Vision Research最新文献_第3页

Biomechanic, proteomic and miRNA transcriptional changes in the trabecular meshwork of primates injected with intravitreal triamcinolone 静脉注射曲安奈德的灵长类动物小梁网的生物力学、蛋白质组和 miRNA 转录变化。

IF 1.5 4区心理学

Vision Research Pub Date : 2024-07-10 DOI: 10.1016/j.visres.2024.108456

Sangwan Park , Vijay Krishna Raghunathan , Raneesh Ramarapu , Ala Moshiri , Glenn Yiu , M. Isabel Casanova , Krista Cosert , Michelle McCorkell , Brian C. Leonard , Sara M. Thomasy

{"title":"Biomechanic, proteomic and miRNA transcriptional changes in the trabecular meshwork of primates injected with intravitreal triamcinolone","authors":"Sangwan Park , Vijay Krishna Raghunathan , Raneesh Ramarapu , Ala Moshiri , Glenn Yiu , M. Isabel Casanova , Krista Cosert , Michelle McCorkell , Brian C. Leonard , Sara M. Thomasy","doi":"10.1016/j.visres.2024.108456","DOIUrl":"10.1016/j.visres.2024.108456","url":null,"abstract":"<div><p>Although biomechanical changes of the trabecular meshwork (TM) are important to the pathogenesis of glucocorticoids-induced ocular hypertension (GC-OHT), there is a knowledge gap in the underlying molecular mechanisms of the development of it. In this study, we performed intravitreal triamcinolone injection (IVTA) in one eye of 3 rhesus macaques. Following IVTA, we assessed TM stiffness using atomic force microscopy and investigated changes in proteomic and miRNA expression profiles. One of 3 macaques developed GC-OHT with a difference in intraocular pressure of 4.2 mmHg and a stiffer TM with a mean increase in elastic moduli of 0.60 kPa versus the non-injected control eye. In the IVTA-treated eyes, proteins associated with extracellular matrix remodeling, cytoskeletal rearrangement, and mitochondrial oxidoreductation were significantly upregulated. The significantly upregulated miR-29b and downregulated miR-335-5p post-IVTA supported the role of oxidative stress and mitophagy in the GC-mediated biomechanical changes in TM, respectively. The significant upregulation of miR-15/16 cluster post-IVTA may indicate a resultant TM cell apoptosis contributing to the increase in outflow resistance. Despite the small sample size, these results expand our knowledge of GC-mediated responses in the TM and furthermore, may help explain steroid responsiveness in clinical settings.</p></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0042698924001007/pdfft?md5=07b604028aea8cfc741284e0298cc7ed&pid=1-s2.0-S0042698924001007-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A bias in transsaccadic perception of spatial frequency changes 对空间频率变化的反累积感知存在偏差。

IF 1.5 4区心理学

Vision Research Pub Date : 2024-07-10 DOI: 10.1016/j.visres.2024.108453

Nino Sharvashidze , Carolin Hübner , Alexander C. Schütz

{"title":"A bias in transsaccadic perception of spatial frequency changes","authors":"Nino Sharvashidze , Carolin Hübner , Alexander C. Schütz","doi":"10.1016/j.visres.2024.108453","DOIUrl":"10.1016/j.visres.2024.108453","url":null,"abstract":"<div><p>Visual processing differs between the foveal and peripheral visual field. These differences can lead to different appearances of objects in the periphery and the fovea, posing a challenge to perception across saccades. Differences in the appearance of visual features between the peripheral and foveal visual field may bias change discrimination across saccades. Previously it has been reported that spatial frequency (SF) appears higher in the periphery compared to the fovea (<span>Davis et al., 1987</span>). In this study, we investigated the visual appearance of SF before and after a saccade and the discrimination of SF changes during saccades. In addition, we tested the contributions of pre- and postsaccadic information to change discrimination performance. In the first experiment, we found no differences in the appearance of SF before and after a saccade. However, participants showed a clear bias to report SF increases. Interestingly, a 200-ms postsaccadic blank improved the precision of the responses but did not affect the bias. In the second experiment, participants showed lower thresholds for SF increases than for decreases, suggesting that the bias in the first experiment was not just a response bias. Finally, we asked participants to discriminate the SF of stimuli presented before a saccade. Thresholds in the presaccadic discrimination task were lower than in the change discrimination task, suggesting that transsaccadic change discrimination is not merely limited by presaccadic discrimination in the periphery. The change direction bias might stem from more effective masking or overwriting of the presaccadic stimulus by the postsaccadic low SF stimulus.</p></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S004269892400097X/pdfft?md5=43a5d9b12a42534b7c8359c7e86c95ba&pid=1-s2.0-S004269892400097X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The adaptive global effect: Luminance contrast modulates the global effect zone 自适应全局效应亮度对比调节全局效应区

