Veterinary dermatology最新文献_第8页

Characterising the expression of the organic cation transporter OCT3 in cutaneous papillomas of dogs. 狗皮肤乳头状瘤中有机阳离子转运体 OCT3 的表达特征。

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-10-02 DOI: 10.1111/vde.13302

Berenice Liyare Sanz Ressel, Gimena Gomez Castro, Eduardo Carlos Mórtola, Adriana Raquel Massone, Claudio Gustavo Barbeito

{"title":"Characterising the expression of the organic cation transporter OCT3 in cutaneous papillomas of dogs.","authors":"Berenice Liyare Sanz Ressel, Gimena Gomez Castro, Eduardo Carlos Mórtola, Adriana Raquel Massone, Claudio Gustavo Barbeito","doi":"10.1111/vde.13302","DOIUrl":"https://doi.org/10.1111/vde.13302","url":null,"abstract":"Background: The identification of the activation of the mammalian target of rapamycin (mTOR) signalling pathway as a frequent molecular event in canine cutaneous papillomas (CPs) has provided the rational foundation to explore novel molecular-targeted therapies. Recent evidence indicates that metformin reduces the size of CPs in mice by inhibiting the mTOR signalling pathway. These effects require the expression of the organic cation transporter 3 (OCT3/SLC22A3), a well-known metformin uptake transporter.Hypothesis/objectives: The aim of the present study was to characterise the expression pattern of the metformin uptake transporter OCT3 in canine samples of CP that have shown activation of the mTOR signalling pathway in order to predict if this hyperplastic epidermal lesion is potentially sensitive to metformin.Methods: The expression of OCT3 was evaluated by immunohistochemical investigation in sections of a previously constructed tissue microarray containing 28 samples of canine CP and compared with that previously evaluated for the mTOR activation marker pS6.Results: OCT3 was highly expressed in the membrane and cytoplasm of the basal and suprabasal epidermal cells in all samples of canine CP. This OCT3 expression was localised at similar epidermal compartments to those observed for pS6.Conclusions and clinical relevance: These results show that canine CPs exhibit the expression of surrogate markers that suggest sensitivity to metformin, such as upregulated OCT3 and pS6 expression. Taken together, these findings provide the rationale for the early assessment of the use of metformin as a mechanism-based therapeutic approach for treating canine patients with persistent or multiple CPs.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A prospective study evaluating the correlation between local weather conditions, pollen counts and pruritus of dogs with atopic dermatitis. 一项前瞻性研究，评估当地天气条件、花粉数量和患有特应性皮炎的狗的瘙痒症之间的相关性。

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-10-01 Epub Date: 2024-06-18 DOI: 10.1111/vde.13268

L Widorn, Y Zabolotski, Ralf S Mueller

{"title":"A prospective study evaluating the correlation between local weather conditions, pollen counts and pruritus of dogs with atopic dermatitis.","authors":"L Widorn, Y Zabolotski, Ralf S Mueller","doi":"10.1111/vde.13268","DOIUrl":"10.1111/vde.13268","url":null,"abstract":"Background: Canine atopic dermatitis (cAD) is a hereditary, generally pruritic and predominantly T-cell-driven inflammatory skin disease, involving an interplay between skin barrier abnormalities, allergen sensitisation and microbial dysbiosis. The individual immunological response is predominantly against environmental allergens, including mite antigens; mould spores; and pollen from grasses, trees and weeds. Airborne pollens show fluctuating patterns during the year.Objective: The aim of this prospective study was to evaluate the influence of local pollen concentrations and weather conditions on the clinical signs of atopic dogs, and to investigate any possible correlations with the results of intradermal testing (IDT).Materials and methods: Thirty-seven privately owned atopic dogs in Bavaria were surveyed from 1 April to 30 November 2021. Owners were asked to record pruritus using a validated Visual Analog Scale (PVAS) score and the weekly medication of their dog. Furthermore, weather data, including pollen count, rainfall, relative humidity, hours of sunshine and temperature from the dog's location were collected daily.Results: Of the evaluated parameters, only humidity and medication scores correlated positively with the PVAS scores of the atopic dogs. There was no correlation between specific pollen counts and PVAS scores of dogs with positive IDT reactions to that pollen.Conclusion and clinical relevance: The outcome of this study highlights the importance of a careful interpretation of positive IDT results in dogs with cAD and questions the validity of airborne pollen trap methodology in representing pollen exposure for dogs at ground level.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"500-507"},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multicentric intermediate-size B-cell lymphoma with epitheliotropism in a Freiberger mare. 一匹弗莱贝格母马患上了多中心中等大小 B 细胞淋巴瘤并伴有上皮细胞增多症。

