VirusDisease最新文献

{"title":"Comprehensive review and early detection strategies for severe fever with thrombocytopenia: insights from epidemiology, diagnostics, and evolving research with machine learning.","authors":"Abhishek S Rao, B H Karthik Pai, K Adithi, Rathika Shenoy, Sneha Nayak","doi":"10.1007/s13337-025-00920-2","DOIUrl":"https://doi.org/10.1007/s13337-025-00920-2","url":null,"abstract":"<p><p>Severe Fever with Thrombocytopenia Syndrome (SFTS) is a neglected tick-borne viral infection caused by <i>Bandavirus dabieense</i> (formerly known as <i>Huaiyangshan banyangvirus</i> and <i>Dabie bandavirus</i>), with the potential for endemic and pandemic transmission through ticks to humans, animals to humans, and human-to-human routes. Low platelet counts in patients (< 150,000 platelets/mm³) lead to severe complications, with a global case fatality ratio of 20-30%. This review aims to summarize <i>Bandavirus dabieense</i>, focusing on its epidemiology, global prevalence, and the impact of geographical and demographic factors on transmission. We conducted a systematic review and bibliometric analysis using the PRISMA framework and Scopus database. The study explores transmission routes of <i>Bandavirus dabieense</i>, diagnostic methods, treatments, and challenges, with an emphasis on machine learning (ML) for diagnosis and awareness initiatives. The results reveal global <i>Bandavirus dabieense</i> prevalence, transmission modes, diagnostic advancements, vector controls, and early detection hurdles. Bibliometric analysis identifies knowledge gaps and emphasizes the study's relevance. The review underscores the importance of understanding and addressing <i>Bandavirus dabieense</i>, advocating for proactive measures such as ML for diagnosis, recommendations for future work, and effective elimination strategies. Heightened awareness and comprehensive research are vital to mitigate the public health impact and reduce mortality associated with <i>Bandavirus dabieense</i>.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"241-262"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of in-vitro antiviral potential of <i>Psidium guajava</i> L. Extract against influenza A/(H1N1)pdm09 virus.","authors":"Sanjit Boora, Sapna Wadhwa, Amit Lath, Anish Khan, Parveen Kumar, Paramjeet Gill, Devender Kumar, Samander Kaushik","doi":"10.1007/s13337-025-00922-0","DOIUrl":"https://doi.org/10.1007/s13337-025-00922-0","url":null,"abstract":"<p><p>The rise of drug-resistant Influenza strains necessitates the development of new antiviral therapies. This study investigated the antiviral potential of aqueous extracts of <i>Psidium guajava</i> L. against the Influenza A/(H1N1)pdm09 virus. The extracts demonstrated significant antiviral activity and therapeutic efficacy in-vitro, achieving 99.98% virus suppression in co-treatment. FTIR analysis confirmed the presence of bioactive compounds such as phenolics, terpenoids, and alkaloids. Additionally, the extracts exhibited potent antioxidant activity, further enhancing their therapeutic potential. The efficacy of the extracts varied depending on the timing of treatment, with co-treatment yielding the best results, followed by some effectiveness in post-treatment scenario. Cytotoxicity assays confirmed the safety of <i>Psidium guajava</i> extracts on MDCK cells at therapeutic concentrations (CC₅₀ > 100 µg/mL). These findings suggest that <i>Psidium guajava</i> extracts hold promise as potential candidates for the development of anti-influenza medications, particularly due to their multi-target efficacy.</p>","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"304-312"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of respiratory viral infections in adults following hematopoietic stem cell transplant (HSCT) at a tertiary care hospital in India.","authors":"Jyoti Jethani, Sameer Abdul Samad, Aashish Choudhary, Megha Brijwal, Bennet Angel, Vinod Joshi, Lalit Dar","doi":"10.1007/s13337-025-00925-x","DOIUrl":"https://doi.org/10.1007/s13337-025-00925-x","url":null,"abstract":"<p><p>Respiratory viral infections carry a major risk of mortality and morbidity for HSCT recipients. It is important to analyze their seasonality, incidence, disease burden and associated risks. Hundred HSCT recipients were followed up prospectively for acute respiratory infection episodes for 18 months. qRT-PCR was performed for influenza virus (influenza A and B), human metapneumovirus (HMPV), respiratory syncytial virus (RSV), adenovirus, rhinovirus and parainfluenza virus (PIV 1-4). A total 318 respiratory episodes occurred, of which 252 episodes were seen in autologous (<i>n</i> = 78) and 66 episodes in allogeneic HSCT (<i>n</i> = 22). Of the total 158 episodes for which samples could be collected, 61(38.6%) tested positive. A higher infection rate (42.2%) was seen in