Veterinary anaesthesia and analgesia最新文献

{"title":"Pharmacokinetics of tramadol and o-desmethyltramadol metabolite in boa (Boa constrictor constrictor)","authors":"M. Lopes , N. Maldonado , L. Fagundes , N. Eleuterio , J. Goncalves , M. Carvalho , F. Leme , N. Fagundes , S. Beier","doi":"10.1016/j.vaa.2025.08.033","DOIUrl":"10.1016/j.vaa.2025.08.033","url":null,"abstract":"","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 6","pages":"Page 976.e4"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145371428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of sedation and recovery following subcutaneous injection of midazolam and two doses of flumazenil in bearded dragons (Pogona vitticeps)","authors":"R.H. Pinho , M. Teng , M. Reed , K. Chapman , D.S.J. Pang","doi":"10.1016/j.vaa.2025.08.017","DOIUrl":"10.1016/j.vaa.2025.08.017","url":null,"abstract":"","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 6","pages":"Page 976.e3"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145371423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ketamine on the minimum anesthetic concentration of isoflurane in chickens (Gallus gallus domesticus)","authors":"André Escobar ,&nbsp;Brighton T. Dzikiti ,&nbsp;Kurt Roman ,&nbsp;Alexandria Rogers ,&nbsp;Jill K. Maney","doi":"10.1016/j.vaa.2025.07.005","DOIUrl":"10.1016/j.vaa.2025.07.005","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the effects of two continuous intravenous (IV) infusion dose rates of ketamine on the minimum anesthetic concentration (MAC) of isoflurane in chickens.</div></div><div><h3>Study design</h3><div>Prospective, randomized, blinded, experimental crossover design.</div></div><div><h3>Animals</h3><div>A group of eight adult ISA Brown hens weighing 2.1 ± 0.19 kg.</div></div><div><h3>Methods</h3><div>Anesthesia was induced and maintained with isoflurane in oxygen and chickens were mechanically ventilated. Body temperature and partial pressure of end-expired carbon dioxide were maintained between 40 and 41 °C and 30 and 40 mmHg (4–5.3 kPa). Isoflurane MAC was determined using electrical stimulation and the bracketing technique. Subsequently, a bolus of low (LD) or high (HD) dose ketamine (5 or 10 mg kg⁻¹ IV) was injected into the brachial vein followed by a constant rate IV infusion (5 or 10 mg kg⁻¹ hour⁻¹, respectively), with a 1 week washout period between treatments. Isoflurane MAC was determined again approximately 1.5 (T1.5) and 3 hours (T3) after bolus injections. Adverse events and time to extubation were recorded. Data analyses consisted of a mixed-effects model for repeated measures (MAC data).</div></div><div><h3>Results</h3><div>Isoflurane MAC was 1.51 ± 0.18% (mean ± standard deviation). Isoflurane MAC at T1.5 and T3 was 1.45 ± 0.16% and 1.53 ± 0.15% (LD) and 1.42 ± 0.24% and 1.46 ± 0.23% (HD). Isoflurane MAC values during LD [(T1.5) <em>p</em> = 0.857 and (T3) <em>p</em> = 0.995] and HD [(T1.5) <em>p</em> = 0.797 and (T3) <em>p</em> = 0.974] ketamine infusion were not different from baseline. Extubation times after isoflurane discontinuation was 12 ± 9 minutes for the LD and 14 ± 5 minutes for the HD treatment. Overall, four animals (both treatments) developed an obstructive mucous plug in the endotracheal tube.</div></div><div><h3>Conclusions and clinical relevance</h3><div>Ketamine did not change isoflurane MAC in chickens. Chickens anesthetized with isoflurane and ketamine should be monitored for endotracheal tube obstruction.