Virology最新文献

{"title":"Genomic diversity of human adenoviruses in Tanzanian children under five: Insights into F40, F41, B, and rare A18 genotypes","authors":"Mariana J. Shayo ,&nbsp;Davis Kuchaka ,&nbsp;Melkiory Beti ,&nbsp;Patrick Kimu ,&nbsp;Boaz Wadugu ,&nbsp;Emilie E.B. Jensen ,&nbsp;Happiness Kumburu ,&nbsp;Paul Kazyoba ,&nbsp;Mohamed Ali ,&nbsp;SeqTZ Consortium ,&nbsp;Philip T.L.C. Clausen ,&nbsp;Florida Muro ,&nbsp;Blandina T. Mmbaga ,&nbsp;Michael Alifrangis ,&nbsp;Frank M. Aarestrup ,&nbsp;Tolbert Sonda","doi":"10.1016/j.virol.2026.110813","DOIUrl":"10.1016/j.virol.2026.110813","url":null,"abstract":"<div><div>Human adenoviruses (HAdVs) are important pathogens that are associated with a wide array of clinical diseases, particularly in the pediatric population. Despite numerous reports of HAdV infections in Tanzania, there are currently no whole genome sequences from this region available in global public databases. This gap presents challenges to our efforts to understand their dissemination and evolution over time. This study employed nanopore-based metagenomic sequencing to detect and sequence the whole genomes of HAdV strains in Tanzanian infants with diarrhea. We present the first whole genome of HAdV-A18 from Africa, representing only the third worldwide. Additionally, it includes the first complete genomes of HAdV-F40, HAdV-F41, and HAdV-B3 obtained from Tanzania. In addition, this study provides information on the enteric adenovirus lineages circulating in Tanzania. These findings provide crucial genomic insights into the diversity of viruses in sub-Saharan Africa and underscore the importance of genomic surveillance to deepen our understanding of adenovirus transmission and evolution.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"617 ","pages":"Article 110813"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mosquito-borne viruses in Australia: An emerging trend of increasing prevalence in Northern Queensland","authors":"Md. Eram Hosen ,&nbsp;Scott Dunsdon ,&nbsp;Subir Sarker","doi":"10.1016/j.virol.2026.110825","DOIUrl":"10.1016/j.virol.2026.110825","url":null,"abstract":"<div><div>Mosquito-borne viruses (MBVs) remain a significant public health concern in Northern Queensland, Australia, with dengue virus (DENV), Ross River virus (RRV), and Barmah Forest virus (BFV) representing the most common pathogens. <em>Wolbachia</em>-based biological control programs have made notable contributions to reducing dengue transmission by suppressing <em>Aedes aegypti</em> vector competence. Recent surveillance data indicates increased MBV activity, with national case numbers nearly doubling between 2023 and 2024 and early 2025 data suggesting sustained transmission during seasonal peak. Traditional surveillance approaches, while highly valuable for disease monitoring, have limitations in detecting novel or divergent viral strains in real time. Over the past decades, more than 919 unclassified flaviviruses have been reported nationwide, including 117 in Queensland. The advent of metagenomic and metatranscriptomic approaches now enable enhanced, field-based detection of both known and emerging arboviruses. Strengthening mosquito control programs through continued <em>Wolbachia</em> releases, alongside integrated genomic surveillance, predictive modelling, and community engagement will enhance early detection, guide targeted interventions, and reduce the MBV burden in Northern Queensland. This integrated framework provides a strategic pathway to sustains and expand vector control effectiveness while safeguarding public health in high-risk regions.