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The battle between infectious bronchitis virus and innate immunity: A mini review 传染性支气管炎病毒和先天免疫之间的斗争：一个小回顾。
IF 2.8 3区 医学
Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2024.110321
Hao Dong , Shengkui Xu , Peng Li , Wenke Ruan
{"title":"The battle between infectious bronchitis virus and innate immunity: A mini review","authors":"Hao Dong ,&nbsp;Shengkui Xu ,&nbsp;Peng Li ,&nbsp;Wenke Ruan","doi":"10.1016/j.virol.2024.110321","DOIUrl":"10.1016/j.virol.2024.110321","url":null,"abstract":"<div><div>Infectious bronchitis virus (IBV) is the causative agent of infectious bronchitis (IB), leading to acute or persistent infections in poultry. IBV triggers innate immune response, and the production of interferon (IFN) varies depending on the viral strains and host cell types. To evade the host immune system, IBV has developed numerous immune escape strategies. These include hijacking host proteins, modulating protein synthesis, antagonizing IFN production, promoting autophagosome formation and expansion, manipulating apoptosis, blocking antigen presentation, stabilizing viral mRNA, and inhibiting stress granule (SG) formation. The ongoing interaction between IBV and the host immune system reflects a dynamic battle, as the virus employs various tactics to ensure its replication. Understanding these pathogenic mechanisms of IBV is crucial for developing effective control measures.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"603 ","pages":"Article 110321"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early evolution of mumps-HCV chimeric viruses in Vero cells induces loss of HCV gene expression and promotes accumulation of substitutions uncharacteristic of mumps strains 在Vero细胞中，腮腺炎-丙型肝炎病毒嵌合病毒的早期进化诱导了丙型肝炎病毒基因表达的缺失，并促进了非腮腺炎毒株特征的取代的积累。
IF 2.8 3区 医学
Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2024.110379
Dorotea Pali , Dubravko Forčić , Maja Jagušić , Tanja Košutić Gulija , Mirna Jurković , Marko Babić , Daniela Kalafatovic , Jelena Ivančić-Jelečki
{"title":"Early evolution of mumps-HCV chimeric viruses in Vero cells induces loss of HCV gene expression and promotes accumulation of substitutions uncharacteristic of mumps strains","authors":"Dorotea Pali ,&nbsp;Dubravko Forčić ,&nbsp;Maja Jagušić ,&nbsp;Tanja Košutić Gulija ,&nbsp;Mirna Jurković ,&nbsp;Marko Babić ,&nbsp;Daniela Kalafatovic ,&nbsp;Jelena Ivančić-Jelečki","doi":"10.1016/j.virol.2024.110379","DOIUrl":"10.1016/j.virol.2024.110379","url":null,"abstract":"","PeriodicalId":23666,"journal":{"name":"Virology","volume":"603 ","pages":"Article 110379"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into the different mechanisms of Autophagy and Apoptosis mediated by Morbilliviruses 深入了解由变形病毒介导的自噬和凋亡的不同机制。
IF 2.8 3区 医学
Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2024.110371
Rashmi Singh, Sharad Kumar Gaur, Rakhi Nagar, Rajeev Kaul
{"title":"Insights into the different mechanisms of Autophagy and Apoptosis mediated by Morbilliviruses","authors":"Rashmi Singh,&nbsp;Sharad Kumar Gaur,&nbsp;Rakhi Nagar,&nbsp;Rajeev Kaul","doi":"10.1016/j.virol.2024.110371","DOIUrl":"10.1016/j.virol.2024.110371","url":null,"abstract":"<div><div>Viruses are obligate intracellular parasites that have co-evolved with the host. During the course of evolution, viruses have acquired abilities to abrogate the host's immune responses by modulating the host proteins which play a pivotal role in various biological processes. One such process is the programmed cell death in virus-infected cells, which can occur <em>vi</em>a autophagy or apoptosis. Morbilliviruses are known to modulate both autophagy and apoptosis. Upon infecting a cell, the morbilliviruses can utilize autophagosomes as their nest and delay the host defense apoptotic response, and/or can promote apoptosis to escalate the virus dissemination. Moreover, there is an active interplay between these two pathways which eventually decides the fate of a virus-infected cell. Recent advances in our understanding of these processes provide a potential rationale to further explore morbilliviruses for therapeutic purposes.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"603 ","pages":"Article 110371"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology and genotypic diversity of duck hepatitis B virus identified from waterfowl in partial areas of Guangdong province, Southern China 广东省部分地区水禽中鸭乙肝病毒的流行病学及基因型多样性
