"Yuhui Tian, Yan Su, Xinyu Jiang, Lingling Su, Baojiang Zhang, Fenfen Lv","doi":"10.1080/21505594.2025.2525964","DOIUrl":"10.1080/21505594.2025.2525964","url":null,"abstract":"The zoonotic pathogen Streptococcus equi subspecies zooepidemicus (SEZ) frequently colonizes equines harmlessly but can occasionally cause disease or cross species barriers. Currently, growing evidence suggests SEZ can lead to severe clinical manifestations in horses and other animals, posing a threat to human and companion animal health. In this study, we sequenced the complete genome of the SEZ strain HT321, a novel sequence type 420 isolated from a donkey with a respiratory infection in China. Subsequently, we conducted comparative genomics, core genome single nucleotide polymorphisms (cgSNP), phylogenetic analysis multilocus sequence typing (MLST), and in vitro pathogenic analysis of this isolate. 118 genes in HT321 were annotated as antibiotic resistance genes (ARGs) and comparative genomics revealed that HT321 contained more lincosamide ARGs compared to other strains. The genomic island of HT321 carried more defensive virulence genes than that in the horse strain JMC111. Furthermore, compared to the reference equine strain JMC111, HT321 exhibited superior antimicrobial resistance and biofilm formation capability but lower pathogenicity. Interestingly, core genome single-nucleotide polymorphism phylogenetic analysis of 51 SEZ strains demonstrated that HT321 clustered with horse and donkey SEZ strains as well as S. canis strains. Notably, MLST analysis of the HT321 and 116 SEZ strains indicated that the HT321 donkey strain was related to SEZ canis isolates. These findings provide valuable insights for understanding, tracking, controlling, and preventing diseases caused by SEZ in donkeys.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":"16 1","pages":"2525964"},"PeriodicalIF":5.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12218574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and clinical significance of HBeAg-positive chronic hepatitis B patients with and without anti-HBe antibody. hbeag阳性慢性乙型肝炎患者伴与不伴抗hbe抗体的患病率及临床意义

IF 5.4 1区农林科学

Virulence Pub Date : 2025-12-01 Epub Date: 2025-07-20 DOI: 10.1080/21505594.2025.2534079

Ruifei Xue, Jian Wang, Jie Zhan, Zhiyi Zhang, Suling Jiang, Jiacheng Liu, Li Wang, Xiaomin Yan, Shengxia Yin, Xin Tong, Weimao Ding, Jie Li, Yuxin Chen, Rui Huang, Chao Wu

{"title":"Prevalence and clinical significance of HBeAg-positive chronic hepatitis B patients with and without anti-HBe antibody.","authors":"Ruifei Xue, Jian Wang, Jie Zhan, Zhiyi Zhang, Suling Jiang, Jiacheng Liu, Li Wang, Xiaomin Yan, Shengxia Yin, Xin Tong, Weimao Ding, Jie Li, Yuxin Chen, Rui Huang, Chao Wu","doi":"10.1080/21505594.2025.2534079","DOIUrl":"10.1080/21505594.2025.2534079","url":null,"abstract":"The clinical significance of the coexistence of hepatitis B e antigen (HBeAg) and antibodies against HBeAg (anti-HBe) in patients with chronic hepatitis B (CHB) remains unclear. This study investigated the clinical features and phase transition of patients with coexisting HBeAg/anti-HBe. A total of 840 treatment-naïve HBeAg-positive CHB patients from two medical centres were included. Cox regression analysis was used to analyze factors associated with HBeAg clearance and seroconversion. Eighty-six patients (10.2%) had coexisting HBeAg/anti-HBe. Patients with anti-HBe were older (39.0 vs. 34.0 years, p=0.016) and had a higher FIB-4 values (1.5 vs. 1.0, p<0.001) than those without anti-HBe. The proportions of HBeAg clearance (41.9% vs. 16.2%, p<0.001) and HBeAg seroconversion (37.2% vs. 11.4%, p<0.001) were significantly higher in patients with coexisting HBeAg/anti-HBe than in those without anti-HBe during the follow-up period. Surprisingly, 39.5% of patients with anti-HBe transitioned to HBeAg-positive and anti-HBe-negative status. A total of 4.7% of patients with HBeAg and anti-HBe coexistence transitioned to HBeAg-negative and anti-HBe-negative status. Patients with anti-HBe had higher cumulative HBeAg clearance and seroconversion rates than those without anti-HBe (p<0.001). HBeAg/anti-HBe coexistence was associated with higher HBeAg clearance (HR 2.960, 95%CI 1.828-4.791, p<0.001) and HBeAg seroconversion (HR 4.018, 95% CI 2.372-6.805, p<0.001). Patients with coexisting HBeAg and anti-HBe had a higher likelihood of HBeAg clearance and seroconversion. Close follow-up is needed to monitor the phase transitions in patients with coexistence of HBeAg and anti-HBe patients.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":"16 1","pages":"2534079"},"PeriodicalIF":5.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A human intestinal organoid derived from fetal human colon cells model for studying enteroviral pathogenesis. 从胎儿人结肠细胞衍生的人肠道类器官模型用于研究肠病毒发病机制。