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"617 ","pages":"Article 110825"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of baculovirus-derived bovine parvovirus VP2based chimeric virus-like particles co-displaying SAT2 FMDV VP1 B- and T-cell epitopes and evaluation of humoral and cellular immune responses in BALB/c mice","authors":"Ashenafi Kiros Wubshet ,&nbsp;Yaozhong Ding ,&nbsp;Luoyi Zhou ,&nbsp;Yang Wang ,&nbsp;Junfei Dai ,&nbsp;Qian Li ,&nbsp;Guoxiu Li ,&nbsp;Nahom Solomon ,&nbsp;Jijun He ,&nbsp;Xiangping Yin ,&nbsp;Chimedtseren Bayasgalan ,&nbsp;Uyangaa Temuujin ,&nbsp;Lijun Guo ,&nbsp;Yujie Sun ,&nbsp;Abrha Bsrat ,&nbsp;Wenxiu Wang ,&nbsp;Na Tang ,&nbsp;Alexei D. Zaberezhny ,&nbsp;Livio Heath ,&nbsp;Yuefeng Sun ,&nbsp;Jie Zhang","doi":"10.1016/j.virol.2026.110812","DOIUrl":"10.1016/j.virol.2026.110812","url":null,"abstract":"<div><h3>Background</h3><div>Recent outbreaks of foot-and-mouth disease virus (FMDV) indicate that the Southern African Territories 2 (SAT2) serotype has rapidly spread to the Middle East, West Asia, and regions bordering Russian. The spread of this strain poses a considerable global threat to the livestock industry, particularly in countries previously free of this serotype. Although less studied, co-infection with FMDV and bovine parvovirus (BPV) can also result in substantial economic losses in the cattle industry. Therefore, developing a safe and cost-effective dual-target vaccine platform is critical to addressing these challenges. Our previous findings demonstrated that BPV VP2 virus-like particles (VLPs) are highly physicochemically stable. In the present study, we developed a potential chimeric virus-like particle (cVLP) vaccine candidate designed to provide protection against both SAT2 FMDV and BPV infections. This dual-target vaccine is novel, as no such vaccine currently exists.</div></div><div><h3>Method</h3><div>In this study, neutralizing B-cell (135–174 aa) and T-cell epitopes (200–213 aa, 66–80 aa, and 21–40 aa) from SAT2 FMDV VP1 (viral protein 1; PAT/1/2012, GenBank: <span><span>JX014256</span><svg><path></path></svg></span>) were identified and inserted into selected sites (395–396 aa, 391–392 aa, 274–275 aa, and 271–272 aa) of BPV VP2 (viral protein 2; GenBank: <span><span>ABC69731</span><svg><path></path></svg></span>) sequences, which were expressed using the baculovirus expression system. We generated a panel of B-derived cVLP candidates: the T-cell epitope-deficient variant (BT0), and variants carrying one, two, or three T-cell epitopes (BT1, BT2, BT3), respectively. Immunogenicity assessments in BALB/c mice demonstrated robust humoral and cellular immune responses, evaluated via ELISA, Elispot, intracellular cytokine staining (ICS), and a VSV-SAT2-VP1 pseudovirus neutralization assay.</div></div><div><h3>Results</h3><div>Our results indicate that displaying more SAT2 FMDV VP1 T-cell epitopes on the surface of BPV-cVLPs enhances both humoral and cellular immune responses. BT3-cVLPs exhibited strong neutralizing potential in pseudo-type neutralization assays, highlighting their promising efficacy in preventing FMDV and BPV co-infections. This innovative bivalent vaccine platform may be suitable for endemic regions and as a strategic reserve for SAT2 FMDVfree countries.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"617 ","pages":"Article 110812"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to dengue vaccine coverage in low- and middle-income countries (LMICs)","authors":"Subashan Vadibeler ,&nbsp;Hansini Mandal ,&nbsp;Shiwei Ooi ,&nbsp;Nadia Atiya","doi":"10.1016/j.virol.2026.110821","DOIUrl":"10.1016/j.virol.2026.110821","url":null,"abstract":"<div><div>Dengue is a climate-sensitive infectious disease and the world's fastest-growing vector-borne disease. It disproportionately affects low- and middle-income countries (LMICs), with children most severely affected. Dengvaxia (CYD-TDV) and Qdenga (TAK-003) are the only two licensed dengue vaccines currently available, while Butantan-DV (TV003) is an advanced candidate with promising Phase 3 clinical trial results. Despite the commercial availability of dengue vaccines, coverage remains low in areas with the greatest need. This is driven by technical, social, and geopolitical challenges, as well as growing vaccine hesitancy. There is also an added layer of clinical complexity associated with vaccination against dengue due to the antibody-dependent enhancement (ADE) phenomenon, which can lead to vaccine-enhanced disease. Here, we review the current global landscape of dengue vaccine licensure and coverage, focusing on countries with the highest disease burden. We show that in many countries