Vision Research最新文献

{"title":"Functional genomics of primary congenital glaucoma by pathway analysis and functional characterization of CYP1B1 mutations.","authors":"Muneeb A Faiq, Himanshu N Singh, Mashooq Ali, Rima Dada, Kevin C Chan, Tanuj Dada, Daman Saluja","doi":"10.1016/j.visres.2024.108534","DOIUrl":"https://doi.org/10.1016/j.visres.2024.108534","url":null,"abstract":"<p><p>CYP1B1 is the most common gene implicated in primary congenital glaucoma (PCG) - the most common form of childhood glaucoma. How CYP1B1 mutations cause PCG is not known. Understanding the mechanism of PCG caused by CYP1B1 mutations is crucial for disease management, therapeutics development, and potential prevention. We performed a comprehensive metabolome/reactome analysis of CYP1B1 to enlist CYP1B1-mediated processes in eye development. The identified metabolic events were classified into major pathways. Functional analysis of these metabolic pathways was performed after cloning the CYP1B1 wild-type gene and expressing the wild-type and selected novel mutants (previously reported by our group L24R, F190L, H279D, and G329D) in heterologous hosts. Stability and enzymatic functions were investigated. Structural modeling of the wild-type and the variants was also performed. Reactome analysis revealed a total of 166 metabolic processes which could be classified into four major pathways including estradiol metabolism, retinoic acid metabolism, arachidonic acid metabolism, and melatonin metabolism. Stability assay revealed rapid denaturing of mutant proteins compared to wild-type. Enzymatic assays showed functional deficit in mutant proteins in metabolizing estradiol, retinoids, arachidonate, and melatonin. Modeling revealed that the examined mutations induced structural changes likely causative in functional loss in CYB1B1 as observed in enzymatic assays. Hence, mutations in the CYP1B1 gene are associated with a functional deficit in critical pathways of eye development. These findings implicate the potential contributions of altered metabolic regulations of estradiol, retinoids, arachidonate and melatonin to the pathogenesis of PCG during the processes of the formation of ocular structures and function.</p>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"227 ","pages":"108534"},"PeriodicalIF":1.5,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived intrinsic 3D shape of faces is robust to changes in lighting direction, image rotation and polarity inversion.","authors":"Jordi M Asher, Paul B Hibbard, Abigail L M Webb","doi":"10.1016/j.visres.2024.108535","DOIUrl":"https://doi.org/10.1016/j.visres.2024.108535","url":null,"abstract":"<p><p>Face recognition from 2D images is influenced by various factors, including lighting conditions, viewing direction, rotation, and polarity inversion. It has been proposed that these techniques affect face recognition by distorting shape from shading. This study investigates the perception of 3D face shape in 2D images using a gauge figure task. Two experiments were conducted where participants adjusted a gauge figure across multiple locations within a 3D image to assess its surface structure. We manipulated face orientation, lighting direction, and polarity inversion (exp 2). While these manipulations resulted in variations from the true surface structure, they could be explained by an affine transformation. This suggests that the perception of the intrinsic 3D shape of faces is stable across these image manipulation techniques. The effects of viewing conditions on face recognition may thus be better interpreted through their influence on the perception of material properties such as pigmentation, or on information closer to the level of the retinal image itself.</p>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"227 ","pages":"108535"},"PeriodicalIF":1.5,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of feedback and task accuracy in serial dependence to orientation.","authors":"Zoë Little, Colin W G Clifford","doi":"10.1016/j.visres.2024.108536","DOIUrl":"https://doi.org/10.1016/j.visres.2024.108536","url":null,"abstract":"<p><p>Assimilative serial dependence in perception occurs where responses about a stimulus (e.g., orientation) are biased towards previously seen perceptual information (e.g., the orientation of the stimulus shown on the previous trial). This bias may occur to perceptual information from the previous trial, or to the response or decision made on the previous trial. We asked whether providing response feedback could change the serial dependence effect on the following trial. Twenty-one participants completed a task in which they adjusted an on-screen pointer to reproduce the orientation of a briefly-presented Gabor stimulus. They received feedback about the accuracy of their response that either reflected their actual accuracy or was random. We found significant positive biases to the stimulus and response only when the participant had received positive (\"correct!