Vaccines最新文献

{"title":"Mpox Vaccine Hesitancy Among Brazilian Men Who Have Sex with Men: A National Cross-Sectional Study.","authors":"Guilherme Reis de Santana Santos, Caíque Jordan Nunes Ribeiro, José Flávio Cerqueira Dos Santos Júnior, Valdemar Silva Almeida, Rita de Cassia Dias Nascimento, Nilo Manoel Pereira Vieira Barreto, Anderson Reis de Sousa, Márcio Bezerra-Santos, Lariane Angel Cepas, Ana Paula Morais Fernandes, Isabel Amélia Costa Mendes, Aires Garcia Dos Santos Júnior, Maria Luisa Pereira Maronesi, Álvaro Francisco Lopes de Sousa","doi":"10.3390/vaccines12111229","DOIUrl":"10.3390/vaccines12111229","url":null,"abstract":"<p><strong>Background: </strong>Mpox is a viral zoonosis that has gained increased attention due to a global outbreak in 2022, significantly impacting men who have sex with men (MSM). Vaccination for this disease poses a public health challenge; because it carries a strong stigma, there may be greater hesitancy in vulnerable groups.</p><p><strong>Objectives: </strong>This study aimed to determine the prevalence and factors associated with Mpox vaccine hesitancy among Brazilian MSM.</p><p><strong>Methods: </strong>A cross-sectional study was conducted between September and December 2022 using an online survey targeted at MSM. Recruitment was carried out through social media and dating apps. The sample consisted of 1449 participants and the analysis involved bivariate logistic regression.</p><p><strong>Results: </strong>The prevalence of Mpox vaccine hesitancy was 7.57%. The significant factors associated with hesitancy were primarily related to sexual practices and attitudes towards Mpox exposure and diagnosis, such as not using \"glory holes\" (aOR: 19.82; 95% CI: 1.60-245.69), reluctance to undergo pre- and post-exposure testing for Mpox (aOR: 9.54; 95% CI: 5.52-16.48), and not knowing close contacts diagnosed with Mpox (aOR: 4.09; 95% CI: 1.72-9.73). Participants who would not take precautions after diagnosis (aOR: 3.00; 95% CI: 1.27-7.07) and those who would not disclose their serological status (aOR: 1.93; 95% CI: 1.13-3.30) also showed a higher likelihood of vaccine hesitancy.</p><p><strong>Conclusion: </strong>Public health strategies should address these factors to expand knowledge about vaccination barriers, plan educational campaigns with targeted messaging for the MSM population, and provide inclusive healthcare environments to increase vaccine acceptance and reduce Mpox transmission in vulnerable groups.</p>","PeriodicalId":23634,"journal":{"name":"Vaccines","volume":"12 11","pages":""},"PeriodicalIF":5.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes, Beliefs, and Self-Reported Rates of Influenza and COVID-19 Vaccinations in the Canadian 2023-2024 National Influenza and Respiratory Viruses Survey.","authors":"Samir Sinha, Natalie Iciaszczyk, Bertrand Roy, Wendy Boivin","doi":"10.3390/vaccines12111230","DOIUrl":"10.3390/vaccines12111230","url":null,"abstract":"<p><p><b>Background:</b> We conducted a cross-sectional, online survey of adult Canadian residents to evaluate their attitudes and beliefs about vaccination against respiratory viruses, particularly influenza and coronavirus 2019 (COVID-19). <b>Methodology:</b> Survey participants aged ≥ 18 years were randomly recruited from the Léger Opinion (LEO) consumer panel. <b>Results:</b> Out of 3002 respondents, 76% reported being \"up-to-date\" on all of their recommended vaccinations, 86% reported understanding why the influenza vaccine was needed annually, 79% reported believing the influenza vaccine was safe, and 83% reported understanding that vaccines, in general, were important for health. However, only 49% reported receiving the influenza vaccine in the fall of 2023, and 46% received a COVID-19 vaccine (68% of those who received one received the other). More than half of the respondents (55%) reported that they found it difficult to keep track of which vaccines were recommended for them, while 74% indicated that they valued the opinion of their healthcare provider (HCP) when deciding whether to be vaccinated against influenza, and 73% said they would not hesitate to receive multiple vaccines at the same time if their HCP recommended it. <b>Conclusions:</b> These findings highlight the ongoing need for education and outreach in Canada.