Veterinary dermatology最新文献

{"title":"Treatment of Canine Pemphigus Foliaceus, Pemphigus Vulgaris and Mucous Membrane Pemphigoid With Oclacitinib: A Retrospective Analysis of 21 Cases.","authors":"Breanna L Scranton, Lara M Tomich, Andrea T H Lam, Verena K Affolter, Catherine A Outerbridge","doi":"10.1111/vde.70078","DOIUrl":"10.1111/vde.70078","url":null,"abstract":"<p><strong>Background: </strong>This study was performed to retrospectively evaluate the efficacy of oclacitinib (OC) (Apoquel; Zoetis) as a treatment option for pemphigus foliaceus (PF), pemphigus vulgaris (PV) and mucous membrane pemphigoid (MMP).</p><p><strong>Objective: </strong>To determine if OC can reduce or replace the corticosteroid use in dogs with PF, PV and MMP.</p><p><strong>Animals: </strong>There were no animal subjects.</p><p><strong>Procedure: </strong>Multicentre retrospective study reviewing medical records from two institutions for dogs diagnosed with PF, PV or MMP and prescribed OC between 2014 and 2025.</p><p><strong>Results: </strong>Twenty-one dogs diagnosed with PF, PV or MMP via histopathological results were included. OC alone was effective in eight of 18 PF dogs at a median dose of 0.65 mg/kg/day per os (range 0.5-1.9 mg/kg/day p.o.). Five dogs reached clinical remission, and three reached partial remission. One PV dog and the MMP dog each reached clinical remission with OC alone at 0.7 mg/kg/day and 0.24 mg/kg every other day, respectively. OC was a corticosteroid-sparing agent or adjunctive therapy in seven of 18 PF dogs at a median dose of 0.6 mg/kg/day (range 0.4-2.4 mg/kg/day). One PV dog reached partial remission at OC 1.9 mg/kg/day and prednisone 1.8 mg/kg/day yet died from pancreatitis. OC was ineffective in three of 18 PF dogs at a median dose of 1.0 mg/kg/day p.o. (range 0.9-1.2 mg/kg/day p.o.). Statistical significance was not analysed.</p><p><strong>Conclusions and clinical relevance: </strong>OC is an effective sole therapeutic agent or adjunctive therapy in a subset of dogs with PF, PV or MMP. The long-term safety of higher doses of OC is unknown.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"522-529"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Analysis of Seasonal Variations in Intradermal Test Reactivity and Serum Allergen-Specific Immunoglobulin E in Dogs With Atopic Dermatitis.","authors":"Jade Faucher, Kim R Love, Amanda R Quinn, Petra Bizikova","doi":"10.1111/vde.70081","DOIUrl":"10.1111/vde.70081","url":null,"abstract":"<p><strong>Background: </strong>In dogs with atopic dermatitis (AD), allergen testing is often timed to pollen exposure. However, data on seasonal effects on intradermal testing (IDT) and allergen-specific immunoglobulin (Ig)E serology (SAT) are limited.</p><p><strong>Objectives: </strong>To evaluate the seasonal effects on IDT and SAT results in dogs with AD by comparing aeroallergen test positivity across four seasons within the same cohort.</p><p><strong>Animals: </strong>Twenty-six client-owned dogs with nonseasonal AD (six) and AD with seasonal pattern (20).</p><p><strong>Materials and methods: </strong>In this prospective longitudinal study, dogs underwent repeated IDT and SAT using two commercial assays during spring, summer, autumn and winter. Seasonal differences in overall and allergen group-specific positivity were analysed using nonparametric statistics and mixed-effects and generalised estimating equation models.</p><p><strong>Results: </strong>There was modest seasonal variation in overall (p = 0.004) and pollen-specific reactions (p = 0.005) on IDT, with autumn having the highest positivity rates. This pattern was seen only in dogs with a seasonal component to their AD (p = 0.007). Grass and weed allergens had higher odds of testing positive in autumn (odds ratio [OR] = 2.696, p = 0.032 and OR = 2.026, p = 0.034, respectively), while other allergens showed no consistent seasonal differences. No significant seasonal differences were detected in SAT, although subtle effects could have been missed owing to the sample size and conservative statistical adjustments. Disease duration did not influence seasonal testing patterns.</p><p><strong>Conclusions and clinical relevance: </strong>These findings suggest that, until further data are available, allergen testing in dogs, especially those with seasonal AD, may be optimally timed later in the season (autumn) to increase the likelihood of positive results.