Virology最新文献_第10页

Novel exploitation of autophagy by tombusviruses 瘤状病毒自噬的新开发。

IF 2.8 3区医学

Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2024.110363

Peter D. Nagy, Judit Pogany, Yuanrong Kang

引用次数: 0

Triticum mosaic virus: An overview of biology, functional genomics, gene expression vector, and management strategies 小麦花叶病毒：生物学、功能基因组学、基因表达载体和管理策略综述。

IF 2.8 3区医学

Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2024.110377

Satyanarayana Tatineni , Shaonpius Mondal , Stephen N. Wegulo , Gary L. Hein

{"title":"Triticum mosaic virus: An overview of biology, functional genomics, gene expression vector, and management strategies","authors":"Satyanarayana Tatineni , Shaonpius Mondal , Stephen N. Wegulo , Gary L. Hein","doi":"10.1016/j.virol.2024.110377","DOIUrl":"10.1016/j.virol.2024.110377","url":null,"abstract":"<div><div>Triticum mosaic virus (TriMV; <em>Poacevirus tritici</em>) is the founding member of the genus <em>Poacevirus</em> within the family <em>Potyviridae</em>. TriMV is one of the components of the wheat streak mosaic disease (WSMD) complex, an economically significant wheat disease in the Great Plains region of the USA. TriMV contains a single-stranded positive-sense RNA genome of 10,266 nts with an unusually long 5′-nontranslated region of 739 nts. TriMV is transmitted only by the Type-2 genotype of wheat curl mites (<em>Aceria tosichella</em> Keifer) and is mostly found as a co-infection with another wheat curl mite-transmitted wheat streak mosaic virus (WSMV). TriMV and WSMV synergistically interact in co-infected wheat with exacerbated disease symptoms. The development of an infectious cDNA clone and GFP or RFP-tagged stable expression vectors has advanced the functional genomics of TriMV, including virus-virus and virus-host interactions. NIa-Pro and CP, and P1 and NIa-Pro cistrons of TriMV are identified as elicitors of superinfection exclusion and determinants of synergistic interaction with WSMV, respectively. TriMV stably maintained P1 (1083 nts) plus NIa (1305 nts) cistrons of WSMV for more than 28 days postinoculation, suggesting that TriMV can be used as a stable gene expression vector in wheat. Because of the synchrony of the mites and viruses in this disease complex, primary management efforts should focus on the timing and presence of vector hosts. Importantly, an enhanced understanding of TriMV biology and its interactions with plants, mites, and WSMV will facilitate the development of effective tools to improve the sustainable management of the wheat-mite-virus complex.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"603 ","pages":"Article 110377"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Segment-specific promoter activity for RNA synthesis in the genome of Oz virus, genus Thogotovirus Oz病毒基因组中RNA合成的片段特异性启动子活性。

IF 2.8 3区医学

Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2025.110410

Lipi Akter , Ryo Matsumura , Daisuke Kobayashi , Hiromichi Matsugo , Haruhiko Isawa , Yusuke Matsumoto

引用次数: 0

Herpes simplex virus-1 targets the 2′-3'cGAMP importer SLC19A1 as an antiviral countermeasure 单纯疱疹病毒-1靶向2'-3'cGAMP入口蛋白SLC19A1作为抗病毒对策。

IF 2.8 3区医学

Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2024.110320

Zsuzsa K. Szemere, Emmanuel Ijezie, Eain A. Murphy

引用次数: 0

Oncolytic senecavirus A in tumor immunotherapy: Mechanisms, progress, and future directions 溶瘤性赛尼卡病毒A在肿瘤免疫治疗中的作用：机制、进展和未来方向。

IF 2.8 3区医学

Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2024.110338

Xiaoya Zhao , Wenjie Li , Yuan Sun , Jingyun Ma

引用次数: 0

Editorial: Viruses and cancer 社论：病毒和癌症。

IF 2.8 3区医学

Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2024.110353

Takayuki Murata, Yoshihiro Izumiya

引用次数: 0

Corrigendum to “Developing adenoviral vectors encoding therapeutic genes toxic to host cells: Comparing binary and single-inducible vectors expressing truncated E2F-1” [Virology 397 (2010) 337–345] “开发对宿主细胞有毒的治疗性基因的腺病毒载体：比较表达截断的E2F-1的双诱导和单诱导载体”的更正[病毒学397(2010)337-345]。

IF 2.8 3区医学

Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2024.110355

Jorge G. Gomez-Gutierrez , Xia-Mei Rao , Aracely Garcia-Garcia , Hongying Hao , Kelly M. McMasters , H. Sam Zhou

引用次数: 0

Cellular takeover: How new world alphaviruses impact host organelle function 细胞接管：新的世界甲病毒如何影响宿主细胞器功能。

