Veterinary anaesthesia and analgesia最新文献

{"title":"Evaluation of an indirect NaV1.7 inhibitor as adjunctive analgesic in burn-related neuropathic pain in a cat","authors":"Ludovica Chiavaccini ,&nbsp;Domenico Santoro ,&nbsp;Colleen E. Dwyer ,&nbsp;Enzo Vettorato ,&nbsp;Tyler S. Nelson ,&nbsp;Rajesh Khanna","doi":"10.1016/j.vaa.2025.01.004","DOIUrl":"10.1016/j.vaa.2025.01.004","url":null,"abstract":"<div><div>Burn-related neuropathic pain (BRNP) can arise following burn-induced nerve damage, affects approximately 6% of burned human patients and can result in chronic pain. Although widely studied in humans, data on BRNP or its treatment in animals is lacking. A 4-year-old domestic shorthair cat was presented with an infected, non-healing wound suspected to be a caustic burn. Initial treatments included surgical debridement, antimicrobials, and corticosteroids, but the cat developed persistent pruritus leading to self-inflicted trauma. Despite various interventions, including prednisone, chloramphenicol and cyclosporine, clinical signs persisted, leading to a referral for suspected BRNP. Additional support for neuropathic pain was provided through thermal sensitivity testing and applying a modified Neuropathic Pain Symptoms Inventory. Treatment with gabapentin, amantadine, and acupuncture yielded little improvement, prompting an increasing escalation in gabapentin dosage. The cat was then treated with gabapentin compounded with compound 194, a small molecule that is a potent and selective inhibitor of voltage-gated sodium channel 1.7 (Na_V1.7). The cat exhibited significant pain relief and improvements in overall condition. After gabapentin was tapered, compound 194 effectively maintained pain control. The cat’s clinical condition stabilized with no adverse effects. Hematology and serum biochemistry results remained within reference intervals throughout the treatment period. This case highlights the potential of Na_V1.7 inhibitors in multimodal management of neuropathic pain in animals.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 2","pages":"Pages 257-261"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of the anesthetic effects of dexmedetomidine–vatinoxan–ketamine combinations in cats","authors":"Yu Hong Law ,&nbsp;Bruno H. Pypendop ,&nbsp;Juhana Honkavaara ,&nbsp;Linda S. Barter","doi":"10.1016/j.vaa.2024.12.002","DOIUrl":"10.1016/j.vaa.2024.12.002","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize the anesthetic effects of dexmedetomidine, vatinoxan and ketamine combinations in cats.</div></div><div><h3>Study design</h3><div>Randomized crossover experimental study.</div></div><div><h3>Animals</h3><div>A group of seven healthy male neutered cats, with body mass 5.2 ± 0.4 kg and aged 1–2 years.</div></div><div><h3>Methods</h3><div>Cats were implanted with a telemetric transmitter for remote recording of mean arterial pressure and heart rate before beginning the study. Each cat received a total of six treatments, coadministered in a single syringe, each at least 2 weeks apart: dexmedetomidine (25 μg kg^–1, D) + vatinoxan (600 μg kg^–1, V) + ketamine (2.5 mg kg^–1, K2.5) intramuscularly (IM) (DVK2.5IM); D + V + ketamine (5 mg kg^–1, K5) IM (DVK5IM); D + V + ketamine (10 mg kg^–1, K10) IM (DVK10IM); D + K5 IM (DK5IM); D + V + K5 subcutaneously (SC) (DVK5SC); or D + V + K5 intravenously (IV) (DVK5IV). Select physiologic variables and time to recumbency, immobilization, first movement, head lift, return to sternal recumbency and walking were recorded. Quality of sedation/anesthesia was assessed using a visual analog score. Response to noxious electrical stimulation was assessed at 10 minute intervals.</div></div><div><h3>Results</h3><div>Heart rate (beats minute^–1) was significantly greater in DVK5IM (overall mean ± standard deviation 142 ± 19) than in DK5IM (115 ± 16). No treatment consistently prevented movement in response to noxious stimulation. Time to first movement was significantly shorter in DVK2.5IM (45 ± 10 minutes) than in DVK10IM (93 ± 25 minutes), and in DVK5IM (53 ± 12 minutes) than in DK5IM (95 ± 39 minutes).</div></div><div><h3>Conclusions and clinical relevance</h3><div>Dexmedetomidine–vatinoxan–ketamine combinations, at the doses studied, may be useful to produce sedation, but do not appear to consistently produce anesthesia as characterized by immobility in response to noxious stimulation.