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"511-521"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Case Series Reporting the Clinical Efficacy and Adverse Events of Oclacitinib Administration for Skin Disease in 238 Cats.","authors":"Marlyse R Wehber, Melissa C Eisenschenk, Amanda J Young, Sandra N Koch","doi":"10.1111/vde.70077","DOIUrl":"10.1111/vde.70077","url":null,"abstract":"<p><strong>Background: </strong>Off-label oclacitinib use for feline dermatoses management is increasing despite the paucity of data regarding optimal dose and adverse events (AEs).</p><p><strong>Objective: </strong>Review AEs, clinical efficacy, and dose regimens in cats prescribed oclacitinib.</p><p><strong>Materials and methods: </strong>Retrospective case series of 238 privately owned cats prescribed oclacitinib for dermatological disease. Signalment, history, laboratory abnormalities, oclacitinib dosage (mg/kg/day), treatment duration and AEs using a modified Naranjo Adverse Drug Reaction Probability Scale were retrieved from medical records spanning August 2014 to May 2024. Clinical efficacy was estimated using a pruritus Visual Analogue Scale and medical record lesional descriptions; categorised as complete, partial or no response.</p><p><strong>Results: </strong>The mean (x̄) initial dosage prescribed was 1.89 mg/kg/day. Monotherapy controlled clinical signs in 140 of 238 cats (59%), including 83 of 140 cats (59%) on twice daily (x̄ = 1.85 mg/kg/day) and 57 of 140 cats (41%) on once daily administration (x̄ = 1.05 mg/kg/day). The median treatment duration was 271.5 days (range 1 day-7.5 years). Main diagnoses successfully managed included feline atopic skin syndrome (61%) and pemphigus foliaceus (29%). Thirty-three 'definite' or 'probable' AEs were observed in 32 of 238 cats including: neutropaenia 6.3% (n = 15), gastrointestinal 4% (n = 9), lethargy 1.7% (n = 4), infection 0.8% (n = 2), hyperactivity 0.4% (n = 1), elevated alanine transaminase 0.4% (n = 1) and elevated creatinine 0.4% (n = 1).</p><p><strong>Conclusions and clinical relevance: </strong>Off-label oclacitinib administration in cats appeared to be well-tolerated and effective with AEs typically mild, responsive to dose reduction, and similar to those reported in dogs.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"557-566"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microarray Gene Expression Analysis of Lesional Skin in Canine Vesicular Cutaneous Lupus Erythematosus (VCLE).","authors":"Treasa Clifford, Lauren W Stranahan, Dominique J Wiener, M Kelly Keating, Renato Leon, Frane Banovic","doi":"10.1111/vde.70084","DOIUrl":"10.1111/vde.70084","url":null,"abstract":"<p><strong>Background: </strong>Vesicular cutaneous lupus erythematosus (VCLE) is a rare autoimmune disease in dogs and is considered the canine counterpart of human subacute cutaneous lupus erythematosus (SCLE). However, the molecular mechanisms underlying VCLE remain incompletely defined.</p><p><strong>Objective/hypothesis: </strong>To characterise gene expression changes in lesional skin from dogs with VCLE and identify immune pathways involved in disease pathogenesis.</p><p><strong>Animals: </strong>Six client-owned dogs with clinically and histopathologically confirmed VCLE, and five healthy control dogs.</p><p><strong>Materials and methods: </strong>Formalin-fixed, paraffin-embedded lesional and control skin samples were analysed using the NanoString nCounter Canine Immuno-Oncology Panel, targeting 780 immune-related genes. Data were normalised using geNorm-selected housekeeping genes. Differential expression, cell type profiling and pathway enrichment analyses were also performed.</p><p><strong>Results: </strong>Principal component analysis showed clear separation between VCLE and healthy control samples. A total of 491 differentially expressed genes were identified, including 439 upregulated and 52 downregulated genes (p-adj < 0.05). Lesional skin showed marked upregulation of interferon-stimulated genes (CXCL10, IDO1, ISG15, IFIT1), cytotoxic molecules (GZMB, PRF1, FASLG), pro-inflammatory chemokines (CXCL8, CCL3, CCL4) and S100 family markers (S100A12, S100A9, S100A8). Downregulated genes included DLA-DQB1, ERBB4, CCL27, GATA3 and RORC. Cell type profiling demonstrated enrichment of CD8⁺ T cells, cytotoxic T cells, natural killer cells, dendritic cells, macrophages and neutrophils. Pathway enrichment analysis identified activation of interferon signalling, Janus kinase signal transducer and activator of transcription (JAK-STAT) signalling, chemotaxis and cytotoxic immune pathways.