Veterinary and comparative oncology最新文献_第4页

Expanding the Spectrum of Canine Diffuse Large B-Cell Lymphoma Genetic Aberrations Through Whole Genome Sequencing Analysis. 通过全基因组测序分析扩大犬弥漫性大b细胞淋巴瘤遗传畸变谱。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-05-04 DOI: 10.1111/vco.13059

Antonella Fanelli, Eugenio Mazzone, Diana Giannuzzi, Laura Marconato, Luca Aresu

{"title":"Expanding the Spectrum of Canine Diffuse Large B-Cell Lymphoma Genetic Aberrations Through Whole Genome Sequencing Analysis.","authors":"Antonella Fanelli, Eugenio Mazzone, Diana Giannuzzi, Laura Marconato, Luca Aresu","doi":"10.1111/vco.13059","DOIUrl":"https://doi.org/10.1111/vco.13059","url":null,"abstract":"Diffuse large B-cell lymphoma (DLBCL) is one of the most prevalent haematological malignancies in both humans and dogs, characterised in both species by significant clinical heterogeneity and limited prognostic predictability. With the introduction of next-generation sequencing (NGS) technologies in veterinary medicine over the past decade, researchers have begun to elucidate the molecular basis of canine DLBCL (cDLBCL); however, much of the clinical heterogeneity associated with this tumour remains unexplained. In this study, we performed whole genome sequencing on 10 cDLBCL cases, all treated with chemo-immunotherapy, which exhibited similar clinico-pathological features but markedly different outcomes. Cases were classified as \"poor\" or \"good\" responders based on whether their lymphoma-specific survival fell below or above the cohort's median. Protein-coding variants and copy number aberrations unique to poor or good responders revealed novel candidate genes not previously identified in cDLBCL studies, while splicing, untranslated regions, and intronic variants were detected in genes already known to be recurrently mutated. In conclusion, our investigation has broadened the spectrum of potentially pathogenic variants implicated in cDLBCL, though further studies with larger cohorts are necessary to validate these findings.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurological Recovery in 14 Cats With Epidural Lymphoma Treated With Chemotherapy. 14只猫硬膜外淋巴瘤化疗后神经功能恢复。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-04-23 DOI: 10.1111/vco.13061

Julya Nathalya Felix Chaves, Mathias Reginatto Wrzesinski, Julia da Silva Rauber, Denis Antonio Ferrarin, Marcelo Luis Schwab, Glaucia Denise Kommers, Mariana Martins Flores, Ana Paula da Silva, Angel Ripplinger, Diego Vilibado Beckmann, Alexandre Mazzanti

{"title":"Neurological Recovery in 14 Cats With Epidural Lymphoma Treated With Chemotherapy.","authors":"Julya Nathalya Felix Chaves, Mathias Reginatto Wrzesinski, Julia da Silva Rauber, Denis Antonio Ferrarin, Marcelo Luis Schwab, Glaucia Denise Kommers, Mariana Martins Flores, Ana Paula da Silva, Angel Ripplinger, Diego Vilibado Beckmann, Alexandre Mazzanti","doi":"10.1111/vco.13061","DOIUrl":"https://doi.org/10.1111/vco.13061","url":null,"abstract":"The purpose of this study was to evaluate the rate and timing of neurological recovery in cats with epidural lymphoma who were treated with chemotherapy. The study included cats with various degrees of neurological impairment, confirmed diagnosis of lymphoma and spinal cord involvement. At the start of treatment, of the 14 cats diagnosed with lymphoma, 14.3% (n = 2) had ambulatory paraparesis, 14.3% (n = 2) had non-ambulatory paraparesis, 7.1% (n = 1) paraplegia with deep nociception, 50% (n = 7) were paraplegic with absent deep nociception and 14.3% (n = 2) had non-ambulatory tetraparesis. The chemotherapy treatment given was COP in 10 cats, COP and CHOP in 2 cats and CHOP in 2 cats. The number of chemotherapy sessions needed for neurological recovery varied from 1 to 4, with a total of 1-13 sessions per cat. The rate of neurological recovery was satisfactory in 83.3% (10/12) of the cats. This study indicates that cats with epidural lymphoma treated with chemotherapy have an 83.3% likelihood of partial neurological recovery and a 50% chance of full neurological recovery within a period of 7-28 days, regardless of the level of neurological impairment.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vinorelbine as a Rescue Treatment for Canine Histiocytic Sarcoma: A Multicentre Retrospective Study of 18 Dogs. 长春瑞滨作为犬组织细胞肉瘤的抢救治疗：18只犬的多中心回顾性研究。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-04-22 DOI: 10.1111/vco.13060