autologous compared with allogeneic HSCT (25.7%). The most common viruses detected were rhinoviruses (31.1%), followed by PIV (19.6%), hMPV (16.3%), RSV (18%) and influenza viruses (14.7%). There were 5 episodes with the involvement of more than one virus and there were 94 episodes of lower respiratory tract infection (LRTI). The commonest viruses detected in LRTI were rhinovirus (18.6 per 100 patient years), followed by PIV (11), RSV (10), hMPV (8.9) and influenza virus (7.9). The in-hospital case fatality ratio was 30% for hMPV and 11.1% for influenza A/H3N2 virus. Respiratory viral infections are common in HSCT recipients. Higher mortality was seen in allogeneic recipients. Rhinoviruses are an important cause of infections in these groups. Immunizations for vaccine preventable viruses like influenza and RSV which shows high incidence needs to be considered.</p>","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"335-342"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marburg virus outbreak: a global health threat, zoonotic risks, and the urgent need for international action.","authors":"Sayak Das, Nagendra Thakur, Arpita S Harnam, Janusz T Paweska, Ahmed S Abdel-Moneim, Shailendra K Saxena","doi":"10.1007/s13337-025-00940-y","DOIUrl":"https://doi.org/10.1007/s13337-025-00940-y","url":null,"abstract":"<p><p>Bats, the archaic natural reservoir hosting a plethora of viruses, are rather a \"Pandora's Box\" and that has been opened. The recent SARS-CoV-2 pandemic has demonstrated the importance of global data sharing and international cooperation for health research. Recent Marburg virus (MARV) outbreaks have put West Africa on alert, and this calls for immediate attention from all travelers and globetrotters, as the situation is alarming. MARV is an enveloped virus with unsegmented negative-sense RNA as its genome, which belongs to the family of <i>Filoviridae</i> in the order Mononegavirales. MARV is a virus of zoonotic origin that can transmit from its natural reservoir in bats to primarily infect other hosts such as C. aethiops or humans. Marburg virus disease (Marburg/MVD) was first noted on the African continent in Uganda beginning in 1967, and subsequently, hemorrhagic fever outbreaks occurred in Belgrade, Yugoslavia, Marburg, and Frankfurt laboratories in 1968. Several preclinical evaluations for the Marburg virus vaccine, including vesicular stomatitis virus or adenoviral vectors, DNA, virus-like replicons, inactivated viruses, and combinatorial modalities, are under trial. However, due to the absence of a vaccine, it is imperative for policymakers and medical professionals to collaborate on developing effective safety and prevention protocols to curb the spread of the Marburg virus and control the ongoing outbreak. This situation underscores the need for proactive measures, timely responses, and international coordination to prevent further health crises linked to zoonotic viruses.</p>","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"233-240"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of temperature on the replication of striped jack nervous necrosis virus in kidney cell line of rainbow trout (RTK).","authors":"Suryakodi Selvam, Nafeez Ahmed Abdul, Mithra Sivaraj, Kanimozhi Kumarasamy, Rajkumar Venkatesan, Taju Gani, Abdul Majeed Seepoo, Sahul Hameed Azeez Sait","doi":"10.1007/s13337-025-00914-0","DOIUrl":"https://doi.org/10.1007/s13337-025-00914-0","url":null,"abstract":"<p><p>In the present study, striped jack nervous necrosis virus (SJNNV) was replicated at different temperatures i.e. 10, 15, 20 and 25°C in kidney cell line of rainbow trout (<i>Oncorhynchus mykiss</i>) to study the virion stability. Cells infected at sub optimal temperature (10 and 15°C) did not cause any significant CPE, but caused typical CPE of multiple vacuoles in the cytoplasm in the cells infected with SJNNV at optimum temperature 20 and 25°C. An expected band in the RT-PCR analysis confirmed the infection, with high viral load of 2.17×10⁸ and 3.08×10⁸ copy number/mL of cDNA was quantified in RTK at 20 and 25°C for SJNNV by qPCR. The TCID₅₀ value of SJNNV in infected RTK cell line gradually increased from low temperatures with maximum value at 25°C in course of infection. The capsid protein of SJNNV at different temperatures in RTK cell line was further confirmed by Western blot and quantified by iELISA. Results revealed that differences were found at different temperatures. The maximum OD value obtained with RTK cells infected was at 20 and 25°C. The results obtained from the present study revealed that the SJNNV possess the ability to cause infections to the fish species culturing in cold water attributes of the Indian aquaculture system, with proper screening and prophylactic measures this infection can be avoided.