Veterinary anaesthesia and analgesia最新文献

{"title":"A randomized, double-blinded, placebo-controlled parallel-group pilot study evaluating the effect of low-dose subcutaneous ketamine as an adjunctive analgesic in dogs with osteoarthritis","authors":"Nielsen M.B. Michelle, Thomsen H. Victor, Dahl H. Kathine, Hoegh F. Rasmus, Poulsen, H. Helle","doi":"10.1016/j.vaa.2026.101338","DOIUrl":"10.1016/j.vaa.2026.101338","url":null,"abstract":"","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"53 5","pages":"Article 101338"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148934830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicenter retrospective evaluation of hyperkalemia of unknown origin in equids during general anesthesia","authors":"C. Hector Rachel, Douglas Hope, M. Varner Kelley","doi":"10.1016/j.vaa.2026.101347","DOIUrl":"10.1016/j.vaa.2026.101347","url":null,"abstract":"","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"53 5","pages":"Article 101347"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148934946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total Intravenous Anaesthesia (TIVA) with propofol in sheep maintains spontaneous ventilation allowing lung nebulisation using an Aeroeclipse® nebuliser","authors":"Gregson Rachael, Tennant Peter, McLachlan Gerry","doi":"10.1016/j.vaa.2026.101327","DOIUrl":"10.1016/j.vaa.2026.101327","url":null,"abstract":"","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"53 5","pages":"Article 101327"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148951837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaesthetic management of two dogs with third-degree atrioventricular block undergoing elective non-cardiac surgery under temporary transvenous pacing","authors":"Vogel Bernadette, Hildebrandt Nicolai, Kneissl Kai, Söbbeler Franz, Schneider Matthias","doi":"10.1016/j.vaa.2026.101323","DOIUrl":"10.1016/j.vaa.2026.101323","url":null,"abstract":"","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"53 5","pages":"Article 101323"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148934716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of haemorrhage and fluid resuscitation with either Plasma-Lyte A or Ringer’s Lactate in Beagle dogs under sevoflurane anaesthesia—part 2: Buccal mucosal microcirculation","authors":"Christina A Gruell,&nbsp;Annette PN Kutter,&nbsp;Federico Gianolli,&nbsp;Barbara Steblaj","doi":"10.1016/j.vaa.2026.101234","DOIUrl":"10.1016/j.vaa.2026.101234","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the effects of haemorrhage and subsequent fluid resuscitation with Plasma-Lyte A (PA) or Ringer’s Lactate (RL) on buccal microcirculation.</div></div><div><h3>Study design</h3><div>Single-centre, randomised, blinded, experimental study.</div></div><div><h3>Animals</h3><div>A group of 12 adult, healthy, intact, purpose-bred Beagle dogs.</div></div><div><h3>Methods</h3><div>In sevoflurane anaesthetised Beagle dogs, a sidestream dark field (SDF) imaging device was positioned on the buccal mucosa to evaluate microcirculatory variables, which included perfused De Backer density (pDBD) and proportion of perfused vessels. Videos were recorded at baseline, following the removal of 30 mL kg^-1 of blood to induce hypovolaemia (HV), and after each 10 mL kg^-1 intravenous fluid bolus (B1 and B2) according to the assigned treatment group. Data were compared between groups and over time using a linear mixed model with group and time point as fixed and dogs as random factors. <em>Post hoc</em> multiple comparisons were performed with Sidak’s corrections. A <em>p</em> value &lt; 0.05 was considered significant.</div></div><div><h3>Results</h3><div>The haemorrhage resuscitation model resulted in significant changes in microcirculation over time. In group RL, pDBD was significantly more reduced compared with group PA at HV [RL: 1.3 (0.9–1.8) n mm^-1 (median ± 95% confidence interval), PA: 2.3 (1.6–2.7) n mm^-1, <em>p</em> = 0.004] and B2 [RL: 2 (1.7–2.7), PA: 3.3 (2.7– 4.2), <em>p</em> &lt; 0.001]. Proportion of perfused vessels was also more reduced in group RL compared with group PA at HV [RL: 57 (53–77)%, PA: 78 (69–93)%, <em>p</em> &lt; 0.001] and B2 [RL: 72 (65–96)%, PA: 85 (77–99)%, <em>p</em> = 0.012].