Journal of the Japan Society of the Reticuloendothelial System最新文献_第9页

Hepatosplenic .GAMMA..DELTA.T-cell Lymphoma: Report of a Case. Hepatosplenic可以. .δ。t细胞淋巴瘤1例报告。

Journal of the Japan Society of the Reticuloendothelial System Pub Date : 1900-01-01 DOI: 10.3960/JSLRT1961.33.209

M. Yamaguchi, T. Ohno, N. Takakura, K. Ohishi, K. Oka, K. Nishii, K. Kita, S. Shirakawa

{"title":"Hepatosplenic .GAMMA..DELTA.T-cell Lymphoma: Report of a Case.","authors":"M. Yamaguchi, T. Ohno, N. Takakura, K. Ohishi, K. Oka, K. Nishii, K. Kita, S. Shirakawa","doi":"10.3960/JSLRT1961.33.209","DOIUrl":"https://doi.org/10.3960/JSLRT1961.33.209","url":null,"abstract":"A case of γδ T-cell lymphoma with severe hepatosplenomegaly was reported. A 17-year-old male was admitted to the Mie university hospital in Nov., 1991, because of jaundice and hepatosplenomegaly. Neither lymphadenopathy nor skin rush was detected. Laboratory data showed mild anemia, thrombocytopenia, and elevated serum lactate dehydrogenase (LDH) level (1338IU). Leucocyte count was 4790/μl with no abnormal finding. Bone marrow aspiration showed that nucleated cell count was 22.9×104/μl with 52.8% abnormal cells. The cells were large and had irregular nuclei and abundant cytoplasm without azulophilic granule. Their phenotype was CD3+ CD4- CD8- WT31- TCRδ1+ TdT-. DNA analysis of bone marrow mononuclear cells revealed rearrangements of T-cell receptor (TCR) γ and δ chain genes, and germline configulation in TCRβ chain gene and immunoglobulin heavy chain gene. He was diagnosed as γδ T-cell lymphoma (clinical stage IV B), and was first treated with combination therapy of CHOP and granulocyte-colony stimulating factor (G-CSF). The hepatosplenomegaly slightly regressed, but the abnormal cells in bone marrow did not decreased. The therapy was switched to one with carboplatin, ifosfamide, etoposide, and dexamethasone. The hepatosplenomegaly disappeared and the abnormal findings of bone marrow returned to normal. He is alive with partial response disease 7 months after the diagnosis.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123210821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Malignant histiocytosis in clinical aspect. 临床方面的恶性组织细胞增多症。

Journal of the Japan Society of the Reticuloendothelial System Pub Date : 1900-01-01 DOI: 10.3960/JSLRT1961.30.287

K. Kita, T. Ono, S. Shirakawa

{"title":"Malignant histiocytosis in clinical aspect.","authors":"K. Kita, T. Ono, S. Shirakawa","doi":"10.3960/JSLRT1961.30.287","DOIUrl":"https://doi.org/10.3960/JSLRT1961.30.287","url":null,"abstract":"Twenty one patients were diagnosed as “malignant histiocytosis (MH)” according to clinical mainifestations, for example severe inflamatory reactions, progressive pancytopenia, huge hepatosplanomegaly, and the presence of hemohagocytic cells in bone marrow. In comparison with large anaplastic cell lymphoma, the clinical features of “MH” patients were characterized by the systemic symptoms and rapid clinical course. Cells with histiocytic appearance in these patients were classified in to 3 subgroups on the basis of the morphologic atypism; blastic, intermediate, or mature type. Histiocytic cells from 17 out of 21 patients belonged to the blastic or intermediate type, suggesting the neoplastic nature. Hemophagocytic cells without remarkable atypism, which were observed in bone marrow of the most patients, showed the mature type appearance, and were recognized as activated histiocytes. In 6 “MH” patients with neoplastic cells, 3 patients were recognized as histiocytic disorder, 2 as T-cell one, and one as B-cell one according to the immunophenotype and immunogenotype.Interestingly, one of the T-cell type showed phenotype of CD2+CD3-CD4-CD8-EAG+with large granular lymphocyte (LGL) appearance, and another CD2+CD3+CD4-CD8-EAG+LGL also increased in the terminal phase of a “MH” patient with B-cell neoplasm. In addition, either neoplastic or benign LGL disorders revealed “MH” like systemic symptoms in occasion. Thus, LGL/Tγ cells as well as the hemophagocytic cells are thought to play a main role for the hematopathologic and clinical manifestation of “MH” in reticuloendotherial system, especially in spleen, and hyper-production of cytokines by thesee cells may closely related the systemic and unreguratable symptoms, tentatively named “cytokine-crisis”","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123297520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hodgkin & Reed-Sternberg細胞がHelper/inducer T細胞型の表面形質を示したホジキン病の1例 Hodgkin & Reed-Sternberg细胞显示Helper/inducer T细胞型表面性状的霍奇金病的一个例子