IF 5.4 1区农林科学

Virulence Pub Date : 2025-12-01 Epub Date: 2025-08-04 DOI: 10.1080/21505594.2025.2542455

Chengcheng Li, Yanxi Chen, Xing Zhou, Jiuxiu Lin, Zhen Luo

{"title":"A human intestinal organoid derived from fetal human colon cells model for studying enteroviral pathogenesis.","authors":"Chengcheng Li, Yanxi Chen, Xing Zhou, Jiuxiu Lin, Zhen Luo","doi":"10.1080/21505594.2025.2542455","DOIUrl":"10.1080/21505594.2025.2542455","url":null,"abstract":"Human enteroviruses, including enterovirus 71 (EV71), cause hand, foot, and mouth disease (HFMD) and may lead to severe neurological diseases in infants. Enteroviruses first infect the gastrointestinal tract and then spread to the main organs, such as the liver, lungs, heart, and brain. Human intestinal organoids (HIOs) provide a physiologically relevant model for studying enterovirus infections. Unlike traditional two-dimensional (2D) monolayer cultures, HIOs maintain complex epithelial cell diversity and three-dimensional (3D) architecture, allowing for a more accurate representation of in vivo viral-host interactions. In this study, we developed efficient and stable HIOs based on fetal human primary colon cells using the 3D culture system. We discriminated cultured HIOs containing goblet, enteroendocrine, and Paneth cells, and examined the replication efficiency of enteroviruses in HIOs compared to 2D monolayer cultures. HIOs were infected with enteroviruses (EV71, coxsackievirus B3, echovirus 6), and viral replication was assessed using molecular and imaging techniques, which exhibit a higher level of dynamic viral replication in HIOs than in 2D culture. The replication level of enteroviruses increased about 10-fold in HIOs with the virus titre in HIOs was 5-10 times higher than that in 2D cell cultures (p < 0.05). Also, our findings demonstrate that goblet cells serve as a primary site of viral replication. This observation highlights the importance of cellular microenvironments in enteroviral infections and provides insights into gut-specific viral tropism. Collectively, we established an infection model with human intestinal organoids for enteroviruses, providing new opportunities into evaluating enterovirus-related antiviral drugs and modelling enterovirus-associated diseases.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":" ","pages":"2542455"},"PeriodicalIF":5.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the differential microRNAs expression in young and aged Drosophila melanogaster following Flock House Virus infection. 研究幼幼黑腹果蝇在禽舍病毒感染后microrna表达的差异。

IF 5.4 1区农林科学

Virulence Pub Date : 2025-12-01 Epub Date: 2025-08-25 DOI: 10.1080/21505594.2025.2549497

Amber Thibeaux, Max Yang Lu, Marshall Martin, Michael Rodwell, Victoria Faber, Lakbira Sheffield, Janna L Fierst, Stanislava Chtarbanova