Nina Vigevani, Carmit Chalfon, Alexandra Guillén, Laura Marconato, Isabel Amores-Fuster, Jean-Benoit Tanis, Riccardo Finotello

{"title":"Vinorelbine as a Rescue Treatment for Canine Histiocytic Sarcoma: A Multicentre Retrospective Study of 18 Dogs.","authors":"Nina Vigevani, Carmit Chalfon, Alexandra Guillén, Laura Marconato, Isabel Amores-Fuster, Jean-Benoit Tanis, Riccardo Finotello","doi":"10.1111/vco.13060","DOIUrl":"https://doi.org/10.1111/vco.13060","url":null,"abstract":"Histiocytic sarcoma (HS) is a highly metastatic cancer, and while response to several chemotherapy agents has been studied, the outcome remains poor. Vinorelbine (VNB) has been considered a possible treatment option, but data are limited. The aim of this study was to assess the efficacy and toxicity of VNB in canine HS. Medical records of dogs with HS, treated with VNB as first-line or rescue treatment, were reviewed. Overall response rate (ORR), progression-free survival (PFS), overall survival post-VNB (post.VNB.OST) and adverse events were evaluated. Associations between outcome measures and signalment, disease extent/location, diagnostic modality and response to previous chemotherapies were analysed. Eighteen dogs were included: 12 disseminated and six localised HS. VNB was a rescue treatment in all dogs. ORR was 38.9% [two complete responses (CR), five partial responses (PR)] including two dogs showing delayed best responses. Median PFS and post-VNB-OST for all dogs were 49 (95% CI: 33-166) and 75.5 days (95% CI: 55-174), respectively. Responders showed significantly longer median PFS (120 days) compared to non-responders (41 days). None of the other factors analysed were associated with ORR, PFS and post-VNB-OST, including pulmonary location. Neutropenia and gastrointestinal toxicity were common; however, the majority were low-grade with no hospitalisation required. Vinorelbine can be an effective and safe treatment for canine HS; disease location alone may not be a key predictive factor for VNB response and outcome. Further prospective studies on larger cohorts are required to confirm these findings.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auranofin Induces ER Stress-Mediated Apoptosis, and Its Combination With Bortezomib Elicits Paraptosis-Like Cell Death in Malignant Canine Mammary Tumour Cells. 金嘌呤诱导内质网应激介导的细胞凋亡，并与硼替佐米联合诱导犬乳腺恶性肿瘤细胞凋亡样细胞死亡。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-04-15 DOI: 10.1111/vco.13062

Yoon-Ho Suh, Se-Hoon Kim, Ki-Hoon Song, Jun-Yeol Choi, Min-Ok Ryu, Robert B Rebhun, Kyoung-Won Seo