IF 2.8 3区 医学
Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2025.110416
Xinyan Yao , Chaoxiang Jia , Anqi Li , Ting Qin , Dai Peng , Yingqian Han , Shuang Guo , Kai Zhong , Guoyu Yang , Yueying Wang , Heping Li
{"title":"Epidemiology and genotypic diversity of duck hepatitis B virus identified from waterfowl in partial areas of Guangdong province, Southern China","authors":"Xinyan Yao ,&nbsp;Chaoxiang Jia ,&nbsp;Anqi Li ,&nbsp;Ting Qin ,&nbsp;Dai Peng ,&nbsp;Yingqian Han ,&nbsp;Shuang Guo ,&nbsp;Kai Zhong ,&nbsp;Guoyu Yang ,&nbsp;Yueying Wang ,&nbsp;Heping Li","doi":"10.1016/j.virol.2025.110416","DOIUrl":"10.1016/j.virol.2025.110416","url":null,"abstract":"<div><div>Duck Hepatitis B virus (DHBV) infection model is extensively utilized as an animal model for studying human hepatitis B virus infection and for comparative research. 557 liver samples from geese and ducks were collected in parts of Guangdong province, southern China. The overall prevalence of DHBV was 45.6% (254/557) in all samples. And the 27 complete genome sequences of DHBV strains in this study share 89.6%–100% genome-wide pairwise identity with previously identified DHBV genomes. Notably, DHBV-1, DHBV-2 and DHBV-3 of were found co-circulating among the waterfowl population in parts of Guangdong. More importantly, seven out of the 16 recombination events were determined involved DHBV sequences obtained in this study as major parent and minor parent, suggesting DHBV strains from Guangdong province play an important role in recombination events. Additionally, purifying selection was the dominant evolutionary pressure acting on the genomes of DHBV.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"603 ","pages":"Article 110416"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antiviral activity of ribosome inactivating proteins for management of plant viral infection 核糖体灭活蛋白在植物病毒感染管理中的抗病毒活性。
IF 2.8 3区 医学
Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2025.110403
Pooja Bhardwaj , Baswaraj Raigond , Pinky Raigond , Ambika Verma , Gaurav Verma , Tarvinder Kochhar , Parashuram Patroti , I.K. Das , C Tara Satyavathi
{"title":"Antiviral activity of ribosome inactivating proteins for management of plant viral infection","authors":"Pooja Bhardwaj ,&nbsp;Baswaraj Raigond ,&nbsp;Pinky Raigond ,&nbsp;Ambika Verma ,&nbsp;Gaurav Verma ,&nbsp;Tarvinder Kochhar ,&nbsp;Parashuram Patroti ,&nbsp;I.K. Das ,&nbsp;C Tara Satyavathi","doi":"10.1016/j.virol.2025.110403","DOIUrl":"10.1016/j.virol.2025.110403","url":null,"abstract":"<div><div>In nature, plants exhibit various defense mechanisms to protect themselves from viral infection. Reported to harbor virus-inhibiting compounds like Ribosome inactivating proteins (RIPs). It's a matter of how we explore, identify, and utilize RIPs in managing a given stress. RIPs have been found to contain antiviral, anticancer, and neurotoxic effects and are used in various biomedical and agricultural fields. The expression of RIPs could be enhanced in plants to improve their defense against biotic and abiotic stresses. Identification of new RIPs and genetic sequencing led to the development of new phylogenetic theories. Studies on the interaction between RIPs and cells have increased the knowledge regarding the handling of exogenous proteins by cells. The review provides a brief historical preview, classification, mode of action, and broader applications with a special focus on managing plant viral diseases and concerns to mankind.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"603 ","pages":"Article 110403"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering the hepatitis E virus ORF1: Functional domains, protein processing, and patient-derived mutations 解密戊型肝炎病毒 ORF1：功能域、蛋白质加工和源自患者的突变。
IF 2.8 3区 医学
Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2024.110350
Fei Zhang , Ling-Dong Xu , Shiying Wu , Bin Wang , Pinglong Xu , Yao-Wei Huang