</p>","PeriodicalId":23634,"journal":{"name":"Vaccines","volume":"12 11","pages":""},"PeriodicalIF":5.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal M2SR and BM2SR Vaccine Viruses Do Not Shed or Transmit in Ferrets.","authors":"Yasuko Hatta, Lindsay Hill-Batorski, Michael J Moser, David Marshall, David A Boltz, Landon Westfall, Renee Herber, Sally Sarawar, Pamuk Bilsel","doi":"10.3390/vaccines12111228","DOIUrl":"10.3390/vaccines12111228","url":null,"abstract":"<p><strong>Background/objectives: </strong>Live influenza vaccines are considered to stimulate better overall immune responses but are associated with safety concerns regarding shedding and the potential for transmission or reassortment with wild-type influenza viruses. Intranasal M2SR and BM2SR (M2- and BM2-deficient single replication), intranasal influenza viruses, have shown promise as broadly cross-reactive next-generation influenza vaccines. The replication deficiency, shedding, and transmissibility of M2SR/BM2SR viruses were evaluated in a ferret model.</p><p><strong>Methods: </strong>Wild-type influenza A and B control viruses replicated in upper respiratory organs and transmitted to both direct and aerosol contact ferrets, whereas M2SR and BM2SR influenza vaccine viruses were not detected in any tissues or in nasal washes after inoculation and were not recovered from any direct or aerosol contact ferrets. Mice were simultaneously infected with wild-type influenza A and M2SR viruses to assess reassortment potential. Sequence and PCR analyses of the genome recovered from individual virus plaques isolated from lung homogenates identified the origin of the segments as exclusively from the replicating wild-type virus.</p><p><strong>Results: </strong>These results indicate that M2SR and BM2SR influenza vaccine viruses are attenuated, do not shed or transmit, and have a low probability for reassortment after coinfection. Absence of shedding was further demonstrated in nasal swabs taken from subjects who were inoculated with H3N2 M2SR in a previously described Phase 1 clinical study.</p><p><strong>Conclusions: </strong>These results indicate that M2SR/BM2SR viruses have the potential to be used in a broader population range than current live influenza vaccines.</p>","PeriodicalId":23634,"journal":{"name":"Vaccines","volume":"12 11","pages":""},"PeriodicalIF":5.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Special Issue: \"Vaccination and Global Health\".","authors":"Shaodi Ma, Qian Bi, Li Liu, Roshan Thapa, Wenle Li, Baocheng Liu, Chuanhui Xu, Chenyu Sun","doi":"10.3390/vaccines12111223","DOIUrl":"10.3390/vaccines12111223","url":null,"abstract":"<p><p>This Special Issue, titled 'Vaccination and Global Health,' compiles 11 broad-ranging papers, each exploring critical facets of vaccination, public health, and global healthcare systems [...].</p>","PeriodicalId":23634,"journal":{"name":"Vaccines","volume":"12 11","pages":""},"PeriodicalIF":5.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Health Education on Vaccination Coverage and Knowledge of the School Population Related to Vaccination and Infection Caused by the Human Papillomavirus.","authors":"Ivana Kotromanović Šimić, Vesna Bilić-Kirin, Maja Miskulin, Darko Kotromanović, Marija Olujić, Jelena Kovacevic, Danijela Nujić, Nika Pavlovic, Ivan Vukoja, Ivan Miskulin","doi":"10.3390/vaccines12111222","DOIUrl":"10.3390/vaccines12111222","url":null,"abstract":"<p><strong>Background/objectives: </strong>Human papillomavirus (HPV) is a causative agent of infections and cancers of the reproductive and digestive tract, and vaccination is the most effective prevention method. This research aimed to assess the impact of health education on vaccination coverage and knowledge of the school population related to HPV infection and vaccination.</p><p><strong>Methods: </strong>This non-randomized clinical trial included 170 participants out of the 221 students in the generation of 2022/2023, who were divided into a group of Subjects and Controls and who self-assessed their knowledge and tested knowledge at four and two time points, respectively.