Vision Research最新文献

{"title":"Functional genomics of primary congenital glaucoma by pathway analysis and functional characterization of CYP1B1 mutations","authors":"Muneeb A. Faiq ,&nbsp;Himanshu N. Singh ,&nbsp;Mashooq Ali ,&nbsp;Rima Dada ,&nbsp;Kevin C. Chan ,&nbsp;Tanuj Dada ,&nbsp;Daman Saluja","doi":"10.1016/j.visres.2024.108534","DOIUrl":"10.1016/j.visres.2024.108534","url":null,"abstract":"<div><div>CYP1B1 is the most common gene implicated in primary congenital glaucoma (PCG) − the most common form of childhood glaucoma. How CYP1B1 mutations cause PCG is not known. Understanding the mechanism of PCG caused by CYP1B1 mutations is crucial for disease management, therapeutics development, and potential prevention. We performed a comprehensive metabolome/reactome analysis of CYP1B1 to enlist CYP1B1-mediated processes in eye development. The identified metabolic events were classified into major pathways. Functional analysis of these metabolic pathways was performed after cloning the CYP1B1 wild-type gene and expressing the wild-type and selected novel mutants (previously reported by our group L24R, F190L, H279D, and G329D) in heterologous hosts. Stability and enzymatic functions were investigated. Structural modeling of the wild-type and the variants was also performed. Reactome analysis revealed a total of 166 metabolic processes which could be classified into four major pathways including estradiol metabolism, retinoic acid metabolism, arachidonic acid metabolism, and melatonin metabolism. Stability assay revealed rapid denaturing of mutant proteins compared to wild-type. Enzymatic assays showed functional deficit in mutant proteins in metabolizing estradiol, retinoids, arachidonate, and melatonin. Modeling revealed that the examined mutations induced structural changes likely causative in functional loss in CYB1B1 as observed in enzymatic assays. Hence, mutations in the CYP1B1 gene are associated with a functional deficit in critical pathways of eye development. These findings implicate the potential contributions of altered metabolic regulations of estradiol, retinoids, arachidonate and melatonin to the pathogenesis of PCG during the processes of the formation of ocular structures and function.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"227 ","pages":"Article 108534"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The saccade target is prioritized for visual stability in naturalistic scenes","authors":"Jessica L. Parker,&nbsp;A. Caglar Tas","doi":"10.1016/j.visres.2025.108541","DOIUrl":"10.1016/j.visres.2025.108541","url":null,"abstract":"<div><div>The present study investigated the mechanisms of visual stability using naturalistic scene images. In two experiments, we asked whether the visual system relies on spatial location of the saccade target, as previously found with simple dot stimuli, or relational positions of the objects in the scene during visual stability decisions. Using a modified version of the saccadic suppression of displacement task, we manipulated the information that is displaced in the scene as well as visual stability using intrasaccadic target blanking paradigm. There were four displacement conditions: saccade target, saccade source (Experiment 2 only), whole scene, and background. We also included a no-displacement control condition where everything remained stationary. Participants reported whether they detected any movement. The results showed that spatial displacements that occur in the saccade target object were more easily detected than any other displacements in the scene. Further, disrupting visual stability with blanking only improved displacement detection for the saccade target and saccade source objects, suggesting that saccade target and saccade source objects are both consulted in the establishment of visual stability, most likely due to both receiving selective attention before saccade execution. The present study is the first to show that the visual system uses similar visual stability mechanisms for simple dot stimuli and more naturalistic stimuli.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"227 ","pages":"Article 108541"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accommodation microfluctuation in individuals with mTBI and the potential effect of chromatic filter on this parameter","authors":"Nawaf M. Almutairi ,&nbsp;John Hayes ,&nbsp;Karen M. Hampson ,&nbsp;Chunming Liu","doi":"10.1016/j.visres.2025.108545","DOIUrl":"10.1016/j.visres.2025.108545","url":null,"abstract":"<div><div>Individuals with mild traumatic brain injury (mTBI) exhibit significant accommodative abnormalities. Accommodation microfluctuation (MFs) plays an important role in the accommodation steady-state control. This study was set to investigate the characteristics of the MFs in mTBI subjects and whether chromatic filter (CF) or neutral density filter (ND) would impact these parameters. 