{"title":"Investigating the differential microRNAs expression in young and aged Drosophila melanogaster following Flock House Virus infection.","authors":"Amber Thibeaux, Max Yang Lu, Marshall Martin, Michael Rodwell, Victoria Faber, Lakbira Sheffield, Janna L Fierst, Stanislava Chtarbanova","doi":"10.1080/21505594.2025.2549497","DOIUrl":"https://doi.org/10.1080/21505594.2025.2549497","url":null,"abstract":"MicroRNAs (miRNAs) are small non-coding RNAs ~ 19-22 nt long that post-transcriptionally regulate their mRNA targets. In Drosophila melanogaster, the role of miRNAs has mostly been studied in regard to bacterial infection, yielding insights about their regulatory function in innate immunity. However, fewer studies have focused on viral infections, and importantly, how miRNAs modulate aging immune responses is not fully understood. Here, we performed small RNA-sequencing demonstrating that systemic Flock House Virus (FHV) infection of Oregon-R flies leads to differential microRNA expression and that this response differs with aging. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses identified cellular pathways and biological processes which may be regulated by dynamic expression of microRNAs during infection. For 17 candidate miRNAs, we tested Drosophila lines with in vivo miRNA knockdown for their survival of systemic FHV challenge. In response to infection, among miRNA knockdown lines, females consistently outlived males, and young flies generally outlived their aged counterparts. Furthermore, miRNA knockdown lines generally displayed increased susceptibility to viral infection in comparison to controls, particularly prominent among males. For one miRNA chosen for further study, miR-311, its dysregulation resulted in decreased survival independent of changes in viral load, suggesting a role in disease tolerance rather than resistance. Lastly, knockdown of the immune deficiency (imd) gene - a predicted target of miR-311 - was associated with improved survival of FHV. This work identifies changes in miRNA expression in the aging antiviral response and highlights one miRNA with a role in disease tolerance to FHV in Drosophila.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":"16 1","pages":"2549497"},"PeriodicalIF":5.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 5.4 1区农林科学

Virulence Pub Date : 2025-12-01 Epub Date: 2025-09-01 DOI: 10.1080/21505594.2025.2553472

引用次数: 0

A systematic survey of type I secretion systems and their substrate proteins in Salmonella. 沙门氏菌I型分泌系统及其底物蛋白的系统调查。

IF 5.4 1区农林科学

Virulence Pub Date : 2025-12-01 Epub Date: 2025-07-15 DOI: 10.1080/21505594.2025.2533414

Mingyang Yu, Yating Chen, Xin Cao, Zefan Chen, Shichao Su, Jiamin Wu, Leting Sun, Qiqi Lu, Chenxia Zhang, Zhixuan Deng, Jialin Li, Jingchao Zhong, Yejun Wang

{"title":"A systematic survey of type I secretion systems and their substrate proteins in Salmonella.","authors":"Mingyang Yu, Yating Chen, Xin Cao, Zefan Chen, Shichao Su, Jiamin Wu, Leting Sun, Qiqi Lu, Chenxia Zhang, Zhixuan Deng, Jialin Li, Jingchao Zhong, Yejun Wang","doi":"10.1080/21505594.2025.2533414","DOIUrl":"10.1080/21505594.2025.2533414","url":null,"abstract":"Type I secretion systems (T1SSs) and the substrates have not been investigated extensively in Salmonella, despite their potential significance. In this research, we screened the comprehensive list of Salmonella T1SSs, observed their evolution and transcriptional regulation, predicted the substrates and explored their sequence and structural properties. In total, 61 sets of T1SSs were captured from the genomes of 26 representative strains covering the known Salmonella species and subspecies. The T1SSs fall into 4 clusters. Clusters I and II are conserved and were potentially acquired anciently before the diversification of the Salmonella genus, Cluster III was also anciently acquired but lost in many S. enterica subspecies and strains, and Cluster IV is unconserved and could have been acquired by individual strains through horizontal transferring events. The Cluster II T1SS gene cluster is transcriptionally co-regulated with the operons of Salmonella Pathogenic Island 1 (SPI-1) type III secretion system (T3SS) gene cluster, the effector genes, and other virulence genes, while HilC could potentially be a key regulator for the network. We also predicted 159 potential T1SS substrates from the strains. The putative SiiE-family Cluster II T1SS substrates showed apparent sequence diversity, attributed to recombination, gene fission, fragmental deletion, and point mutation. However, the variants of SiiE proteins appeared structurally conserved and secretable through T1SS conduits, including the two shorter peptides derived from the split siiE genes in S. Typhi strains. Taken together, the study broadened our knowledge about the T1SSs in Salmonella, their evolution and the SiiE-mediated bacterial pathogenicity.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":"16 1","pages":"2533414"},"PeriodicalIF":5.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary iron attenuates Clostridioides difficile infection via modulation of intestinal immune response and gut microbiota. 膳食铁通过调节肠道免疫反应和肠道微生物群来减弱艰难梭菌感染。