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 6","pages":"Pages 786-793"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter to the Editor from authors Dawn Sheppard and Dr Muhammed Aslam Nasir","authors":"José M. Gómez-Silvestre ,&nbsp;Ana García-Fernández ,&nbsp;José Ignacio Redondo ,&nbsp;María de Los Reyes Marti-Scharhausen ,&nbsp;Ariel Cañón ,&nbsp;Eva Z. Hernández ,&nbsp;Agustín Martínez ,&nbsp;David McCallum Neilson ,&nbsp;Jaime Viscasillas","doi":"10.1016/j.vaa.2025.07.001","DOIUrl":"10.1016/j.vaa.2025.07.001","url":null,"abstract":"","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 6","pages":"Pages 966-968"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of adverse effects after inadvertent intrathecal injection of morphine in a dog undergoing thoracotomy","authors":"Hannah M. Fisher,&nbsp;Latifa Khenissi","doi":"10.1016/j.vaa.2025.02.006","DOIUrl":"10.1016/j.vaa.2025.02.006","url":null,"abstract":"<div><div>A 33-kg adult Labrador Retriever dog presented for investigation of pneumothorax. A computed tomography scan confirmed the diagnosis, and right lateral thoracotomy and lung lobectomy were performed under general anaesthesia. During surgery, anaesthesia was maintained with a propofol constant-rate intravenous (IV) infusion (premedication with methadone and dexmedetomidine) and IV atracurium was given to facilitate surgery. A lumbosacral epidural injection of preservative-free morphine (0.3 mg kg^-1 diluted to 6.6 mL with sterile saline) was performed. Using a spinal needle, the ‘hanging drop’ method of detecting the epidural space was attempted but the saline drop was not aspirated, and cerebrospinal fluid entered the needle hub, indicating inadvertent dural puncture. The needle was partially withdrawn and a lack of resistance to injection confirmed before injection of morphine. Following injection, myoclonus of the tail was observed throughout surgery, continuing after atracurium administration. Following surgery, the propofol infusion was reduced from 0.3 to 0.1 mg kg^-1 minute^-1 to encourage spontaneous ventilation after confirmation of neuromuscular function. Spontaneous ventilation, swallow and palpebral reflexes did not return. The following treatments were unsuccessful in eliciting spontaneous ventilation: allowing end-tidal CO₂ to increase [up to 60 mmHg (8 kPa)], reducing inspired oxygen fraction to 0.4, injection of neostigmine and glycopyrrolate, and stopping propofol delivery. Three doses of butorphanol (each 0.5 mg kg^-1 IV) were given 30 minutes apart to antagonize the effects of morphine as it was suspected that inadvertent intrathecal injection had been performed. Butorphanol administration was associated with return of spontaneous ventilation, palpebral and swallow reflexes, and full recovery from anaesthesia. Continuous rate infusions of butorphanol and dexmedetomidine were used for 12 hours to treat any residual respiratory depression and provide sedation to manage continued myoclonus. Myoclonus resolved within 24 hours. The dog was discharged 3 days later and suffered no ongoing adverse effects.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 6","pages":"Pages 955-959"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retroperitoneal haematoma after ultrasound-guided ventro-dorsal quadratus lumborum interfascial plane block in two dogs","authors":"K. Fontana,&nbsp;T. Mozzillo,&nbsp;E. Bortolami","doi":"10.1016/j.vaa.2025.08.022","DOIUrl":"10.1016/j.vaa.2025.08.022","url":null,"abstract":"","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 6","pages":"Page 976.e3"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145371425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenging peri-anaesthetic management in a one-day-old dog undergoing diaphragmatic hernia repair","authors":"L. Tucci,&nbsp;E. Savio,&nbsp;M. Cecchetto,&nbsp;P. Rocchi,&nbsp;F. Cinti,&nbsp;E. Bortolami","doi":"10.1016/j.vaa.2025.08.025","DOIUrl":"10.1016/j.vaa.2025.08.025","url":null,"abstract":"","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 6","pages":"Page 976.e3"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145371458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burnout among veterinary anaesthesia specialists: time to ‘rock the boat’ (part 1)","authors":"Hamaseh Tayari ,&nbsp;Derek Flaherty ,&nbsp;Alex Dugdale ,&nbsp;Rachel Bennett ,&nbsp;Adam Auckburally","doi":"10.1016/j.vaa.2024.10.139","DOIUrl":"10.1016/j.vaa.2024.10.139","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the prevalence of burnout among veterinary anaesthesia specialists and explore correlations with sociodemographic variables.