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 2","pages":"Pages 161-173"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General anesthesia for dental extractions in a dog with hyperadrenocorticism and myotonia","authors":"Charlotte C. Burns ,&nbsp;Han Chia","doi":"10.1016/j.vaa.2025.01.003","DOIUrl":"10.1016/j.vaa.2025.01.003","url":null,"abstract":"","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 2","pages":"Pages 262-263"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided intercostal nerve injection in rabbit cadavers: Technique description and comparison with blind approach","authors":"Laura AB. Aguilar ,&nbsp;Diego A. Portela ,&nbsp;Raiane A. Moura ,&nbsp;Enzo Vettorato ,&nbsp;Pablo E. Otero ,&nbsp;Marta Romano","doi":"10.1016/j.vaa.2024.12.008","DOIUrl":"10.1016/j.vaa.2024.12.008","url":null,"abstract":"<div><h3>Objective</h3><div>To develop an ultrasound-guided technique for intercostal nerve blocks in rabbit cadavers and to compare the success rate and potential complications of this technique to blind injection.</div></div><div><h3>Study design</h3><div>Prospective, randomized, blinded, descriptive experimental cadaveric study.</div></div><div><h3>Animals</h3><div>A group of nine adult domestic rabbit cadavers (body mass 1.8–2.4 kg).</div></div><div><h3>Methods</h3><div>Anatomic landmarks were identified by dissection of one cadaver and used to develop the ultrasound-guided technique. Eight cadavers were administered blind injections on one hemithorax and ultrasound-guided injections on the opposite hemithorax. The side used for each treatment was randomly assigned. For both techniques, the third to ninth intercostal nerves were targeted and 0.1 mL of yellow dye solution was injected per site. Medial displacement of the parietal pleura was assessed during ultrasound-guided injections. Rabbits were dissected following injection, and injections were considered successful if the circumference of the intercostal nerve was stained with dye. Additionally, the internal aspect of the parietal pleura was assessed for the presence of free dye to determine whether perforation of the parietal pleura had occurred. The number of stained nerves and incidence of pleural perforations were compared between injection techniques using Fisher’s exact test. Data were considered statistically different if <em>p</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>A total of 56 blind and 56 ultrasound-guided intercostal injections were performed. Success rates of the blind and ultrasound-guided techniques were 35.7 % and 66.0 %, respectively (<em>p</em> = 0.002). The internal aspect of the pleura was stained in 23.2 % of blind and 21.4 % of ultrasound-guided injections, with no significant difference between groups (<em>p</em> &gt; 0.999).</div></div><div><h3>Conclusions and clinical relevance</h3><div>Ultrasound guidance improves the accuracy of intercostal nerve injections when compared with a blind technique; however, pleural puncture is a common complication when performing intercostal injections with both techniques studied.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 2","pages":"Pages 228-235"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of potential rapidly progressing osteoarthritis in a dog during bedinvetmab treatment","authors":"Isabelle Iff ,&nbsp;Bettina Hohermuth ,&nbsp;Danielle Bass ,&nbsp;Martin Bass","doi":"10.1016/j.vaa.2024.11.041","DOIUrl":"10.1016/j.vaa.2024.11.041","url":null,"abstract":"","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 2","pages":"Pages 263-265"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Veterinary anesthesia curricula beliefs and practices","authors":"Erik H. Hofmeister ,&nbsp;Paulo Steagall ,&nbsp;Lydia Love ,&nbsp;Rachel Reed ,&nbsp;Jeannette Cremer","doi":"10.1016/j.vaa.2024.12.001","DOIUrl":"10.1016/j.vaa.2024.12.001","url":null,"abstract":"<div><h3>Objective</h3><div>To document the anesthesia curricula in colleges of veterinary medicine and compare it with student clinical supervision and expectations of new graduates by anesthesia staff.</div></div><div><h3>Study design</h3><div>Cross-sectional open survey study.</div></div><div><h3>Population</h3><div>American Veterinary Medical Association-accredited colleges of veterinary medicine (41 out of 49) and members of the American College of Veterinary Anesthesia-L (ACVA-L) listserv (88 of 128 responses).