IF 1.5 4区心理学

Vision Research Pub Date : 2024-07-09 DOI: 10.1016/j.visres.2024.108454

Jessica Heeman , Jan Theeuwes , Stefan Van der Stigchel

{"title":"The adaptive global effect: Luminance contrast modulates the global effect zone","authors":"Jessica Heeman , Jan Theeuwes , Stefan Van der Stigchel","doi":"10.1016/j.visres.2024.108454","DOIUrl":"10.1016/j.visres.2024.108454","url":null,"abstract":"<div><p>When two peripheral objects are presented in close proximity, saccades towards one of these objects land at a weighted average location between the two objects. This phenomenon, known as the ‘global effect’ or ‘saccade averaging’, disappears when the distance between the objects increases. When objects are further apart, outside the averaging zone, saccades land on one of the objects with little or no saccade averaging. Although it is known that the strength of the global effect is dependent on the specific features of the two objects, it is unclear if the size of the zone in which averaging can occur (i.e., the averaging zone) is adaptive. The aim of the current study was to investigate whether the size of the averaging zone adapts to variations in object luminance contrast of the objects. In order to systematically assess changes in the averaging zone, in two experiments, observers made saccadic eye movements while the luminance of the target and the distractor varied. We report three major findings: 1) When a distractor was more luminant relative to the target, the averaging zone increased (Exp. 1). Notably, saccade averaging never entirely ceased to exist, even for remote distractors. 2) When target and distractor were equiluminant, the averaging zone did not change with absolute luminance (Exp. 2). 3) Higher (relative and absolute) luminance increased the averaging zone especially for shorter saccadic response times (SRT). We conclude that the averaging zone is adaptive and becomes larger with increasing relative luminance and especially when SRTs are short.</p></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of extrinsic and intrinsic factors in perceptual filling-in of the blind-spot with variegated color and texture stimuli 外在和内在因素在不同颜色和纹理刺激盲点知觉填充中的作用。

IF 1.5 4区心理学

Vision Research Pub Date : 2024-07-04 DOI: 10.1016/j.visres.2024.108452

Amrita Mukherjee , Avijit Paul , Rajarshi Roy , Kuntal Ghosh

{"title":"The role of extrinsic and intrinsic factors in perceptual filling-in of the blind-spot with variegated color and texture stimuli","authors":"Amrita Mukherjee , Avijit Paul , Rajarshi Roy , Kuntal Ghosh","doi":"10.1016/j.visres.2024.108452","DOIUrl":"10.1016/j.visres.2024.108452","url":null,"abstract":"<div><p>Vision scientists dedicated their efforts to unraveling the mechanism of filling-in at the blind-spot (BS) through numerous psychophysical experiments. The prevalent interpretation, emphasizing active filling-in, has spurred extensive research endeavors. In a parallel vein, a pertinent study highlighted the predominance of the nasal Visual Field (VF) over the temporal one and postulated the role of the Cortical Magnification Factor (CMF) in explaining the asymmetry of filling-in. In this study, we first replicated this experiment and then conducted BS-specific psychophysical experiments employing various bi-colored and bi-textured (patterned) stimuli. We observed that nasal dominance is not persistent in the context of the spread of perception for BS filling-in. We posit that the visual information processing priority index (VIPPI), comprising the CMF (an intrinsic factor unaffected by stimulus characteristics) and relative luminance (an extrinsic factor dependent on stimulus characteristics), governs the spread of perception for filling-in in case of diverse neighborhoods of the BS.</p></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colour expectations across illumination changes 不同光照条件下的色彩预期