{"title":"Deciphering the hepatitis E virus ORF1: Functional domains, protein processing, and patient-derived mutations","authors":"Fei Zhang ,&nbsp;Ling-Dong Xu ,&nbsp;Shiying Wu ,&nbsp;Bin Wang ,&nbsp;Pinglong Xu ,&nbsp;Yao-Wei Huang","doi":"10.1016/j.virol.2024.110350","DOIUrl":"10.1016/j.virol.2024.110350","url":null,"abstract":"<div><div>Hepatitis E virus (HEV) is a major cause of acute and chronic hepatitis in humans. The HEV open reading frames (ORF1) encodes a large non-structural protein essential for viral replication, which contains several functional domains, including helicase and RNA-dependent RNA polymerase. A confusing aspect is that, while RNA viruses typically encode large polyproteins that rely on their enzymatic activity for processing into functional units, the processing of the ORF1 protein and the mechanisms involved remain unclear. The ORF1 plays a pivotal role in the viral life cycle, thus mutations in this region, especially those occurring under environmental pressures such as during antiviral drug treatment, could significantly affect viral replication and survival. Here, we summarize the recent advances in the functional domains, processing, and mutations of ORF1. Gaining a deeper understanding of HEV biology, particularly focusing on ORF1, could facilitate the development of new strategies to control HEV infections.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"603 ","pages":"Article 110350"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intra-host variability of SARS-CoV-2: Patterns, causes and impact on COVID-19 SARS-CoV-2 的宿主内变异：模式、原因和对 COVID-19 的影响。
IF 2.8 3区 医学
Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2024.110366
Leandro R. Jones
{"title":"Intra-host variability of SARS-CoV-2: Patterns, causes and impact on COVID-19","authors":"Leandro R. Jones","doi":"10.1016/j.virol.2024.110366","DOIUrl":"10.1016/j.virol.2024.110366","url":null,"abstract":"<div><div>Intra-host viral variability is related to pathogenicity, persistence, drug resistance, and the emergence of new clades. This work reviews the large amount of data on SARS-CoV-2 intra-host variability accumulated to date, addressing known and potential implications in COVID-19 and the emergence of VOCs and lineage-defining mutations. Topics covered include the distribution of intra-host polymorphisms across the genome, the corresponding mutational signatures, their patterns of emergence and extinction throughout infection, and the processes governing their abundance, frequency, and type (synonymous, nonsynonymous, indels, nonsense). Besides, evidence is reviewed that the virus can replicate and mutate in isolation at different anatomical compartments, which may imply that what we have learned from respiratory samples could be part of a broader picture.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"603 ","pages":"Article 110366"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LEF3 phosphorylation attenuates the replication of Bombyx mori nucleopolyhedrovirus by suppressing its interaction with alkaline nuclease LEF3磷酸化通过抑制家蚕核多角体病毒与碱性核酸酶的相互作用而减弱其复制。
IF 2.8 3区 医学
Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2024.110369
Chaoguang Gu , Yuqian Mo , Jiaqi Li , Xizhen Zhang , Siqi Xu , Meng Miao , Yanping Quan , Wei Yu
{"title":"LEF3 phosphorylation attenuates the replication of Bombyx mori nucleopolyhedrovirus by suppressing its interaction with alkaline nuclease","authors":"Chaoguang Gu ,&nbsp;Yuqian Mo ,&nbsp;Jiaqi Li ,&nbsp;Xizhen Zhang ,&nbsp;Siqi Xu ,&nbsp;Meng Miao ,&nbsp;Yanping Quan ,&nbsp;Wei Yu","doi":"10.1016/j.virol.2024.110369","DOIUrl":"10.1016/j.virol.2024.110369","url":null,"abstract":"<div><div>Late expression factor 3 (LEF3), a multifunctional single-stranded DNA binding protein encoded by baculoviruses, is indispensable for viral DNA replication and plays a pivotal role in viral infection. Our previous quantitative analysis of phosphorylomics revealed that the phosphorylation levels of two serine residues (S8 and S25) located in LEF3 nuclear localization sequence were significantly up-regulated after <em>Bombyx mori</em> nucleopolyhedrovirus (BmNPV) infection, but the underlying mechanism remained unknown. To investigate the impact of phosphorylation on BmNPV infection, site-direct mutagenesis was performed on LEF3 to obtain phosphorylated mimic (S/D) or dephosphorylated mimic (S/A) mutants. The results demonstrated that the viral replication and proliferation were inhibited by phosphorylation of S8 or S25. Furthermore, we found that the N-terminal 125 amino acids region was responsible for interacting with virus-encoded alkaline nuclease, but this interaction could be suppressed by the phosphorylation. Our findings indicated that phosphorylation may serve as an antiviral strategy for host.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"603 ","pages":"Article 110369"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the diagnostic techniques of African swine fever 非洲猪瘟诊断技术进展。
