Virologica Sinica最新文献_第2页

In vivo quantitative proteomic analysis of porcine alveolar macrophages in PRRSV-infected pigs. prrsv感染猪肺泡巨噬细胞的体内定量蛋白质组学分析。

IF 5.5 3区医学

Virologica Sinica Pub Date : 2025-03-15 DOI: 10.1016/j.virs.2025.03.002

Ying Wei, Chuangchao Zou, Siying Zeng, Ouyang Peng, Guangli Hu, Yihui Huang, Qiuping Xu, Fangyu Hu, Yongchang Cao, Hao Zhang

{"title":"In vivo quantitative proteomic analysis of porcine alveolar macrophages in PRRSV-infected pigs.","authors":"Ying Wei, Chuangchao Zou, Siying Zeng, Ouyang Peng, Guangli Hu, Yihui Huang, Qiuping Xu, Fangyu Hu, Yongchang Cao, Hao Zhang","doi":"10.1016/j.virs.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.virs.2025.03.002","url":null,"abstract":"<p><p>Porcine reproductive and respiratory syndrome (PRRS), a highly infectious immunosuppressive disease caused by porcine reproductive and respiratory syndrome virus (PRRSV), has led to significant economic losses in the global swine industry. The complexity of preventing and controlling PRRS, compounded by the limited efficacy of current vaccines, underscores the urgent need to identify antiviral targets and develop effective therapeutics against PRRSV. From the perspective of virus-host interactions, the discovery of target molecules associated with PRRSV resistance offers a promising strategy for future disease management. In this study, we conduct a comprehensive proteomic analysis using data-independent acquisition (DIA) mode to investigate the host response throughout the acute phase of PRRSV infection. This approach provides critical insights into the regulation of host antiviral and immune pathways during acute infection, advancing our theoretical understanding of PRRSV-host interactions and host gene dynamics during this critical phase. Notably, we identified SCARB2, a major lysosomal membrane protein associated with cholesterol metabolism, as a potential regulator of PRRSV replication. These findings offer novel perspectives for the prevention and control of PRRSV, contributing to the development of targeted antiviral strategies.</p>","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of an immunodominant neutralizing epitope of porcine astrovirus type 5 capsid protein. 猪星状病毒5型衣壳蛋白免疫显性中和表位的鉴定。

IF 5.5 3区医学

Virologica Sinica Pub Date : 2025-03-15 DOI: 10.1016/j.virs.2025.03.003

Yixin Hu, Zehui Li, Chenlin Hao, Hao Lu, Yunfei Xing, Kexin Liu, Xiaohui Jin, Zhanyong Wei

引用次数: 0

Artemisia annua L. leaf extracts suppress influenza virus infection by targeting the viral nucleoprotein and blocking mitochondria-mediated apoptosis. 黄花蒿叶提取物通过靶向病毒核蛋白和阻断线粒体介导的细胞凋亡抑制流感病毒感染。

IF 5.5 3区医学

Virologica Sinica Pub Date : 2025-03-03 DOI: 10.1016/j.virs.2025.03.001

Xiwen Zhao, Xuan Dai, Fuyi Wang, Chenyang Li, Xun Song, Yingying Han, Chaowei Zhang, Lu Wang, Zhendan He, Rongping Zhang, Liang Ye

引用次数: 0

Sphingomyelin phosphodiesterase 3 as a novel host factor inhibiting hepatitis B virus transcription. 鞘磷脂二酯酶3作为抑制乙型肝炎病毒转录的新宿主因子。

IF 5.5 3区医学

Virologica Sinica Pub Date : 2025-02-27 DOI: 10.1016/j.virs.2025.02.004

Chen Li, Meng Zhou, Kaitao Zhao, Wenbo Liu, Chengliang Zhu, Xiaoming Cheng, Yuchen Xia

引用次数: 0

Phylogenitc analysis and immunogenicity comparision of porcine genotype G9 rotavirus in China from 2020-2023. 2020-2023年中国猪基因型G9轮状病毒系统发育分析及免疫原性比较