\") feedback on that trial. When the inducer response had been incorrect, the effect was significant only to the response itself and not to the stimulus. Overall, we suggest that our participants demonstrated a bias towards the percept from the previous trial, which is better represented by the response than the stimulus for incorrect trials, and that this effect can be modulated post-perceptually by feedback.</p>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"227 ","pages":"108536"},"PeriodicalIF":1.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging strategies targeting genes and cells in glaucoma.","authors":"Suva Roy","doi":"10.1016/j.visres.2024.108533","DOIUrl":"https://doi.org/10.1016/j.visres.2024.108533","url":null,"abstract":"<p><p>Glaucoma comprises a heterogeneous set of eye conditions that cause progressive vision loss. Glaucoma has a complex etiology, with different genetic and non-genetic risk factors that differ across populations. Although difficult to diagnose in early stages, compromised cellular signaling, dysregulation of genes, and homeostatic imbalance are common precursors to injury and subsequent death of retinal ganglion cells (RGCs). Lowering intraocular pressure (IOP) remains the primary approach for managing glaucoma but IOP alone does not explain all glaucoma risks. Orthogonal approaches such as large-scale genetic screening, combined with studies of animal models have been instrumental in identifying genes and molecular pathways involved in glaucoma pathogenesis. Cell type dependent vulnerability among RGCs can reveal genetic basis for specific visual deficits. A growing body of knowledge and availability of modern tools to perform targeted assessments of cellular health in different animal models facilitate development of effective and timely interventions for vision rescue. This review highlights recent findings on genes, molecules, and cell types in the context of glaucoma pathophysiology and treatment.</p>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"227 ","pages":"108533"},"PeriodicalIF":1.5,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scene complexity and the detail trace of human long-term visual memory.","authors":"Cameron Kyle-Davidson, Oscar Solis, Stephen Robinson, Ryan Tze Wang Tan, Karla K Evans","doi":"10.1016/j.visres.2024.108525","DOIUrl":"https://doi.org/10.1016/j.visres.2024.108525","url":null,"abstract":"<p><p>Humans can remember a vast amount of scene images; an ability often attributed to encoding only low-fidelity gist traces of a scene. Instead, studies show a surprising amount of detail is retained for each scene image allowing them to be distinguished from highly similar in-category distractors. The gist trace for images can be relatively easily captured through both computational and behavioural techniques, but capturing detail is much harder. While detail can be broadly estimated at the categorical level (e.g. man-made scenes more complex than natural), there is a lack of both ground-truth detail data at the sample level and a way to operationalise it for measurement purposes. Here through three different studies, we investigate whether the perceptual complexity of scenes can serve as a suitable analogue for the detail present in a scene, and hence whether we can use complexity to determine the relationship between scene detail and visual long term memory for scenes. First we examine this relationship directly using the VISCHEMA datasets, to determine whether the perceived complexity of a scene interacts with memorability, finding a significant positive correlation between complexity and memory, in contrast to the hypothesised U-shaped relation often proposed in the literature. In the second study we model complexity via artificial means, and find that even predicted measures of complexity still correlate with the overall ground-truth memorability of a scene, indicating that complexity and memorability cannot be easily disentangled. Finally, we investigate how cognitive load impacts the influence of scene complexity on image memorability. Together, findings indicate complexity and memorability do vary non-linearly, but generally it is limited to the extremes of the image complexity ranges. The effect of complexity on memory closely mirrors previous findings that detail enhances memory, and suggests that complexity is a suitable analogue for detail in visual long-term scene memory.</p>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"227 ","pages":"108525"},"PeriodicalIF":1.5,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual comfort models based on coloured text and neutral background combinations","authors":"Zhenzhen Li,&nbsp;Yu Liu,&nbsp;Yuechen Zhu,&nbsp;Ming Ronnier Luo","doi":"10.1016/j.visres.2024.108524","DOIUrl":"10.1016/j.visres.2024.108524","url":null,"abstract":"<div><div>Reading on mobile phones can cause visual discomfort, negatively affecting visual health. Most studies have focused on neutral text-background combinations, with limited validation for coloured text-background combinations. This study investigates the impact of coloured text on neutral backgrounds and the colour difference between text and background on visual comfort during digital reading. A