with a high dengue incidence, dengue vaccines have yet to be licensed, particularly in parts of Africa and South Asia. Even in regions where licensure is more widespread, such as Latin America and Southeast Asia, dengue vaccines are not well integrated into national immunisation programmes and can only be obtained through out-of-pocket payment. We therefore identify several state and market-driven systemic factors, as well as declining vaccine confidence, as barriers to scaling up dengue vaccine access in LMICs. These barriers must be addressed through creative solutions to ensure the equitable distribution of dengue vaccines to the populations and countries that need them the most.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"617 ","pages":"Article 110821"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral metagenomics reveals the RNA viral composition of herbivorous wildlife on the Qinghai-Tibet Plateau","authors":"Yue Chen ,&nbsp;Shiyin Huang ,&nbsp;Shuang Zhang ,&nbsp;Haixuan Wang ,&nbsp;Xiaofei Song ,&nbsp;Likai Ji ,&nbsp;Quan Shen ,&nbsp;Shixing Yang ,&nbsp;Yuwei Liu ,&nbsp;Xiaochun Wang ,&nbsp;Ping Wu ,&nbsp;Hongfeng Yang ,&nbsp;Tongling Shan ,&nbsp;Xiaolong Wang ,&nbsp;Wen Zhang","doi":"10.1016/j.virol.2026.110814","DOIUrl":"10.1016/j.virol.2026.110814","url":null,"abstract":"<div><div>RNA viruses, a widely distributed group of pathogens in nature, possess exceptionally high genetic diversity and rapid evolutionary potential. High-altitude ecosystems, represented by the Qinghai-Tibet Plateau, with their unique environmental conditions, may harbor distinct viral communities. However, there remains a lack of systematic understanding regarding the composition and distribution of RNA viruses in wildlife under such extreme environments. In this study, a total of 741 fecal samples were collected from three regions on the Qinghai-Tibet Plateau, and viral metagenomics technology was used to reveal the composition and diversity of RNA viruses in the fecal samples of six species of herbivorous wild animals on the plateau. We identified a substantial abundance of RNA viruses, classified into 18 distinct viral families. Furthermore, the structure of the viral communities varied among different host species. Through assembly, 28 viral sequences belonging to the families <em>Astroviridae</em>, <em>Picornaviridae</em>, <em>Picobirnaviridae</em>, <em>Tobaniviridae</em>, and <em>Caliciviridae</em> were identified. Phylogenetic analysis revealed that the newly identified viral strains share close relationships with viruses found in humans, marmots, and other mammals. The results indicate that wildlife in this region are reservoirs of unidentified RNA viruses, some of which may pose potential threats to public health and the animal husbandry. These findings provide crucial scientific evidence and data support for future virus surveillance, ecological risk assessment, and the prevention and control of emerging infectious diseases at their source.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"617 ","pages":"Article 110814"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silencing the ubiquitin-protein ligases gene (E3-UBR7) alters acquisition, replication, and transmission of groundnut bud necrosis virus by Thrips palmi","authors":"V. Rakesh ,&nbsp;Amalendu Ghosh","doi":"10.1016/j.virol.2026.110793","DOIUrl":"10.1016/j.virol.2026.110793","url":null,"abstract":"<div><div>Insect-borne plant viruses pose a serious threat to global crop production. Melon thrips, <em>Thrips palmi</em> Karny, transmits tospoviruses such as groundnut bud necrosis virus (GBNV) in a persistent propagative manner. Identifying thrips genes that regulate tospovirus transmission is crucial for developing targeted management strategies; however, these genes remain poorly characterized. The present study investigated the functional role of a candidate gene of <em>T. palmi, E3 ubiquitin-protein ligase component N-recognin 7</em> (<em>E3-UBR7</em>), in the transmission of GBNV. Expression of the <em>E3-UBR7</em> transcript was altered in a life-stage-specific manner, with the highest activity 11.31-fold in