Virulence最新文献_第6页

Distinctive function of Tetraspanins: Implication in viral infections. 四跨蛋白的独特功能：在病毒感染中的意义。

IF 5.5 1区农林科学

Virulence Pub Date : 2025-12-01 Epub Date: 2025-03-07 DOI: 10.1080/21505594.2025.2474188

Yuzhi Zhang, Chengwei Pan, Sijie Wang, Yidan Zhou, Jiawei Chen, Xiaoyu Yu, Ruining Peng, Nu Zhang, Hui Yang

{"title":"Distinctive function of Tetraspanins: Implication in viral infections.","authors":"Yuzhi Zhang, Chengwei Pan, Sijie Wang, Yidan Zhou, Jiawei Chen, Xiaoyu Yu, Ruining Peng, Nu Zhang, Hui Yang","doi":"10.1080/21505594.2025.2474188","DOIUrl":"10.1080/21505594.2025.2474188","url":null,"abstract":"Harboring four transmembrane domains in their structural hallmark, Tetraspanins (Tspans) are a family of glycoproteins with pivotal functions in a variety of biological and cellular processes. Through interacting laterally with each other or specific membrane proteins, Tspans organize tetraspanin-enriched microdomains (TEMs), modulating cellular signaling, adhesion, fusion, and proliferation. An abundance of evidence has identified the multiple functions in the progression of cancer as well as the underlying molecular mechanisms. Recently, plenty of studies have focused on the utilities of Tspans by pathogens for infection, especially the infection of viruses. The expression of Tspans correlates with the phase of viral infection, the type of virus, and targeted therapies. In particular, perturbations of Tspans in host cells can affect viral attachment, intracellular trafficking, translation, virus assembly, and release. In this review, we summarize and provide a historical overview of the discovery and characterization of various kinds of virus infection and highlight their diversity and complexity, along with the virus life cycle. Furthermore, we examined the current understanding of how various Tspans are involved in the regulatory mechanisms underlying viral infection. This review aims to offer a comprehensive understanding of the targeting of Tspans for therapeutic intervention in infections caused by diverse pathogens.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":"16 1","pages":"2474188"},"PeriodicalIF":5.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The molybdate transport protein ModA regulates nitrate reductase activity to increase the intestinal colonization and extraintestinal dissemination of Klebsiella pneumoniae in the inflamed gut. 钼酸盐转运蛋白ModA调节硝酸盐还原酶活性，增加肺炎克雷伯菌在炎症肠道内的定植和肠外传播。

IF 5.5 1区农林科学

Virulence Pub Date : 2025-12-01 Epub Date: 2025-03-11 DOI: 10.1080/21505594.2025.2474185

Jichen Xie, Hui Wang, Renhui Ma, Jinming Fan, Qiuhang Quan, Zhiqiang Zhang, Moran Li, Bei Li

{"title":"The molybdate transport protein ModA regulates nitrate reductase activity to increase the intestinal colonization and extraintestinal dissemination of Klebsiella pneumoniae in the inflamed gut.","authors":"Jichen Xie, Hui Wang, Renhui Ma, Jinming Fan, Qiuhang Quan, Zhiqiang Zhang, Moran Li, Bei Li","doi":"10.1080/21505594.2025.2474185","DOIUrl":"10.1080/21505594.2025.2474185","url":null,"abstract":"The mammalian intestine is a major site of colonization and a starting point of severe infections by Klebsiella pneumoniae. Inflammatory bowel disease (IBD) is an inflammatory disorder of the gut, and host-derived nitrate in IBD confers a luminal growth advantage upon Escherichia coli and Salmonella typhimurium through nitrate respiration in the inflamed gut. However, the impact of nitrate on the growth and pathogenicity of K. pneumoniae in this microenvironment is poorly understood. In this study, we used oral administration of dextran sodium sulphate to induce IBD in mouse models. We then analysed the colonization levels of K. pneumoniae wild-type (WT), the nitrate reductase gene mutant strains (ΔnarG, ΔnarZ and ΔnarGΔnarZ), and the molybdate uptake gene mutant strain (ΔmodA) in the inflamed intestinal tract. Results showed that the growth, intestinal colonization, and extraintestinal dissemination of K. pneumoniae were increased in the intestines of dextran sulphate sodium (DSS)-treated mice. Nitrate in the inflamed bowel conferred a growth advantage to K. pneumoniae through nitrate respiration. The molybdate transport protein ModA regulated nitrate reductase activity to increase the growth, intestinal colonization, and extraintestinal dissemination of K. pneumoniae. Tungstate will be a promising antibacterial agent to tackle K. pneumoniae infections in IBD patients.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":" ","pages":"2474185"},"PeriodicalIF":5.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of non-coding RNAs in the pathogenesis of viral myocarditis. 非编码rna在病毒性心肌炎发病机制中的作用。