{"title":"Auranofin Induces ER Stress-Mediated Apoptosis, and Its Combination With Bortezomib Elicits Paraptosis-Like Cell Death in Malignant Canine Mammary Tumour Cells.","authors":"Yoon-Ho Suh, Se-Hoon Kim, Ki-Hoon Song, Jun-Yeol Choi, Min-Ok Ryu, Robert B Rebhun, Kyoung-Won Seo","doi":"10.1111/vco.13062","DOIUrl":"https://doi.org/10.1111/vco.13062","url":null,"abstract":"Canine mammary tumours (CMT) are common in female dogs, often associated with malignancy and limited responses to conventional therapies. This study explores the potential of Auranofin (AF) in malignant CMT, focusing on its ability to induce distinct cell deaths. AF inhibited thioredoxin reductase (TrxR) activity, cell proliferation, and colony formation across malignant CMT cell lines, demonstrating significant anticancer effects. In AF-sensitive cell lines (CMT-U27, CHMm, and CHMp), 0.5-2 μM AF induced endoplasmic reticulum (ER) stress-mediated apoptosis, while concentrations above 3 μM caused near-complete cell death via additional proteasome inhibition. However, in AF-resistant cell lines (CIPp and CIPm), AF concentrations required for near-complete cell death were higher, expected to be challenging to achieve clinically. Therefore, we combined sublethal doses of AF (~2 μM) with the proteasome inhibitor Bortezomib (Bz) in these cells. The combination exhibited synergistic cytotoxicity and induced extensive cytoplasmic vacuolation. Live-cell staining revealed the ER origin of vacuoles, and cycloheximide pretreatment inhibited both vacuolation and AF + Bz-induced cell death, indicating features of paraptosis. While apoptosis could not be excluded, it was classified as paraptosis-like cell death occurring concurrently with apoptosis. Further analysis supported that this cell death is related to enhanced ER stress from AF-induced TrxR inhibition and Bz-induced proteasome inhibition. Based on these findings, we propose AF alone or combined with Bz as a promising therapeutic strategy for malignant CMT. Our findings highlight AF's potential to induce ER stress-mediated apoptosis and paraptosis-like cell death in canine cancer cells, expanding therapeutic options for targeting cancers in dogs.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "DNA Methylation and Its Effects on TRIM29 Gene Expression in the Equine Sarcoid Tissue". 修正“DNA甲基化及其对马肉瘤组织TRIM29基因表达的影响”。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-03-01 Epub Date: 2024-12-03 DOI: 10.1111/vco.13033

引用次数: 0

Outcomes and Perioperative Complications of Surgical Resection on Canine Carotid Paragangliomas (21 Cases): A Veterinary Society of Surgical Oncology Study. 犬颈动脉旁神经节瘤手术切除的结果和围手术期并发症（21 例）：兽医肿瘤外科学会的一项研究。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-03-01 Epub Date: 2024-11-04 DOI: 10.1111/vco.13023

Kathryn Marie Paskoff, Brad Matz, Quentin Fournier, Josep Aisa, Michelle L Oblak, Jonathan Bray, Daniel Linden

{"title":"Outcomes and Perioperative Complications of Surgical Resection on Canine Carotid Paragangliomas (21 Cases): A Veterinary Society of Surgical Oncology Study.","authors":"Kathryn Marie Paskoff, Brad Matz, Quentin Fournier, Josep Aisa, Michelle L Oblak, Jonathan Bray, Daniel Linden","doi":"10.1111/vco.13023","DOIUrl":"10.1111/vco.13023","url":null,"abstract":"Carotid body paragangliomas represent an uncommon neoplasm in dogs. The objective of this study was to report outcomes and complications associated with surgical excision of carotid body paragangliomas in 21 dogs. Cases were recruited retrospectively via medical record review from 9 veterinary speciality centres. The perioperative complication rate was 52% (11/21). Complications encountered in this cohort related to removal of carotid body tumour included airway obstruction, aspiration pneumonia, megaesophagus, unilateral laryngeal paralysis, coughing and Horner's syndrome. The overall perioperative mortality rate was 4.7% (1/21 dogs) and median survival time was 554 days for the six patients with known dates of death. One- and two-year survival rates were 61% and 42%, respectively. This is the largest collection of carotid body paraganglioma cases reported in veterinary literature. Based on these results, surgical resection of carotid body paragangliomas was associated with low perioperative mortality and long survival times.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"37-41"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flow Cytometry for the Detection and Quantification of Mast Cells in Lymph Nodes: A Prospective Study in 64 Dogs With Mast Cell Tumour. 用于检测和量化淋巴结中肥大细胞的流式细胞术：64只患有肥大细胞瘤的狗的前瞻性研究。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-03-01 Epub Date: 2024-10-17 DOI: 10.1111/vco.13019

Giulia Iamone, Carmit Chalfon, Laura Marconato, Barbara Miniscalco, Silvia Sabattini, Chiara Agnoli, Marina Martano, Kevin Pascal Spindler, Emanuela Morello, Selina Iussich, Erica Ilaria Ferraris, Fulvio Riondato