adults, and less during larval stages. Oral delivery of double-stranded RNA targeting <em>E3-UBR7</em> (ds<em>E3-UBR7</em>, 10 μg/mL, 48 h) resulted in up to 6.15-fold suppression of target gene expression in adults. Silencing induced moderate adult mortality, with no notable mortality in larvae. Exposure of ds<em>E3-UBR7</em> prior to virus acquisition in the larval stage did not show a significant effect on the virus copies in <em>T. palmi</em> larvae (1.59 × 10⁵ copies) and adults (1.15 × 10⁵ copies). There was also no significant alteration in the expression of the target gene in pre-acquisition dsRNA exposure. Conversely, post- virus acquisition silencing of <em>E3-UBR7</em> during the adult stage markedly reduced GBNV titre (1.53 × 10³ copies), indicating suppression of viral replication. GBNV copies decreased up to 104 times in adults exposed to ds<em>E3-UBR7</em>. Post-acquisition silencing of <em>E3-UBR7</em> was more effective in suppressing virus transmission to healthy plants (15.66 %) by <em>T. palmi</em> adults. The results identified <em>E3-UBR7</em> as a key regulatory gene influencing GBNV transmission by <em>T. palmi</em>, offering a promising molecular target for management of thrips-transmitted tospoviruses.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"617 ","pages":"Article 110793"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically distinct H5N2 high pathogenicity avian influenza virus isolated from a peregrine falcon on Amami-Oshima Island, Japan, harboring enhanced pathogenicity-associated amino acids in the PA protein","authors":"Mana Esaki ,&nbsp;Kosuke Okuya ,&nbsp;Manabu Onuma ,&nbsp;Makoto Ozawa","doi":"10.1016/j.virol.2026.110794","DOIUrl":"10.1016/j.virol.2026.110794","url":null,"abstract":"<div><div>We report the first confirmed case of high pathogenicity avian influenza virus (HPAIV) infection in a peregrine falcon (<em>Falco peregrinus</em>) on Amami-Oshima Island, a region known for its unique biodiversity. The isolate, A/peregrine falcon/Kagoshima/5704A001/2025 (H5N2), showed genetic and phylogenetic divergence across all eight gene segments. Specific amino acids in the PA protein associated with increased pathogenicity in birds and mammals were also identified. Despite global surveillance, related ancestral viruses remain unreported. These findings highlight the need for expanded geographic surveillance and timely, transparent data sharing to better track and respond to emerging HPAIV threats.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"617 ","pages":"Article 110794"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of virus-cell interactions for two early Brazilian SARS-CoV-2 variants","authors":"Lucio Ayres Caldas ,&nbsp;Fabiana Avila Carneiro ,&nbsp;Fábio Luís Lima Monteiro ,&nbsp;Tiago Souza Salles ,&nbsp;Noemia Rodrigues Gonçalves ,&nbsp;Luiza Mendonça Higa ,&nbsp;Monica Ferreira Moreira ,&nbsp;Renata Campos Azevedo ,&nbsp;Amilcar Tanuri ,&nbsp;Wanderley de Souza","doi":"10.1016/j.virol.2026.110822","DOIUrl":"10.1016/j.virol.2026.110822","url":null,"abstract":"<div><div>The ultrastructural details of SARS-CoV-2 morphogenesis and cell-to-cell spread, particularly during the later stages of infection, are still incompletely understood. In this study, we employed a multi-modal microscopy approach to characterise the late-stage infectious cell cycle of two early SARS-CoV-2 variants, A.2 and B.1.1.33, in a Vero E6 cell model. Using a combination of transmission and scanning electron microscopy, immunofluorescence, and RT-qPCR, we analysed viral-host cell interactions at key time points post-infection. Our analysis showed distinct subcellular localisations for the S and N proteins at 24 hpi, the high density of virions adhering to the host cell surface and the morphological indication that these adhered virions can directly mediate cell-cell fusion, leading to syncytium formation via a fusion-from-without (FFWO) mechanism between Vero E6 cells. Quantitative analysis of viral RNA revealed that the A.2 variant exhibited more robust replication kinetics than B.1.1.33. Furthermore, we provide direct ultrastructural indications for alternative viral propagation strategies beyond canonical exocytosis. These mechanisms, which may contribute to immune evasion, also offer new insights into viral pathogenesis relevant to the consequences of COVID-19.