</div></div><div><h3>Methods</h3><div>We created two separate surveys: one distributed to colleges and one distributed to individuals. Anesthesia faculty members of each college were encouraged to complete the survey together; only one survey was submitted for each accredited veterinary college. The college survey asked about current practices of teaching veterinary anesthesia. The individual survey was distributed to the ACVA-L listserv and asked members about tasks they permit students to perform on clinic rotations, knowledge, and skills they believe are Day One Competencies.</div></div><div><h3>Results</h3><div>Communicating with clients about anesthesia was a Day One Competency for 95% of respondents, but not taught in almost 50% of colleges. Students are not allowed to perform this duty on their clinical rotation by almost 60% of instructors. Cardiac arrest and resuscitation, euthanasia, patient safety/systems thinking, and professionalism were cited as Day One Competencies by 97% of participants but were not taught in the anesthesia core course in at least 25% of colleges. Use of simulations for education was mentioned as important but was rare as an instructional tool.</div></div><div><h3>Conclusions and clinical relevance</h3><div>Veterinary anesthesia curricula generally agree with each other and the content generally aligns with what are expected Day One Competencies, as judged by anesthetists. Some topics are taught in the core anesthesia course although they were rarely considered Day One Competencies. Removal of these topics may allow room in the curriculum for the content cited more commonly as Day One Competencies.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 2","pages":"Pages 208-220"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing intramuscular ketamine with peri-incisional bupivacaine with or without ketamine in dogs undergoing hemilaminectomy","authors":"Martina Cambruzzi ,&nbsp;William JM. McFadzean ,&nbsp;Gwen Covey-Crump ,&nbsp;Julia Deutsch","doi":"10.1016/j.vaa.2025.01.002","DOIUrl":"10.1016/j.vaa.2025.01.002","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate whether infiltrating bupivacaine with ketamine into the epaxial muscles improves quality and duration of analgesia perioperatively compared with bupivacaine alone or ketamine intramuscularly.</div></div><div><h3>Study design</h3><div>Prospective blinded randomized clinical study.</div></div><div><h3>Animals</h3><div>A group of 66 dogs randomized into three groups (<em>n</em> = 22).</div></div><div><h3>Methods</h3><div>Before surgery, bupivacaine 0.5% 2 mg kg^–1 alone (group B) or combined with ketamine 2 mg kg^–1 (group BK) was infiltrated peri-incisionally into the epaxial muscles. Group K received ketamine 2 mg kg^–1 injected intramuscularly into a cervical muscle without infiltration. Meloxicam 0.2 mg kg^–1 was given intravenously (IV) before moving to theatre. Cardiovascular variables: heart rate and systolic, mean and diastolic blood pressure were recorded. Intraoperative fentanyl 5 μg kg^–1 IV was administered if these variables increased by 20% from baseline. Fentanyl continuous infusion (5 μg kg^–1 hour^–1) was started if more than three boluses were required. The Glasgow Composite Pain Scale-Short Form was used pre- and postoperatively for acute pain assessment at different time intervals; methadone 0.2 mg kg^–1 IV was administered if scores were greater 5/20. Analgesia requirements, time to first administration, pain scores, total opioids interventions, need for sedation, first food intake and adverse effects were recorded. Continuous, normally distributed and non-normally distributed variables were analysed using ANOVA or Kruskal Wallis test, respectively.</div></div><div><h3>Results</h3><div>No significant difference was found for cardiovascular variables between groups over time, intra- or postoperative analgesia requirements, time to administration, pain scores total opioids, time to first food intake, sedation and occurrence of adverse effects.</div></div><div><h3>Conclusions and clinical relevance</h3><div>No difference in perioperative rescue analgesia was found between groups.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 2","pages":"Pages 244-251"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of intramuscular atipamezole on head height and sedation scores in detomidine-sedated horses","authors":"Camila Mascarenhas,&nbsp;Douglas Castro,&nbsp;Kara M. Lascola,&nbsp;Erik Hofmeister,&nbsp;Stuart C. Clark-Price","doi":"10.1016/j.vaa.2024.11.008","DOIUrl":"10.1016/j.vaa.2024.11.008","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the effect of two different doses of intramuscular atipamezole on head height (HH) in horses after sedation with detomidine.