Veterinary dermatology最新文献

{"title":"Toll-like receptor 2 activation induces C-C motif chemokine ligand 5 production in canine keratinocytes.","authors":"Kaho Takahashi, Rina Yoshimatsu, Yuzuki Kaida, Takehiro Hasegawa, Keitaro Ohmori","doi":"10.1111/vde.13330","DOIUrl":"10.1111/vde.13330","url":null,"abstract":"<p><strong>Background: </strong>Toll-like receptor 2 (TLR2) in keratinocytes can be activated by Staphylococcus spp. that are frequently detected on the skin of dogs with atopic dermatitis (AD). C-C motif chemokine ligand 5 (CCL5) produced by keratinocytes has been considered to be involved in the pathogenesis of canine AD (cAD). However, whether TLR2 activation induces CCL5 production in canine keratinocytes remains unclear.</p><p><strong>Hypothesis/objectives: </strong>To elucidate the effect of TLR2 agonists on CCL5 production in canine keratinocytes, possible synergy with interferon (IFN)-γ, interleukin (IL)-13 or IL-4 and underlying mechanisms.</p><p><strong>Materials and methods: </strong>Canine progenitor epidermal keratinocyte (CPEK) cells were stimulated with TLR2 agonists with or without inhibitors of the TLR2 signalling pathway or IFN-γ, a T-helper (Th)1-type cytokine and/or IL-13 or IL-4, a Th2-type cytokine. CCL5 protein concentrations in the culture supernatant were measured by enzyme-linked immunosorbent assay. Additionally, TLR2 mRNA expression was measured by real-time PCR in CPEK cells stimulated with IFN-γ.</p><p><strong>Results: </strong>TLR2 agonists increased CCL5 production in CPEK cells. Inhibitors of the TLR2 signalling pathway suppressed CCL5 production. IFN-γ, but not IL-13 or IL-4, synergistically enhanced TLR2 agonist-induced CCL5 production. IFN-γ partially increased TLR2 mRNA expression in CPEK cells.</p><p><strong>Conclusions and clinical relevance: </strong>TLR2 activation by Staphylococcus spp. may produce CCL5 in canine keratinocytes, thereby recruiting immune cells into the skin of dogs with AD. During the Th1-activated chronic phase of cAD, where TLR2 expression may be partially upregulated, Staphylococcus spp. may exacerbate skin inflammation. Further studies are warranted to determine the clinical significance and mechanisms of skin bacteria-mediated CCL5 production in keratinocytes.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"117-126"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and lesion distribution of atopic dermatitis in small-to-medium breed dogs in Korea.","authors":"Ji-Hye Ryu, Jung-Hun Kang, Yeong-Hun Kang, Min-Sun Kim, Hyun-Jung Kim, Eun-A Huh, Sung-Hoon Kim, Jong-Soo Jeon, Cheol-Yong Hwang","doi":"10.1111/vde.13329","DOIUrl":"10.1111/vde.13329","url":null,"abstract":"<p><strong>Background: </strong>Canine atopic dermatitis (cAD) varies in prevalence and lesion distribution across breeds. In contrast to Western countries, many Asian countries favour small-to-medium dog breeds. However, previous studies have focused primarily on medium-to-large dog breeds.</p><p><strong>Objectives: </strong>To analyse the prevalence and lesion distribution of cAD in common breeds in Korea, focusing on breed-specific characteristics.</p><p><strong>Animals: </strong>Nine small-to-medium breeds (<25 kg body weight) were selected from 331 client-owned dogs with cAD, representing 77% of the total cAD group.</p><p><strong>Materials and methods: </strong>Breeds selected included Maltese, miniature/toy poodle, shih tzu, bichon frise, cocker spaniel, Pomeranian, French bulldog, Yorkshire terrier and Dachshund. The prevalence of these breeds was compared to the registered dog population. Photographs of skin lesions from each dog were reviewed, and the lesion distribution was analysed by breed.</p><p><strong>Results: </strong>Shih tzu, cocker spaniel and French bulldog had a higher prevalence of cAD compared to the registered dog population (p < 0.01). Lesions were most commonly present on the ventral aspects of the body in 51% of shih tzus; lip folds (64%), tail folds (27%) and paws (73%) in French bulldog; and 71% of Dachshunds had dorso-lumbar distribution.</p><p><strong>Conclusions and clinical relevance: </strong>Of the small-to-medium breeds in this study, shih tzu, cocker spaniel and French bulldog had a higher prevalence of cAD compared to the registered dog population, while specific body sites were affected in shih tzu, French bulldog and Dachshund.