Virologica Sinica最新文献

A dual-glycoprotein-targeting bispecific nanoantibody confers potent neutralization against Nipah virus. 一种双糖蛋白靶向双特异性纳米抗体可有效中和尼帕病毒。

IF 4.7 3区医学

Virologica Sinica Pub Date : 2026-10-09 DOI: 10.1016/j.virs.2026.09.014

Shengdong Wang, Xinghai Zhang, Haiwei Zhang, Guibo Rao, Yanfeng Yao, Guihong Tian, Ge Gao, Yun Peng, Wujian Li, Sheng Cao, Sandra Chiu, Rui Gong, Li Chen

{"title":"A dual-glycoprotein-targeting bispecific nanoantibody confers potent neutralization against Nipah virus.","authors":"Shengdong Wang, Xinghai Zhang, Haiwei Zhang, Guibo Rao, Yanfeng Yao, Guihong Tian, Ge Gao, Yun Peng, Wujian Li, Sheng Cao, Sandra Chiu, Rui Gong, Li Chen","doi":"10.1016/j.virs.2026.09.014","DOIUrl":"10.1016/j.virs.2026.09.014","url":null,"abstract":"Nipah virus (NiV) is a biosafety level 4 pathogen that has consistently posed a significant threat to public health. The two envelope proteins on the viral surface, the receptor-binding protein (RBP) and the fusion (F) protein, are the primary targets of neutralizing antibodies. However, the use of antibodies targeting a single viral antigen often leads to the emergence of resistant strains. Here, by panning phage display library, we obtained a C-type nanoantibody (C-Nab), G-3-1, targeting the head domain of RBP. The half-life-extended G-3-1-HLE effectively protected hamsters against authentic NiV challenge. Furthermore, we constructed a fusion protein, 2A1-3-8-(AP)12-G-3-1, by linking G-3-1 to the F-targeting nanobody 2A1-3-8 via a rigid (AP)12 linker. This fusion protein exhibited improved and balanced neutralizing activity. In addition, the in vivo prophylactic efficacy of 2A1-3-8-(AP)12-G-3-1 was validated in a mouse model of NiV pseudovirus infection. Collectively, this study on a dual-envelope-protein-targeting bispecific antibody not only provides a promising antiviral candidate, but also offers an important design strategy for next-generation antibody optimization.","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monocyte-associated C1q upregulation and complement activation contribute to vascular endothelial and multi-organ injury in severe dengue. 单核细胞相关的C1q上调和补体激活有助于严重登革热的血管内皮和多器官损伤。

IF 4.7 3区医学

Virologica Sinica Pub Date : 2026-10-07 DOI: 10.1016/j.virs.2026.10.002

Wei Yang, Qian Chen, Nan Yao, Zhe Li, Yi-Teng Zhang, Sheng-Nan Wang, Wei Wang

{"title":"Monocyte-associated C1q upregulation and complement activation contribute to vascular endothelial and multi-organ injury in severe dengue.","authors":"Wei Yang, Qian Chen, Nan Yao, Zhe Li, Yi-Teng Zhang, Sheng-Nan Wang, Wei Wang","doi":"10.1016/j.virs.2026.10.002","DOIUrl":"10.1016/j.virs.2026.10.002","url":null,"abstract":"Dengue virus (DENV) infection causes a broad spectrum of clinical manifestations, ranging from self-limiting dengue fever (DF) to life-threatening severe dengue (SD). Increased vascular permeability and endothelial dysfunction are hallmarks of SD and contribute to plasma leakage, shock, and multi-organ injury, yet the underlying mechanisms remain incompletely understood. Here, we integrated dynamic bulk and single-cell RNA sequencing data from peripheral blood mononuclear cells (PBMCs) of dengue patients at different disease stages to investigate the mechanisms associated with disease progression. Complement-related signatures were prominently altered in patients with dengue with warning signs (DWS) and SD, with monocytes emerging as a major cellular source of increased C1Q genes (C1QA, C1QB, and C1QC) expression. These findings implicated monocyte-derived C1q and classical complement pathway activation in dengue progression. Using a severe dengue mouse model, we further demonstrated systemic complement activation and deposition of the terminal complement effector membrane attack complex (MAC), which was associated with microvascular endothelial damage and multi-organ injury. Importantly, inhibition of the classical complement pathway with C1INH (C1 esterase inhibitor) significantly alleviated vascular barrier dysfunction and multi-organ injury in severe dengue mice. Collectively, our findings identify monocyte-derived C1q and dysregulated classical complement activation as important contributors to vascular endothelial and multi-organ injury in SD and suggest that targeting the classical complement pathway may represent a potential therapeutic strategy for severe dengue.","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent intrahost G-gene haplotype structures suggest potential co-transmission in RSV-A. 宿主内复发的g基因单倍型结构提示RSV-A可能共传播。