Journal of the Japan Society of the Reticuloendothelial System Pub Date : 1900-01-01 DOI: 10.3960/JSLRT1961.31.73

豊森村, 栄子和知, 正文阿部, 治毅若狭, 恵基川上, 堅吉北

{"title":"Hodgkin & Reed-Sternberg細胞がHelper/inducer T細胞型の表面形質を示したホジキン病の1例","authors":"豊森村, 栄子和知, 正文阿部, 治毅若狭, 恵基川上, 堅吉北","doi":"10.3960/JSLRT1961.31.73","DOIUrl":"https://doi.org/10.3960/JSLRT1961.31.73","url":null,"abstract":"We report a case of Hodgkin's disease showing helper/inducer T cell phenotype on Hodgkin & Reed-Sternberg cells.A 21 years-old Japanese female was admitted for right cervical lymphadenopathy. Laboratory tests including human T lymphocyte virus-I antibody (HTLV-I antibody) were within normal. A biopsy specimen of the cervical lymph node showed Hodgkin's disease, nodular sclerosis (NS).Immunohistologically, Hodgkin & Reed-Sternberg cells were positive for CD30 (Ki-1), CD15 (Leu-M1), CD25 (IL-2R), HLA-DR, transferrin receptor, CD2 (Leu-5b), CD3 (Leu-4), CD4 (Leu-3a), and CD5 (Leu-1), but were negative for B cell associated antigens and myeloid-monocyte associated antigens. The immunohistochemical data indicate helper/inducer T cell phenotype on Hodgkin & Reed-Sternberg cells.Southern blot analysis revealed six rearranged bands using T cell receptor gene probe (TCR Jγ1 probe), when genomic DNA of the biopsied lymph node was digested with EcoRI. Although the TCRγ gene rearrangement bands were not well evaluated, the finding of TCRγ gene rearrangement is unlikely to consider a clonal prolifaration of Hodgkin & Reed-Stenberg cells with T cell phenotype. It would be speculated in this case that rearranged bands for TCRγ may originate from functional T cell clones with transcription of the CD3 molecule and unique TCRγ rearrangements.The patient is free from the disease 2 years after the biopsy.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122270507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

未分化大細胞型リンパ腫(Ki-1リンパ腫といわゆる悪性組織球症) 未分化大细胞型淋巴瘤(Ki-1淋巴瘤和恶性组织细胞病)

Journal of the Japan Society of the Reticuloendothelial System Pub Date : 1900-01-01 DOI: 10.3960/JSLRT1961.29.293

栄男中村, 規夫高木, 勝小島, 邦吉鬼頭, 龍三上田, 泰山須知

引用次数: 1

Discordant lymphoma: Report a case of possible transformation from initial large cell B lymphoma to histiocytic sarcoma. 不协调型淋巴瘤:报告一例可能由最初的大细胞B淋巴瘤转变为组织细胞肉瘤的病例。

Journal of the Japan Society of the Reticuloendothelial System Pub Date : 1900-01-01 DOI: 10.3960/JSLRT1961.29.201

H. Tsutani, H. Yoshida, N. Domae, H. Sugihara, T. Shiraishi, K. Nakakuki, H. Konishi, Toru Nakamura

{"title":"Discordant lymphoma: Report a case of possible transformation from initial large cell B lymphoma to histiocytic sarcoma.","authors":"H. Tsutani, H. Yoshida, N. Domae, H. Sugihara, T. Shiraishi, K. Nakakuki, H. Konishi, Toru Nakamura","doi":"10.3960/JSLRT1961.29.201","DOIUrl":"https://doi.org/10.3960/JSLRT1961.29.201","url":null,"abstract":"An autopsy case of discordant lymphoma comprising large cell B lymphoma and histiocytic sarcoma (true histiocytic lymphoma) was reported. A 70-year-old woman with large cell B lymphoma of 14 months duration developed fever, anemia, and jaundice. She died of gastric bleeding shortly after the initiation of chemotherapy. Autopsy findings revealed multiple nodular masses throughout the liver, lungs, bone marrow and paraaortic lymph nodes. These masses consisted of containing atypical histiocytes associating with common phagocytic figures, with immunohistochemical features of histiocytic sarcoma. The original large cell B lymphoma was still present in the right adrenal gland. Discordant lymphomas are those in which two distinct histological patterns occur in separate anatomic disease sites. This is the first reported case of histiocytic sarcoma arising in association with large B cell lymphoma. Sequential presence of histiocytic sarcoma seemed to be different mutation stages of the neoplastic B lymphocyte in the cell cycle of a single cell type.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"254 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125785223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical aspects of malignant histiocytosis and its related disorders in childhood. 儿童恶性组织细胞增多症及其相关疾病的临床特点。