IF 5.5 3区医学

Virologica Sinica Pub Date : 2025-02-21 DOI: 10.1016/j.virs.2025.02.003

Yudi Pan, Zixin Li, Qian Miao, Hongyan Shi, Longjun Guo, Li Feng, Jin Tian

{"title":"Phylogenitc analysis and immunogenicity comparision of porcine genotype G9 rotavirus in China from 2020-2023.","authors":"Yudi Pan, Zixin Li, Qian Miao, Hongyan Shi, Longjun Guo, Li Feng, Jin Tian","doi":"10.1016/j.virs.2025.02.003","DOIUrl":"https://doi.org/10.1016/j.virs.2025.02.003","url":null,"abstract":"<p><p>As an emerging genotype, the G9 genotype rotaviruses (RVs) are widespread among humans and pigs, and have been reported in many countries and regions in the recent years. Moreover, porcine G9 strains could cross the interspecies barrier to infect human. To investigate the epidemic trends of porcine G9 strains as well as the cross-immunoreactivity among different isolates, an epidemiological investigation about porcine G9 genotype RVs (PoRVs) was performed during the period 2020-2023 in multiple provinces of China. A total of nine representative strains were identified. The phylogenetic analysis based on viral VP7 gene showed that these strains mainly clustered with lineages III and VI, which revealed the predominant G9 PoRVs in China. Moreover, a new lineage, lineage VII, was identified, and strains of this lineage were found to be circulating in Guangdong and Taiwan. Except lineages I and IV, some isolates from other lineages could co-circulate in pigs and humans. Three G9 strains, namely 923H, 923E, and 923X, which belonged to the largest sub-lineage III, were isolated. Then, the significant cross-reactivity was observed among strains of the same or different lineages. This study is the first to systematically investigate the genetic and immunogenetic characteristics of porcine G9 genotype rotavirus in China, as well as the potential cross-species transmission between pigs and humans, providing a valuable direction for the effective prevention of porcine rotavirus.</p>","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and genetic analysis of new ephemeroviruses in wild boars in China. 中国野猪新蜉蝣病毒的鉴定与遗传分析。

IF 5.5 3区医学

Virologica Sinica Pub Date : 2025-02-15 DOI: 10.1016/j.virs.2025.02.002

Zhongzhong Tu, Tong Wang, Yu Xu, Heting Sun, Peng Peng, Siyuan Qin, Changchun Tu

引用次数: 0

Zika virus transmission in Aedes aegypti: A systematic study on the ability of mosquitoes to transmit the virus horizontally and vertically. 寨卡病毒在埃及伊蚊中的传播：蚊子水平和垂直传播病毒能力的系统研究。

IF 5.5 3区医学

Virologica Sinica Pub Date : 2025-02-11 DOI: 10.1016/j.virs.2025.02.001

Xugang Wang, Chaonan Qian, Chenxi Zhang, Siyun Hu, Muhammad Asad, Chengjie Yang, Bingrui Liao, Xiaotong Guo, Chen Zhang, Quanzhi Li, Xinyao Li, Qiuying Huang, Youhui Si, Bibo Zhu, Shengbo Cao, Jing Ye

{"title":"Zika virus transmission in Aedes aegypti: A systematic study on the ability of mosquitoes to transmit the virus horizontally and vertically.","authors":"Xugang Wang, Chaonan Qian, Chenxi Zhang, Siyun Hu, Muhammad Asad, Chengjie Yang, Bingrui Liao, Xiaotong Guo, Chen Zhang, Quanzhi Li, Xinyao Li, Qiuying Huang, Youhui Si, Bibo Zhu, Shengbo Cao, Jing Ye","doi":"10.1016/j.virs.2025.02.001","DOIUrl":"10.1016/j.virs.2025.02.001","url":null,"abstract":"<p><p>Zika virus (ZIKV) is a mosquito-borne virus belonging to the genus Orthoflavivirus, and the family Flaviviridae. It commonly presents with febrile-like symptoms, neurological issues, and pregnancy complications in humans. Currently, there is no commercial vaccine or specific treatment available to prevent ZIKV infection. Therefore, controlling the epidemic's spread relies on preventing mosquitoes from transmitting the virus. Although various studies have explored the transmission of ZIKV between mosquitoes and vertebrate hosts, comprehensive research on potential mosquito-to-mosquito transmission of ZIKV remains limited. In this study, we conducted systematic laboratory investigations to assess the ability of ZIKV to spread among mosquitoes, and to evaluate the impact of ZIKV infection on mosquito development. Our findings revealed that ZIKV can be transmitted between Aedes aegypti mosquitoes both vertically and horizontally, through oviposition and contact between mosquitoes of the same or opposite sex. Additionally, we observed that ZIKV infection resulted in a reduction in the number of mosquito eggs but an increase in their size. The widespread distribution of ZIKV in infected mosquitoes and the altered levels of hormone related genes following viral infection were noted, which may contribute to viral transmission among mosquitoes and affect mosquito development. This research provides systematic experimental evidence of ZIKV transmission among mosquitoes, which is crucial for developing novel strategies to disrupt the spread of orthoflaviviruses and other mosquito-borne pathogens.</p>","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into recent advancements in human and animal rotavirus vaccines: Exploring new frontiers 人类和动物轮状病毒疫苗的最新进展：探索新领域。