IF 4.7 3区医学

Virologica Sinica Pub Date : 2026-10-07 DOI: 10.1016/j.virs.2026.10.003

Jingqi Yang, Yuhua Liao, Luyao Qin, Haoyang Wang, Yun Ma, Ye Tong, Fei Deng, Liguo Zhu, Hang-Yu Zhou, Aiping Wu

{"title":"Recurrent intrahost G-gene haplotype structures suggest potential co-transmission in RSV-A.","authors":"Jingqi Yang, Yuhua Liao, Luyao Qin, Haoyang Wang, Yun Ma, Ye Tong, Fei Deng, Liguo Zhu, Hang-Yu Zhou, Aiping Wu","doi":"10.1016/j.virs.2026.10.003","DOIUrl":"10.1016/j.virs.2026.10.003","url":null,"abstract":"Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization worldwide. Its molecular epidemiology rests on consensus G-gene sequences, which capture only the dominant virus in each infection. Deep sequencing reveals far more variation inside each host. Linking those variants to one another gives a finer view of transmission. Here we reconstructed G-gene haplotypes from two independent RSV-A deep-sequencing datasets (Australia, n = 37; United States, n = 72). We phased variants using read-level linkage, then placed each haplotype on a global phylogeny. More than 90% of samples carry multiple haplotypes, which often sit on distinct phylogenetic branches. One cross-branch pair dominates each dataset: C4+C6 in 23 of 37 Australian samples (62%), and C18 + C21 in 26 of 72 US samples (36%). Both pairs recur far more often than month- and region-matched permutations predict (both P = 5.0 × 10-5). Mutation-probability calculations suggest that recurrent within-host de novo mutation is unlikely to fully account for these patterns, particularly for the five linked sites in C4+C6 (probability ≤5.36 × 10-15). Repeated joint introduction of pre-existing haplotypes offers a simpler explanation, and transmission-chain sampling can now test it directly. All branch-defining sites mapped to G-HVR2. In the examined global consensus G-gene set, dominant-branch states appeared, while minor-branch combinations were not detected under our criteria. Haplotype-resolved analysis thus turns sub-consensus diversity into linked, interpretable epidemiological signal.","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiomics reveals alterations in the gut microbiome, host proteins, and host metabolites correlating with SADS-CoV pathogenicity and the immune response in piglets. 多组学揭示了仔猪肠道微生物组、宿主蛋白和宿主代谢物与SADS-CoV致病性和免疫反应相关的变化。

IF 4.7 3区医学

Virologica Sinica Pub Date : 2026-10-06 DOI: 10.1016/j.virs.2026.10.001

Xiaoyu Tang, Huang Chao, Chenyu Li, Jingshuai Sun, Wenjie Li, Yuan Sun, Tian Lan, Jingyun Ma