</div></div><div><h3>Conclusions and clinical relevance</h3><div>Dogs administered PA showed fewer changes in pDBD and proportion of perfused vessels values after haemorrhage and resuscitation with 20 mL kg^-1 PA compared with those administered RL. Due to the small sample size these preliminary findings warrant further research.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"53 4","pages":"Article 101234"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148273190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of opiranserin (Unafra) on mechanical nociceptive thresholds in Beagle dogs: a randomized crossover study","authors":"Nahyun Kim,&nbsp;Seonbin Oh,&nbsp;Seolhee Lee,&nbsp;Seongwon Lee,&nbsp;Inhyung Lee,&nbsp;Won-gyun Son","doi":"10.1016/j.vaa.2026.101259","DOIUrl":"10.1016/j.vaa.2026.101259","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the antinociceptive efficacy and safety of the novel analgesic opiranserin (a dual glycine transporter-2 inhibitor and 5-hydroxytryptamine 2A antagonist) in dogs using mechanical nociceptive threshold (MNT) testing, with low-dose remifentanil (positive control) and normal saline (negative control).</div></div><div><h3>Study design</h3><div>Randomized, blinded, crossover study.</div></div><div><h3>Animals</h3><div>Six healthy male Beagle dogs [aged 3.4–5.3 years, 13.1 ± 0.5 kg (mean ± standard deviation)].</div></div><div><h3>Methods</h3><div>Each dog was given a 4-hour intravenous constant rate infusion (CRI) of opiranserin (5 mg kg⁻¹ hour⁻¹), remifentanil (4 μg kg⁻¹ hour⁻¹), or normal saline with ≥ 7 days inter-treatment interval. MNT (left metacarpal, carpal and metatarsal pad), pulse rate, and sedation scores were recorded at 0 (baseline), 30, 60, 120, 180, and 240 minutes. MNT and pulse rate were analyzed using linear mixed-effects models. Sedation scores were analyzed using Friedman’s test.</div></div><div><h3>Results</h3><div>With opiranserin, MNT increased from 30–240 minutes <em>versus</em> baseline (<em>p</em> &lt; 0.001), and the opiranserin-saline difference increased over time (<em>p</em> &lt; 0.001). With remifentanil, MNT increased <em>versus</em> baseline from 30 minutes (<em>p</em> &lt; 0.001) without additional time-dependent increase. In a secondary comparison, MNT was higher with opiranserin than remifentanil from 60–240 minutes (all <em>p</em> values ≤ 0.036). Pulse rate decreased with remifentanil (<em>p</em> &lt; 0.001), but not opiranserin or saline. Sedation was 0/12 with opiranserin and saline, and increased minimally with remifentanil (1/12). Vomiting (2/6 dogs) and nausea-like signs (5/6 dogs) were the main adverse events with opiranserin. All adverse effects resolved within 30 minutes of stopping the CRI. No psychomimetic or neurological signs were observed.</div></div><div><h3>Conclusions and clinical relevance</h3><div>A 4-hour CRI of opiranserin (5 mg kg⁻¹ hour⁻¹) increased MNTs during infusion in dogs without clinically relevant sedation or cardiovascular depression. These findings are consistent with antinociceptive activity under this experimental model.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"53 4","pages":"Article 101259"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148266348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed tomographic evaluation of tracheal anatomy of tigers (Panthera tigris)","authors":"Matthew Pickens,&nbsp;Chiara E. Hampton,&nbsp;Silke Hecht,&nbsp;Zhu Xiaojuan,&nbsp;Julie Sheldon,&nbsp;Christopher K. Smith,&nbsp;Geneviève Bussières,&nbsp;Reza Seddighi","doi":"10.1016/j.vaa.2025.08.037","DOIUrl":"10.1016/j.vaa.2025.08.037","url":null,"abstract":"<div><h3>Objective</h3><div>To describe tracheal dimensions of male and female tigers using computed tomography (CT) scans, and to assess correlation between body mass and theoretical maximum endotracheal tube (ETT) size (Max ETT size).