</p><p><strong>Conclusions and clinical relevance: </strong>VCLE lesions feature a dominant interferon-stimulated gene signature, with downstream activation of JAK-STAT signalling and cytotoxic lymphocyte-mediated immune responses, suggesting that interferon and JAK-STAT signalling are potential therapeutic targets.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"478-487"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147875895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Invasive Opportunistic Fungal Infections in Dogs Receiving Ciclosporin for Immune-Mediated Diseases: A Case-Control Study.","authors":"Paola Orlandini, Erika Carli, Laura Ventura, Patrizia Danesi, Laura Berto, Carolina Mendes, Michela De Lucia","doi":"10.1111/vde.70075","DOIUrl":"10.1111/vde.70075","url":null,"abstract":"<p><strong>Background: </strong>Cutaneous opportunistic invasive fungal infections (OIFIs) are mainly reported in immunosuppressed dogs, especially those receiving ciclosporin (CsA). Studies investigating factors other than CsA that favour cutaneous OIFIs in dogs are lacking.</p><p><strong>Hypothesis/objectives: </strong>To identify host factors, clinicopathological data, and therapeutic regimens associated with the development of cutaneous OIFIs in dogs receiving CsA for immune-mediated diseases.</p><p><strong>Animals: </strong>Client-owned dogs treated with CsA, with or without systemic glucocorticoids (GCs) for various immune-mediated diseases. Dogs were classified as cases if they had developed cutaneous OIFIs during CsA treatment, or as controls if they had not.</p><p><strong>Materials and methods: </strong>Cases and controls were matched based on the immune-mediated disease and the duration of CsA treatment. Signalment, anamnestic and pertinent clinical data as well as selected laboratory parameters, including blood cell count, neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-monocyte ratio (NMR), C-reactive protein, haptoglobin, total globulins and immunoglobulin (Ig)G and IgM serum levels, were retrospectively collected and analysed.</p><p><strong>Results: </strong>Eight OIFI-affected dogs were matched with 20 control dogs. Among the examined variables, only higher neutrophil count and neutrophil ratios (NLR, NMR) were significantly associated with cutaneous OIFIs.</p><p><strong>Conclusions and clinical relevance: </strong>No significant associations were observed between host factors, treatment regimens, and OIFI development in dogs receiving CsA. Further research is needed to clarify the role of GCs and to evaluate NLR and NMR as monitoring tools in immunosuppressed dogs.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"500-510"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotic Engraftment and Suppression of Canine Otitis Externa Pathogens by Probiotic Ear Drops.","authors":"Marta Salichs, Shea Beasley, Hanne Gagroo, Alix Simons, Tim Henkens, Josep Homedes, Ingmar Claes","doi":"10.1111/vde.70080","DOIUrl":"10.1111/vde.70080","url":null,"abstract":"<p><strong>Background: </strong>Lactobacillaceae have shown promise with their potential to outcompete pathogens and restore a healthy microbial balance in otitis externa (OE).</p><p><strong>Hypothesis/objectives: </strong>This study aimed to evaluate the presence of viable Lactobacillaceae over time and in vitro ability to inhibit growth of common OE pathogens.</p><p><strong>Animals: </strong>Fifteen healthy dogs were enrolled and randomised into five groups (n = 3 per group) to receive six probiotic ear drops containing live Lactiplantibacillus plantarum YUN-V2.0 and Lacticaseibacillus rhamnosus YUN-S1.0.</p><p><strong>Materials and methods: </strong>Ear swabs were taken 24, 48, 72, 96 h and 7 days post single application for culturing. For pathogen inhibition, clinical isolates of Pseudomonas aeruginosa, Staphylococcus pseudintermedius and Malassezia pachydermatis were tested against the probiotic ear drop and antimicrobial disks of florfenicol 30 μg, gentamicin 30 μg, marbofloxacin 5 μg, miconazole 10 μg, neomycin 120 μg and terbinafine 1.5 μg.