IF 5.5 1区农林科学

Virulence Pub Date : 2025-12-01 Epub Date: 2025-02-20 DOI: 10.1080/21505594.2025.2466480

Zhijuan Kang, Liang Zhang, Zuocheng Yang

引用次数: 0

Porphyromonas gulae and canine periodontal disease: Current understanding and future directions. 古卟啉单胞菌与犬牙周病：目前的认识和未来的方向。

IF 5.5 1区农林科学

Virulence Pub Date : 2025-12-01 Epub Date: 2025-01-21 DOI: 10.1080/21505594.2024.2449019

Kyu Hwan Kwack, Eun-Young Jang, Cheul Kim, Young-Suk Choi, Jae-Hyung Lee, Ji-Hoi Moon

{"title":"Porphyromonas gulae and canine periodontal disease: Current understanding and future directions.","authors":"Kyu Hwan Kwack, Eun-Young Jang, Cheul Kim, Young-Suk Choi, Jae-Hyung Lee, Ji-Hoi Moon","doi":"10.1080/21505594.2024.2449019","DOIUrl":"10.1080/21505594.2024.2449019","url":null,"abstract":"Porphyromonas gulae has emerged as a notable pathogen in canine periodontal disease, akin to Porphyromonas gingivalis in human periodontitis. This review examines the initial isolation, phylogenetic analysis, habitat, host range, relationships with host health status and age, and key pathogenic determinants, including fimbriae, proteases, citrullinating enzyme, and lipopolysaccharide. Control strategies discussed include polyphosphate to disrupt haeme/iron utilization, clindamycin with interferon alpha to reduce bacterial load and enhance the immune response, and a protease inhibitor. Further research is needed to understand strain-level diversity of virulence factors and interactions between P. gulae and other oral bacteria, particularly Fusobacterium nucleatum, a common pathogen in both dogs and humans. The potential for interspecies transmission between dogs and humans warrants further research into these interactions. Extensive in vivo studies across various breeds are crucial to validate the effectiveness of proposed treatment strategies. This review emphasizes P. gulae's role in periodontal health and disease, setting the stage for future research and improved management of canine periodontal disease.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":"16 1","pages":"2449019"},"PeriodicalIF":5.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative use of gram-positive enhancer matrix particles and affinity peptides in a vaccine against coxsackievirus B3. 革兰氏阳性增强子基质颗粒和亲和肽在柯萨奇病毒B3疫苗中的创新应用

IF 5.5 1区农林科学

Virulence Pub Date : 2025-04-02 DOI: 10.1080/21505594.2025.2481657

Shaoju Qian, Ruixue Li, Guanyu Chen, Yinghua Ma, Zhou Tang, Yihang Song, Zhishan Xu, Zihan Zhang, Yeqing He, Xingyi Zhang, Shuao Lu, Zishan Yang, Xiangfeng Song, Wenfa Yu, Lili Yu

{"title":"Innovative use of gram-positive enhancer matrix particles and affinity peptides in a vaccine against coxsackievirus B3.","authors":"Shaoju Qian, Ruixue Li, Guanyu Chen, Yinghua Ma, Zhou Tang, Yihang Song, Zhishan Xu, Zihan Zhang, Yeqing He, Xingyi Zhang, Shuao Lu, Zishan Yang, Xiangfeng Song, Wenfa Yu, Lili Yu","doi":"10.1080/21505594.2025.2481657","DOIUrl":"https://doi.org/10.1080/21505594.2025.2481657","url":null,"abstract":"Viral myocarditis (VM) is an inflammatory disease posing a serious threat to public health, with various viral pathogens contributing to its pathogenesis. Coxsackievirus B3 (CVB3) is the most frequently implicated causative agent and has been extensively studied because of its high prevalence and severity. No specific therapeutic interventions for VM exist, and vaccine development has encountered substantial challenges. Therefore, we aimed to develop a novel CVB3 mucosal vaccine as a preventive strategy against VM. Gram-positive enhancer matrice (GEM) particles serve as innovative mucosal vaccine adjuvants and antigen delivery systems that enhance antigen immunogenicity by facilitating effective mucosal immune responses. In this study, GEM particle display technology was used to develop two novel CVB3 vaccines: (1) a GEM particle-based vaccine displaying the CVB3 capsid protein VP1 via a PA anchor protein (GEM-PA-VP1), and (2) a GEM particle-based vaccine displaying VP1 via the FcSP peptide (GEM-Fc-VP1). Both, GEM-PA-VP1 and GEM-Fc-VP1 elicited significantly elevated levels of specific IgG, IgG1, IgG2a, SigA and neutralizing antibodies in a mouse model, along with enhanced secretion of Th1- and Th2-associated cytokines, compared to controls. Notably, GEM-Fc-VP1 demonstrated superior immunogenicity compared with that of GEM-PA-VP1, evidenced by higher antibody titres and cytokine responses. In challenge protection experiments, both vaccines significantly improved survival rates, reduced myocardial enzyme levels, and decreased inflammatory cell infiltration in myocardial tissue, with GEM-Fc-VP1 exhibiting greater efficacy. These findings establish a foundation for the development of a safe and effective CVB3 candidate vaccine and provide novel insights into the potential of peptide-mediated subunit vaccine approaches.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":" ","pages":"2481657"},"PeriodicalIF":5.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dry eye disease caused by viral infection: Past, present and future. 由病毒感染引起的干眼病:过去、现在和未来。

