Evaluation of in-vitro antiviral potential of Psidium guajava L. Extract against influenza A/(H1N1)pdm09 virus.

Q2 Medicine

VirusDisease Pub Date : 2025-06-01 Epub Date: 2025-05-16 DOI:10.1007/s13337-025-00922-0

Sanjit Boora, Sapna Wadhwa, Amit Lath, Anish Khan, Parveen Kumar, Paramjeet Gill, Devender Kumar, Samander Kaushik

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Abstract

The rise of drug-resistant Influenza strains necessitates the development of new antiviral therapies. This study investigated the antiviral potential of aqueous extracts of Psidium guajava L. against the Influenza A/(H1N1)pdm09 virus. The extracts demonstrated significant antiviral activity and therapeutic efficacy in-vitro, achieving 99.98% virus suppression in co-treatment. FTIR analysis confirmed the presence of bioactive compounds such as phenolics, terpenoids, and alkaloids. Additionally, the extracts exhibited potent antioxidant activity, further enhancing their therapeutic potential. The efficacy of the extracts varied depending on the timing of treatment, with co-treatment yielding the best results, followed by some effectiveness in post-treatment scenario. Cytotoxicity assays confirmed the safety of Psidium guajava extracts on MDCK cells at therapeutic concentrations (CC₅₀ > 100 µg/mL). These findings suggest that Psidium guajava extracts hold promise as potential candidates for the development of anti-influenza medications, particularly due to their multi-target efficacy.

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番石榴提取物对甲型H1N1流感病毒pdm09的体外抗病毒潜力评价。

耐药流感病毒株的增加要求开发新的抗病毒疗法。本研究研究了番石榴水提物对甲型H1N1流感病毒pdm09的抗病毒作用。提取物在体外表现出显著的抗病毒活性和治疗效果，在共处理中达到99.98%的病毒抑制。FTIR分析证实了酚类、萜类和生物碱等生物活性化合物的存在。此外，提取物表现出强大的抗氧化活性，进一步增强了其治疗潜力。提取物的功效取决于治疗的时间，共同治疗产生最好的结果，其次是治疗后的一些效果。细胞毒性实验证实了番石榴提取物在治疗浓度（CC50 bb0 100µg/mL）下对MDCK细胞的安全性。这些发现表明，番石榴提取物具有开发抗流感药物的潜力，特别是由于其多靶点功效。

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来源期刊

VirusDisease Medicine-Infectious Diseases

CiteScore

7.00

自引率

0.00%

发文量

期刊介绍： VirusDisease, formerly known as ''Indian Journal of Virology'', publishes original research on all aspects of viruses infecting animal, human, plant, fish and other living organisms.