IF 5.5 3区医学

Virologica Sinica Pub Date : 2025-02-01 DOI: 10.1016/j.virs.2024.12.001

Ahmed H. Ghonaim , Sherin R. Rouby , Wedad M. Nageeb , Ashraf Ahmed Elgendy , Rong Xu , Changsheng Jiang , Noha H. Ghonaim , Qigai He , Wentao Li

引用次数: 0

Distinct tropisms of HCMV and SARS-CoV-2 in lung tissue of a patient with advanced HIV disease 晚期HIV患者肺组织中HCMV和SARS-CoV-2的明显趋向性

IF 5.5 3区医学

Virologica Sinica Pub Date : 2025-02-01 DOI: 10.1016/j.virs.2025.01.001

Jingjing Xu , Bo Yang , Ye Zheng , Yuexiang Yang , Min-Hua Luo , Yun Ling , Xiaohong Fan , Han Cheng

引用次数: 0

A low pathogenic avian influenza A/Mallard/South Korea/KNU2019-34/2019 (H1N1) virus has the potential to increase the mammalian pathogenicity 低致病性禽流感A/野鸭/韩国/KNU2019-34/2019 （H1N1）病毒具有提高哺乳动物致病性的潜力。

IF 5.5 3区医学

Virologica Sinica Pub Date : 2025-02-01 DOI: 10.1016/j.virs.2024.12.005

Jaemoo Kim , Jungho Kim , Suhyeon Heo , Chang-Hun Yeom , Bao Tuan Duong , Haan Woo Sung , Seon-Ju Yeo , Hyun Park , Haryoung Poo , Jihyun Yang

{"title":"A low pathogenic avian influenza A/Mallard/South Korea/KNU2019-34/2019 (H1N1) virus has the potential to increase the mammalian pathogenicity","authors":"Jaemoo Kim , Jungho Kim , Suhyeon Heo , Chang-Hun Yeom , Bao Tuan Duong , Haan Woo Sung , Seon-Ju Yeo , Hyun Park , Haryoung Poo , Jihyun Yang","doi":"10.1016/j.virs.2024.12.005","DOIUrl":"10.1016/j.virs.2024.12.005","url":null,"abstract":"<div><div>Influenza, a highly contagious respiratory infectious disease caused by an influenza virus, is a threat to public health worldwide. Avian influenza viruses (AIVs) have the potential to cause the next pandemic by crossing the species barrier through mutation of viral genome. Here, we investigated the pathogenicity of AIVs obtained from South Korea and Mongolia during 2018–2019 by measuring viral titers in the lungs and extrapulmonary organs of mouse models. In addition, we assessed the pathogenicity of AIVs in ferret models. Moreover, we compared the ability of viruses to replicate in mammalian cells, as well as the receptor-binding preferences of AIV isolates. Genetic analyses were finally performed to identify the genetic relationships and amino acid substitutions between viral proteins during mammalian adaptation. Of the 24 AIV isolates tested, A/Mallard/South Korea/KNU2019-34/2019 (KNU19-34; H1N1) caused severe bodyweight loss and high mortality in mice. The virus replicated in the lungs, kidneys, and heart. Importantly, KNU19-34-infected ferrets showed high viral loads in both nasal washes and lungs. KNU19-34 replicated rapidly in A549 and bound preferentially to human like α2,6-linked sialic acids rather than to avian-like α2,3-linked sialic acids, similar to the pandemic A/California/04/2009 (H1N1) strain. Gene segments of KNU19-34 were distributed in Egypt and Asia lineages from 2015 to 2018, and the virus had several amino acid substitutions compared to H1N1 AIV isolates that were non-pathogenic in mice. Collectively, the data suggest that KNU19-34 has zoonotic potential and the possibility of new mutations responsible for mammalian adaptation.</div></div>","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":"40 1","pages":"Pages 24-34"},"PeriodicalIF":5.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0