{"title":"Multiomics reveals alterations in the gut microbiome, host proteins, and host metabolites correlating with SADS-CoV pathogenicity and the immune response in piglets.","authors":"Xiaoyu Tang, Huang Chao, Chenyu Li, Jingshuai Sun, Wenjie Li, Yuan Sun, Tian Lan, Jingyun Ma","doi":"10.1016/j.virs.2026.10.001","DOIUrl":"10.1016/j.virs.2026.10.001","url":null,"abstract":"Swine acute diarrhea syndrome coronavirus (SADS-CoV) infection causes severe acute diarrhea, vomiting, and lethality in piglets. To explore the molecular mechanisms by which intestinal flora regulate viral infection, we conducted multi-omics analysis [proteomics, metabolomics, short-chain fatty acids (SCFA) quantification] and 16S rRNA sequencing on intestinal mucosal and fecal samples from piglets infected with highly pathogenic SADS-CoV P7 stain or low-pathogenic SADS-CoV P83 strain. In both ileal mucosa and fecal samples, the abundance of Enterobacteriaceae was markedly higher in the highly pathogenic strain infection group than in either the control group or the low-pathogenic strain infection group. The concentration of SCFAs was significantly lower in the highly pathogenic SADS-CoV infected pigs than the low-pathogenic strain infected pigs, and SCFA levels were negatively correlated with the abundance of Enterobacteriaceae and Escherichia coli in the ileal mucosa. Compared with the low-pathogenic group, differentially expressed proteins in the highly pathogenic group were mainly associated with extracellular matrix-receptor interaction and focal adhesion pathways. SADS-CoV P7 infection increased both the adhesion capacity and the number of adherent Escherichia coli O157 on IPEC-J2 cells. This study demonstrates that the highly pathogenic SADS-CoV P7 strain remodels gut microbiota to exacerbate intestinal inflammation and tissue damage via activating integrin alpha5-mediated extracellular matrix-pathogen interactions. In contrast, the low-pathogenic SADS-CoV P83 strain exhibits attenuated virulence due to a lack of these regulatory pathways. This study elucidates the distinct pathogenic mechanisms of highly pathogenic and low-pathogenic SADS-CoV strains and provides critical insights for the development of broad-spectrum anti-coronavirus therapeutics and rational vaccine design.","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SwiVirScan, a high-throughput platform for profiling antibodies to swine-associated viruses, reveals extensive viral exposure histories in pigs. SwiVirScan是一个分析猪相关病毒抗体的高通量平台，揭示了猪的广泛病毒暴露史。

IF 4.7 3区医学

Virologica Sinica Pub Date : 2026-09-30 DOI: 10.1016/j.virs.2026.09.013

Qian Zhang, Junhua Dong, Pengju Guo, Wenlong Wang, Xueting Zhang, Siyang Pei, Zhaoxu Dong, Ping Qian, Pan Tao

{"title":"SwiVirScan, a high-throughput platform for profiling antibodies to swine-associated viruses, reveals extensive viral exposure histories in pigs.","authors":"Qian Zhang, Junhua Dong, Pengju Guo, Wenlong Wang, Xueting Zhang, Siyang Pei, Zhaoxu Dong, Ping Qian, Pan Tao","doi":"10.1016/j.virs.2026.09.013","DOIUrl":"10.1016/j.virs.2026.09.013","url":null,"abstract":"Pigs are crucial as food sources, biomedical models, and reservoirs of some zoonotic viruses, yet their comprehensive viral exposure history remains poorly understood. Here, we developed SwiVirScan, a T7 phage display-based serological platform containing 36,416 peptides derived from 140 known swine-associated viruses. Application of SwiVirScan to 127 field serum samples from adult breeding pigs revealed extensive and diverse antibody signatures: every sample recognized peptides assigned to multiple viruses, including viruses with reported zoonotic relevance or potential for cross-species transmission. Pairwise analysis identified enriched co-seropositivity patterns, including a robust association between porcine bufavirus (PBuV) and porcine circovirus 3 (PCV3), and uncovered distinct associations between seroreactivity to vaccine-targeted viruses and other viral exposures. These findings establish SwiVirScan as a high-throughput platform for mapping viral exposure histories in pig populations and prioritizing viral targets for focused surveillance and investigation.","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology-guided discovery of a K1-specific lytic phage with therapeutic potential against ST23-K1 multidrug-resistant hypervirulent Klebsiella pneumoniae. 流行病学指导下k1特异性裂解噬菌体的发现，具有治疗ST23-K1多药耐药高致病性肺炎克雷伯菌的潜力。

