HBV and host metabolic crosstalk: reprogramming pathways for viral replication and pathogenesis.

IF 4 3区医学 Q1 Medicine

Virologica Sinica Pub Date : 2025-09-27 DOI:10.1016/j.virs.2025.09.008

YanYing Yan, Zhiqiang Wei, Min Zheng, Mengji Lu, Xueyu Wang

引用次数: 0

Abstract

Hepatitis B virus (HBV) establishes chronic infection through strategic manipulation of host metabolic networks, driving a spectrum of hepatic pathologies ranging from hepatitis to cirrhosis and hepatocellular carcinoma. Mechanistically, HBV reprograms core metabolic pathways, including glycolysis, tricarboxylic acid (TCA) cycle, oxidative phosphorylation, and lipid homeostasis, to fuel its replication machinery and evade immune surveillance. This review systematically synthesizes current evidence on HBV-induced glucose/lipid metabolic rewiring, with particular emphasis on how viral-host crosstalk at the metabolic interface sustains viral pathogenesis.

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HBV和宿主代谢串扰：病毒复制和发病机制的重编程途径。

乙型肝炎病毒（HBV）通过对宿主代谢网络的战略性操纵建立慢性感染，驱动一系列肝脏病理，从肝炎到肝硬化和肝细胞癌。在机制上，HBV重编程核心代谢途径，包括糖酵解、三羧酸（TCA）循环、氧化磷酸化和脂质稳态，以促进其复制机制并逃避免疫监视。这篇综述系统地综合了目前关于hbv诱导的糖/脂代谢重布线的证据，特别强调了代谢界面上的病毒-宿主串扰如何维持病毒的发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Virologica Sinica Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

7.70

自引率

1.80%

发文量

3149

期刊介绍： Virologica Sinica is an international journal which aims at presenting the cutting-edge research on viruses all over the world. The journal publishes peer-reviewed original research articles, reviews, and letters to the editor, to encompass the latest developments in all branches of virology, including research on animal, plant and microbe viruses. The journal welcomes articles on virus discovery and characterization, viral epidemiology, viral pathogenesis, virus-host interaction, vaccine development, antiviral agents and therapies, and virus related bio-techniques. Virologica Sinica, the official journal of Chinese Society for Microbiology, will serve as a platform for the communication and exchange of academic information and ideas in an international context. Electronic ISSN: 1995-820X; Print ISSN: 1674-0769