IF 2.8 3区医学

Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2024.110365

Morgen VanderGiessen , Abdullahi Jamiu , Brittany Heath , Ivan Akhrymuk , Kylene Kehn-Hall

引用次数: 0

First identification and whole genome characterization of rotavirus C in pigs in Zambia 赞比亚猪中轮状病毒C的首次鉴定和全基因组鉴定。

IF 2.8 3区医学

Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2024.110385

Hayato Harima , Yongjin Qiu , Michihito Sasaki , Joseph Ndebe , Kapila Penjaninge , Edgar Simulundu , Masahiro Kajihara , Aiko Ohnuma , Keita Matsuno , Naganori Nao , Yasuko Orba , Ayato Takada , Kanako Ishihara , William W. Hall , Bernard M. Hang'ombe , Hirofumi Sawa

{"title":"First identification and whole genome characterization of rotavirus C in pigs in Zambia","authors":"Hayato Harima , Yongjin Qiu , Michihito Sasaki , Joseph Ndebe , Kapila Penjaninge , Edgar Simulundu , Masahiro Kajihara , Aiko Ohnuma , Keita Matsuno , Naganori Nao , Yasuko Orba , Ayato Takada , Kanako Ishihara , William W. Hall , Bernard M. Hang'ombe , Hirofumi Sawa","doi":"10.1016/j.virol.2024.110385","DOIUrl":"10.1016/j.virol.2024.110385","url":null,"abstract":"<div><div>Rotavirus C (RVC) causes acute gastroenteritis in neonatal piglets. Despite the clinical importance of RVC infection, the distribution and prevalence in pig populations in most African countries remains unknown. In this study, we identified RVC in Zambian pigs by metagenomic analysis. The full genome sequence of the RVC revealed two different VP4 sequences, implying that two different RVC strains (ZP18-77-c1 and ZP18-77-c2) were present in the same sample. Genetic analyses demonstrated that all segments of ZP18-77-c1 and ZP18-77-c2 showed high nucleotide sequence identities (87.7–94.5%) to known porcine RVC strains, and ZP18-77-c1 and ZP18-77-c2 strains were assigned to genotype constellations, G1-P[4]/P[14]-I13-R5-C5-M1-A7-N9-T10-E5-H1. We further screened RVC genomes among pig feces collected in Zambia (n = 147) by RT-qPCR, and 78 samples (53.1%) were positive. This study demonstrated the first full genome sequence of African RVC strains with a relatively high prevalence of RVC infection in the pig populations in Zambia.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"603 ","pages":"Article 110385"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of a highly pathogenic porcine Teschoviruses 5 emerged in Western China 中国西部出现的猪高致病性teschovirus 5的特征分析。

IF 2.8 3区医学

Virology Pub Date : 2025-02-01 DOI: 10.1016/j.virol.2025.110398

Yongheng Shao , Yabin Lu , Shuxian Li , Shengyu Lin , Jiao Tang , Chen Tan , Zhenli Gong , Wenhui Wang , Guangliang Liu , Jianing Chen

{"title":"Characterization of a highly pathogenic porcine Teschoviruses 5 emerged in Western China","authors":"Yongheng Shao , Yabin Lu , Shuxian Li , Shengyu Lin , Jiao Tang , Chen Tan , Zhenli Gong , Wenhui Wang , Guangliang Liu , Jianing Chen","doi":"10.1016/j.virol.2025.110398","DOIUrl":"10.1016/j.virol.2025.110398","url":null,"abstract":"<div><div>Porcine teschovirus (PTV) is a devastating virus that targets the central nervous system and led to great economic losses in Europe between the 1920s and 1960s. Since 1973, PTV variants with lower pathogenicity have been prevalent globally, whereas highly pathogenic PTV strains have rarely emerged. In 2022, diarrhea with high mortality occurred on a pig farm in Gansu China. Virome analysis revealed that PTV was enriched among diarrheal samples. A PTV strain was then isolated and characterized by TEM, IFA, and growth kinetic features. Phylogenetic analyses revealed that the isolate shared an identity of approximately 90% with the most related PTV strain and with various mutant clusters among VP1. Further animal tests demonstrated that the isolate can result in serious respiratory distress, watery diarrhea, paralysis and high mortality in challenged pigs. H&E staining revealed the presence of lymphocyte cells infiltration and hemorrhage in the tissues. Overall, a PTV variant with high mortality was identified in western China, which could result in interstitial pneumonia, hemorrhage, and diarrhea. Although most PTV strains are associated with asymptomatic infection now, the sporadic occurrence of highly pathogenic PTVs is worthy of alarm.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"603 ","pages":"Article 110398"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0