</div></div><div><h3>Study design</h3><div>Retrospective case series.</div></div><div><h3>Animals</h3><div>A group of 19 anesthetized tigers (<em>Panthera tigris</em>).</div></div><div><h3>Methods</h3><div>Medical records of tigers that underwent general anesthesia and CT scan between June 2014 and August 2024 were collected, and CT images selected according to inclusion criteria were evaluated. Tracheal length, vertical and transverse diameters and their ratio (T:V) and cross-sectional areas (CSA) were spot-measured at five locations (M1, 1 cm caudal to the cricoid cartilage; M2, at the level of C4–C5 intervertebral disc; M3, at cranial end of the manubrium sterni; M4, at the level of second costae; and M5, 1 cm cranial to origin of the most cranial bronchus) along the tracheal length and averaged. Minimum cross-sectional area (CSA_min) was calculated and compared with the CSA of commercial ETTs to obtain the Max ETT size. Correlations between body mass and averaged tracheal measurements were analyzed using Pearson’s correlation. Significance was set as <em>p</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>At M1–M5, T:V ratios were 0.9, 0.9, 1, 1 and 1, respectively. Based on the tracheal mean CSA_min [858.2 mm² ± 308.3 (mean ± standard deviation)], the Max ETT size was 22 mm ± 3.0 (ETT internal diameter). CSA_min was not significantly correlated with body mass (<em>p</em> = 0.416), nor were other tracheal measurements, including length of the trachea.</div></div><div><h3>Conclusions and clinical relevance</h3><div>The trachea of <em>Panthera tigris</em> was elliptical with a mild latero-lateral flattening in the cervical portion and circular along the rest of its length. This information characterizes the tracheal anatomy of tigers and provides the basis for further investigations to better understand the optimal ETT diameter and airway management for this species.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"53 4","pages":"Article 101132"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148284526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authorship","authors":"Daniel SJ. Pang,&nbsp;Michael Z. Teng,&nbsp;Grace PS. Kwong","doi":"10.1016/j.vaa.2026.101268","DOIUrl":"10.1016/j.vaa.2026.101268","url":null,"abstract":"","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"53 4","pages":"Article 101268"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148284551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri-anaesthetic complications in dogs undergoing lateral thoracotomy or median sternotomy: A retrospective study","authors":"Clara Maria de Celis Perez ,&nbsp;Luiz Santos ,&nbsp;Rob Ward","doi":"10.1016/j.vaa.2025.10.007","DOIUrl":"10.1016/j.vaa.2025.10.007","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the incidence of peri-anaesthetic complications in dogs undergoing general anaesthesia for thoracic surgery (lateral thoracotomy or median sternotomy) and to identify differences in the rate of peri-anaesthetic complications depending on the surgical approach and American Society of Anesthesiologists (ASA) physical status classification system.</div></div><div><h3>Study design</h3><div>Retrospective study.</div></div><div><h3>Animals</h3><div>Dogs that underwent either thoracotomy or sternotomy at The Small Animal Hospital, University of Edinburgh, between January 2019 and August 2022.