</div></div><div><h3>Study design</h3><div>Cross-sectional, online, anonymous, voluntary survey.</div></div><div><h3>Population</h3><div>A total of 530 worldwide veterinary anaesthesia specialists affiliated to American (ACVAA) and/or European (ECVAA) Veterinary Anaesthesia and Analgesia Colleges.</div></div><div><h3>Methods</h3><div>An electronic questionnaire, incorporating the Maslach Burnout Inventory-Human Services Survey for Medical Personnel [MBI-HSS (MP)] and a sociodemographic questionnaire, was used.</div><div>The MBI-HSS (MP) assessed the three burnout dimensions: emotional exhaustion (EE), depersonalization (DP) and personal accomplishment (PA) using 22 questions, each with a 7-point Likert-type scale answer option, to compute a total score for each dimension. Thresholds for high levels of EE ≥ 27, DP ≥ 10 and for low level of PA ≤ 33. Responders were categorized as high risk for burnout with EE ≥ 27 and DP ≥ 10, and as having burnout syndrome with EE ≥ 27, DP ≥ 10 and PA ≤ 33. Data were investigated with descriptive statistical and regression analysis; <em>p</em>-value &lt; 0.05.</div></div><div><h3>Results</h3><div>Participation rate was 54% (286/530 Diplomates); 65% were identified as women; mean age was 44 years; 59% were married/civil partnership; 52% were ACVAA affiliated; 50% were working in North America; and 51% in academia. The prevalence of high risk for burnout was 42.6% (122/286), and for burnout syndrome was 24.5% (70/286). Number of hours worked per week positively correlated with EE (<em>p</em> &lt; 0.0001) and DP (<em>p</em> = 0.02). Out-of-hours duty positively correlated with EE (<em>p</em> = 0.01) and DP (<em>p</em> = 0.04) and negatively correlated with PA (<em>p</em> = 0.04). Higher burnout prevalence was identified among younger Diplomates, those working ≥ 40 hours per week, in academia/research, and in North America.</div></div><div><h3>Conclusions and clinical relevance</h3><div>Concerted effort is required to address the unacceptably high risk of developing burnout and burnout syndrome observed among ACVAA/ECVAA Diplomates.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 6","pages":"Pages 850-860"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the ratio of arterial partial pressure of oxygen to inspired oxygen fraction and dynamic compliance following anesthetic induction for predicting postanesthetic hypoxemia in dogs","authors":"Minha Kim,&nbsp;Taehoon Sung,&nbsp;Changhoon Nam,&nbsp;Inhyung Lee,&nbsp;Won-gyun Son","doi":"10.1016/j.vaa.2025.07.003","DOIUrl":"10.1016/j.vaa.2025.07.003","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate correlation between postanesthetic induction ratio of arterial partial pressure of oxygen to inspired oxygen fraction (PaO₂:FIO₂) and dynamic compliance (C_dyn) with postanesthetic hypoxemia [PaO₂ &lt; 80 mmHg (10.7 kPa)] in mechanically ventilated dogs, and to compare PaO₂:FIO₂ and C_dyn for predicting postanesthetic hypoxemia.</div></div><div><h3>Study design</h3><div>Retrospective, single-cohort, observational study.</div></div><div><h3>Animals</h3><div>A total of 168 dogs anesthetized with isoflurane under pressure-controlled ventilation.</div></div><div><h3>Methods</h3><div>Postinduction arterial blood gas (ABG) analysis was performed 5–40 minutes postintubation and following postextubation (room-air). C_dyn values were matched to the nearest postinduction ABG measurement (within 15 minutes). PaO₂:FIO₂ and C_dyn values were categorized using thresholds of 300 mmHg (40.0 kPa) and 400 mmHg (53.3 kPa), and 1.0 and 1.5 mL cmH₂O⁻¹ kg^-1. Linear-by-linear association was used to evaluate PaO₂:FIO₂ and C_dyn with the prevalence of postanesthetic hypoxemia. Diagnostic accuracy of these variables was assessed using receiver operating characteristic (ROC) curve analysis. Optimal cut-off values for distinguishing hypoxemia were determined using the empirical quantile bootstrap method (fixed sensitivity of 95%).