psychophysical experiment was conducted, where 230 images of coloured text on neutral backgrounds were evaluated by 20 participants using a 6-point scale for visual comfort. Results showed that reading coloured text on a black background generally provided higher comfort compared to a white background. Additionally, visual comfort decreased as the text colour approached that of the background. The effect of text hue on comfort was not significant. Furthermore, several visual comfort models for mobile displays were developed and compared. The VC_1-LAB model is based on Bern’s attributes, while the VC_2-LAB model focuses on the lightness of text and background. The VC_3-LAB model includes both lightness and chroma attributes. Comparisons revealed that VC_3-LAB outperformed the others in predicting visual comfort, highlighting the importance of lightness and chroma in improving predictive accuracy. Therefore, the VC_3-LAB model is useful for evaluating the visual comfort of coloured text on neutral backgrounds.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"227 ","pages":"Article 108524"},"PeriodicalIF":1.5,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trans-saccadic integration for object recognition peters out with pre-saccadic object eccentricity as target-directed saccades become more saliency-driven","authors":"Junhao Liang,&nbsp;Li Zhaoping","doi":"10.1016/j.visres.2024.108500","DOIUrl":"10.1016/j.visres.2024.108500","url":null,"abstract":"<div><div>Bringing objects from peripheral locations to fovea via saccades facilitates their recognition. Human observers integrate pre- and post-saccadic information for recognition. This integration has only been investigated using instructed saccades to prescribed locations. Typically, the target has a fixed pre-saccadic location in an uncluttered scene and is viewed by a pre-determined post-saccadic duration. Consequently, whether trans-saccadic integration is limited or absent when the pre-saccadic target eccentricity is too large in cluttered scenes in unknown. Our study revealed this limit during visual exploration, when observers decided themselves when and to where to make their saccades. We asked thirty observers (400 trials each) to find and report as quickly as possible a target amongst 404 non-targets in an image spanning <span><math><mrow><mn>57</mn><mo>.</mo><mn>3</mn><mo>°</mo><mo>×</mo><mn>33</mn><mo>.</mo><mn>8</mn><mo>°</mo></mrow></math></span> in visual angle. We measured the target’s pre-saccadic eccentricity <span><math><mi>e</mi></math></span>, the duration <span><math><msub><mrow><mi>T</mi></mrow><mrow><mi>p</mi><mi>r</mi><mi>e</mi></mrow></msub></math></span> of the fixation before the saccade, and the post-saccadic foveal viewing duration <span><math><msub><mrow><mi>T</mi></mrow><mrow><mi>p</mi><mi>o</mi><mi>s</mi><mi>t</mi></mrow></msub></math></span>. This <span><math><msub><mrow><mi>T</mi></mrow><mrow><mi>p</mi><mi>o</mi><mi>s</mi><mi>t</mi></mrow></msub></math></span> increased with <span><math><mi>e</mi></math></span> before starting to saturate around eccentricity <span><math><mrow><msub><mrow><mi>e</mi></mrow><mrow><mi>p</mi></mrow></msub><mo>=</mo><mn>10</mn><mo>°</mo><mo>−</mo><mn>20</mn><mo>°</mo></mrow></math></span>. Meanwhile, <span><math><msub><mrow><mi>T</mi></mrow><mrow><mi>p</mi><mi>r</mi><mi>e</mi></mrow></msub></math></span> increased much more slowly with <span><math><mi>e</mi></math></span> and started decreasing before <span><math><msub><mrow><mi>e</mi></mrow><mrow><mi>p</mi></mrow></msub></math></span>. These observations imply the following at sufficiently large pre-saccadic eccentricities: the trans-saccadic integration ceases, target recognition relies exclusively on post-saccadic foveal vision, decision to saccade to the target relies exclusively on target saliency rather than identification. These implications should be applicable to general behavior, although <span><math><msub><mrow><mi>e</mi></mrow><mrow><mi>p</mi></mrow></msub></math></span> should depend on object and scene properties. They are consistent with the Central-peripheral Dichotomy that central and peripheral vision are specialized for seeing and looking, respectively.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"226 ","pages":"Article 108500"},"PeriodicalIF":1.5,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applying the efficient coding principle to understand encoding of multisensory and multimodality sensory signals","authors":"Li Zhaoping","doi":"10.1016/j.visres.2024.108489","DOIUrl":"10.1016/j.visres.2024.108489","url":null,"abstract":"<div><div>Sensory neurons often encode multisensory or multimodal signals. For example, many medial superior temporal (MST) neurons are tuned to heading direction of self-motion based on visual (optic flow) signals and vestibular signals. Middle temporal (MT) cortical neurons are tuned to object depth from signals of two visual modalities: motion parallax and binocular disparity. A MST neuron’s preferred heading directions from different senses can be congruent (matched) or opposite from each other. Similarly, the