</p><p><strong>Results: </strong>A relatively basal low abundance of commensal and Lactobacillaceae micro-organisms was detected (1.34 × 10³ colony-forming units [cfu]/mL). At 24 h post-application, Lactobacillaceae increased significantly (2.3 × 10⁶ cfu/mL; p < 0.001), and remained above 10⁵ cfu/mL at 1 week post-application (1.6 × 10⁵ cfu/mL). Lactobacilli demonstrated better growth inhibition of P. aeruginosa than gentamicin and marbofloxacin, and of S. pseudintermedius than gentamicin, neomycin and marbofloxacin. For M. pachydermatis similar growth inhibition versus miconazole and terbinafine was observed.</p><p><strong>Conclusions and clinical relevance: </strong>These results suggest that probiotic strains exhibit excellent retention and can inhibit the growth of S. pseudintermedius, P. aeruginosa, and M. pachydermatis.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"534-540"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Fluorescence Photobiomodulation on Canine Progenitor Epidermal Keratinocytes With and Without Staphylococcus pseudintermedius Colonisation.","authors":"Annette T Lundberg, Amelia White, Linda Archer, Domenico Santoro","doi":"10.1111/vde.70076","DOIUrl":"10.1111/vde.70076","url":null,"abstract":"<p><strong>Background: </strong>Fluorescence photobiomodulation (FPB) is a treatment for canine dermatitis, yet no studies exist assessing its effect on canine keratinocytes in vitro.</p><p><strong>Objectives: </strong>To determine: (i) the anti-inflammatory and antimicrobial effect of FPB on canine progenitor epidermal keratinocytes (CPEK) with and without colonisation by Staphylococcus pseudintermedius (SP); (ii) changes in CPEK viability following FPB exposure; and (iii) SP colony count following FPB exposure.</p><p><strong>Materials and methods: </strong>Keratinocytes were grown in chamber slides, with and without SP, and treated with two, 2 min exposures to FPB. Supernatant was collected at 0, 1, 6, and 24 h post-FPB to evaluate cytokines (interleukin [IL]-2, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, interferon-γ induced protein 10 [IP-10], tumour necrosis factor-α, interferon-γ, keratinocyte chemotactic-like, granulocyte-macrophage colony-stimulating factor, and monocyte chemoattractant protein-1), and host defence peptides (β-defensin 3-like and cathelicidin) secretion. Cell cytotoxicity was assessed via lactate dehydrogenase and adenosine triphosphate assays. The supernatant pellet was collected at 0 and 24 h, resuspended, and plated. Bacterial colonies were counted after 24 h of incubation. Experiments were performed in duplicate and repeated five times.</p><p><strong>Results: </strong>At 6 h post-FPB, IP-10 fluorescence intensity was mildly yet significantly decreased in CPEK+SP (p = 0.04). No other statistically significant differences were found for cytokine, β-defensin, cathelicidin, or SP colony counts. A lack of cytotoxicity was observed post-FPB over a 24 h period.</p><p><strong>Conclusions and clinical relevance: </strong>Fluorescence photobiomodulation may have a mild anti-inflammatory effect on CPEKs colonised by SP in vitro based on the significant decrease in IP-10 production 6 h post-FBP exposure, yet does not affect CPEK cell viability.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"488-495"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Compatibility and Stability of Compounded Otic Solutions Containing Enrofloxacin Over a 20-Day Period.","authors":"Shae Atterberg, Amelia White, Crisanta Cruz-Espindola, Kamoltip Thungrat, Alex Jenkins, Zachary Lough, Dawn Boothe","doi":"10.1111/vde.70085","DOIUrl":"10.1111/vde.70085","url":null,"abstract":"<p><strong>Background: </strong>Compounded otic solutions containing enrofloxacin are commonly used in the management of otitis.</p><p><strong>Hypothesis/objectives: </strong>The study objective was to evaluate the compatibility and stability of enrofloxacin in compounded otic solutions, as determined by physical changes and quantitated strength.</p><p><strong>Materials and methods: </strong>Twelve solutions containing 100 mg/mL enrofloxacin (Baytril 100; Elanco) or 22.7 mg/mL enrofloxacin (Baytril; Elanco) were quantitatively analysed on Day (D)0, D10, D15, and D20. Both concentrations of enrofloxacin were combined with sterile water (Hospira), tris-EDTA (TrizEDTA; Dechra), sterile water and 4 mg/mL dexamethasone sodium phosphate (dexamethasone, Dexium-SP; Bimeda), tris-EDTA and dexamethasone, tris-EDTA with 0.15% ketoconazole (TrizULTRA Keto; Dechra) and dexamethasone, and 1% miconazole nitrate lotion (Covetrus) and dexamethasone. Gross and microscopic evaluation, pH, and temperature were used to assess physical compatibility. Mass spectrometry was used to evaluate precipitate. High-performance liquid chromatography was used to quantitate drug concentration, indicating strength. Initial separation of ingredients indicating lack of homogenous mixing, immediate precipitate formation, and an exothermic reaction deterred drug strength measurement in solutions containing an antifungal.