IF 5.4 1区农林科学

Virulence Pub Date : 2025-12-01 Epub Date: 2025-07-16 DOI: 10.1080/21505594.2025.2529454

Xiao Li, Xiaoxiao Wu, Wanqing Zang, Zhou Zhou, Wenwen Cui, Ying Chen, Huan Yang

{"title":"Dietary iron attenuates Clostridioides difficile infection via modulation of intestinal immune response and gut microbiota.","authors":"Xiao Li, Xiaoxiao Wu, Wanqing Zang, Zhou Zhou, Wenwen Cui, Ying Chen, Huan Yang","doi":"10.1080/21505594.2025.2529454","DOIUrl":"10.1080/21505594.2025.2529454","url":null,"abstract":"Clostridioides difficile (C. difficile) is one of the majors causes of antibiotic-associated diarrhea globally. Host vulnerability to C. difficile infection (CDI) is largely affected by gut microbiota, which in turn is influenced by diet. However, the mechanism underlying the interplay between diet and the gut microbiota that regulates host susceptibility to CDI remains unclear. This study aimed to investigate how a high-iron diet affects the intestinal immune response, microbiota, and metabolism in mice infected with C. difficile. We explored the specific role of the unique gut microbiota and metabolites on CDI. A mouse model of CDI was constructed with or without high dietary iron treatment. The effect of high iron levels on gut microbiota was analyzed by 16S rRNA gene sequencing, and the role of gut microbiota was confirmed by fecal microbiota transplantation (FMT). High dietary iron (400 mg/kg ferrous sulfate) alleviated CDI by decreasing C. difficile pathogenicity and altering host intestinal neutrophil recruitment. Furthermore, E. coli AVS0501, enriched in the gut microbiota of iron-treated CDI mice, showed prophylactic and therapeutic effects on CDI. Moreover, the production of L-proline and tauroursodeoxycholic acid (TUDCA) in CDI mice treated with high dietary iron influenced C. difficile colonization, toxin production, and in turn, regulates the intestinal neutrophil response. Thus, high dietary iron alleviates C. difficile induced enteritis by regulating gut microbiota maintaining gut homeostasis, suggesting that high dietary iron may be an important determinant of disease control.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":"16 1","pages":"2529454"},"PeriodicalIF":5.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Klebsiella pneumoniae derived outer membrane vesicles mediated bacterial virulence, antibiotic resistance, host immune responses and clinical applications. 肺炎克雷伯菌外膜囊泡介导的细菌毒力、抗生素耐药性、宿主免疫反应及临床应用

IF 5.4 1区农林科学

Virulence Pub Date : 2025-12-01 Epub Date: 2025-01-10 DOI: 10.1080/21505594.2025.2449722

Lifeng Li, Xinxiu Xu, Ping Cheng, Zengyuan Yu, Mingchao Li, Zhidan Yu, Weyland Cheng, Wancun Zhang, Huiqing Sun, Xiaorui Song

{"title":"Klebsiella pneumoniae derived outer membrane vesicles mediated bacterial virulence, antibiotic resistance, host immune responses and clinical applications.","authors":"Lifeng Li, Xinxiu Xu, Ping Cheng, Zengyuan Yu, Mingchao Li, Zhidan Yu, Weyland Cheng, Wancun Zhang, Huiqing Sun, Xiaorui Song","doi":"10.1080/21505594.2025.2449722","DOIUrl":"10.1080/21505594.2025.2449722","url":null,"abstract":"Klebsiella pneumoniae is a gram-negative pathogen that can cause multiple diseases including sepsis, urinary tract infections, and pneumonia. The escalating detections of hypervirulent and antibiotic-resistant isolates are giving rise to growing public concerns. Outer membrane vesicles (OMVs) are spherical vesicles containing bioactive substances including lipopolysaccharides, peptidoglycans, periplasmic and cytoplasmic proteins, and nucleic acids. Emerging studies have reported various roles of OMVs in bacterial virulence, antibiotic resistance, stress adaptation, and host interactions, whereas knowledge on their roles in K. pneumoniae is currently unclear. In this review, we summarized recent progress on the biogenesis, components, and biological function of K. pneumoniae OMVs, the impact and action mechanism in virulence, antibiotic resistance, and host immune response. We also deliberated on the potential of K. pneumoniae OMVs in vaccine development, as diagnostic biomarkers, and as drug nanocarriers. In conclusion, K. pneumoniae OMVs hold great promise in the prevention and control of infectious diseases, which merits further investigation.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":"16 1","pages":"2449722"},"PeriodicalIF":5.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exogenous proline promotes serum killing of Klebsiella pneumoniae. 外源性脯氨酸促进肺炎克雷伯菌的血清杀伤。