</p><p><strong>Results: </strong>The study examined whether there is a difference in the share of vaccinated students of the entire generation compared to the previous generation (62% vs. 47%). The self-assessment and assessment of one's knowledge in the group of subjects was significantly lower before education than during other time points during the research. At \"moment zero\", there was no significant difference in the knowledge assessment between the groups. However, after 8 weeks, the knowledge assessment was significantly higher in the Subject group.</p><p><strong>Conclusions: </strong>The results suggest a positive impact of health education, which may contribute to raising awareness about the importance of prevention and vaccination against HPV.</p>","PeriodicalId":23634,"journal":{"name":"Vaccines","volume":"12 11","pages":""},"PeriodicalIF":5.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing HPV Vaccination Communication Strategies: Assessing Knowledge, Attitudes, and Barriers Among Healthcare Professionals in Kazakhstan.","authors":"Fatima Kassymbekova, Alexander Rommel, Dilyara Kaidarova, Ardak Auyezova, Saule Nukusheva, Gauhar Dunenova, Raikhan Bolatbekova, Indira Zhetpisbayeva, Gulzada Abdushukurova, Natalya Glushkova","doi":"10.3390/vaccines12111225","DOIUrl":"10.3390/vaccines12111225","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer, predominantly caused by human papillomavirus, remains a major public health issue globally and in Kazakhstan, where it ranks among the most common cancers in women. A pilot HPV vaccination programme in Kazakhstan was suspended in 2017 due to mass parental refusals, and it is planned to be restarted in the coming years. This study aims to assess the knowledge, attitudes, barriers, and sources of information about HPV and the HPV vaccine among healthcare professionals in Kazakhstan.</p><p><strong>Methods: </strong>A cross-sectional study (December 2022-May 2023) involving 1189 healthcare professionals in Kazakhstan used a self-administered questionnaire. Statistical analysis included descriptive statistics, mean knowledge score, between-group comparisons, and binary logistic regression to identify factors linked to higher knowledge and vaccine recommendation.</p><p><strong>Results: </strong>The study found that the average knowledge score for HPV and the HPV vaccine among participants was 11 out of a possible 18. Correct answers to the questionnaire were observed more frequently among physicians than among nurses (<i>p</i> < 0.001). In our study, 72.6% of healthcare professionals expressed a positive intention to recommend the HPV vaccine. The likelihood of recommending the HPV vaccine was significantly higher among those with higher knowledge of HPV and its vaccine (OR 1.8; 95% CI 1.3-2.5; <i>p</i> < 0.001), those familiar with cervical cancer patients (OR 2.0; 95% CI 1.5-2.8; <i>p</i> < 0.001), and those with positive attitudes towards the COVID-19 vaccine and childhood vaccination (OR 2.3 and 1.5, respectively). Healthcare professionals identified key barriers to HPV vaccination, including public mistrust (49.4%), fear of side effects (45.9%), and insufficient knowledge among healthcare professionals themselves (30.3%). Information from the internet, including articles and journals, was the most commonly used source of information, followed by social media and colleagues.</p><p><strong>Conclusions: </strong>The disparities identified call for a tailored, multifaceted communication strategy that addresses the diverse needs of health professionals to address the differences in awareness between different groups, in order to ensure successful implementation and coverage of HPV vaccination across Kazakhstan.</p>","PeriodicalId":23634,"journal":{"name":"Vaccines","volume":"12 11","pages":""},"PeriodicalIF":5.