Virologica Sinica最新文献

{"title":"Isolation and characterization of mpox virus from the first mpox case in Shenzhen, China","authors":"Lin Cheng , Liuqing Yang , Miao Wang , Yabo Peng , Haiyan Wang , Xiaoxiang Yang , Juanjuan Zhao , Mingxia Zhang , Fuxiang Wang , Zheng Zhang","doi":"10.1016/j.virs.2024.01.004","DOIUrl":"10.1016/j.virs.2024.01.004","url":null,"abstract":"","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":"39 2","pages":"Pages 335-337"},"PeriodicalIF":5.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1995820X2400004X/pdfft?md5=cf19698e37b5bdd93e232c44968b9361&pid=1-s2.0-S1995820X2400004X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139513595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-species transmission and host range genes in poxviruses","authors":"Chen-Hui Yang,&nbsp;A-Ling Song,&nbsp;Ye Qiu,&nbsp;Xing-Yi Ge","doi":"10.1016/j.virs.2024.01.007","DOIUrl":"10.1016/j.virs.2024.01.007","url":null,"abstract":"<div><p>The persistent epidemic of human mpox, caused by mpox virus (MPXV), raises concerns about the future spread of MPXV and other poxviruses. MPXV is a typical zoonotic virus which can infect human and cause smallpox-like symptoms. MPXV belongs to the <em>Poxviridae</em> family, which has a relatively broad host range from arthropods to vertebrates. Cross-species transmission of poxviruses among different hosts has been frequently reported and resulted in numerous epidemics. Poxviruses have a complex linear double-strand DNA genome that encodes hundreds of proteins. Genes related to the host range of poxvirus are called host range genes (HRGs). This review briefly introduces the taxonomy, phylogeny and hosts of poxviruses, and then comprehensively summarizes the current knowledge about the cross-species transmission of poxviruses. In particular, the HRGs of poxvirus are described and their impacts on viral host range are discussed in depth. We hope that this review will provide a comprehensive perspective about the current progress of researches on cross-species transmission and HRG variation of poxviruses, serving as a valuable reference for academic studies and disease control in the future.</p></div>","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":"39 2","pages":"Pages 177-193"},"PeriodicalIF":5.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1995820X24000075/pdfft?md5=9e69e0b65bb866590c27edcc9e779495&pid=1-s2.0-S1995820X24000075-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139564534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precore mutation enhances viral replication to facilitate persistent infection especially in HBeAg-negative patients","authors":"Guixin Li ,&nbsp;Danli Yang ,&nbsp;Xin Liu ,&nbsp;Ting Zhang ,&nbsp;Hui Liu ,&nbsp;Jun Zou ,&nbsp;Zimeng Xu ,&nbsp;Xiangmei Chen ,&nbsp;Lizhong Dai ,&nbsp;Hongsong Chen ,&nbsp;Fengmin Lu","doi":"10.1016/j.virs.2024.03.003","DOIUrl":"10.1016/j.virs.2024.03.003","url":null,"abstract":"<div><p>Naturally occurred precore (PC, G1896A) and/or basal core promoter (BCP, A1762T/G1764A) mutations are prevalent in chronic HBV-infected patients, especially those under HBeAg-negative status. However, the replicative capacity of HBV with PC/BCP mutations remains ambiguous. Herein, meta-analysis showed that, only under HBeAg-negative status, the serum HBV DNA load in patients with PC mutation was 7.41-fold higher than those without the mutation. Both PC mutation alone and BCP ​+ ​PC mutations promoted HBV replication in cell and hydrodynamic injection mouse models. In human hepatocyte chimeric mouse model, BCP ​+ ​PC mutations led to elevated replicative capacity and intrahepatic core protein accumulation. Mechanistically, preC RNA harboring PC mutation could serve as mRNA to express core and P proteins, and such pgRNA-like function favored the maintenance of cccDNA pool under HBeAg-negative status. Additionally, BCP ​+ ​PC mutations induced more extensive and severe human hepatocyte damage as well as activated endoplasmic reticulum stress and TNF signaling pathway in livers of chimeric mice. This study indicates that HBeAg-negative patients should be monitored on HBV mutations regularly and are expected to receive early antiviral treatment to prevent disease progression.</p></div>","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":"39 2","pages":"Pages 319-330"},"PeriodicalIF":5.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1995820X24000294/pdfft?md5=500878c6d29f3177221229c7776ec447&pid=1-s2.0-S1995820X24000294-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Cover","authors":"","doi":"10.1016/S1995-820X(24)00055-5","DOIUrl":"https://doi.org/10.1016/S1995-820X(24)00055-5","url":null,"abstract":"","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":"39 2","pages":"Page OFC"},"PeriodicalIF":5.