IF 5.4 1区农林科学

Virulence Pub Date : 2025-12-01 Epub Date: 2025-08-11 DOI: 10.1080/21505594.2025.2545558

Tian-Shun Kou, Yan-Yan Shang, Qi-Chao Zhang, Si-Qi Tian, Juan Li, Li-Na Yang, Ling Min, Bo Peng

{"title":"Exogenous proline promotes serum killing of Klebsiella pneumoniae.","authors":"Tian-Shun Kou, Yan-Yan Shang, Qi-Chao Zhang, Si-Qi Tian, Juan Li, Li-Na Yang, Ling Min, Bo Peng","doi":"10.1080/21505594.2025.2545558","DOIUrl":"10.1080/21505594.2025.2545558","url":null,"abstract":"Klebsiella pneumoniae, a common pathogen responsible for bloodstream infections, can evade clearance by the complement-dependent killing in serum, known as serum resistance. However, strategy in managing K. pneumoniae serum resistance is still lacking. In this study, we employed metabolomics to identify the metabolic features of K. pneumoniae. We found that the pyruvate/TCA cycle and alanine, aspartate, and glutamate metabolic pathways were significantly downregulated. Proline, identified as a key biomarker, effectively increased the serum sensitivity to multiple K. pneumoniae clinical isolates and restored the bactericidal activity of complement. The in vivo synergistic effect of proline was validated in a murine infection model. Furthermore, we demonstrated that proline activates the pyruvate/TCA cycle, increases proton motive force, and enhances complement proteins binding to bacterial surface, forming membrane attack complex to kill serum-resistant K. pneumoniae. Our findings provide new insights for the development of metabolism-based approach to manage K. pneumoniae serum resistance and offer potential targets and strategies for host immunity-based anti-infection therapies.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":" ","pages":"2545558"},"PeriodicalIF":5.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Siderophores and beyond: A comprehensive review of iron acquisition in Klebsiella pneumoniae. 铁载体及其他：肺炎克雷伯菌铁获取的综合综述。

IF 5.4 1区农林科学

Virulence Pub Date : 2025-12-01 Epub Date: 2025-09-03 DOI: 10.1080/21505594.2025.2550621

Peng Lan, Ye Lu, Ying Fu, Yunsong Yu, Jiancang Zhou

{"title":"Siderophores and beyond: A comprehensive review of iron acquisition in Klebsiella pneumoniae.","authors":"Peng Lan, Ye Lu, Ying Fu, Yunsong Yu, Jiancang Zhou","doi":"10.1080/21505594.2025.2550621","DOIUrl":"10.1080/21505594.2025.2550621","url":null,"abstract":"Iron is an essential nutrient for Klebsiella pneumoniae, a significant opportunistic pathogen. The host's innate immune system attempts to limit iron availability through nutritional immunity; however, K. pneumoniae has evolved sophisticated strategies to circumvent these defenses. This review explores the intricate mechanisms employed by K. pneumoniae to acquire iron from the host environment. We focus on the roles of siderophores, TonB-dependent transporters (TBDTs), and other iron acquisition systems in K. pneumoniae. Additionally, we discuss the regulation of iron acquisition, emphasizing the importance of intracellular iron storage and the Ferric Uptake Regulator (Fur). Novel therapeutic approaches based on these iron acquisition systems, including siderophore-associated antimicrobials, the use of gallium as an iron analog, and vaccines targeting siderophores and TBDTs, offer new insights into curbing severe K. pneumoniae infections. By elucidating the mechanisms of iron acquisition in K. pneumoniae, this review provides valuable insights into the pathogenesis of this opportunistic pathogen and presents potential strategies to combat multidrug-resistant and hypervirulent strains of K. pneumoniae.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":"16 1","pages":"2550621"},"PeriodicalIF":5.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0