Vascular MedicinePub Date : 2025-02-01Epub Date: 2025-01-01DOI: 10.1177/1358863X241309832
Anu Aggarwal, A Phillip Owens, Scott J Cameron
{"title":"Platelet pals: How blood cells shape the future of the aorta.","authors":"Anu Aggarwal, A Phillip Owens, Scott J Cameron","doi":"10.1177/1358863X241309832","DOIUrl":"10.1177/1358863X241309832","url":null,"abstract":"","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":" ","pages":"48-49"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vascular MedicinePub Date : 2025-02-01Epub Date: 2024-12-03DOI: 10.1177/1358863X241298926
Muhammad Yogi Pratama, Benjamin King, Katherine A Teter, Christina Bi, Natalie Presedo, Keerthi B Harish, Catarina Santos Giardinetto, Sheehan Belleca, Ethan Chervonski, Thomas S Maldonado, Bhama Ramkhelawon
{"title":"Altered platelet phenotype in patients with type II endoleaks following abdominal aortic aneurysm repair.","authors":"Muhammad Yogi Pratama, Benjamin King, Katherine A Teter, Christina Bi, Natalie Presedo, Keerthi B Harish, Catarina Santos Giardinetto, Sheehan Belleca, Ethan Chervonski, Thomas S Maldonado, Bhama Ramkhelawon","doi":"10.1177/1358863X241298926","DOIUrl":"10.1177/1358863X241298926","url":null,"abstract":"<p><strong>Background: </strong>Endovascular abdominal aortic aneurysm repair (EVAR) is a preferred surgery to prevent aneurysm sac enlargement and minimize the risk of life-threatening rupture in patients with AAA. Serious complications of type II endoleaks following EVAR can cause sac expansion and increase rupture risk. This study focused on evaluating clinical and blood characteristics in patients with type II endoleaks to refine our understanding of systemic fluctuations associated with unsuccessful EVAR.</p><p><strong>Methods: </strong>This retrospective study included 146 patients with AAA who underwent primary elective endovascular procedures (EVAR/fEVAR) between 2013 and 2021. Clinical characteristics, complete blood count (CBC) and imaging data were analyzed from patients who did and did not develop type II endoleaks.</p><p><strong>Results: </strong>Mean platelet volume (MPV) was significantly increased in patients who developed type II endoleaks after EVAR. Receiver operating characteristic analysis showed that MPV has a satisfactory discriminatory performance in distinguishing post-EVAR patients who developed type II endoleaks, yielding an area under the curve (AUC) value of 0.64. A risk stratification panel incorporating MPV, type II diabetes history, and administration of dual antiplatelet therapies yielded an AUC of 0.70 and predicted an endoleak-free survival rate with a hazard ratio of 2.94. A nomogram revealed that MPV had the highest scoring weight among all significant variables.</p><p><strong>Conclusion: </strong>Patients with type II endoleaks following EVAR have elevated MPV indicative of different phenotypes of circulating platelets. MPV presents an attractive predictive criteria for assessing the occurrence of type II endoleaks in patients with AAA.</p>","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":" ","pages":"38-47"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vascular MedicinePub Date : 2025-02-01Epub Date: 2024-10-17DOI: 10.1177/1358863X241288139
Daniel K Sweet, P Daniel Patterson, Steven Reis, Dave Hostler
{"title":"Changes in the reactive hyperemia index after continuous and interval exercise.","authors":"Daniel K Sweet, P Daniel Patterson, Steven Reis, Dave Hostler","doi":"10.1177/1358863X241288139","DOIUrl":"10.1177/1358863X241288139","url":null,"abstract":"<p><strong>Introduction: </strong>High-intensity interval exercise (HIIE) is more effective than moderate-intensity interval exercise (MICE) for improving macrovascular function (e.g., flow-mediated dilation), but less is known regarding the effect of HIIE on microvascular function. We used peripheral artery tonometry to measure the reactive hyperemia index (RHI) and examine the acute effects of HIIE and MICE on microvascular function.</p><p><strong>Methods: </strong>Ten healthy participants (50% men, age: 26 ± 5 years, mass: 75.6 ± 15.1 kg, height: 170 ± 10 cm, body mass index: 26.0 ± 3.1 kg∙m<sup>-2</sup>) performed single bouts of HIIE and MICE cycling on separate occasions. The MICE protocol was 20 min at 60% of maximum power output. The HIIE protocol was a 12-min warm up at 50% of maximum power output immediately followed by an 8-min Tabata protocol where participants alternated between cycling at ⩾ 100% max power (20 sec) and rest (10 sec). The RHI was measured before, immediately after, and 1 h after exercise and compared by two-way repeated measures analysis of variance (condition [MICE, HIIE] and time [pre-, post-, and 1-h postexercise]).