54 healthy and 30 mTBI young adults participated. Tonic accommodation (TA) was recorded in complete darkness after dark adaptation. The steady-state accommodation response (AR) for various stimulus distances was recorded at baseline (no filter; NF), with CF and ND. The low and high frequency component (LFC and HFC respectively) of MFs was analyzed. Subjects with mTBI exhibited significantly lower MFs, especially at higher stimulus levels. There was a strong negative correlation between the accommodation error (AE) and the LFC. Increased lag of accommodation (AE &gt; 0 D) was associated with lower LFC and vice versa. Both filter conditions exerted a minimum impact on the MFs overall. A strong positive correlation between MFs and TA was revealed for both groups. Our study showed that mTBI significantly impaired the MFs of accommodation. The observed lower MFs power in mTBI appears to be subsequent to the higher lag of accommodation, suggesting an underlying deficit in the accommodative motor controller to generate sufficient response. The strong correlation between TA and MFs, as well as the lack of effect from different filters, further supports the theory that sensory blur detection does not play a significant role in MFs of accommodation.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"227 ","pages":"Article 108545"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived intrinsic 3D shape of faces is robust to changes in lighting direction, image rotation and polarity inversion","authors":"Jordi M. Asher ,&nbsp;Paul B. Hibbard ,&nbsp;Abigail L.M. Webb","doi":"10.1016/j.visres.2024.108535","DOIUrl":"10.1016/j.visres.2024.108535","url":null,"abstract":"<div><div>Face recognition from 2D images is influenced by various factors, including lighting conditions, viewing direction, rotation, and polarity inversion. It has been proposed that these techniques affect face recognition by distorting shape from shading. This study investigates the perception of 3D face shape in 2D images using a gauge figure task. Two experiments were conducted where participants adjusted a gauge figure across multiple locations within a 3D image to assess its surface structure. We manipulated face orientation, lighting direction, and polarity inversion (exp 2). While these manipulations resulted in variations from the true surface structure, they could be explained by an affine transformation. This suggests that the perception of the intrinsic 3D shape of faces is stable across these image manipulation techniques. The effects of viewing conditions on face recognition may thus be better interpreted through their influence on the perception of material properties such as pigmentation, or on information closer to the level of the retinal image itself.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"227 ","pages":"Article 108535"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Task-modulated neural responses in scene-selective regions of the human brain","authors":"Aysu Nur Koc ,&nbsp;Burcu A. Urgen ,&nbsp;Yasemin Afacan","doi":"10.1016/j.visres.2024.108539","DOIUrl":"10.1016/j.visres.2024.108539","url":null,"abstract":"<div><div>The study of scene perception is crucial to the understanding of how one interprets and interacts with their environment, and how the environment impacts various cognitive functions. The literature so far has mainly focused on the impact of low-level and categorical properties of scenes and how they are represented in the scene-selective regions in the brain, PPA, RSC, and OPA. However, higher-level scene perception and the impact of behavioral goals is a developing research area. Moreover, the selection of the stimuli has not been systematic and mainly focused on outdoor environments. In this fMRI experiment, we adopted multiple behavioral tasks, selected real-life indoor stimuli with a systematic categorization approach, and used various multivariate analysis techniques to explain the neural modulation of scene perception in the scene-selective regions of the human brain. Participants (N = 21) performed categorization and approach-avoidance tasks during fMRI scans while they were viewing scenes from built environment categories based on different affordances ((i)access and (ii)circulation elements, (iii)restrooms and (iv)eating/seating areas). ROI-based classification analysis revealed that the OPA was significantly successful in decoding scene category regardless of the task, and that the task condition affected category decoding performances of all the scene-selective regions. Model-based representational similarity analysis (RSA) revealed that the activity patterns in scene-selective regions are best explained by task. These results contribute to the literature by extending the task and stimulus content of scene perception research, and uncovering the impact of behavioral goals on the scene-selective regions of the brain.