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"186-195"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy and safety of ilunocitinib and oclacitinib for the control of pruritus and associated skin lesions in dogs with atopic dermatitis.","authors":"Sophie Forster, Annette Boegel, Simona Despa, Candace Trout, Stephen King","doi":"10.1111/vde.13319","DOIUrl":"10.1111/vde.13319","url":null,"abstract":"<p><strong>Background: </strong>Janus kinase inhibitors (JAKi) have been shown to reduce pruritus and improve associated inflammatory skin lesions in canine atopic dermatitis (cAD).</p><p><strong>Objective: </strong>To evaluate the efficacy and safety of ilunocitinib, in comparison to oclacitinib, for the control of cAD in a randomised, blinded trial.</p><p><strong>Animals: </strong>Three-hundred-and-thirty-eight dogs with cAD.</p><p><strong>Materials and methods: </strong>Dogs were randomised to receive oclacitinib (0.4-0.6 mg/kg twice daily for 14 days; then once daily) or ilunocitinib (0.6-0.8 mg/kg once daily), for up to 112 days. Owners assessed pruritus using an enhanced Visual Analog Scale (PVAS). Investigators assessed skin lesions using the Canine Atopic Dermatitis Extent and Severity Index, 4th interaction (CADESI-04).</p><p><strong>Results: </strong>Reduction in pruritus and CADESI-04 scores was similar for both treatment groups from Day (D)0-D14. PVAS scores increased between D14 and D28 for oclacitinib and decreased for ilunocitinib. On D28 to D112, mean PVAS and CADESI-04 scores were significantly lower for ilunocitinib compared to oclacitinib (p ≤ 0.003 and p ≤ 0.023, respectively). On D28 to D112, a greater number of ilunocitinib-treated dogs achieved clinical remission of pruritus (i.e. PVAS score <2). Subjective assessment of overall response was significantly better for ilunocitinib on D28 to D112 (p ≤ 0.002). Both drugs demonstrated similar safety throughout the study.</p><p><strong>Conclusions and clinical relevance: </strong>Ilunocitinib rapidly and safely controlled signs of cAD. Ilunocitinib demonstrated significantly better control of pruritus and skin lesions compared to oclacitinib, with more dogs achieving clinical remission of pruritus.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"165-176"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous epitheliotropic T-cell lymphoma in a sugar glider (Petaurus breviceps).","authors":"Piercarlo Amati, Carla Dedola, Roberta Demontis, Chiara Brachelente","doi":"10.1111/vde.13318","DOIUrl":"10.1111/vde.13318","url":null,"abstract":"<p><p>A 3-year-old male sugar glider presented with pruritus and alopecia primarily affecting the back and neck regions. Dermatologic diagnostics ruled out common causes. Skin biopsies revealed cutaneous epitheliotropic T-cell lymphoma, a rare condition in sugar gliders. Despite treatment, the glider's condition worsened, leading to death. This case highlights the importance of thorough diagnostic evaluation in exotic pets.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"218-221"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of intraepithelial canine melanocytes in different somatic areas.","authors":"Ilaria Porcellato, Adriana Lo Giudice, Monica Sforna, Giuseppe Giglia, Margherita Orlandi, Luca Mechelli, Chiara Brachelente","doi":"10.1111/vde.13322","DOIUrl":"10.1111/vde.13322","url":null,"abstract":"<p><strong>Background: </strong>In humans, the presence of an even distribution of melanocytes within the epidermal basal layer allows for uniform pigmentation in healthy and young individuals. Moreover, despite high variability in skin colours and tones, interindividual melanocyte density variability is low. However, dogs display a high intraindividual pigmentary variability in different anatomical areas.</p><p><strong>Hypothesis/objective: </strong>Data on canine melanocytes, including their distribution and density, are limited. This study aimed to assess melanocyte density across different anatomical areas in dogs of various breeds.</p><p><strong>Materials and methods: </strong>Samples were harvested postmortem from 22 dogs of different breeds and ages. Samples were collected from the following: haired skin (back, ventral abdomen, head and pinnae), oral and conjunctival mucocutaneous junctions, oral mucosa (buccal mucosa, gingiva, palate) and nose. Immunohistochemical investigation using a cocktail containing Melan-A and SOX-10 antibodies was performed to evaluate the melanocytes:keratinocytes ratio (M:K ratio).