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-10-01 Epub Date: 2024-06-07 DOI: 10.1111/vde.13270

Inês Berenguer Veiga, Verena K Affolter, Peter F Moore, Päivi de Jesus Maia-Nussbaumer, Vincenz Gerber, Lucia Unger, Martina Dettwiler

引用次数: 0

Subcutaneous fat sclerosis in a domestic short-hair cat. 一只家养短毛猫的皮下脂肪硬化。

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-10-01 Epub Date: 2024-06-03 DOI: 10.1111/vde.13271

Alexandra Dehesa Golding, Luca Pazzini, Edoardo Auriemma, Dario Drudi, Silvia Colombo

引用次数: 0

Comparison of selected cytomorphological features of canine pemphigus foliaceus and superficial pyoderma. 犬丘疹性荨麻疹与表皮脓皮病部分细胞形态学特征的比较。

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-10-01 Epub Date: 2024-06-05 DOI: 10.1111/vde.13267

Tyler S Spriggs, Natalie K Y Gedon, Keith E Linder, Petra Bizikova

{"title":"Comparison of selected cytomorphological features of canine pemphigus foliaceus and superficial pyoderma.","authors":"Tyler S Spriggs, Natalie K Y Gedon, Keith E Linder, Petra Bizikova","doi":"10.1111/vde.13267","DOIUrl":"10.1111/vde.13267","url":null,"abstract":"Background: Cytological detection of acantholytic keratinocytes (acantholytic cells [AC]) helps to identify canine pemphigus foliaceus (cPF) yet AC also occurs in superficial pyoderma (SP), the main differential diagnosis.Hypothesis/objectives: To compare selected cytomorphological features of cPF and SP and to establish cytological diagnostic criteria that could differentiate cPF from SP.Animals: 40 and 51 client-owned dogs with PF and SP, respectively.Materials and methods: Impression smears from cPF (64), impetigo (40) and exfoliative superficial pyoderma (ESP) (17) samples were stained with Romanowsky stain, randomised, blinded and evaluated by two investigators independently. The entire sample was screened (×500 or ×1000 magnification) for round (AC1), boat (AC2) and raft AC, eosinophils and bacteria. Interobserver agreements were calculated.Results: The average number of the 10 highest ×500 fields for AC1 and AC2 was significantly higher in PF than SP (p < 0.0001; Kruskal-Wallis test). Rafts and eosinophils were more common in PF than SP (p < 0.0001; chi-square test), while bacteria were rare in PF (5%; p < 0.0001; chi-square test). Observations between the experienced and novice investigators were highly correlated. An ROC analysis identified five AC1/×500-magnification field as a suitable cut-off value for predicting PF diagnosis. This cut-off value was tested by two additional investigators, who identified sensitivity of 84%-100%, specificity of 95%-97% and accuracy of 95%-96% for the diagnosis of cPF.Conclusions and clinical relevance: Criterion-based impression smear cytological evaluation can provide strong evidence to support the clinical diagnosis. Acantholytic cell morphology varies in cPF and SP, and experience can improve accuracy in cytological differentiation.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"524-535"},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oclacitinib therapy in two cats with refractory proliferative and necrotising otitis externa. 奥克替尼治疗两只患有难治性增生性和坏死性外耳道炎的猫。