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"227 ","pages":"Article 108539"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Working memory capacity modulates Serial dependence in facial Identity: Evidence from behavioral and EEG data","authors":"Anette Lidström,&nbsp;Inês Bramão","doi":"10.1016/j.visres.2025.108542","DOIUrl":"10.1016/j.visres.2025.108542","url":null,"abstract":"<div><div>Serial dependence (SD) is said to occur when the judgment of a current stimulus is drawn toward a no longer relevant stimulus from the recent past. Working memory (WM) contributes to the ability to discriminate between irrelevant and relevant sensory impressions. How WM contributes to SD in facial identity remains to be fully understood. In the present study, we used a WM task with varying load interleaved with a facial matching task to investigate the relations between SD in facial identity and WM. EEG was recorded to capture perceptual face processing and WM maintenance. Overall, statistically significant SD effects were obtained only at high WM load. In addition, individual differences in WM capacity predicted SD. Participants with low WM capacity showed significant SD effects regardless of changes in WM load, while participants with high WM capacity showed significant SD only at high WM load. EEG results showed significant differences in perceptual and WM processing for participants with high WM capacity, while no significant differences were obtained for participants with low WM capacity. Neural correlates of WM maintenance, and perceptual processing of a previous face were directly related to SD. The results suggest that WM capacity contributes to SD in facial identity, in terms of selective suppression of task-irrelevant and selective maintenance of task-relevant information.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"227 ","pages":"Article 108542"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brief memory reactivation may not improve visual perception","authors":"Jun-Ping Zhu,&nbsp;Jun-Yun Zhang","doi":"10.1016/j.visres.2025.108543","DOIUrl":"10.1016/j.visres.2025.108543","url":null,"abstract":"<div><div>Visual perceptual learning often requires a substantial number of trials to observe significant learning effects. Previously <span><span>Amar-Halpert et al. (2017)</span></span> have shown that brief reactivation (5 trials/day) is sufficient to improve the performance of the texture discrimination task (TDT), yielding comparable improvements to those achieved through full practice (252 trials/day). The finding is important since it would refine our understanding of learning mechanisms and applications. In the current study, we attempted to replicate these experiments using a larger number of observers and an improved experimental design. Using between-group comparison, we did find significant improvements in the reactivation group and the full-practice group as <span><span>Amar-Halpert et al. (2017)</span></span> showed. However, these improvements were comparable to those of the no-reactivation group with no exposure to the TDT task over the same period. Importantly, our within-group comparison showed that both the reactivation and no-reactivation groups exhibited additional significant improvements after further practicing the TDT task for an additional three days, demonstrating that the full-practice effect was significantly superior to the effects of brief memory reactivation or simple test–retest. Besides, when refining the constant stimuli method with fewer stimulus levels and more trials per level, we still observed comparable improvements brought by the reactivation and no-reactivation groups. Therefore, our results suggested that brief memory reactivation may not significantly contribute to the improvement of perceptual learning, and traditional perceptual training could still be a necessary and effective approach for substantial improvements.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"227 ","pages":"Article 108543"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of feedback and task accuracy in serial dependence to orientation","authors":"Zoë Little ,&nbsp;Colin W.G. Clifford","doi":"10.1016/j.visres.2024.108536","DOIUrl":"10.1016/j.visres.2024.108536","url":null,"abstract":"<div><div>Assimilative serial dependence in perception occurs where responses about a stimulus (e.g., orientation) are biased towards previously seen perceptual information (e.g., the orientation of the stimulus shown on the previous trial). This bias may occur to perceptual information from the previous trial, or to the response or decision made on the previous trial. We asked whether providing response feedback could change the serial dependence effect on the following trial. Twenty-one participants completed a task in which they adjusted an on-screen pointer to reproduce the orientation of a briefly-presented Gabor stimulus. They received feedback about the accuracy of their response that either reflected their actual accuracy or was random. We found significant positive biases to the stimulus and response only when the participant had received positive (“correct!”) feedback on that trial. When the inducer response had been incorrect, the effect was significant only to the response itself and not to the stimulus. Overall, we suggest that our participants demonstrated a bias towards the percept from the previous trial, which is better represented by the response than the stimulus for incorrect trials, and that this effect can be modulated post-perceptually by feedback.