IF 1.5 4区心理学

Vision Research Pub Date : 2024-07-03 DOI: 10.1016/j.visres.2024.108451

Hamed Karimipour, Christoph Witzel

{"title":"Colour expectations across illumination changes","authors":"Hamed Karimipour, Christoph Witzel","doi":"10.1016/j.visres.2024.108451","DOIUrl":"10.1016/j.visres.2024.108451","url":null,"abstract":"<div><p>This study investigates human expectations towards naturalistic colour changes under varying illuminations. Understanding colour expectations is key to both scientific research on colour constancy and applications of colour and lighting in art and industry. We reanalysed data from asymmetric colour matches of a previous study and found that colour adjustments tended to align with illuminant-induced colour shifts predicted by naturalistic, rather than artificial, illuminants and reflectances. We conducted three experiments using hyperspectral images of naturalistic scenes to test if participants judged colour changes based on naturalistic illuminant and reflectance spectra as more plausible than artificial ones, which contradicted their expectations. When we consistently manipulated the illuminant (Experiment 1) and reflectance (Experiment 2) spectra across the whole scene, observers chose the naturalistic renderings significantly above the chance level (>25 %) but barely more often than any of the three artificial ones, collectively (>50 %). However, when we manipulated only one object/area’s reflectance (Experiment 3), observers more reliably identified the version in which the object had a naturalistic reflectance like the rest of the scene. Results from Experiments 2–3 and additional analyses suggested that relational colour constancy strongly contributed to observer expectations, and stable cone-excitation ratios are not limited to naturalistic illuminants and reflectances but also occur for our artificial renderings. Our findings indicate that relational colour constancy and prior knowledge about surface colour shifts help to disambiguate surface colour identity under illumination changes, enabling human observers to recognise surface colours reliably in naturalistic conditions. Additionally, relational colour constancy may even be effective in many artificial conditions.</p></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0042698924000956/pdfft?md5=21788695361ade89f75d4aa626880faf&pid=1-s2.0-S0042698924000956-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Standard models of spatial vision mispredict edge sensitivity at low spatial frequencies 空间视觉的标准模型错误地预测了低空间频率下的边缘敏感性。

IF 1.5 4区心理学

Vision Research Pub Date : 2024-07-03 DOI: 10.1016/j.visres.2024.108450

Lynn Schmittwilken , Felix A. Wichmann , Marianne Maertens

{"title":"Standard models of spatial vision mispredict edge sensitivity at low spatial frequencies","authors":"Lynn Schmittwilken , Felix A. Wichmann , Marianne Maertens","doi":"10.1016/j.visres.2024.108450","DOIUrl":"10.1016/j.visres.2024.108450","url":null,"abstract":"<div><p>One well-established characteristic of early visual processing is the contrast sensitivity function (CSF) which describes how sensitivity varies with the spatial frequency (SF) content of the visual input. The CSF prompted the development of a now standard model of spatial vision. It represents the visual input by activity in orientation- and SF selective channels which are nonlinearly recombined to predict a perceptual decision. The standard spatial vision model has been extensively tested with sinusoidal gratings at low contrast because their narrow SF spectra isolate the underlying SF selective mechanisms. It is less studied how well these mechanisms account for sensitivity to more behaviourally relevant stimuli such as sharp edges at high contrast (i.e. object boundaries) which abound in the natural environment and have broader SF spectra. Here, we probe sensitivity to edges (2-AFC, edge localization) in the presence of broadband and narrowband noises. We use Cornsweet luminance profiles with peak frequencies at 0.5, 3 and 9 cpd as edge stimuli. To test how well mechanisms underlying sinusoidal contrast sensitivity can account for edge sensitivity, we implement a single- and a multi-scale model building upon standard spatial vision model components. Both models account for most of the data but also systematically deviate in their predictions, particularly in the presence of pink noise and for the lowest SF edge. These deviations might indicate a transition from contrast- to luminance-based detection at low SFs. Alternatively, they might point to a missing component in current spatial vision models.</p></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0042698924000944/pdfft?md5=ba4fef6cf9a14b49ddddc4d93f3ade67&pid=1-s2.0-S0042698924000944-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pupillometry indexes ocular dominance plasticity 瞳孔测量法是眼球优势可塑性的指标。