Journal of the Japan Society of the Reticuloendothelial System Pub Date : 1900-01-01 DOI: 10.3960/JSLRT1961.30.293

S. Imashuku

引用次数: 1

正常ヒト血液細胞におけるリゾチームの局在: Immumogold staimimg methodによる超微形態学的観察解析组在正常人类血液细胞中的位置:Immumogold staimimg method的超微形态学观察

Journal of the Japan Society of the Reticuloendothelial System Pub Date : 1900-01-01 DOI: 10.3960/JSLRT1961.27.307

永仁斎藤, 信男竹森, 法子立花, 尚之林下, 恵右桜田, 保宮崎

{"title":"正常ヒト血液細胞におけるリゾチームの局在: Immumogold staimimg methodによる超微形態学的観察","authors":"永仁斎藤, 信男竹森, 法子立花, 尚之林下, 恵右桜田, 保宮崎","doi":"10.3960/JSLRT1961.27.307","DOIUrl":"https://doi.org/10.3960/JSLRT1961.27.307","url":null,"abstract":"Ultrastrutural localization of lysozyme in human blood cells which were obtained from 10 nonmal volunteers was investigated by electron microscopy applying an immunogold staining method.The presence of lysozyme was demonstrated as the deposition of gold particles by this staining. Lysozyme was detected in neutrophils, monocytes, eosinophils, reticlum cells and mast cells. On the other hand, no lysozyme was detected in basophils, megakaryocytes, platelets, lymphocytes, plasma cells and erythroid cells.Generally, lysozyme was preferentially contained in the granules of lysozyme-positive blood cells. In contrast, no lysozyme was detected in the nucleus, perinuclear space, rough endoplasmic reticulum and mitochondria. In neutrophils, both primary and secondary granules contained abundant lysozyme. In monocytes, the granules were remarkably positive for lysozyme. In eosinophils, the granules were positive for lysozyme, but crystalloids negative. In some reticulum cells, phagolysosomes contained small amount of lysozyme. In some mast cells, abundant lysozyme was present in the granules.Electron microscopic immunogold staining is a useful method to know the exact localization of lysozyme in blood cells.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128225010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Defense mechanisms of pulmonary alveolar macrophages against microbial infection. 肺泡巨噬细胞对微生物感染的防御机制。

Journal of the Japan Society of the Reticuloendothelial System Pub Date : 1900-01-01 DOI: 10.3960/JSLRT1961.30.45

M. Suga

引用次数: 0

An immunohistochemical study of alveolar macrophages, with special reference to class II MHC expression. 肺泡巨噬细胞的免疫组织化学研究，特别参考II类MHC表达。

Journal of the Japan Society of the Reticuloendothelial System Pub Date : 1900-01-01 DOI: 10.3960/JSLRT1961.30.25

A. Nakayama, H. Nagura

{"title":"An immunohistochemical study of alveolar macrophages, with special reference to class II MHC expression.","authors":"A. Nakayama, H. Nagura","doi":"10.3960/JSLRT1961.30.25","DOIUrl":"https://doi.org/10.3960/JSLRT1961.30.25","url":null,"abstract":"To elucidate the role of alveolar macrophages in inflammatory and fibrosing processes of lung, the paraquat-induced alveolitis in rats was investigated by the immunohistochemical method with especial references to the class II major histocompatibility antigen complex (MHC) expression. Two days after the peritoncal injection of paraquat, the class II MHC expression by type II alveolar epithelial cells was observed prior to obvious histological and immunohistochemical changes except for pulmonary edema. From four days after the injection, alveolar macrophages increased in number, and expressed class II MHC, which was not demonstrated in the normal control. The intensity of the expression was variable, and alveolar macrophages containing abundant dust particles were still absent for class II MHC. On the contrary, the class II MHC expression by alveolar epithelial cells turned obscure. Two weeks after the injection, alveolar fibrosis developed and inflammatory cell infiltration was almost disappeared. A small number of class II MHC negative foamy cells were observed in the alveolar spaces. Alveolar capillary endothelial cells and alveolar septal cells, which expressed class II MHC in the normal control, did not show significant changes in paraquat-induced alveolitis. These results suggest that resident alveolar macrophages with the active phagocytic activity are not the main component in inflammatory reactions in the lung. In contrast, type II alveolar epithelial cells participate invariably in inflammatory process of alveolitis.","PeriodicalId":237003,"journal":{"name":"Journal of the Japan Society of the Reticuloendothelial System","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134147249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphology and function of resident macrophages in hematopoietic tissues. 造血组织中巨噬细胞的形态和功能。

Journal of the Japan Society of the Reticuloendothelial System Pub Date : 1900-01-01 DOI: 10.3960/JSLRT1961.35.261

Y. Sadahira

引用次数: 0