IF 5.2 1区农林科学

Virulence Pub Date : 2024-12-01 Epub Date: 2023-12-04 DOI: 10.1080/21505594.2023.2289779

Min Wu, Cuilian Sun, Qin Shi, Yalu Luo, Ziyu Wang, Jianxiang Wang, Yun Qin, Weihang Cui, Chufeng Yan, Huangyi Dai, Zhiyang Wang, Jia Zeng, Yamei Zhou, Manhui Zhu, Xiaojuan Liu

引用次数: 0

Pathogenicity and virulence of Acinetobacter baumannii: Factors contributing to the fitness in healthcare settings and the infected host. 鲍曼不动杆菌的致病性和毒性：医疗机构和受感染宿主的致病因素。

IF 5.2 1区农林科学

Virulence Pub Date : 2024-12-01 Epub Date: 2023-12-06 DOI: 10.1080/21505594.2023.2289769

Massimiliano Lucidi, Daniela Visaggio, Antonella Migliaccio, Giulia Capecchi, Paolo Visca, Francesco Imperi, Raffaele Zarrilli

{"title":"Pathogenicity and virulence of Acinetobacter baumannii: Factors contributing to the fitness in healthcare settings and the infected host.","authors":"Massimiliano Lucidi, Daniela Visaggio, Antonella Migliaccio, Giulia Capecchi, Paolo Visca, Francesco Imperi, Raffaele Zarrilli","doi":"10.1080/21505594.2023.2289769","DOIUrl":"10.1080/21505594.2023.2289769","url":null,"abstract":"Acinetobacter baumannii is a common cause of healthcare-associated infections and hospital outbreaks, particularly in intensive care units. Much of the success of A. baumannii relies on its genomic plasticity, which allows rapid adaptation to adversity and stress. The capacity to acquire novel antibiotic resistance determinants and the tolerance to stresses encountered in the hospital environment promote A. baumannii spread among patients and long-term contamination of the healthcare setting. This review explores virulence factors and physiological traits contributing to A. baumannii infection and adaptation to the hospital environment. Several cell-associated and secreted virulence factors involved in A. baumannii biofilm formation, cell adhesion, invasion, and persistence in the host, as well as resistance to xeric stress imposed by the healthcare settings, are illustrated to give reasons for the success of A. baumannii as a hospital pathogen.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":"15 1","pages":"2289769"},"PeriodicalIF":5.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 更正。

IF 5.2 1区农林科学

Virulence Pub Date : 2024-12-01 Epub Date: 2023-12-13 DOI: 10.1080/21505594.2023.2289756

引用次数: 0

Rhinovirus infection and co-infection in children with severe acute respiratory infection during the COVID-19 pandemic period. COVID-19 大流行期间严重急性呼吸道感染儿童的鼻病毒感染和合并感染。

IF 5.2 1区农林科学

Virulence Pub Date : 2024-12-01 Epub Date: 2024-02-21 DOI: 10.1080/21505594.2024.2310873

Célia Regina Malveste Ito, Mônica Oliveira Santos, Marcos de Oliveira Cunha, Kelliane Martins de Araújo, Guilherme Rocha Lino de Souza, Geovana Sôffa Rézio, Pollyanna Neta de Brito, Alana Parreira Costa Rezende, Jakeline Godinho Fonseca, Isabela Jubé Wastowski, José Daniel Gonçalves Vieira, Melissa Ameloti Gomes Avelino, Lilian Carla Carneiro