</p><p><strong>Results: </strong>On D10, in solutions containing tris-EDTA, average enrofloxacin concentration decreased 25.4% with 100 mg/mL enrofloxacin, 29.3% with 100 mg/mL enrofloxacin and dexamethasone, 45.6% with 22.7 mg/mL enrofloxacin, and 49.8% with 22.7 mg/mL enrofloxacin and dexamethasone. Precipitate formed in all solutions containing tris-EDTA and filtration of the precipitate did not impact the measured enrofloxacin concentration. Compatibility and stability of enrofloxacin were verified in all solutions containing sterile water.</p><p><strong>Conclusions and clinical relevance: </strong>Clinical use of solutions containing enrofloxacin combined with tris-EDTA or an antifungal is injudicious owing to incompatibility and instability.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"541-548"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence-Based Identification of Common Canine Skin Lesions From Clinical Images.","authors":"Soh-Yoon Kang, Yeong-Hun Kang, Hyun-Jung Kim, Eun-A Huh, Jong-Soo Jeon, Hyun-Su Kim, Min-Sun Kim, Anisha Tiwari, Cheol-Yong Hwang","doi":"10.1111/vde.70083","DOIUrl":"10.1111/vde.70083","url":null,"abstract":"<p><strong>Background: </strong>Accurate evaluation of skin lesions is an essential component of dermatological examination, yet it can be time-consuming and subject to interobserver variability. While artificial intelligence (AI) models have shown reliability in diagnosing specific skin diseases, lesion-level identification remains underexplored in veterinary dermatology.</p><p><strong>Objectives: </strong>To develop and evaluate a convolutional neural network (CNN)-based AI model for the automated identification of four skin lesion types in dogs: erythema, lichenification, alopecia and erosion/ulcer.</p><p><strong>Animals: </strong>Clinical skin images were collected from dogs presented to a veterinary medical teaching hospital.</p><p><strong>Materials and methods: </strong>Four EfficientNet models were independently trained, one for each lesion type. Model performance was evaluated by comparing the prediction results with veterinary surgeon-labelled data, using six metrics: accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and F1 score.</p><p><strong>Results: </strong>All four CNN models achieved an accuracy of > 90%, indicating a reliable performance across all lesion types. The alopecia model yielded the highest accuracy (98.12%) and F1 score (98.18%). The erythema and erosion/ulcer models exhibited balanced performance across all metrics. For the lichenification model, the sensitivity (87.02%) and F1 score (89.88%) were the lowest among the four lesion types.</p><p><strong>Conclusions and clinical relevance: </strong>The CNN-based AI models developed in this study demonstrated validity in identifying common canine skin lesions from clinical images. These models may facilitate rapid and objective dermatological evaluation, supporting clinical diagnosis and lesion monitoring throughout treatment.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"471-477"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Suspected Congenital Hypothyroidism Causing Generalised Alopecia in a Wombat (Lasiorhinus latifrons).","authors":"Amelia Sy Ho, Meng K Siak","doi":"10.1111/vde.70074","DOIUrl":"10.1111/vde.70074","url":null,"abstract":"<p><p>An 18-month-old southern hairy-nosed wombat (Lasiorhinus latifrons) was presented with progressive alopecia. Histopathological investigation revealed atrophic hair follicles in telogen. Thyroid hormone levels were decreased compared to age-matched controls. Treatment with thyroxine improved the haircoat. This case highlights the consideration of congenital endocrinopathies as a cause of noninflammatory alopecia in young wombats.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"496-499"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}