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-10-01 Epub Date: 2024-05-31 DOI: 10.1111/vde.13269

Tim Chan, Sandra Nogueira Koch, Samuel Devine, Ekaterina Mendoza-Kuznetsova

引用次数: 0

Efficacy of verdinexor for the treatment of naïve canine epitheliotropic cutaneous T-cell lymphoma: An open-label pilot study. 维丁索治疗初生犬上皮细胞皮肤T细胞淋巴瘤的疗效：一项开放标签试验研究。

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-10-01 Epub Date: 2024-07-29 DOI: 10.1111/vde.13280

Elana M Vlodaver, M Kelly Keating, Willie A Bidot, David S Bruyette, Wayne S Rosenkrantz

{"title":"Efficacy of verdinexor for the treatment of naïve canine epitheliotropic cutaneous T-cell lymphoma: An open-label pilot study.","authors":"Elana M Vlodaver, M Kelly Keating, Willie A Bidot, David S Bruyette, Wayne S Rosenkrantz","doi":"10.1111/vde.13280","DOIUrl":"10.1111/vde.13280","url":null,"abstract":"Background: Verdinexor (Laverdia-CA1; Dechra Veterinary Products), a selective inhibitor of nuclear export, has been utilised for treatment of non-Hodgkin T-cell lymphoma in dogs. However, the efficacy of verdinexor has not been evaluated for cutaneous epitheliotropic T-cell lymphoma (CETL).Hypothesis/objectives: To evaluate the efficacy of verdinexor for the treatment of CETL.Animals: Eight client-owned animals with CETL.Materials and methods: Patients received between 1.28 and 1.45 mg/kg verdinexor per os twice weekly with a minimum of 72 h between doses until disease progression or voluntary withdrawal. Adjunctive therapy with lokivetmab or prednisone was permitted after Day (D)14. Assessment of clinical lesions (canine Response Evaluation Criteria in Solid Tumors [cRECIST v1.0] and novel Canine Epitheliotropic Lymphoma Extent and Severity Index [CELESI]), pruritus (Visual Analog Scale) and treatment efficacy (owner global assessment of treatment efficacy [OGATE]) were evaluated every 14 days for 3 months, then monthly thereafter (mean 70 ± 43.4 days).Results: Seventy-five percent of patients achieved complete response, partial response or stable disease. The mean time to disease progression was 56 ± 41 days. There was a significant reduction (p = 0.026) in total CELESI score when the lowest score for each dog was compared to their score at D0. Verdinexor did not significantly reduce pruritus at any time point (p = 0.45), including when given as a monotherapy or concurrently with lokivetmab ± glucocorticoids. On D28, 75% of owners rated response to treatment as 'fair' to 'excellent'. The most common adverse effects included weight loss, inappetence, vomiting and lethargy.Conclusions and clinical relevance: Verdinexor could be considered a safe, palliative treatment for canine CETL.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"536-546"},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of cytological findings between direct impression smears and adhesive slides in canine superficial bacterial folliculitis. 犬浅表性细菌性毛囊炎直接印模涂片与粘合切片细胞学结果的比较。

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-10-01 Epub Date: 2024-07-29 DOI: 10.1111/vde.13279