IF 2.8 3区 医学
Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2024.110351
Xin Zhang , Lei Zhou , Xinna Ge , Peng Gao , Qiongqiong Zhou , Jun Han , Xin Guo , Yongning Zhang , Hanchun Yang
{"title":"Advances in the diagnostic techniques of African swine fever","authors":"Xin Zhang ,&nbsp;Lei Zhou ,&nbsp;Xinna Ge ,&nbsp;Peng Gao ,&nbsp;Qiongqiong Zhou ,&nbsp;Jun Han ,&nbsp;Xin Guo ,&nbsp;Yongning Zhang ,&nbsp;Hanchun Yang","doi":"10.1016/j.virol.2024.110351","DOIUrl":"10.1016/j.virol.2024.110351","url":null,"abstract":"<div><div>African swine fever (ASF) is a highly contagious disease of pigs caused by African swine fever virus, which poses a huge threat to the global swine industry and is therefore listed as a notifiable disease by the World Organization for Animal Health. Due to the global lack of safe and efficacious vaccines and therapeutic drugs, early diagnosis of cases, whether on-site or laboratory, are crucial for the prevention and control of ASF. Therefore, rapid and reliable diagnosis and detection have become the main means to combat ASF. In this paper, various diagnostic techniques developed globally for ASF diagnosis, including etiological, molecular biological and serological diagnostic techniques, as well as conventional and novel diagnostic techniques, were comprehensively reviewed, and the main advantages and disadvantages of currently commonly used diagnostic techniques were introduced. It is expected that this paper will provide references for selecting appropriate ASF diagnostic techniques in different application scenarios, and also provide directions for the development of innovative diagnostic techniques for ASF in the future.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"603 ","pages":"Article 110351"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complex interplay: The interactions between citrus tristeza virus and its host 复杂相互作用：柑橘tristeza病毒与其宿主之间的相互作用。
IF 2.8 3区 医学
Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2024.110388
Maryam Khalilzadeh , Dirk Jacobus Aldrich , Hans Jacob Maree , Amit Levy
{"title":"Complex interplay: The interactions between citrus tristeza virus and its host","authors":"Maryam Khalilzadeh ,&nbsp;Dirk Jacobus Aldrich ,&nbsp;Hans Jacob Maree ,&nbsp;Amit Levy","doi":"10.1016/j.virol.2024.110388","DOIUrl":"10.1016/j.virol.2024.110388","url":null,"abstract":"<div><div>Citrus tristeza virus (CTV) is one of the largest and most economically important RNA viruses infecting plants. CTV's interactions with various citrus hosts can result in three diseases: quick decline, stem pitting, or seedling yellows. Studying CTV poses several challenges owing to its significant genetic diversity and the highly specific occurrence of disease symptoms when different genotypes infect different citrus hosts. Considerable progress has been made to functionally characterize the virus-host interactions involved in the induction of CTV's three diseases, revealing that the four CTV ORFs (<em>p33</em>, <em>p18</em>, <em>p13</em> and <em>p23</em>) play significant roles in determining the pathogenicity of CTV infections. These ORFs are unique to CTV and are not conserved among other members of the family <em>Closteroviridae.</em> This minireview aims to capture the complexity of the factors that have been shown to be involved in CTV disease induction and highlights recent work that provides novel insights into this pathosystem.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"603 ","pages":"Article 110388"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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