</p><p><strong>Results: </strong>Compared to baseline, RHI increased 1 h after MICE only (<i>p</i> = 0.02). Heart rate was higher during MICE at 5 and 10 min (<i>p</i> = 0.02) and higher during HIIE at min 20 (<i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>Within a sample of healthy adults, the RHI was improved 1 h after a single session of MICE but not HIIE. Future research is needed to determine the significance of the differential effects of exercise regimens on the macro- and microvasculature.</p>","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":" ","pages":"3-9"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mid-term effect of customized graduated elastic compression stockings for managing occupational edema: A randomized controlled trial.","authors":"Sheng-Xing Wang, Wen-Tao Yang, Zhen-Yi Jin, Jia-Hao Wen, Hua-Liang Ren, Ying Xiong, Xiao-Ming Tao, Chun-Min Li","doi":"10.1177/1358863X241290801","DOIUrl":"10.1177/1358863X241290801","url":null,"abstract":"<p><strong>Introduction: </strong>This study compared the effectiveness of customized graduated elastic compression stockings (c-GECS) based on individual lower-leg parameter models with standard graduated elastic compression stockings (s-GECS) in patients with occupational edema (OE).</p><p><strong>Methods: </strong>A single-blind, randomized controlled trial was conducted with 70 patients with OE, randomly assigned to the c-GECS or s-GECS group. Follow-up assessments were performed at 1 and 3 months. Primary outcomes comprised visual analog scale scores (1-10) for lower-limb symptoms and comfort level of GECS. Secondary outcomes included GECS usage duration, calf volume, and interface pressure at B and C points (B: minimal ankle circumference point; C: maximum calf circumference point).</p><p><strong>Results: </strong>Both groups exhibited significant improvements in pain, heaviness, and swelling symptoms at the 1- and 3-month follow up. At the 3-month follow up, the c-GECS group showed significantly superior improvement in symptoms. Comfort assessment revealed that c-GECS (16.2 ± 2.9) provided significantly greater comfort than s-GECS (13.6 ± 3.2) (<i>p</i> < 0.001). However, the two groups showed no significant difference in GECS wear duration. At 3 months, the c-GECS group showed superior maintenance of stocking tension at point B (<i>p</i> = 0.018). Both types of GECS significantly reduced calf volume at both time points, with no notable difference between the groups.</p><p><strong>Conclusion: </strong>c-GECS effectively alleviated pain, heaviness, and swelling symptoms in patients with OE. Although c-GECS did not exhibit a clear advantage in reducing calf volume as compared to s-GECS, it provided more stable and enduring pressure, enhanced the overall fit of GECS, and improved comfort during wear. <b>Chinese Clinical Trial Registry No. ChiCTR2100042894.</b></p>","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":" ","pages":"50-57"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vascular MedicinePub Date : 2025-02-01Epub Date: 2024-12-23DOI: 10.1177/1358863X241302751
Elmira Javanmardi, Ross A Okazaki, Naomi M Hamburg
{"title":"Contemporary insights into the management of pulmonary embolism in women.","authors":"Elmira Javanmardi, Ross A Okazaki, Naomi M Hamburg","doi":"10.1177/1358863X241302751","DOIUrl":"10.1177/1358863X241302751","url":null,"abstract":"","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":" ","pages":"76-78"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vascular MedicinePub Date : 2025-02-01Epub Date: 2024-10-27DOI: 10.1177/1358863X241291450
Mateja Kaja Jezovnik, Pavel Poredos, Peter Poredos
{"title":"Benefits of prophylactic carotid revascularization in patients with asymptomatic carotid artery stenosis undergoing coronary artery bypass surgery: A narrative review.","authors":"Mateja Kaja Jezovnik, Pavel Poredos, Peter Poredos","doi":"10.1177/1358863X241291450","DOIUrl":"10.1177/1358863X241291450","url":null,"abstract":"<p><p>Patients undergoing coronary artery bypass grafting (CABG) are at increased risk of perioperative stroke. Carotid atherosclerosis has been identified as an independent risk factor for stroke during and in the early postoperative period of cardiac surgery. However, the pathogenesis of peri-CABG stroke is multifactorial and frequently involves other noncarotid causes, such as cardiac emboli and aortic atheroma. Therefore, routine population-wide screening of