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1995820X24000555/pdfft?md5=8eaf9f3548b9c329f3eb15c674ecc416&pid=1-s2.0-S1995820X24000555-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140645655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mice with type I interferon signaling deficiency are prone to epilepsy upon HSV-1 infection","authors":"Wei Yang ,&nbsp;Chong-Yang Tang ,&nbsp;Dong-Ying Fan ,&nbsp;Yi-Song Wang ,&nbsp;Pei-Gang Wang ,&nbsp;Jing An ,&nbsp;Guo-Ming Luan","doi":"10.1016/j.virs.2024.01.002","DOIUrl":"10.1016/j.virs.2024.01.002","url":null,"abstract":"<div><p>Viral encephalitis continues to be a significant public health concern. In our previous study, we discovered a lower expression of antiviral factors, such as IFN-β, STING and IFI16, in the brain tissues of patients with Rasmussen's encephalitis (RE), a rare chronic neurological disorder often occurred in children, characterized by unihemispheric brain atrophy. Furthermore, a higher cumulative viral score of human herpes viruses (HHVs) was also found to have a significant positive correlation with the unihemispheric atrophy in RE. Type I IFNs (IFN-I) signaling is essential for innate anti-infection response by binding to IFN-α/β receptor (IFNAR). In this study, we infected WT mice and IFNAR-deficient A6 mice with herpes simplex virus 1 (HSV-1) via periocular injection to investigate the relationship between IFN-I signaling and HHVs-induced brain lesions. While all mice exhibited typical viral encephalitis lesions in their brains, HSV-induced epilepsy was only observed in A6 mice. The gene expression matrix, functional enrichment analysis and protein-protein interaction network revealed four gene models that were positively related with HSV-induced epilepsy. Additionally, ten key genes with the highest scores were identified. Taken together, these findings indicate that intact IFN-I signaling can effectively limit HHVs induced neural symptoms and brain lesions, thereby confirming the positive correlation between IFN-I signaling repression and brain atrophy in RE and other HHVs encephalitis.</p></div>","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":"39 2","pages":"Pages 251-263"},"PeriodicalIF":5.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1995820X24000026/pdfft?md5=f41a52ba029cf8c31729482d38daa75f&pid=1-s2.0-S1995820X24000026-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139467091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “3Cpro of FMDV inhibits type II interferon-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation” [Virol Sin 38 (2023) 387–397]","authors":"Xiangju Wu ,&nbsp;Lei Chen ,&nbsp;Chao Sui ,&nbsp;Yue Hu ,&nbsp;Dandan Jiang ,&nbsp;Fan Yang ,&nbsp;Laura C. Miller ,&nbsp;Juntong Li ,&nbsp;Xiaoyan Cong ,&nbsp;Nataliia Hrabchenko ,&nbsp;Changhee Lee ,&nbsp;Yijun Du ,&nbsp;Jing Qi","doi":"10.1016/j.virs.2023.12.007","DOIUrl":"10.1016/j.virs.2023.12.007","url":null,"abstract":"","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":"39 2","pages":"Pages 351-354"},"PeriodicalIF":5.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1995820X23001608/pdfft?md5=de45e282ae149268dace91beb2e1cdda&pid=1-s2.0-S1995820X23001608-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interconnection of cellular autophagy and endosomal vesicle trafficking and its role in hepatitis B virus replication and release","authors":"Jia Li ,&nbsp;Yong Lin ,&nbsp;Xueyu Wang ,&nbsp;Mengji Lu","doi":"10.1016/j.virs.2024.01.001","DOIUrl":"10.1016/j.virs.2024.01.001","url":null,"abstract":"<div><p>Hepatitis B virus (HBV) produces and releases various particle types, including complete virions, subviral particles with envelope proteins, and naked capsids. Recent studies demonstrate that HBV exploits distinct intracellular membrane trafficking pathways, including the endosomal vesicle trafficking and autophagy pathway, to assemble and release viral and subviral particles. Herein, we summarize the findings about the distinct roles of autophagy and endosomal membrane trafficking and the interaction of both pathways in HBV replication, assembly, and release.</p></div>","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":"39 1","pages":"Pages 24-30"},"PeriodicalIF":5.