{"title":"Flow Cytometry for the Detection and Quantification of Mast Cells in Lymph Nodes: A Prospective Study in 64 Dogs With Mast Cell Tumour.","authors":"Giulia Iamone, Carmit Chalfon, Laura Marconato, Barbara Miniscalco, Silvia Sabattini, Chiara Agnoli, Marina Martano, Kevin Pascal Spindler, Emanuela Morello, Selina Iussich, Erica Ilaria Ferraris, Fulvio Riondato","doi":"10.1111/vco.13019","DOIUrl":"10.1111/vco.13019","url":null,"abstract":"Nodal metastasis is a negative prognostic factor in dogs with mast cell tumours (MCTs), thus early detection enables more informed decision-making and provides valuable prognostic information. The aim of this study is to assess the concordance between histopathologic findings of LNs and cytology and flow cytometry (FC), respectively, and to evaluate the ability of FC to differentiate between metastatic (HN2-HN3) and non-metastatic (HN0-HN1) LNs. Overall, 117 LNs from 64 dogs with first occurring MCTs were submitted for cytology, histology and FC. LNs were cytologically and histologically classified according to Krick and Weishaar systems, respectively. Using FC, mast cells (MCs) were identified as IgE+ CD117+ CD5- CD21- cells and quantified as a percentage. When compared with histologic classification, cytology showed an accuracy of 88.2% in distinguishing between metastatic and non-metastatic LNs but did not detect 25.3% of metastatic cases. FC revealed an increase in the median percentages of MCs across histologic classes, progressing from HN0 to HN3. ROC curves pinpointed 0.3% as the optimal cut-off for distinguishing between metastatic and non-metastatic LNs, with an accuracy of 84.3%. A 1.1% cut-off proved valuable in identifying HN3 LNs. The combined interpretation of cytology and FC increased accuracy to 92.2%. An algorithm for guiding the combined interpretation of cytology and FC is suggested based on these findings. In conclusion, FC proves beneficial in enhancing the early detection of metastatic LNs, particularly when utilised alongside cytology. Histopathology remains essential for confirmation, enabling the discrimination of HN classes or, in doubtful cases, for the detection or exclusion of nodal metastases.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"1-9"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lymphoid Aggregates in Canine Cutaneous and Subcutaneous Sarcomas: Immunohistochemical and Gene Expression Evidence for Tertiary Lymphoid Structures. 犬皮肤和皮下肉瘤中的淋巴细胞聚集：三级淋巴结构的免疫组织化学和基因表达证据。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-03-01 Epub Date: 2024-10-27 DOI: 10.1111/vco.13020

Kristin Marie Rugh, Laura Vary Ashton, Paula Andrea Schaffer, Christine Swardson Olver

{"title":"Lymphoid Aggregates in Canine Cutaneous and Subcutaneous Sarcomas: Immunohistochemical and Gene Expression Evidence for Tertiary Lymphoid Structures.","authors":"Kristin Marie Rugh, Laura Vary Ashton, Paula Andrea Schaffer, Christine Swardson Olver","doi":"10.1111/vco.13020","DOIUrl":"10.1111/vco.13020","url":null,"abstract":"Canine cutaneous/subcutaneous soft-tissue sarcomas (STS) are diversely derived mesenchymal neoplasms with a risk of recurrence and/or metastasis depending on the extent of surgical excision and histologic grade. Lymphoid aggregates (LAs) are often described in these tumours but not characterised. In humans, LA characterised as tertiary lymphoid structures (TLSs) improve the prognosis of many tumours, including sarcomas. We sought to determine if LA meeting a size criterion (> 700 cells) in canine sarcomas met the criteria of TLS and the overall prevalence of LA of any size. RNA expression in large LAs versus aggregate-adjacent sarcoma tissue (AAS) was measured in laser capture microdissected tissue and compared to curl-derived RNA from aggregate-free sarcomas and lymph nodes. CD3, CD20, MUM-1 and PNAd expressions were measured using immunohistochemistry. CD20 and CD3 mRNA were more highly expressed in LA versus AAS (13.8 fold, p = 0.0003 and 2.3 fold, p = 0.043). This was supported by the IHC findings. The large LAs were also enriched in chemokine RNA expression characteristic of TLS (CXCR5 5.8 fold, p < 00001, CCL19 3.68 fold, p = 0.0209, CCL21 6.87 fold, p = 0.0209 and CXCL13 2.68 fold, p = 0.0924). Plasma cells and high endothelial venules were identified in LA containing tumours but not in control tissue. Large LAs were present in 12% of tumours, and LA of any size in 30%. We conclude that large LAs in canine STS are consistent with TLS.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"10-19"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision in Parsing: Evaluation of an Open-Source Named Entity Recognizer (NER) in Veterinary Oncology. 解析精度：兽医肿瘤学中一个开源命名实体识别器（NER）的评价。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-03-01 Epub Date: 2024-12-23 DOI: 10.1111/vco.13035