IF 1.5 4区心理学

Vision Research Pub Date : 2024-06-22 DOI: 10.1016/j.visres.2024.108449

Miriam Acquafredda, Paola Binda

{"title":"Pupillometry indexes ocular dominance plasticity","authors":"Miriam Acquafredda, Paola Binda","doi":"10.1016/j.visres.2024.108449","DOIUrl":"10.1016/j.visres.2024.108449","url":null,"abstract":"<div><p>Short-term monocular deprivation in normally sighted adult humans produces a transient shift of ocular dominance, boosting the deprived eye. This effect has been documented with both perceptual tests and through physiological recordings, but no previous study simultaneously measured physiological responses and the perceptual effects of deprivation. Here we propose an integrated experimental paradigm that combines binocular rivalry with pupillometry, to introduce an objective physiological index of ocular dominance plasticity, acquired concurrently with perceptual testing. Ten participants reported the perceptual dynamics of binocular rivalry, while we measured pupil diameter. Stimuli were a white and a black disk, each presented monocularly. Rivalry dynamics and pupil-size traces were compared before and after 2 h of monocular deprivation, achieved by applying a translucent patch over the dominant eye. Consistent with prior research, we observed that monocular deprivation boosts the deprived-eye signal and consequently increases ocular dominance. In line with previous studies, we also observed subtle but systematic modulations of pupil size that tracked alternations between exclusive dominance phases of the black or white disk. Following monocular deprivation, the amplitude of these pupil-size modulations increased, which is consistent with the post-deprivation boost of the deprived eye and the increase of ocular dominance. This provides evidence that deprivation impacts the effective strength of monocular visual stimuli, coherently affecting perceptual reports and the automatic and unconscious regulation of pupil diameter. Our results show that a combined paradigm of binocular rivalry and pupillometry gives new insights into the physiological mechanisms underlying deprivation effects.</p></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0042698924000932/pdfft?md5=4d2a5581650daf41ab929b81bbb2caf3&pid=1-s2.0-S0042698924000932-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low luminance contrast’s effect on the color appearance of S-cone patterns 低亮度对比对 S 锥形图案色彩外观的影响

IF 1.5 4区心理学

Vision Research Pub Date : 2024-06-20 DOI: 10.1016/j.visres.2024.108448

Robert Shapley , Valerie Nunez , James Gordon

{"title":"Low luminance contrast’s effect on the color appearance of S-cone patterns","authors":"Robert Shapley , Valerie Nunez , James Gordon","doi":"10.1016/j.visres.2024.108448","DOIUrl":"https://doi.org/10.1016/j.visres.2024.108448","url":null,"abstract":"<div><p>There is a surprisingly strong effect on color appearance when low levels of luminance contrast are added to visual targets in which only S-cones are modulated. This phenomenon can be studied with checkerboard patterns composed of alternating S-cone-modulated checks and gray checks. + S checks look purple when surrounded by slightly brighter gray checks but look highly desaturated (lavender, almost white) when surrounded by darker gray checks. −S checks change in hue with luminance contrast; they look yellow when surrounded by darker gray checks but are greener when surrounded by lighter checks. Psychophysical paired comparisons confirm these perceptions. Furthermore, visual evoked potentials (VEPs) recorded from human posterior cortex indicate that signals evoked by low luminance contrast interact nonlinearly with S-cone-evoked signals in early cortical color processing. Our new psychophysics and electrophysiology results prove that human perception of color appearance is not based on neural computations within a separate, isolated color system. Rather, signals evoked by color contrast and luminance contrast interact to produce the colors we see.</p></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141434593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The genomic evolution of visual opsin genes in amphibians 两栖动物视觉蛋白基因的基因组进化