M Tully, C Milley, A Bourgeois, W Bidot

{"title":"Comparison of cytological findings between direct impression smears and adhesive slides in canine superficial bacterial folliculitis.","authors":"M Tully, C Milley, A Bourgeois, W Bidot","doi":"10.1111/vde.13279","DOIUrl":"10.1111/vde.13279","url":null,"abstract":"Background: Cutaneous cytological investigation is a valuable tool for the diagnosis of superficial bacterial folliculitis (SBF). Studies comparing tape strips and direct impression (DI) smears have demonstrated that DI may recover more inflammatory cells and nuclear streaming (NS). Adhesive slides (AS) have not been evaluated in cutaneous cytological investigation.Objective: To compare cytological findings between AS and DI for the same lesion in SBF.Animals: Fifteen client-owned dogs with clinical signs suggestive of SBF were enrolled.Materials and methods: Fifty lesions consistent with SBF comprising collarettes, papules and crusts were included. Half of each lesion was sampled using DI and the other half sampled using AS. Papules were sampled sequentially in a randomised order between techniques. Three investigators blinded to the sample pairings read the slides in duplicate. Ten adjacent oil immersion fields were examined. Bacteria were recorded on a quantitative scale, polymorphonuclear cells (PMN), NS and 'miscellaneous' on a qualitative scale, and keratinocytes (KC) on a semiquantitative scale.Results: Significant differences were identified for KC (DI mean 2.5, SD ±0.08; AS mean 3.3, SD ±0.06, p < 0.0001), 'miscellaneous' (DI mean 0.72, SD ±0.03; AS mean 0.83, SD ±0.02 p < 0.0001), NS (DI mean 0.69, SD ±0.03; AS mean 0.56; SD ±0.03, p < 0.0001) and extracellular cocci (DI mean 5.03, ±SD 7.2; AS mean 3.91, ±SD 4.3, p = 0.01).Conclusions and clinical relevance: DI identified more EC cocci and NS, while AS detected more KC and debris. Intra- and interobserver agreement varied, with AS having poorer agreement for several parameters. These results can be used to inform the clinician of the best methodology to use in confirming a diagnosis of SBF.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"492-499"},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conducting a successful diet trial for the diagnosis of food allergy in dogs and cats. 成功开展饮食试验，诊断猫狗的食物过敏症。

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-10-01 Epub Date: 2024-07-02 DOI: 10.1111/vde.13274

Hilary A Jackson, Veronique Dembele

引用次数: 0

Brief communication: Carrier rate, antimicrobial resistance and molecular typing of Staphylococcus aureus and Staphylococcus pseudintermedius in healthy dogs from Morogoro, Tanzania. 简讯：坦桑尼亚莫罗戈罗健康狗体内金黄色葡萄球菌和假中间葡萄球菌的携带率、抗菌药耐药性和分子分型。

IF 1.9 3区农林科学

Veterinary dermatology Pub Date : 2024-10-01 Epub Date: 2024-06-18 DOI: 10.1111/vde.13272

Abdul A S Katakweba, Christine M Iversen, John B Tsaxra, Amandus P Muhairwa, Arshnee Moodley, John E Olsen

{"title":"Brief communication: Carrier rate, antimicrobial resistance and molecular typing of Staphylococcus aureus and Staphylococcus pseudintermedius in healthy dogs from Morogoro, Tanzania.","authors":"Abdul A S Katakweba, Christine M Iversen, John B Tsaxra, Amandus P Muhairwa, Arshnee Moodley, John E Olsen","doi":"10.1111/vde.13272","DOIUrl":"10.1111/vde.13272","url":null,"abstract":"Background: Staphylococcus pseudintermedius and S. aureus are important pathogens in dogs. This study established carrier rates, strain diversity and antimicrobial resistance of these bacteria among healthy dogs in Tanzania.Results: Based on cultures of mouth and perineal swabs, 11.3% and 50.3% of 151 healthy dogs were carriers of S. aureus and S. pseudintermedius, respectively. Only four dogs (3%) carried meticillin-resistant S. aureus (MRSA), while none of the S. pseudintermedius strains were meticillin-resistant. 12 of 19 S. aureus strains tested were resistant to penicillin G, and resistance to enrofloxacin and tetracycline was also commonly detected. The most common resistances in 103 S. pseudintermedius strains tested were to penicillin G (28.2%) and tetracycline (22.3%). S. pseudintermedius strains showed 65 different random amplified polymorphic DNA (RAPD) fingerprints, and S. aureus strains belonged to eight different spa types, including two novel types (t18988 and t18989). MRSA strains carried SCCmec type V.Conclusions and clinical relevance: Healthy dogs in Tanzania were carriers of MRSA at low frequency, and half of the dogs carried S. pseudintermedius with high strain diversity.","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"557-562"},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0