Christopher J Pinard, Andrew C Poon, Andrew Lagree, Kuan-Chuen Wu, Jiaxu Li, William T Tran

{"title":"Precision in Parsing: Evaluation of an Open-Source Named Entity Recognizer (NER) in Veterinary Oncology.","authors":"Christopher J Pinard, Andrew C Poon, Andrew Lagree, Kuan-Chuen Wu, Jiaxu Li, William T Tran","doi":"10.1111/vco.13035","DOIUrl":"10.1111/vco.13035","url":null,"abstract":"Integrating Artificial Intelligence (AI) through Natural Language Processing (NLP) can improve veterinary medical oncology clinical record analytics. Named Entity Recognition (NER), a critical component of NLP, can facilitate efficient data extraction and automated labelling for research and clinical decision-making. This study assesses the efficacy of the Bio-Epidemiology-NER (BioEN), an open-source NER developed using human epidemiological and medical data, on veterinary medical oncology records. The NER's performance was compared with manual annotations by a veterinary medical oncologist and a veterinary intern. Evaluation metrics included Jaccard similarity, intra-rater reliability, ROUGE scores, and standard NER performance metrics (precision, recall, F1-score). Results indicate poor direct translatability to veterinary medical oncology record text and room for improvement in the NER's performance, with precision, recall, and F1-score suggesting a marginally better alignment with the oncologist than the intern. While challenges remain, these insights contribute to the ongoing development of AI tools tailored for veterinary healthcare and highlight the need for veterinary-specific models.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"102-108"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body Composition Measurements as Predictive Variables for Outcomes of Canine Appendicular Osteosarcoma Treated With Stereotactic Body Radiation Therapy. 体成分测量作为犬尾骨肉瘤立体定向放射治疗结果的预测变量。

IF 2.3 2区农林科学

Veterinary and comparative oncology Pub Date : 2025-03-01 Epub Date: 2025-01-02 DOI: 10.1111/vco.13037

Johnny Altwal, Lynn Griffin, Tiffany Wormhoudt Martin

{"title":"Body Composition Measurements as Predictive Variables for Outcomes of Canine Appendicular Osteosarcoma Treated With Stereotactic Body Radiation Therapy.","authors":"Johnny Altwal, Lynn Griffin, Tiffany Wormhoudt Martin","doi":"10.1111/vco.13037","DOIUrl":"10.1111/vco.13037","url":null,"abstract":"Body composition measurements (BCM), obtained via computed tomography (CT), have been used as predictors of survival, tumour recurrence, and post-surgical infections in human oncology. There are no reports on using BCM to predict outcomes of dogs with cancer. Elevated BCM is hypothesised to place extra stress on bones weakened by cancer. Pathologic fracture following stereotactic body radiation therapy for canine appendicular osteosarcoma (OSA) frequently results in limb amputation or euthanasia. Additional tools are needed to better predict the risk of fracture development. Our objectives were to determine if any relationships could be identified between BCM and the occurrence of a pathologic fracture and/or survival time in dogs with naturally occurring OSA. Forty-seven dogs with a confirmed OSA and whole-body CT pre-SBRT were included. Several BCM were evaluated, including abdominal volume, visceral adipose tissue volume, whole-body volume, whole-body adipose tissue volume, normalised cross-sectional area of the epaxial muscles at the mid-body of the 13th thoracic vertebra, and attenuations of adipose tissue and epaxial muscles. No BCMs were correlated with survival time. The volume of the entire body (cm3) was significantly positively associated with development of a fracture. No other BCM were correlated with the development of a fracture. The volume of the abdomen (cm3) among our patient subset was positively correlated with the volume of the entire body, and the volume of visceral adipose tissue (cm3) was positively correlated with the total body volume of adipose tissue (cm3). Additional research is needed to verify whether these findings are replicable in larger sample sizes and in prospective settings.","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"116-122"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0