甲型流感病毒非结构蛋白 1（NS1）的研究进展。

IF 5.5 1区农林科学 Q1 IMMUNOLOGY

Virulence Pub Date : 2024-12-01 Epub Date: 2024-06-25 DOI:10.1080/21505594.2024.2359470

Xiaoyan Zhang, Yuying Zhang, Fanhua Wei

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引用次数: 0

摘要

甲型流感病毒（IAV）是造成高度传染性呼吸道感染的主要原因，对公众健康构成严重威胁。非结构蛋白 1（NS1）由 IAV 基因组第 8 段编码，感染 IAV 后在宿主细胞中高水平表达。它是病毒毒力的决定因素，并具有多种功能，包括靶向Ι型干扰素（IFN-I）和Ⅲ型干扰素（IFN-Ⅲ）的产生、破坏 IAV 感染细胞的细胞凋亡和自噬，以及调节流感病毒的宿主适应性。本综述将总结目前有关 NS1 的研究，包括 NS1 的结构和相关生物学功能，以及 NS1 与宿主细胞之间的相互作用。希望能为预防和控制流感病毒提供一些科学依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Research progress on the nonstructural protein 1 (NS1) of influenza a virus.

Influenza A virus (IAV) is the leading cause of highly contagious respiratory infections, which poses a serious threat to public health. The non-structural protein 1 (NS1) is encoded by segment 8 of IAV genome and is expressed in high levels in host cells upon IAV infection. It is the determinant of virulence and has multiple functions by targeting type Ι interferon (IFN-I) and type III interferon (IFN-III) production, disrupting cell apoptosis and autophagy in IAV-infected cells, and regulating the host fitness of influenza viruses. This review will summarize the current research on the NS1 including the structure and related biological functions of the NS1 as well as the interaction between the NS1 and host cells. It is hoped that this will provide some scientific basis for the prevention and control of the influenza virus.

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来源期刊

Virulence IMMUNOLOGY-MICROBIOLOGY

CiteScore

9.20

自引率

1.90%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Virulence is a fully open access peer-reviewed journal. All articles will (if accepted) be available for anyone to read anywhere, at any time immediately on publication. Virulence is the first international peer-reviewed journal of its kind to focus exclusively on microbial pathogenicity, the infection process and host-pathogen interactions. To address the new infectious challenges, emerging infectious agents and antimicrobial resistance, there is a clear need for interdisciplinary research.