Virology最新文献_第3页

Multifunctional noncoding regions in the mammarenavirus genome

IF 2.8 3区医学

Virology Pub Date : 2025-02-24 DOI: 10.1016/j.virol.2025.110464

Masaharu Iwasaki

引用次数: 0

Shared and unique mechanisms of RNAi-mediated antiviral immunity in C. elegans

IF 2.8 3区医学

Virology Pub Date : 2025-02-21 DOI: 10.1016/j.virol.2025.110459

Teng Yan , Rui Lu

{"title":"Shared and unique mechanisms of RNAi-mediated antiviral immunity in C. elegans","authors":"Teng Yan , Rui Lu","doi":"10.1016/j.virol.2025.110459","DOIUrl":"10.1016/j.virol.2025.110459","url":null,"abstract":"<div><div>Small interfering RNAs (siRNAs), generated by Dicer proteins, play a pivotal role in antiviral immunity in eukaryotes. Dicer proteins also produce microRNAs (miRNAs), a class of endogenous small non-coding RNAs that regulate essential cellular functions through post-transcriptional mechanisms. In plants and insects, multiple Dicer proteins are produced and deployed to separately manage the biogenesis of antiviral siRNAs and miRNAs. This separation ensures that viral infections, especially the production of viral RNAi suppressors, do not severely compromise host growth or development. In contrast, nematode worms, such as <em>Caenorhabditis elegans,</em> rely on a single Dicer protein to produce both types of small RNAs. Probably as a strategy to mitigate the potential disruption of miRNA production by viral infections, nematodes have evolved distinct strategies for generating primary and secondary siRNAs for antiviral defense. This review explores the shared and unique features of siRNA-mediated antiviral immunity in <em>Caenorhabditis elegans</em>, shedding light on the specialized adaptations that enable robust antiviral defenses without compromising miRNA-mediated function.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"605 ","pages":"Article 110459"},"PeriodicalIF":2.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunity responses as checkpoints for efficient transmission of begomoviruses by whiteflies

IF 2.8 3区医学

Virology Pub Date : 2025-02-21 DOI: 10.1016/j.virol.2025.110462

Ilana Kuzminsky , Murad Ghanim

{"title":"Immunity responses as checkpoints for efficient transmission of begomoviruses by whiteflies","authors":"Ilana Kuzminsky , Murad Ghanim","doi":"10.1016/j.virol.2025.110462","DOIUrl":"10.1016/j.virol.2025.110462","url":null,"abstract":"<div><div>Begomoviruses are a group of single stranded DNA plant viruses exclusively transmitted by the sweet potato whitefly <em>Bemisia tabaci</em> in a persistent, circulative manner. After acquisition from plant phloem, this group of viruses circulate and are retained within the whitefly, interacting with tissues, cells and molecular pathways for maintaining the safety of the infective intact virions, by exploiting cellular mechanisms and avoiding degradation by the insect immune responses. During retention, the virions are internalized in the midgut cells, exit and spend hours-days in the hemolymph and cross into salivary gland cells, before transmission. Destroying this group of viruses by the insect immune system seems inefficient for the most part, by examining their very efficient transmission. Thus, within the various sites along the transmission pathway especially in the midgut, it is thought that the immune system with its various layers is activated for avoiding the damage caused by the viruses on one hand, and for ensuring their safe circulation and transmission on the other hand. Begomoviruses have evolved mechanisms for counteracting and exploiting the activated immune system for their safe translocation within the whitefly. In this review, we discuss the various levels of immunity activated against begomoviruses in <em>B. tabaci,</em> taking other pathogen-vector systems as examples and reflecting relevant components on the interactions between <em>B. tabaci</em> and Begomoviruses.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"605 ","pages":"Article 110462"},"PeriodicalIF":2.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viral oncogenesis of δ-retroviruses, HTLV-1 and BLV, and recent advances in its diagnosis

IF 2.8 3区医学

Virology Pub Date : 2025-02-21 DOI: 10.1016/j.virol.2025.110461

Md Belal Hossain , Benjy Jek Yang Tan , Yorifumi Satou

引用次数: 0

Altered receptor-binding specificity of gull-adapted H13 avian influenza viruses corresponds to their unique host preferences

IF 2.8 3区医学

Virology Pub Date : 2025-02-21 DOI: 10.1016/j.virol.2025.110460

Rio Harada , Takahiro Hiono , Manabu Igarashi , Daiki Kobayashi , Hinako Ban , Norikazu Isoda , Yoshihiro Sakoda