</div></div><div><h3>Study design</h3><div>Randomized, blinded, triple crossover study.</div></div><div><h3>Animals</h3><div>Eight healthy adult horses.</div></div><div><h3>Methods</h3><div>Baseline HH was measured before detomidine (40 μg kg^–1) was injected intravenously. HH was measured at 10 and 20 minutes after injection. Then, saline, atipamezole 60 μg kg^–1 (AT60) or 120 μg kg^–1 (AT120) was injected intramuscularly. HH measurements were repeated at 10 minutes intervals for 100 minutes. HH data were analyzed with a linear mixed model. Significance was set at <em>p</em> &lt; 0.05. Data are reported as mean ± standard deviation.</div></div><div><h3>Results</h3><div>Baseline HH (cm) was 118 ± 14 for saline, 120 ± 10 for AT60, and 115 ± 14 for AT120 and was not significantly different among groups (<em>p</em> &gt; 0.05). AT60 HH was greater than saline at 80 (33 ± 11 <em>versus</em> 28 ± 11), 90 (45 ± 15 <em>versus</em> 26 ± 13), and 110 (57 ± 24 <em>versus</em> 32 ± 11) minutes (all <em>p</em> &lt; 0.002). AT120 HH was greater than saline at 50 (33 ± 16 <em>versus</em> 22 ± 8), 80 (44 ± 11 <em>versus</em> 28 ± 11), 90 (45 ± 11 <em>versus</em> 26 ± 13), 100 (52 ± 18 <em>versus</em> 30 ± 16) and 110 (64 ± 23 <em>versus</em> 32 ± 11) minutes (all <em>p</em> &lt; 0.002). HH was not significantly different at any time between AT60 and AT120 (all <em>p</em> &gt; 0.05).</div></div><div><h3>Conclusions and clinical relevance</h3><div>Horses administered atipamezole showed signs of reversal of sedation, as evaluated by HH compared with saline. Horses administered the higher dose of atipamezole had HH greater than saline sooner than horses administered the lower dose. Intramuscular atipamezole may be useful for reversal of detomidine sedation in horses.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 2","pages":"Pages 153-160"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the fatal chain: A detailed investigation into catastrophic events following anaesthesia in a feline patient","authors":"Latifa Khenissi,&nbsp;Paul Macfarlane","doi":"10.1016/j.vaa.2025.02.012","DOIUrl":"10.1016/j.vaa.2025.02.012","url":null,"abstract":"<div><div>An 8-year-old male neutered British Shorthair cat, weighing 5.12 kg, was referred for chronic mild inappetence, lethargy, bilirubinuria, weight loss and icterus. Diagnostic imaging and serum biochemistry suggested a partial biliary tract obstruction caused by an enlarged pancreas. An exploratory laparotomy was scheduled to perform biopsies of the liver, pancreas and duodenum. Preanaesthetic medication included fentanyl (10 μg kg^-1) and midazolam (0.3 mg kg^-1), given intravenously (IV) through a catheter in a cephalic vein. General anaesthesia was induced with IV propofol (3 mg kg^-1). After endotracheal intubation with a cuffed endotracheal tube (4.5 mm inner diameter), general anaesthesia was maintained with isoflurane in oxygen (fresh gas flow 3 L minute^-1) using a mini Mapleson D (modified T piece). A cholecystoduodenostomy was performed. Intraoperatively, the cat was hypotensive and tachycardic and unresponsive to analgesic therapy (ketamine and fentanyl boluses) and a fluid bolus. At the end of surgery, a concern raised by a nurse that the catheter site was wet, potentially indicating the catheter no longer being in the vein, was dismissed. In recovery, this suspicion was confirmed when bandage material overlying the catheter was removed. An attempt was made to place a central venous catheter but, during placement, the cat showed signs consistent with agonal gasps, followed by cardiopulmonary arrest. Cardiopulmonary resuscitation attempts were unsuccessful. Retrospective analysis of this case allowed identification of a series of active failures, such as not checking the patency of the intravenous catheter by unwrapping it before beginning anaesthesia and system failures, such as inadequate communication.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 5","pages":"Pages 666-670"},"PeriodicalIF":1.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morbidity and mortality: Errors, accidents and lessons learned","authors":"Daniel SJ. Pang ,&nbsp;Regula Bettschart-Wolfensberger","doi":"10.1016/j.vaa.2025.02.008","DOIUrl":"10.1016/j.vaa.2025.02.008","url":null,"abstract":"","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 5","pages":"Pages 513-515"},"PeriodicalIF":1.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}