</div></div><div><h3>Results</h3><div>Postanesthetic hypoxemia was observed in 22/168 dogs. Lower postinduction PaO₂:FIO₂ (<em>p</em> = 0.033) and C_dyn (<em>p</em> = 0.002) values were associated with a significantly higher prevalence of postanesthetic hypoxemia. The area under the ROC curve (AUC) of PaO₂:FIO₂ {0.696 [95% confidence interval (CI): 0.599–0.807]} and C_dyn [0.716 (95% CI 0.602–0.824)] exhibited good (AUC 0.6–0.7) to satisfactory (AUC 0.7–0.8) diagnostic accuracy, with no significant difference between variables (<em>p</em> = 0.432). Optimal cut-off values were 332.80 mmHg (44.4 kPa) (95% CI 274.41–374.52 mmHg, 36.6–49.9 kPa) for PaO₂:FIO₂ and 1.01 (95% CI 0.86–1.13) mL cmH₂O⁻¹ kg^-1 for C_dyn.</div></div><div><h3>Conclusions and clinical relevance</h3><div>Postanesthetic hypoxemia was more frequently observed in dogs with low postinduction PaO₂:FIO₂ and C_dyn. These variables had good to satisfactory diagnostic accuracy.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 6","pages":"Pages 794-802"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of a transdermal eutectic lidocaine/prilocaine cream and subcutaneous lidocaine injection prior to jugular vein catheterization in horses: a randomized crossover study","authors":"Biancia Amiet ,&nbsp;Joanne Rainger ,&nbsp;Steven Zedler ,&nbsp;Allison Stewart ,&nbsp;Solomon Woldeyohannes ,&nbsp;Wendy Goodwin","doi":"10.1016/j.vaa.2025.06.009","DOIUrl":"10.1016/j.vaa.2025.06.009","url":null,"abstract":"<div><h3>Objective</h3><div>To compare horses’ aversive behavioural responses to the application of 5% prilocaine/lidocaine eutectic mixture of local anaesthetics (EMLA) cream <em>versus</em> subcutaneous infiltration of 2% lidocaine, followed by jugular vein catheterization.</div></div><div><h3>Study design</h3><div>Blinded, randomized study.</div></div><div><h3>Animals</h3><div>A group of 26 university-owned research horses.</div></div><div><h3>Methods</h3><div>Each horse received both treatments at opposite jugular sites with ≥ 12 hours between procedures. One randomly assigned jugular site received 1 g cm^-2 of 5% EMLA cream 60 minutes before catheterization, while the contralateral site received 1.5 mL of 2% lidocaine subcutaneously 15 minutes prior. A 14 gauge catheter was introduced percutaneously and maintained for 20 minutes. A total of four blinded evaluators scored aversive behaviours during treatment application and catheterization using a simple descriptive scale (SDS). Treatment sites were assessed for erythema, blanching, or pain immediately after application and at 20 minutes and 24 hours post-catheter removal. Stratified multivariate Mann–Whitney <em>U</em> tests compared SDS values with significance at <em>p</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>Horses showed significantly lower SDS scores during EMLA application <em>versus</em> lidocaine injection (0.3 ± 0.3 and 0.5 ± 0.4, respectively; <em>p</em> = 0.012). However, during catheterization, horses treated with lidocaine had lower SDS scores than those treated with EMLA (0.4 ± 0.4 and 0.8 ± 0.5, respectively; <em>p</em> = 0.006), although this difference was not significant when corrected for catheter placement side (<em>p</em> = 0.077). Neither treatment caused adverse effects at application sites.</div></div><div><h3>Conclusions and clinical relevance</h3><div>The application of 5% EMLA cream was well tolerated in horses and may provide an alternative to subcutaneous infiltration of lidocaine prior to jugular vein catheterization in horses.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 6","pages":"Pages 933-940"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}