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunogenicity and Antibody Persistence of the Inactivated Quadrivalent Influenza Vaccine in Pediatric Patients Post-Chemotherapy or Allogeneic Hematopoietic Stem Cell Transplantation Versus Healthy Controls.","authors":"Mi Yeon Hur, Kyu Ri Kang, Ye Ji Kim, Yoon Kyung Cho, Jae Wook Lee, Nack-Gyun Chung, Bin Cho, Dae Chul Jeong, Jin Han Kang, Hyun Mi Kang","doi":"10.3390/vaccines12111224","DOIUrl":"10.3390/vaccines12111224","url":null,"abstract":"<p><p>Pediatric patients who have undergone hematopoietic stem cell transplantation (HSCT) or chemotherapy are at increased risk for severe influenza complications, necessitating annual vaccination. This study evaluated the immunogenicity and antibody persistence of the 2021-2022 seasonal quadrivalent influenza vaccine in pediatric patients post-HSCT or chemotherapy, compared to healthy controls. A prospective cohort study included 80 pediatric participants divided into three groups: chemotherapy (<i>n</i> = 33), HSCT (<i>n</i> = 27), and healthy controls (<i>n</i> = 20). All participants were vaccinated with the 2021-2022 GC FLU Quadrivalent vaccine. Hemagglutination inhibition (HI) assays measured seroprotection rates (SPR), geometric mean titers (GMT), and seroconversion rates (SCR) for the four vaccine antigens (A/H1N1, A/H3N2, B/Victoria, B/Yamagata) at one, three, and six months post-vaccination. At one month post-vaccination, all groups met the 70% SPR threshold for A/H1N1 and A/H3N2, but not for B/Victoria. For B/Yamagata, the SPR was low in the chemotherapy and HSCT groups (18.18% and 33.33%, respectively), compared to 80.00% in controls (<i>p</i> < 0.0001 and <i>p</i> = 0.0015). While A/H1N1 and A/H3N2 GMTs were protective in all groups, only controls achieved protective levels for B/Yamagata. Over time, the control group maintained >70% SPR for A/H1N1 up to six months, but the chemotherapy and HSCT groups declined by three and six months, respectively. For A/H3N2, the SPR in controls dropped below 70% at three months, while it remained above 70% in the chemotherapy and HSCT groups until three months. None of the groups achieved protective GMTs for B strains at three or six months. Pediatric patients post-HSCT or chemotherapy demonstrated a comparable immune response to healthy controls for A/H1N1 and A/H3N2, but the rapid decline in A/H1N1 antibody levels suggests the need for ongoing monitoring and adjusted vaccination schedules. The poor response to B antigens, particularly B/Yamagata, underscores the need for improved vaccination strategies in these vulnerable populations.</p>","PeriodicalId":23634,"journal":{"name":"Vaccines","volume":"12 11","pages":""},"PeriodicalIF":5.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combating Emerging Respiratory Viruses: Lessons and Future Antiviral Strategies.","authors":"Palaniyandi Muthukutty, Jaime MacDonald, So Young Yoo","doi":"10.3390/vaccines12111220","DOIUrl":"10.3390/vaccines12111220","url":null,"abstract":"<p><p>Emerging viral diseases, including seasonal illnesses and pandemics, pose significant global public health risks. Respiratory viruses, particularly coronaviruses and influenza viruses, are associated with high morbidity and mortality, imposing substantial socioeconomic burdens. This review focuses on the current landscape of respiratory viruses, particularly influenza and SARS-CoV-2, and their antiviral treatments. It also discusses the potential for pandemics and the development of new antiviral vaccines and therapies, drawing lessons from past outbreaks to inform future strategies for managing viral threats.</p>","PeriodicalId":23634,"journal":{"name":"Vaccines","volume":"12 11","pages":""},"PeriodicalIF":5.2,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of COVID-19 Vaccination and Infection on the Exacerbation of Myasthenia Gravis.","authors":"Yuting Jiang, Jingsi Wang, Shengyao Su, Shu Zhang, Qi Wen, Yaye Wang, Ling Li, Jianxin Han, Nairong Xie, Haoran Liu, Yanan Sun, Yan Lu, Li Di, Min Wang, Min Xu, Hai Chen, Suobin Wang, Xinmei Wen, Wenjia Zhu, Yuwei Da","doi":"10.3390/vaccines12111221","DOIUrl":"10.3390/vaccines12111221","url":null,"abstract":"<p><strong>Objectives: </strong>Myasthenia Gravis (MG) is an autoimmune disorder that can exacerbate for various reasons, including vaccination and infection. This study aimed to investigate the safety of COVID-19 vaccines for MG patients, factors influencing MG exacerbation after COVID-19 infection (MECI), the course and prognosis of MECI, and the impact of COVID-19 vaccine on infected MG patients.