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1995820X24000014/pdfft?md5=c73d68376191040718efb2fbc8f412c6&pid=1-s2.0-S1995820X24000014-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferroptosis contributes to JEV-induced neuronal damage and neuroinflammation","authors":"Wenjing Zhu ,&nbsp;Qi Li ,&nbsp;Yong Yin ,&nbsp;Huanchun Chen ,&nbsp;Youhui Si ,&nbsp;Bibo Zhu ,&nbsp;Shengbo Cao ,&nbsp;Zikai Zhao ,&nbsp;Jing Ye","doi":"10.1016/j.virs.2023.12.004","DOIUrl":"10.1016/j.virs.2023.12.004","url":null,"abstract":"<div><p>Ferroptosis is a newly discovered prototype of programmed cell death (PCD) driven by iron-dependent phospholipid peroxidation ​accumulation, and it has been linked to numerous organ injuries and degenerative pathologies. Although studies have shown that a variety of cell death processes contribute to JEV-induced neuroinflammation and neuronal injury, there is currently limited research on the specific involvement of ferroptosis. In this study, we explored the neuronal ferroptosis induced by JEV infection <em>in vitro</em> and <em>in vivo</em>. Our results indicated that JEV infection induces neuronal ferroptosis through inhibiting the function of the antioxidant system mediated by glutathione (GSH)/glutathione peroxidase 4 (GPX4), as well as by promoting lipid peroxidation mediated by yes-associated protein 1 (YAP1)/long-chain acyl-CoA synthetase 4 (ACSL4). Further analyses revealed that JEV E and prM proteins function as agonists, inducing ferroptosis. Moreover, we found that treatment with a ferroptosis inhibitor in JEV-infected mice reduces the viral titers and inflammation in the mouse brains, ultimately improving the survival rate of infected mice. In conclusion, our study unveils a critical role of ferroptosis in the pathogenesis of JEV, providing new ideas for the prevention and treatment of viral encephalitis.</p></div>","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":"39 1","pages":"Pages 144-155"},"PeriodicalIF":5.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1995820X23001566/pdfft?md5=e515cb7d1dc167809611203bdd188cd5&pid=1-s2.0-S1995820X23001566-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138686805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Cover","authors":"","doi":"10.1016/S1995-820X(24)00012-9","DOIUrl":"https://doi.org/10.1016/S1995-820X(24)00012-9","url":null,"abstract":"","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":"39 1","pages":"Page OFC"},"PeriodicalIF":5.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1995820X24000129/pdfft?md5=e16f206ee72badb78c48142f46b6c92b&pid=1-s2.0-S1995820X24000129-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139731869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RNA barcode segments for SARS-CoV-2 identification from HCoVs and SARSr-CoV-2 lineages","authors":"Changqiao You ,&nbsp;Shuai Jiang ,&nbsp;Yunyun Ding ,&nbsp;Shunxing Ye ,&nbsp;Xiaoxiao Zou ,&nbsp;Hongming Zhang ,&nbsp;Zeqi Li ,&nbsp;Fenglin Chen ,&nbsp;Yongliang Li ,&nbsp;Xingyi Ge ,&nbsp;Xinhong Guo","doi":"10.1016/j.virs.2024.01.006","DOIUrl":"10.1016/j.virs.2024.01.006","url":null,"abstract":"<div><p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen responsible for coronavirus disease 2019 (COVID-19), continues to evolve, giving rise to more variants and global reinfections. Previous research has demonstrated that barcode segments can effectively and cost-efficiently identify specific species within closely related populations. In this study, we designed and tested RNA barcode segments based on genetic evolutionary relationships to facilitate the efficient and accurate identification of SARS-CoV-2 from extensive virus samples, including human coronaviruses (HCoVs) and SARSr-CoV-2 lineages. Nucleotide sequences sourced from NCBI and GISAID were meticulously selected and curated to construct training sets, encompassing 1733 complete genome sequences of HCoVs and SARSr-CoV-2 lineages. Through genetic-level species testing, we validated the accuracy and reliability of the barcode segments for identifying SARS-CoV-2. Subsequently, 75 main and subordinate species-specific barcode segments for SARS-CoV-2, located in <em>ORF1ab</em>, <em>S</em>, <em>E</em>, <em>ORF7a</em>, and <em>N</em> coding sequences, were intercepted and screened based on single-nucleotide polymorphism sites and weighted scores. Post-testing, these segments exhibited high recall rates (nearly 100%), specificity (almost 30% at the nucleotide level), and precision (100%) performance on identification. They were eventually visualized using one and two-dimensional combined barcodes and deposited in an online database (<span>http://virusbarcodedatabase.top/</span><svg><path></path></svg>). The successful integration of barcoding technology in SARS-CoV-2 identification provides valuable insights for future studies involving complete genome sequence polymorphism analysis. Moreover, this cost-effective and efficient identification approach also provides valuable reference for future research endeavors related to virus surveillance.</p></div>","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":"39 1","pages":"Pages 156-168"},"PeriodicalIF":5.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1995820X24000063/pdfft?md5=d17814d2aee23bb4d075d608e8b938aa&pid=1-s2.0-S1995820X24000063-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139508329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}