{"title":"Rhinovirus infection and co-infection in children with severe acute respiratory infection during the COVID-19 pandemic period.","authors":"Célia Regina Malveste Ito, Mônica Oliveira Santos, Marcos de Oliveira Cunha, Kelliane Martins de Araújo, Guilherme Rocha Lino de Souza, Geovana Sôffa Rézio, Pollyanna Neta de Brito, Alana Parreira Costa Rezende, Jakeline Godinho Fonseca, Isabela Jubé Wastowski, José Daniel Gonçalves Vieira, Melissa Ameloti Gomes Avelino, Lilian Carla Carneiro","doi":"10.1080/21505594.2024.2310873","DOIUrl":"10.1080/21505594.2024.2310873","url":null,"abstract":"Rhinovirus causes respiratory tract infections in children and is found in co-infections. The objective of this research was to study the clinical profile of rhinovirus infection and co-infection in children with severe acute respiratory infection (SARI) during the COVID-19 pandemic period. We included 606 children ranging in age from 0.1 to 144 months of age from March 2020 to December 2021, hospitalized in the Pediatric Intensive Care Unit (PICU). The samples were collected by secretion from the nasopharynx region. A total of 259 children were tested positive for viral infection, 153 (59.07%) of them had a single rhinovirus infection and, 56 (36.6%) were aged between 60.1 and 144 months. Nine types of co-infections were identified and were found coinfection with three or more viruses (22/104, 21.15%). Observing the seasonality, the number of cases was similar between 2020 (49.53%) and 2021 (51.47%). Patients with a single infection (86.88%) and coinfection (67.30%) were more likely to have coughed. Patients with co-infection required the use of O2 for longer than those with a single rhinovirus infection. Hemogram results obtained from individuals with a single infection had higher levels of urea when compared to patients with co-infection with and other respiratory viruses. Multiple correspondence analyses indicated different clinical symptoms and comorbidities in patients with co-infection compared to those with single infection. The results found that the rhinovirus was much prevalent virus during the pandemic period and was found in co-infection with other virus types, what is important to diagnostic for the correct treatment of patients.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":"15 1","pages":"2310873"},"PeriodicalIF":5.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10885176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139933146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and immunogenicity of CoronaVac in healthy adults: A prospective observational multicenter real-world study in Henan Province, China. CoronaVac 在健康成人中的安全性和免疫原性：中国河南省前瞻性多中心真实世界观察研究。

IF 5.2 1区农林科学

Virulence Pub Date : 2024-12-01 Epub Date: 2024-02-07 DOI: 10.1080/21505594.2024.2310450

Benchen Rao, Ling Wang, Mengzhao Yang, Hong Luo, Junyi Sun, Shanshuo Liu, Haiyu Wang, Xuemei Wang, Lei Li, Chengyu Yuan, Zujiang Yu, Zhigang Ren

{"title":"Safety and immunogenicity of CoronaVac in healthy adults: A prospective observational multicenter real-world study in Henan Province, China.","authors":"Benchen Rao, Ling Wang, Mengzhao Yang, Hong Luo, Junyi Sun, Shanshuo Liu, Haiyu Wang, Xuemei Wang, Lei Li, Chengyu Yuan, Zujiang Yu, Zhigang Ren","doi":"10.1080/21505594.2024.2310450","DOIUrl":"10.1080/21505594.2024.2310450","url":null,"abstract":"Vaccination has emerged as the primar approach for managing the COVID-19 pandemic. Despite certain clinical trials reporting the safety and immunogenicity of CoronaVac, additional multicenter real-world studies are still necessary. In this study, we recruited 506 healthy volunteers who were not infected with COVID-19 or vaccinated. Each participant provided peripheral blood samples three times: prior to the first dose of vaccine, prior to the second dose, and 8 weeks following the second dose. Ultimately, 388 participants completed the entire follow-up process. No serious adverse events were observed among any of the participants. Within 1 week of vaccination, 13.4% of participants experienced systemic adverse reactions, with fatigue (5.93%) and dizziness (3.35%) being the most frequent. Although some clinical indicators, including creatinine, significantly changed after vaccination (p < 0.05), the mean of all altered indicators remained within the normal range. The positive rates of neutralizing antibodies (NAb), IgG, and IgM were 12.3%, 18.85%, and 5.24% prior to the second dose, respectively; and 57.99%, 86.34%, and 2.32% at 8 weeks following the second dose, respectively. Additionally, seven indicators, such as sex, age, and BMI, were significantly correlated with NAb (p < 0.05). Finally, a prediction model was developed based on age, monocytes, and alanine aminotransferase (ALT) with an AUC value of 87.56% in the train set and 80.71% in the test set. This study demonstrated that safety and immunogenicity of CoronaVac were good. The prediction model based on the baseline clinical characteristics prior to vaccination can help to develop more suitable vaccination strategies.","PeriodicalId":23747,"journal":{"name":"Virulence","volume":"15 1","pages":"2310450"},"PeriodicalIF":5.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10854291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0