IF 4.7 3区医学

Virologica Sinica Pub Date : 2026-09-28 DOI: 10.1016/j.virs.2026.09.012

Hang Zhang, Yifei Wei, Jiabao Xing, Yichao Zhang, Xinyu Sun, Zhuang Li, YuYing Zhang, Yushan Pan, Meng Zhang, Shanmei Wang, Yajun Zhai, Hua Wu

{"title":"Epidemiology-guided discovery of a K1-specific lytic phage with therapeutic potential against ST23-K1 multidrug-resistant hypervirulent Klebsiella pneumoniae.","authors":"Hang Zhang, Yifei Wei, Jiabao Xing, Yichao Zhang, Xinyu Sun, Zhuang Li, YuYing Zhang, Yushan Pan, Meng Zhang, Shanmei Wang, Yajun Zhai, Hua Wu","doi":"10.1016/j.virs.2026.09.012","DOIUrl":"10.1016/j.virs.2026.09.012","url":null,"abstract":"Phage therapy has emerged as a promising alternative for combating multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-hvKP) infections. Recent advances suggest that tailoring phage cocktails based on genomic surveillance of circulating strains might yield more effective regimens (Koncz et al., 2024). Here, we combined publicly available epidemiological records with regional strain analysis to examine the distribution of the ST23-K1 lineage and to place the selected target in genomic and clinical context. Among the 227 isolates in our Henan collection, ST23-K1 accounted for 11.01% of isolates. We isolated a novel lytic phage, vB_KpnS_P10HW, from urban sewage using a clinically representative high-risk ST23-K1 MDR-hvKP strain, KH1127-5, as the host. vB_KpnS_P10HW exhibited lytic activity against K1-type K. pneumoniae isolates across four sequence types. The phage displayed rapid adsorption (80% within 10 min), a short latent period (5 min), and remarkable stability across temperature (4-60 °C) and pH (4-10) ranges. Whole-genome sequencing revealed a 49,682bp linear dsDNA genome devoid of lysogeny, virulence, or antibiotic resistance genes. Phylogenomic analysis placed vB_KpnS_P10HW within the family Drexlerviridae, genus Webervirus. Functionally, vB_KpnS_P10HW rapidly reduced viable bacterial cells within 30 min at high multiplicities of infection and effectively disrupted preformed biofilms in a dose-dependent manner. In vivo, phage administration increased the survival rates in both Galleria mellonella and mouse infection models. These results support vB_KpnS_P10HW as a genetically safe and promising therapeutic candidate against clinically relevant ST23-K1-associated MDR-hvKP and suggest that integrating genomic epidemiological context with phage characterization may help prioritize regional targets for precision phage therapy against K. pneumoniae.","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SFTSV exploits PPM1K to inhibit apoptosis through the Bcl-2/BAX/Caspase-3 axis for efficient replication. SFTSV利用PPM1K通过Bcl-2/BAX/Caspase-3轴抑制细胞凋亡，实现高效复制。

IF 4.7 3区医学

Virologica Sinica Pub Date : 2026-09-24 DOI: 10.1016/j.virs.2026.09.010

Qianruo Wang, Baoyan Wang, Penghui Liu, Yuanyuan Li

{"title":"SFTSV exploits PPM1K to inhibit apoptosis through the Bcl-2/BAX/Caspase-3 axis for efficient replication.","authors":"Qianruo Wang, Baoyan Wang, Penghui Liu, Yuanyuan Li","doi":"10.1016/j.virs.2026.09.010","DOIUrl":"10.1016/j.virs.2026.09.010","url":null,"abstract":"SFTSV (Severe fever with thrombocytopenia syndrome virus) causes severe febrile illness with high case fatality rates and poses a growing public health threat, while the molecular basis by which it subverts host survival pathways remains poorly understood. In this study, transcriptomic profiling identified PPM1K as a prominently induced host factor in SFTSV-infected THP-1-derived macrophages. We further demonstrate that SFTSV infection promotes endoplasmic reticulum-mitochondria coupling, enabling the viral glycoprotein Gc to interact with mitochondrial PPM1K and enhance its expression at both transcriptional and protein levels. Mechanistically, the S248 residue of PPM1K is required for its dephosphorylation of Bcl-2, thereby decreasing Bcl-2 ubiquitination and stabilizing its anti-apoptotic activity, which ultimately suppresses the BAX-caspase-3 signaling cascade. This anti-apoptotic remodeling markedly limits apoptosis in infected cells and facilitates efficient SFTSV replication. These findings uncover a previously unrecognized viral strategy in which SFTSV hijacks host PPM1K-dependent mitochondrial signaling to evade apoptosis and promote replication.","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human brain organoids and neural progenitor cells model oropouche virus infection and reveal varied responses to antiviral therapies. 人脑类器官和神经祖细胞模拟Oropouche病毒感染并揭示对抗病毒治疗的不同反应。