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"617 ","pages":"Article 110822"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolving landscape of Mpox: Clinical and genomic insights into Clade Ib emergence in India","authors":"Rima R. Sahay ,&nbsp;Anita M. Shete ,&nbsp;Juhi Khurana ,&nbsp;Rajlaxmi Jain ,&nbsp;Shubin Chenayil ,&nbsp;Savita Yadav ,&nbsp;Triparna Majumdar ,&nbsp;Shruti Rani ,&nbsp;Neetu Vijay ,&nbsp;Deepak Y. Patil ,&nbsp;P.S. Kannan Sabarinath ,&nbsp;J. Aravind ,&nbsp;Shubhangi Gavari ,&nbsp;Pranita Gawande ,&nbsp;Pratiksha Pandita ,&nbsp;Shalini Singh ,&nbsp;P.M. Anitha ,&nbsp;Niyas K. Pulloor ,&nbsp;Pushpa Kizhakkekarammel ,&nbsp;S. Manjusree ,&nbsp;Pragya D. Yadav","doi":"10.1016/j.virol.2026.110800","DOIUrl":"10.1016/j.virol.2026.110800","url":null,"abstract":"<div><h3>Background</h3><div>The re-emergence of Mpox virus (MPXV) Clade Ib has posed a global public health threat, prompting a WHO Public Health Emergency of International Concern in May 2022 and August 2024. This study aims to outline the clinical, viral, and genomic characterization of MPXV Clade Ib cases found in Kerala, India.</div></div><div><h3>Methods</h3><div>We profiled ten laboratory-confirmed MPXV cases from September 2024 to March 2025. Mpox DNA was screened using real-time PCR, and anti-MPXV IgM and IgG antibodies were detected by ELISA. Full-length genomic sequencing and phylogenetic analysis were performed on the clinical samples.</div></div><div><h3>Results</h3><div>The median age of the cases was 34 years, with a male predominance (80 %). Most (90 %) had a recent history of international travel, primarily to the United Arab Emirates (UAE), with one documented case of local transmission. All cases presented with vesiculo-pustular lesions, fever, and lymphadenopathy, and all recovered without complications. Mpox DNA was cleared between 20 and 28 days, though prolonged shedding was observed in some. Phylogenetic analysis clustered the Indian sequences with those from Oman, Pakistan and Thailand, suggesting a shared regional lineage. The presence of APOBEC3-mediated mutational signatures was high, indicative of sustained human-to-human transmission.</div></div><div><h3>Conclusion</h3><div>This research presents the first in-depth analysis of the clinical and genomic characteristics of MPXV Clade Ib identified in India. The findings highlight the critical role of international travel in virus introduction and indicate local transmission following introduction, with regional linkage inferred from epidemiological evidence. These findings suggest ongoing viral evolution and the need for enhanced surveillance.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"617 ","pages":"Article 110800"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the parvovirus life cycle: Molecular mechanisms of cellular entry, trafficking, and replication","authors":"Aofei Yang ,&nbsp;Jian Chen ,&nbsp;Chengshui Liao ,&nbsp;Bichen Miao ,&nbsp;Songbiao Chen","doi":"10.1016/j.virol.2026.110819","DOIUrl":"10.1016/j.virol.2026.110819","url":null,"abstract":"<div><div>Parvoviruses exhibit a broad host spectrum and possess the potential of cross-species transmission. This evolutionary adaptability raises concerns regarding the potential expansion of their host range into human populations, thus posing a significant public health threat. This review systematically summarizes the current knowledge regarding the molecular interactions between parvoviruses and host cellular components, elaborating on the entire viral life cycle—encompassing cellular entry, intracellular trafficking, nuclear transport, DNA replication, and nuclear egress. It aims to lay a foundation for advancing research on parvovirus pathogenesis and identifying novel targets for vaccine and drug development.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"617 ","pages":"Article 110819"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}