</p>","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"275-284"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic variants underlying congenital Zika syndrome and severe microcephaly: a systematic review and meta-analysis.","authors":"Ali A Rabaan, Abdulsalam Alawfi, Sarah Yahya Alsharif, Aref A Alamri, Mohammed Abdullah Haddad, Ali J Abushaheen, Mohammed Garout, Amer Alshengeti","doi":"10.1007/s13337-025-00924-y","DOIUrl":"https://doi.org/10.1007/s13337-025-00924-y","url":null,"abstract":"<p><p>Congenital Zika syndrome (CZS) is a condition caused by the infection of the Zika virus (ZIKV) during pregnancy, with severe microcephaly as an additional condition commonly associated with CZS. Although not all embryos or fetuses exposed to ZIKV infection develop CZS, various genetic factors have been linked to the condition, which can cause other neurodevelopmental disorders. In this study, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol was employed to gather a total of 7191 studies from different sources, which were then filtered to 2794 unique studies after the removal of 4397 duplicates. From these studies, 107 met the inclusion criteria and were used to examine the relationship between genetic variants and CZS and severe microcephaly conditions. Subsequently, 32 studies were selected for meta-analysis to determine the statistical significance of the genes associated with microcephaly and CZS. The results of the meta-analysis revealed that microcephaly was significantly associated with genetic variation primarily found in ASPM, WDR62, STIL, and CEP135 genes, while the CDK5RAP2 gene did not demonstrate a statistically significant association with microcephaly. The study concluded that mutations in the assembly factor for the spindle microtubules (ASPM) gene frequently cause microcephaly across different geographical locations. The analysis also identified 39 genes reported in 580 cases, and the meta-analysis of the prime genes showed a direct association with microcephaly.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13337-025-00924-y.</p>","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"313-325"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mumps genotypes circulating in Tamilnadu: A cross-sectional study.","authors":"Jayalakshmi Raghavan, Merlin Sabastin, ArunKumar Manivel, Nivas Chakravarthy, V Krishnalakshmi, Mary Ajitha, Saravana Kumar, Kaveri Krishnasamy, Neetu Vijay, T S Selvavinayagam","doi":"10.1007/s13337-025-00921-1","DOIUrl":"https://doi.org/10.1007/s13337-025-00921-1","url":null,"abstract":"<p><p>Mumps is an acute viral infection marked by fever and swelling of the parotid glands. While effective live-attenuated vaccines have significantly reduced mumps cases in developed nations, outbreaks persist in developing regions with limited vaccination coverage. The mumps virus, a member of the Paramyxoviridae family, encodes eight proteins, including structural and non-structural ones. This study explores the epidemiology and genetic variation of the mumps virus in Tamil Nadu, India. Clinical specimens from suspected cases were analyzed using serological assays, real-time PCR, and Sanger sequencing, focusing on the SH gene, a critical genomic region for mumps virus genotype differentiation. The sequencing revealed amino acid substitutions in the clinical sample when compared with reference strains. Phylogenetic analysis highlighted the genetic diversity of the virus, indicating variations in the SH gene. These findings enhance understanding of MuV's epidemiology in India and highlight its relevance to global mumps epidemiology, especially in regions with suboptimal vaccine coverage. This research emphasizes the importance of continuous molecular surveillance and genetic analysis to monitor the evolution of MuV, improve vaccination strategies, and address challenges posed by outbreaks in resource-limited settings.</p>","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"295-303"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a novel <i>Gammapartitivirus</i> associated with endophytic <i>Fusarium oxysporum</i> through transcriptome dataset mining.","authors":"Megha Das, A I Bhat","doi":"10.1007/s13337-025-00918-w","DOIUrl":"https://doi.org/10.1007/s13337-025-00918-w","url":null,"abstract":"<p><p>Next Generation Sequencing (NGS) and bioinformatic analysis have made identifying viruses from transcriptome datasets in the public domain more popular. Here, we have identified the coding-complete genome sequence of a novel dsRNA mycovirus of the genus, <i>Gammapartitivirus</i> from an endophytic <i>Fusarium oxysporum</i> for which the name, Fusarium oxysporum partitivirus 2 is proposed. It has a bisgmented, monocistronic genome with 1742 bp long dsRNA 1 and 1421 bp long dsRNA 2. The dsRNA1 and dsRNA2 contain a single open reading frame (ORF) coding for the RNA-dependent RNA polymerase (RdRp) of 536 amino acids and the coat protein of 419 amino acids, respectively. This is the first report of a fungal virus identified by the transcriptome data mining of <i>Fusarium oxysporum</i> from India.