</p><p><strong>Methods: </strong>Patients were enrolled from the MG database in the Department of Neurology, Xuanwu Hospital, Capital Medical University. Two questionnaires were administered to collect data concerning COVID-19 vaccination (questionnaire 1, Q1) and infection (questionnaire 2, Q2) during two distinct periods. MG exacerbation was defined as an increase of at least two points in the MG activity of daily living (MG-ADL) score. COVID-19 severity was categorized as \"hospitalization\" or \"home management\"; Results: During the first data-collecting period, our database registered 1013 adult patients: 273 (26.9%) had received COVID-19 vaccinations and completed Q1, and 8 (2.9%) experienced MG exacerbation after vaccination. During the second data-collecting period, among the newly registered patients, 366 patients completed Q2. Of these, 244 were infected, with 39 (16.0%) experiencing MECI and 21 (8.6%) requiring hospitalization. Multivariate analysis showed that generalized myasthenia gravis was associated with MECI (OR 3.354, 95% CI: 1.423-7.908, <i>p</i> = 0.006). Among the 244 infected patients, 143 had received COVID-19 vaccinations, including 14 who received their booster dose within 6 months before COVID-19 and 129 who were vaccinated more than 6 months before COVID-19. The remaining 101 were unvaccinated. No significant associations were found between COVID-19 vaccination and COVID-19 severity (<i>p</i> = 0.292) or MECI incidence (<i>p</i> = 0.478); Conclusions: COVID-19 vaccines were found to be safe for MG patients in stable condition. Patients with gMG were more susceptible to experiencing MECI. No significant impact of the vaccine on COVID-19 severity or MECI incidence was observed.</p>","PeriodicalId":23634,"journal":{"name":"Vaccines","volume":"12 11","pages":""},"PeriodicalIF":5.2,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination Knowledge, Attitudes, Perceptions, and Educational Needs of Pharmacists in Singapore: A Cross-Sectional Study.","authors":"Ally L Au, Deborah M Chia, Pei-Shi Ong","doi":"10.3390/vaccines12111219","DOIUrl":"10.3390/vaccines12111219","url":null,"abstract":"<p><strong>Background: </strong>Singapore's adult vaccination coverage is suboptimal, and this can be attributed to a lack of vaccination recommendations and misconceptions. Studies have explored pharmacists' vaccination knowledge, attitudes, and practice behaviour overseas but limited information about pharmacists in Singapore is available. This study aims to investigate pharmacists' vaccination knowledge, attitudes towards providing vaccination services, and their educational needs.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on pharmacists in various practice settings using an anonymous online survey.</p><p><strong>Results: </strong>Pharmacists' vaccination knowledge (median: 2; IQR: 1-3), confidence in providing vaccination services (median: 6; IQR: 5-8), and frequency of providing vaccination services (median: 2; IQR: 1-3) were only average. However, 74.3% of pharmacists agreed that they play an important role as vaccine advocates. Apparent differences in knowledge level (<i>p</i> = 0.008), confidence level (<i>p</i> = 0.001), attitude (<i>p</i> < 0.001), and the frequency of educating patients (<i>p</i> = 0.001) and recommending vaccinations (<i>p</i> < 0.001) were observed among pharmacists from different practice settings. The main barriers identified were discomfort with giving injections (38.5%) and a lack of skills or knowledge (28.3%) at the point of survey.</p><p><strong>Conclusions: </strong>Pharmacists see the importance of their role as vaccine advocates. However, their vaccination knowledge, confidence in providing vaccination services, and practice behaviours are only average due to inadequate training. Continuous professional education is required to increase pharmacists' readiness to provide vaccination services.</p>","PeriodicalId":23634,"journal":{"name":"Vaccines","volume":"12 11","pages":""},"PeriodicalIF":5.2,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}