preferred depths of a MT neuron from the two modalities are congruent in some neurons and opposite in other neurons. While the congruent tuning appears natural for cue integration, the functions of the opposite tuning have been puzzling. This paper explains these tunings from the efficient coding principle that sensory encoding extracts as much sensory information as possible while minimizing neural cost. It extends the previous applications of this principle to understand neural receptive fields in retina and the primary visual cortex, particularly multimodal encoding of cone signals or binocular signals. Congruent and opposite sensory signals that excite the congruent and opposite neurons, respectively, are the decorrelated sensory components that provide a general purpose, efficient, representation of sensory inputs before task specific object segmentation and recognition. It can be extended to encoding signals from more than two sensory sources, e.g., from three cone types. This framework also predicts a wider tuning width for the opposite than congruent neurons, neurons that are neither congruent nor opposite, and how neural receptive fields adapt to statistical changes of sensory environments.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"226 ","pages":"Article 108489"},"PeriodicalIF":1.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracking cortical entrainment to stages of optic-flow processing","authors":"Cai Wingfield ,&nbsp;Andrew Soltan ,&nbsp;Ian Nimmo-Smith ,&nbsp;William D. Marslen-Wilson ,&nbsp;Andrew Thwaites","doi":"10.1016/j.visres.2024.108523","DOIUrl":"10.1016/j.visres.2024.108523","url":null,"abstract":"<div><div>In human visual processing, information from the visual field passes through numerous transformations before perceptual attributes such as motion are derived. Determining the sequence of transforms involved in the perception of visual motion has been an active field since the 1940s. One plausible family of models are the spatiotemporal energy models, based on computations of motion energy computed from the spatiotemporal features the visual field. One of the most venerated is that of <span><span>Heeger (1988)</span></span>, which hypotheses that motion is estimated by matching the predicted spatiotemporal energy in frequency space. In this study, we investigate the plausibility of Heeger’s model by testing for evidence of cortical entrainment to its components. Entrainment of cortical activity to these components was estimated using measurements of electro- and magnetoencephalographic (EMEG) activity, recorded while healthy subjects watched videos of dots moving left and right across their visual field. We find entrainment to several components of Heeger’s model bilaterally in occipital lobe regions, including representations of motion energy at a latency of 80 ms, overall velocity at 95 ms, and acceleration at 130 ms. We find little evidence of entrainment to displacement. We contrast Heeger’s biologically inspired model with alternative baseline models, finding that Heeger’s model provides a closer fit to the observed data. These results help shed light on the processes through which perception of motion arises in the visual processing stream.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"226 ","pages":"Article 108523"},"PeriodicalIF":1.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles as emerging players in glaucoma: Mechanisms, biomarkers, and therapeutic targets","authors":"Maral Namdari ,&nbsp;Fiona S. McDonnell","doi":"10.1016/j.visres.2024.108522","DOIUrl":"10.1016/j.visres.2024.108522","url":null,"abstract":"<div><div>In recent years, extracellular vesicles (EVs) have attracted significant scientific interest due to their widespread distribution, their potential as disease biomarkers, and their promising applications in therapy. Encapsulated by lipid bilayers these nanovesicles include small extracellular vesicles (sEV) (30–150 nm), microvesicles (100–1000 nm), and apoptotic bodies (100–5000 nm) and are essential for cellular communication, immune responses, biomolecular transport, and physiological regulation. As they reflect the condition and functionality of their originating cells, EVs play critical roles in numerous physiological processes and diseases. Therefore, EVs offer valuable opportunities for uncovering disease mechanisms, enhancing drug delivery systems, and identifying novel biomarkers. In the context of glaucoma, a leading cause of irreversible blindness, the specific roles of EVs are still largely unexplored.</div><div>This review examines the emerging role of EVs in the pathogenesis of glaucoma, with a focus on their potential as diagnostic biomarkers and therapeutic agents. Through a thorough analysis of current literature, we summarize key advancements in EV research and identify areas where further investigation is needed to fully understand their function in glaucoma.</div></div>","PeriodicalId":23670,"journal":{"name":"Vision Research","volume":"226 ","pages":"Article 108522"},"PeriodicalIF":1.5,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}