犬高级别淋巴瘤首次缓解后半体放射治疗导致无进展时间延长。

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES
Veterinary and comparative oncology Pub Date : 2025-06-01 Epub Date: 2025-03-15 DOI:10.1111/vco.13050
Yen-Hao Erik Lai, Sarah Lyles, Mark Mitchell, Jayme Looper
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引用次数: 0

摘要

在淋巴瘤犬的多药化疗中加入宽视场照射的最佳方案尚未建立。本回顾性病例对照研究的目的是评估化疗和半体照射(HBI)联合治疗高级别淋巴瘤犬的疗效。治疗组犬在完成第二周期多药化疗方案2周后接受颅脑HBI。放射治疗方案包括4 Gy/分数,每天一次,连续2天,用于头半体,2周后对尾半体进行相同的治疗方案。对照组仅接受多药化疗。所有患者都需要细胞学证实为高级别淋巴瘤,并在两个周期的多药化疗后完全缓解。HBI组14例,对照组11例。HBI组的中位无进展间期(PFI)(1143天)明显长于对照组(316天,p = 0.004)。在HBI组中,T细胞淋巴瘤犬的PFI(292天)比B细胞淋巴瘤犬的PFI(2127天,p = 0.0013)短。HBI组的中位生存时间(1924天)明显长于单纯化疗组(566天,p = 0.0077)。在接受HBI和化疗的患者中发现PFI和ST延长的预测因素(p分别= 0.0062和0.0252)。对于完成多药方案的化疗应答患者,与仅化疗组相比,HBI显着延长了肿瘤复发时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Half-Body Radiation Therapy Results in a Prolonged Progression-Free Interval in Canine High-Grade Lymphoma After First Remission.

An optimal protocol of adding wide-field irradiation to multi-agent chemotherapy for dogs with lymphoma has not been established. The aim of this retrospective case-control study was to evaluate the efficacy of a protocol combining chemotherapy and half-body irradiation (HBI) for dogs with high-grade lymphoma. Dogs in the treatment group received cranial HBI 2 weeks after completing the second cycle of the multi-agent chemotherapy protocol. The radiation therapy protocol consisted of 4 Gy/fraction once per day for 2 consecutive days for the cranial half body, followed by the same protocol for the caudal half 2 weeks later. The control group only received multi-agent chemotherapy. All patients were required to have cytological confirmation of high-grade lymphoma and achieve complete remission after two cycles of multi-agent chemotherapy. Fourteen patients receiving HBI and 11 patients in the control group were included. The median progression-free interval (PFI) in the HBI group (1143 days) was significantly longer than that in the control group (316 days, p = 0.004). In the HBI group, dogs with T cell lymphoma had statistically shorter PFI (292 days) than dogs with B cell lymphoma (2127 days, p = 0.0013). The median survival time in the HBI group (1924 days) was significantly longer than that in the chemotherapy-only group (566 days, p = 0.0077). The predictive factors for longer PFI and ST were found in the patients who received HBI and chemotherapy (p = 0.0062 and 0.0252, respectively). For chemotherapy-responding patients that completed a multi-agent protocol, HBI significantly prolonged the time to tumour relapse compared with the chemotherapy-only group.

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来源期刊
Veterinary and comparative oncology
Veterinary and comparative oncology 农林科学-兽医学
CiteScore
4.80
自引率
9.50%
发文量
75
审稿时长
>24 weeks
期刊介绍: Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.
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