carotid stenosis is not recommended, but target screening of patients at high risk of carotid-related perioperative stroke can have benefits. Carotid duplex sonography is recommended as an initial screening tool. Elimination of carotid stenosis before cardiac surgery is indicated in patients in whom carotid atherosclerosis is suspected to be the primary contributor to perioperative stroke. In patients with advanced carotid atherosclerosis, an individualized revascularization approach, including simultaneous or staged procedures, is advocated. The prevailing consensus is that synchronous surgery is safer than staged procedures. Carotid artery stenting represents a less invasive alternative, but its role in high-risk patients requires further investigation. In conclusion, the risk of perioperative stroke in patients undergoing CABG involves different factors, and carotid artery stenosis is involved in its pathogenesis only in some patients. Therefore, individualized approaches and careful consideration of patient risk factors are essential in determining the need for carotid screening and revascularization before CABG.</p>","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":" ","pages":"93-102"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vascular MedicinePub Date : 2025-02-01Epub Date: 2024-12-23DOI: 10.1177/1358863X241306354
Kevin P Cohoon, Stanislav Henkin, Roger T Tomihama, Sneha E Thomas, Mateo Porres-Aguilar, Nichole E Brunton, Deborah Hornacek, Eric A Secemsky
{"title":"Implementing the 2024 ACC/AHA Multisocietal PAD guidelines into clinical practice: Key changes from the 2016 guidelines.","authors":"Kevin P Cohoon, Stanislav Henkin, Roger T Tomihama, Sneha E Thomas, Mateo Porres-Aguilar, Nichole E Brunton, Deborah Hornacek, Eric A Secemsky","doi":"10.1177/1358863X241306354","DOIUrl":"10.1177/1358863X241306354","url":null,"abstract":"","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":" ","pages":"110-113"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vascular MedicinePub Date : 2025-02-01Epub Date: 2024-12-23DOI: 10.1177/1358863X241305093
Bhavraj Khalsa, Meena Archie, Babak Nazer, Mahmood K Razavi
{"title":"Noninvasive therapeutic ultrasound to increase perfusion in chronic limb-threatening ischemia: An early feasibility study.","authors":"Bhavraj Khalsa, Meena Archie, Babak Nazer, Mahmood K Razavi","doi":"10.1177/1358863X241305093","DOIUrl":"10.1177/1358863X241305093","url":null,"abstract":"<p><strong>Background: </strong>Preclinical studies have demonstrated that therapeutic ultrasound (TUS) increases perfusion in peripheral artery disease (PAD). This pilot study assessed the safety and effectiveness of a noninvasive TUS device in patients with advanced PAD.</p><p><strong>Methods: </strong>A phased array of TUS transducers was fabricated on a wearable sleeve, designed to sonicate the posterior and anterior tibial arteries (and their collaterals) at the calf level. Twelve patients with PAD (Rutherford classes 3-5) were enrolled in a single-arm study in which they underwent 30-40 daily 90-minute TUS sessions to the diseased limb. Changes in pedal flow and tissue oxygenation (StO<sub>2</sub>) were measured by laser speckle and spatial frequency domain imaging, respectively. A subset of five patients underwent evaluation by laser Doppler, transcutaneous oximetry (TcPO<sub>2</sub>), and quality of life questionnaires (Vascular Quality of Life Questionnaire [VascuQoL] and the Walking Impairment Questionnaire [WIQ]).</p><p><strong>Results: </strong>Eleven out of 12 enrolled patients completed the study. During 90-minute TUS sessions pedal flow improved by 180% (<i>p</i> < 0.001) on laser speckle imaging, and 18% (<i>p</i> = 0.12) on laser Doppler. Tissue oxygenation improved by 18% (<i>p</i> = 0.43) on TcPO<sub>2</sub> and by 6% (<i>p</i> = 0.097) on StO<sub>2</sub>. After all sessions, tissue oxygenation improved by 17% (<i>p</i> = 0.020) on StO<sub>2</sub>, without significant changes in laser Doppler (+39%, <i>p</i> = 0.41) or TcPO<sub>2</sub> (-3%, <i>p</i> = 0.70), which was largely in the normal range (56 ± 15 mmHg) at baseline. VascuQoL improved by 2.4 points (14%, <i>p</i> = 0.080) and WIQ improved by 8.2 points (11%, <i>p</i> = 0.053).</p><p><strong>Conclusions: </strong>TUS for patients with symptomatic PAD was safe and well tolerated. Most metrics of tissue perfusion and oxygenation improved, but future sham-controlled studies are needed and planned.</p>","PeriodicalId":23604,"journal":{"name":"Vascular Medicine","volume":" ","pages":"20-26"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}