IF 4.7 3区医学

Virologica Sinica Pub Date : 2026-09-24 DOI: 10.1016/j.virs.2026.09.011

Jiajing Li, Marieke Alzeer, Xin Wang, Amber Hof, Debbie L C van den Berg, Qiuwei Pan

引用次数: 0

Establishment of a Tandem Dimeric Replication System for Torque Teno Virus In Vitro. Torque Teno病毒体外串联二聚体复制体系的建立。

IF 4.7 3区医学

Virologica Sinica Pub Date : 2026-09-23 DOI: 10.1016/j.virs.2026.09.008

Zulihuma Amat, Yibo Jia, Feifei Yin, Yuchen Xia, Xiaoming Cheng

引用次数: 0

Subcutaneous immunization with replication-competent live influenza virus confers durable protective immunity without respiratory pathology in mice. 小鼠皮下接种具有复制能力的活流感病毒可获得持久的保护性免疫，且无呼吸道病理。

IF 4.7 3区医学

Virologica Sinica Pub Date : 2026-09-21 DOI: 10.1016/j.virs.2026.09.009

Zhoulang Wang, Chengxing Zhou, Lixin Yin, Xiaohong Liao, Xiao Li, Lei Li, Zhichao Zhou, Kangtian Li, Meiyun Chen, Dingbin Chen, Minglei Liu, Duo Xu, Weibin She, Qinhai Ma, Hui Cai, Rong Zhou

{"title":"Subcutaneous immunization with replication-competent live influenza virus confers durable protective immunity without respiratory pathology in mice.","authors":"Zhoulang Wang, Chengxing Zhou, Lixin Yin, Xiaohong Liao, Xiao Li, Lei Li, Zhichao Zhou, Kangtian Li, Meiyun Chen, Dingbin Chen, Minglei Liu, Duo Xu, Weibin She, Qinhai Ma, Hui Cai, Rong Zhou","doi":"10.1016/j.virs.2026.09.009","DOIUrl":"10.1016/j.virs.2026.09.009","url":null,"abstract":"Current influenza vaccination strategies are constrained by the trade-off between the safety of inactivated platforms and the immunogenic potency of live attenuated vaccines. Here, we provide a comprehensive demonstration that subcutaneous (SC) immunization with a non-attenuated, replication-competent live influenza A virus (LIV) decouples immunogenicity from pathogenicity. Using a murine model, we show that a single high-dose SC immunization of A/Puerto Rico/8/34 (H1N1) elicited sterile pulmonary immunity against lethal challenge, significantly outperforming intramuscular delivery and inactivated vaccines. Biodistribution analysis confirms viral replication is transient (<7 days) and strictly restricted to the injection site and draining lymph nodes, with no systemic dissemination to the lungs or central nervous system. Mechanistically, single-cell transcriptomics reveal that SC delivery triggers a localized type I interferon \"firewall\" that transitions into a robust germinal center (GC) reaction, fostering extensive plasma cell differentiation and superior memory B cell formation compared to phosphate-buffered saline (PBS)-treated controls. This regimen conferred 100% protection at 277 days post-immunization. Together, these findings establish peripheral LIV administration as a high-potency paradigm for next-generation rapid-response vaccines.","PeriodicalId":23654,"journal":{"name":"Virologica Sinica","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0