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13337-025-00918-w.</p>","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"353-357"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular characterization of a begomovirus associated with yellow mosaic disease of <i>Acalypha indica</i>.","authors":"Sunil Kumar, Deepak Kumar, Olawale Arogundade, Supriya Chakraborty","doi":"10.1007/s13337-025-00919-9","DOIUrl":"https://doi.org/10.1007/s13337-025-00919-9","url":null,"abstract":"<p><p><i>Begomovirus</i>, a genus within the family <i>Geminiviridae</i>, is the largest genus of plant-infecting viruses. Several recent studies have reported the prevalence of begomoviruses in common weeds. In the present study, <i>Acalypha indica</i>, a euphorbiaceous weed exhibiting yellow mosaic symptoms, was screened for begomovirus infection. The analyzed samples revealed the presence of a bipartite begomovirus with a complete sequence of DNA-A and B components, each of approximately 2.7 kb in size, showing genome organization typical of Old World bipartite begomoviruses. While the DNA-A (GenBank accession number PQ067511) component showed 93% similarity with Jatropha leaf yellow mosaic Katarniaghat virus (JLYMKV-A, JN135236.1), the DNA-B (PQ067512) component closely resembled Rose leaf curl virus (RoLCV-B, OQ440773.1) with approximately 83% similarity. Notably, previous studies have not reported an association of DNA-B components with JLYMKV-A. The sequence analysis revealed that the DNA-B genome has a single recombination event between Sri Lankan cassava mosaic virus DNA-B (SLCMV-B) and RoLCV DNA-B. Further, the common region (CR) analysis revealed a high nucleotide identity of 97% between the DNA-A and B components isolated in this study, suggesting that these are cognate molecules. In summary, the current study, for the first time, reports a novel recombinant DNA-B component with JLYMKV-A causing yellow mosaic disease in <i>A. indica</i> in India.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13337-025-00919-9.</p>","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"343-352"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of miRNA-mRNA Co-expression by network analysis in dengue virus infection.","authors":"Rajesh Das, Sasivarman Selvam, Vigneshwar Suriya Prakash Sinnarasan, Dahrii Paul, Md Mujibur Rahman Sheikh, Amouda Venkatesan","doi":"10.1007/s13337-025-00915-z","DOIUrl":"https://doi.org/10.1007/s13337-025-00915-z","url":null,"abstract":"<p><p>Dengue virus (DENV), transmitted by Aedes mosquitoes, causes various illnesses, from mild dengue fever to severe dengue hemorrhagic fever and dengue shock syndrome. Understanding the molecular mechanisms underlying DENV infection is crucial for developing effective diagnostics and treatments. This study integrates mRNA and miRNA sequencing data to explore the regulatory networks involved in DENV infection. Samples from both DENV-infected and control conditions were analyzed. Differential expression analysis identified significantly altered genes and miRNAs. Target genes of differentially expressed miRNAs (DEMs) were identified using miRNet. Metascape is used to perform the functional enrichment analysis of target genes. Employing Pearson correlation analysis, potential regulatory relationships between miRNAs and mRNAs were determined. Receiver Operating Characteristic (ROC) analysis assessed the diagnostic potential of key miRNA-mRNA pairs. Differential expression analysis revealed a distinct set of Differentially Expressed Genes (DEGs) and miRNAs. Functional enrichment analysis indicated that upregulated genes were involved in processes such as DNA-templated transcription and cell division, while downregulated genes were associated with TNF-alpha signaling and blood vessel development. Pearson correlation analysis highlighted key negatively correlated miRNA-mRNA pairs. ROC analysis demonstrated high diagnostic potential for pairs such as TUBA1A-hsa-mir-205-5p, CXCL16-hsa-mir-205-5p, MED29-hsa-mir-148b-5p, PPARA-hsa-mir-3614-5p, and PTPRJ-hsa-mir-96-5p, with Area Under the Curve (AUC) values of 1. The study provides valuable insights into the miRNA-mRNA regulatory networks in DENV infection, identifying potential therapeutic targets and diagnostic key genes. The identified miRNA-mRNA interactions offer promising avenues for developing targeted therapies and improving DENV diagnostics, contributing to better management of dengue virus infections.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13337-025-00915-z.</p>","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"285-294"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}