{"title":"Altered receptor-binding specificity of gull-adapted H13 avian influenza viruses corresponds to their unique host preferences","authors":"Rio Harada , Takahiro Hiono , Manabu Igarashi , Daiki Kobayashi , Hinako Ban , Norikazu Isoda , Yoshihiro Sakoda","doi":"10.1016/j.virol.2025.110460","DOIUrl":"10.1016/j.virol.2025.110460","url":null,"abstract":"<div><div>Avian influenza viruses (AIVs) recognize α2-3 sialosides as receptors. Previous studies showed that the structural diversity within α2-3 sialosides is related to the host specificity of AIVs. H13 AIVs are primarily isolated from gulls, although almost all AIV subtypes have been isolated from ducks, the natural hosts of AIVs. To elucidate the molecular basis of the host specificity of H13 viruses to gulls, the receptor-binding specificity of H13 hemagglutinins (HAs) and the distribution of viral receptors in gulls were investigated. The results revealed that recombinant HA (rHA) of H13 viruses had a binding preference for fucosylated α2-3 sialosides, which were distributed widely in the respiratory tract and intestines of gulls but not in the colon of ducks. Moreover, the receptor-binding specificity of mutant rHAs revealed that amino acids in the 130-loop and at position 227 of H13 HA were critical for the preference for fucosylated α2-3 sialosides. The results of the present study suggest that the binding specificity of H13 HA to fucosylated α2-3 sialosides is a key factor for the host susceptibility of H13 viruses to gulls.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"605 ","pages":"Article 110460"},"PeriodicalIF":2.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the virological response to direct-acting antiviral therapies in the HBV cure programme

IF 2.8 3区医学

Virology Pub Date : 2025-02-21 DOI: 10.1016/j.virol.2025.110458

James Lok , James M. Harris , Ivana Carey , Kosh Agarwal , Jane A. McKeating

引用次数: 0

Emergence, prevalence and evolution of porcine reproductive and respiratory syndrome virus 1 in China from 1994 to 2024

IF 2.8 3区医学

Virology Pub Date : 2025-02-20 DOI: 10.1016/j.virol.2025.110457

Yuejia Qiu , Ming Qiu , Shubin Li , Shubo Li , Jianzhong Zhu , Kegong Tian , Nanhua Chen

{"title":"Emergence, prevalence and evolution of porcine reproductive and respiratory syndrome virus 1 in China from 1994 to 2024","authors":"Yuejia Qiu , Ming Qiu , Shubin Li , Shubo Li , Jianzhong Zhu , Kegong Tian , Nanhua Chen","doi":"10.1016/j.virol.2025.110457","DOIUrl":"10.1016/j.virol.2025.110457","url":null,"abstract":"<div><div>Porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) was first detected in Chinese swine herds during an epidemiological investigation since 1994. Even though PRRSV-1 has been existed in China for 30 years, much less attention was paid on PRRSV-1 than PRRSV-2. This review systematically evaluated the emergence, prevalence and evolution of Chinese PRRSV-1 from 1994 to 2024. Here we showed that PRRSV-1 has been detected in at least 28 regions of China, which can be divided into eight subgroups within subtype 1. During the evolution in Chinese swine herds, a large number of substitutions, insertions and deletions were identified. Recombination events were also commonly detected accompanying with nsp1-nsp3, nsp9-nsp10 and ORF2-ORF6 regions as the cross-over hotspots. Remarkably, Chinese PRRSV-1 isolates showed a trend of increasing in pathogenicity in recent years. At last, we discussed the differential detection methods and cross-protection strategies against PRRSV-1 isolates. Overall, PRRSV-1 has become one of the widely-spread viruses in China posing a significant threat to China's swine industry.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"605 ","pages":"Article 110457"},"PeriodicalIF":2.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in the structure and assembly of non-enveloped spherical viruses

IF 2.8 3区医学

Virology Pub Date : 2025-02-20 DOI: 10.1016/j.virol.2025.110454

Sangita Venkataraman , Handanahal S. Savithri , M.R.N. Murthy

引用次数: 0

Origin and function of anti-interferon type I viral proteins

IF 2.8 3区医学

Virology Pub Date : 2025-02-20 DOI: 10.1016/j.virol.2025.110456

Marta Acchioni , Chiara Acchioni , John Hiscott , Marco Sgarbanti

{"title":"Origin and function of anti-interferon type I viral proteins","authors":"Marta Acchioni , Chiara Acchioni , John Hiscott , Marco Sgarbanti","doi":"10.1016/j.virol.2025.110456","DOIUrl":"10.1016/j.virol.2025.110456","url":null,"abstract":"<div><div>Type I interferons (IFN-I) are the most important innate immune cytokines produced by vertebrate host cells following, virus infection. Broadly speaking, detection of infecting viral nucleic acids by pattern recognition receptors (PRR) and subsequent downstream signaling triggers synthesis of a large number of IFN-I-stimulated genes (ISGs), endowed with diverse antiviral effector function. The co-evolution of virus-host interactions over million years has resulted in the emergence of viral strategies that target and inhibit host PRR-mediated detection, signal transduction pathways and IFN-I-mediated stimulation of ISGs. In this review, we illustrate the multiple mechanisms of viral immune evasion and discuss the co-evolution of anti-IFN-I viral proteins by summarizing key examples from recent literature. Due to the large number of anti-IFN-I proteins described, we provide here an evaluation of the prominent examples from different virus families. Understanding the unrelenting evolution of viral evasion strategies will provide mechanistic detail concerning these evolving interactions but will further enhance the development of tailored antiviral approaches.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"605 ","pages":"Article 110456"},"PeriodicalIF":2.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of soybean vein necrosis virus (SVNV) proteins: Sequence analysis of field strains and comparison of localization patterns in differing cell types

IF 2.8 3区医学

Virology Pub Date : 2025-02-15 DOI: 10.1016/j.virol.2025.110450

Abdelaal H.A. Shehata , Michael A. Mayfield , Edward J. Sikora , Kathleen M. Martin

引用次数: 0