IF 1.5 4区心理学

Vision Research Pub Date : 2024-06-20 DOI: 10.1016/j.visres.2024.108447

Jinn-Jy Lin , Feng-Yu Wang , Wen-Yu Chung , Tzi-Yuan Wang

{"title":"The genomic evolution of visual opsin genes in amphibians","authors":"Jinn-Jy Lin , Feng-Yu Wang , Wen-Yu Chung , Tzi-Yuan Wang","doi":"10.1016/j.visres.2024.108447","DOIUrl":"https://doi.org/10.1016/j.visres.2024.108447","url":null,"abstract":"<div><p>Among tetrapod (terrestrial) vertebrates, amphibians remain more closely tied to an amphibious lifestyle than amniotes, and their visual opsin genes may be adapted to this lifestyle. Previous studies have discussed physiological, morphological, and molecular changes in the evolution of amphibian vision. We predicted the locations of the visual opsin genes, their neighboring genes, and the tuning sites of the visual opsins, in 39 amphibian genomes. We found that all of the examined genomes lacked the <em>Rh2</em> gene. The caecilian genomes have further lost the <em>SWS1</em> and <em>SWS2</em> genes; only the <em>Rh1</em> and <em>LWS</em> genes were retained. The loss of the <em>SWS1</em> and <em>SWS2</em> genes in caecilians may be correlated with their cryptic lifestyles. The opsin gene syntenies were predicted to be highly similar to those of other bony vertebrates. Moreover, dual syntenies were identified in allotetraploid <em>Xenopus laevis</em> and <em>X. boreali</em>s. Tuning site analysis showed that only some Caudata species might have UV vision. In addition, the S164A that occurred several times in LWS evolution might either functionally compensate for the <em>Rh2</em> gene loss or fine-tuning visual adaptation. Our study provides the first genomic evidence for a caecilian <em>LWS</em> gene and a genomic viewpoint of visual opsin genes by reviewing the gains and losses of visual opsin genes, the rearrangement of syntenies, and the alteration of spectral tuning in the course of amphibians’ evolution.</p></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141434594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The development of meridional anisotropies in neurotypical children with and without astigmatism: Electrophysiological and psychophysical findings 有散光和无散光的神经畸形儿童子午线各向异性的发展：电生理学和心理物理学发现

IF 1.8 4区心理学

Vision Research Pub Date : 2024-06-18 DOI: 10.1016/j.visres.2024.108439

Tiong Peng Yap , Chi D. Luu , Catherine M. Suttle , Audrey Chia , Mei Ying Boon

{"title":"The development of meridional anisotropies in neurotypical children with and without astigmatism: Electrophysiological and psychophysical findings","authors":"Tiong Peng Yap , Chi D. Luu , Catherine M. Suttle , Audrey Chia , Mei Ying Boon","doi":"10.1016/j.visres.2024.108439","DOIUrl":"https://doi.org/10.1016/j.visres.2024.108439","url":null,"abstract":"<div><p>It is important to understand the development of meridional anisotropies in neurotypical children since those with poor visual development, such as amblyopia, can have different patterns of meridional anisotropies. While the oblique effect is usually observed in adults, neurotypical children who have normal 20/20 visual acuity tend to demonstrate a horizontal effect electrophysiologically. In this longitudinal study, orientation-specific visual evoked potentials (osVEPs) and psychophysical grating acuity were used to investigate the changes in the meridional anisotropies in children aged 3.8 to 9.2 years over two visits averaging four months apart. While it was hypothesized that the electrophysiological horizontal effect may shift towards an oblique effect, it was found that the electrophysiological horizontal effect persisted to be present in response to the suprathreshold moderate contrast 4 cycles-per-degree grating stimuli. Psychophysical grating acuity, however, demonstrated an oblique effect when assessed binocularly. In addition, a significant effect of visit, representing an increase in the average age over this period, was observed in the average osVEP C3 amplitudes (4.5 μV) and psychophysical grating acuity (0.28 octaves or approximately 1-line on the logMAR chart). These findings are relevant when evaluating amblyopia treatments and interventions, as it confirms the necessity to take into account of the effect of normal maturation and learning effects when evaluating young children. Special attention should also be given to children with early-onset myopia and high astigmatism even when their visual acuity is 20/20 as the electrophysiological findings are suggestive of poor visual development, which warrants further investigation.</p></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S004269892400083X/pdfft?md5=26f2182809b736e1b11a7b10fa0810ce&pid=1-s2.0-S004269892400083X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0