</div></div><div><h3>Methods</h3><div>Data recorded included signalment, surgical approach, indication for surgery, general anaesthesia time, surgery time, time to extubation, anaesthetic management and the use of locoregional anaesthetic techniques, neuromuscular blockers, anticholinergics and/or vasopressor and inotropic agents. The occurrence of peri-anaesthetic complications (yes/no) was analysed by surgical approach and ASA classification using chi-square analysis and logistic regression. Statistical significance was set at <em>p</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>A total of 127 anaesthetic records were reviewed, of which 90 met the inclusion criteria; ASA scores were missing from nine leaving 81. Median sternotomy was associated with a significantly longer surgical (<em>p</em> = 0.03) and anaesthetic time (<em>p</em> &lt; 0.01) as well as the time to extubation (<em>p</em> = 0.023). Hypothermia (<em>n</em> = 72) and hypotension <em>(n</em> = 54) were the most prevalent complications observed despite surgical approach or ASA status. Hypoxaemia was more likely to occur in dogs with ASA status IV <em>(n</em> = 10/29) than in dogs with ASA status II and III (<em>n</em> = 7/52) in chi-square analysis (<em>p</em> = 0.026) and binomial logistic regression (<em>p</em> = 0.046).</div></div><div><h3>Conclusions and clinical relevance</h3><div>Hypothermia and hypotension were common peri-anaesthetic complications. Higher ASA status was associated with a higher likelihood of hypoxaemia, and no significant association was found between complications and surgical approach. Active warming from the premedication stage and ensuring prompt access to fluid therapy, vasopressors, inotropes and anticholinergics are recommended.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"53 3","pages":"Article 101151"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of PetMAP digital and Mindray wrist oscillometric blood pressure measurements with invasive blood pressure in anaesthetized bonobos (Pan paniscus)","authors":"Philippa Bucknell ,&nbsp;Florence Hillen ,&nbsp;Phillipa Dobbs ,&nbsp;Samantha Ashfield ,&nbsp;Kate White","doi":"10.1016/j.vaa.2025.10.009","DOIUrl":"10.1016/j.vaa.2025.10.009","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the agreement of the PetMAP noninvasive blood pressure (NIBP) device with digital cuff and the Mindray NIBP device with wrist cuff with invasive blood pressure (IBP) in bonobos.</div></div><div><h3>Study design</h3><div>Prospective clinical study (non-blinded or -randomized).</div></div><div><h3>Animals</h3><div>A group of 12 bonobos aged 5–44 years undergoing anaesthesia for enclosure movement and health checks.</div></div><div><h3>Methods</h3><div>Systolic (SAP), diastolic (DAP) and mean (MAP) arterial pressure measurements were recorded simultaneously at 5-minute intervals using the NIBP devices and IBP via anterior tibial artery cannulation. Modified Bland–Altman and adapted error grid analyses assessed agreement between IBP and NIBP and the clinical implications of any biases respectively. A 95% limit of agreement (LOA) estimated the possible magnitude of sampling error. Pearson <em>r</em> correlations between IBP and NIBP measurements were calculated. A <em>p</em> &lt; 0.05 was considered significant.</div></div><div><h3>Results</h3><div>IBP ranges were SAP 50–137 mmHg, MAP 32–85 mmHg and DAP 20–69 mmHg. Biases with the PetMAP were −6.8 mmHg for SAP (LOA −41.3 to 27.7 mmHg), −7.2 mmHg for MAP (LOA −30.7 to 16.3 mmHg) and −3.1 mmHg for DAP (LOA −25.5 to 19.3 mmHg) from 84 PetMAP–IBP paired measurements. Correlation coefficients were 0.6 for SAP and DAP and 0.7 for MAP. Whilst 70% of MAP values were clinically acceptable, 13% demonstrated unrecognised hypotension. The Mindray demonstrated biases of −25.3 mmHg for SAP (LOA −69.5 to 18.9 mmHg), −17.5 mmHg for MAP (LOA −51.4 to 16.5 mmHg) and −14.4 mmHg for DAP (LOA −42.2 to 13.5 mmHg) from 95 Mindray–IBP paired measurements. Correlation coefficients were 0.7 for all. Only 45% of MAP values were clinically acceptable and 26% demonstrated unrecognised hypotension.</div></div><div><h3>Conclusions and clinical relevance</h3><div>Whilst the PetMAP agreed more closely with IBP, neither device met all the American College of Veterinary Internal Medicine validation criteria, and neither should be used to identify hypotension.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"53 3","pages":"Article 101153"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}