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"227 ","pages":"Article 108536"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attention modulates subjective time perception across eye movements","authors":"Chuyao Yan ,&nbsp;Hao Wang ,&nbsp;Xueyan Jiang ,&nbsp;Zhiguo Wang","doi":"10.1016/j.visres.2025.108540","DOIUrl":"10.1016/j.visres.2025.108540","url":null,"abstract":"<div><div>Prior research has established that actions, such as eye movements, influence time perception. However, the relationship between pre-saccadic attention, which is often associated with eye movement, and subjective time perception is not explored. Our study examines the impact of pre-saccadic attention on the subjective experience of time during eye movements, particularly focusing on its influence on subjective time perception at the saccade target. Participants were presented with two clocks featuring spinning hands, positioned at distinct locations corresponding to fixation and the saccade target. They were required to report the perceived time of these clocks across the eye movements, enabling us to measure and compare both the perceived and actual timing at these specific clock locations. In Experiment 1, we observed that participants tended to report the timing of their eyes’ arrival at the target location as occurring slightly ahead of the actual time. In contrast, in Experiment 2, when participants divert their attention to the fixation clock prior to the imperative saccade, this perceptual bias diminishes. These results indicate that subjective time perception is strongly impacted by attentional conditions across the two experiments. Together, these findings offer further evidence for the notion that stable time perception during eye movements is not solely an inherent property of the eye movement system but also encompasses other cognitive mechanisms, such as attention.</div></div><div><h3>Statement of relevance</h3><div>While we often remain unaware of the frequent saccades (rapid eye movements) we make, they have a profound impact on our perception of the world and the flow of time. Nevertheless, the connection between pre-saccadic attention, often associated with eye movements, and our subjective perception of time remains largely unexplored. In our research, we investigated the relationship between attention and our subjective experience of time. Our findings revealed the crucial role of attention, serving as a bridge between the physical movements of our eyes and our internal sense of temporal continuity. In essence, although previous studies have demonstrated the impact of eye movements on time perception, our current study emphasizes the critical influence of attention during the preparatory phase of saccades on the subjective experience of time during eye movements.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"227 ","pages":"Article 108540"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scene complexity and the detail trace of human long-term visual memory","authors":"Cameron Kyle-Davidson,&nbsp;Oscar Solis,&nbsp;Stephen Robinson,&nbsp;Ryan Tze Wang Tan,&nbsp;Karla K. Evans","doi":"10.1016/j.visres.2024.108525","DOIUrl":"10.1016/j.visres.2024.108525","url":null,"abstract":"<div><div>Humans can remember a vast amount of scene images; an ability often attributed to encoding only low-fidelity gist traces of a scene. Instead, studies show a surprising amount of detail is retained for each scene image allowing them to be distinguished from highly similar in-category distractors. The gist trace for images can be relatively easily captured through both computational and behavioural techniques, but capturing detail is much harder. While detail can be broadly estimated at the categorical level (e.g. man-made scenes more complex than natural), there is a lack of both ground-truth detail data at the sample level and a way to operationalise it for measurement purposes. Here through three different studies, we investigate whether the perceptual complexity of scenes can serve as a suitable analogue for the detail present in a scene, and hence whether we can use complexity to determine the relationship between scene detail and visual long term memory for scenes. First we examine this relationship directly using the VISCHEMA datasets, to determine whether the perceived complexity of a scene interacts with memorability, finding a significant positive correlation between complexity and memory, in contrast to the hypothesised U-shaped relation often proposed in the literature. In the second study we model complexity via artificial means, and find that even predicted measures of complexity still correlate with the overall ground-truth memorability of a scene, indicating that complexity and memorability cannot be easily disentangled. Finally, we investigate how cognitive load impacts the influence of scene complexity on image memorability. Together, findings indicate complexity and memorability do vary non-linearly, but generally it is limited to the extremes of the image complexity ranges. The effect of complexity on memory closely mirrors previous findings that detail enhances memory, and suggests that complexity is a suitable analogue for detail in visual long-term scene memory.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"227 ","pages":"Article 108525"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}