</p><p><strong>Results: </strong>Variable melanocyte density was recorded in different anatomical areas, with a higher M:K ratio on the eyelid (median: 1:4; interquartile range [IQR]: 1:3.8-1:5.1) and on the nose (median: 1:6.5; IQR: 1:5.2-1:9.6). Lower ratios were observed on the haired skin, particularly on the head (median: 1:113.6; IQR: 1:37.8-1:255.1).</p><p><strong>Conclusions and clinical relevance: </strong>Together with different melanocyte densities in different anatomical areas, dogs showed a high interindividual variability, particularly on haired skin. This finding could be associated with colour phenotype, sun exposure, and breed. Variable densities of melanocytes also might justify different incidence of melanocytic tumours in hyperpigmented breeds and in different somatic areas, as well as provide an increased protective effect in chronically sun-exposed areas.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"127-136"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of phenotypic risk indicators for the development of alopecia X (hair cycle arrest) in Pomeranian dogs in the Netherlands and Belgium.","authors":"Ilse van Hensbergen, Jan van den Broek, Kelly van Amersfort, Annette van der Lee","doi":"10.1111/vde.13326","DOIUrl":"10.1111/vde.13326","url":null,"abstract":"<p><strong>Background: </strong>Alopecia X (AX) is a common noninflammatory alopecic condition of Pomeranian dogs with an unknown cause. While a genetic aetiology is suspected, no current tests can predict the development of this disorder or confirm the aetiology. Therefore, identifying potential risk indicators for the development of AX would be of value in this breed.</p><p><strong>Objectives: </strong>This study aimed to identify risk indicators for AX in Pomeranians in the Netherlands and Belgium.</p><p><strong>Materials and methods: </strong>A retrospective epidemiological study was conducted in the Netherlands and the Dutch-speaking parts of Belgium between March 2022 and August 2023, using an online survey of Pomeranian owners. Variables such as sex, birth season, neutering status, coat type, coat colour, grooming frequency and whether the dog experienced an 'ugly stage' of hair coat growth or not were recorded, along with the presence or absence of alopecia and the age of onset of the condition.</p><p><strong>Results: </strong>Of 234 completed surveys, 211 were eligible for analysis. Statistical analysis with a Cox proportional-hazard model indicated that the risk of developing alopecia was greater for a woolly versus shiny coat and for males versus females.</p><p><strong>Conclusions and clinical relevance: </strong>A woolly hair coat type and male sex were identified as risk indicators for developing AX in Pomeranian dogs in this study.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"196-204"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the in vitro antibiofilm activities of otic cleansers against canine otitis externa pathogens.","authors":"Bhumika F Savaliya, Sorae Kim, Tania Veltman, Darren J Trott","doi":"10.1111/vde.13331","DOIUrl":"10.1111/vde.13331","url":null,"abstract":"<p><strong>Background: </strong>Biofilm production by canine otitis externa (COE) pathogens and resistance development to multiple antimicrobials are commonly reported problems in veterinary practice. The use of adjuvants to disrupt biofilms may be a viable adjunctive therapy.</p><p><strong>Hypothesis/objectives: </strong>To compare the in vitro antibiofilm activity against COE pathogens of three otic cleansers: PHMB-EDTA (poly [hexamethylene] biguanide hydrochloride and disodium edetate), N-acetylcysteine (NAC) and Triz-EDTA.</p><p><strong>Animals/isolates: </strong>Thirty isolates of each species, including Staphylococcus pseudintermedius, Pseudomonas aeruginosa, Streptococcus canis, Proteus mirabilis, Escherichia coli, and Malassezia pachydermatis, were collected from COE cases and stored at -80°C until tested.</p><p><strong>Methods and materials: </strong>Biofilm production was determined by Congo-red agar and microtitre plate-assay methods. Ten of the best biofilm-producing isolates per species were selected to determine minimum biofilm eradication concentration (MBEC) values. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values were determined to compare MBEC/MIC and MBEC/MBC.</p><p><strong>Results: </strong>PHMB-EDTA possessed antibiofilm activity at low concentrations (MBEC range 3.9/2.3-500/300 μg/mL) against all tested COE pathogens. NAC demonstrated antibiofilm activity for all tested bacterial COE pathogens (MBEC range 4,925-19,700 μg/mL); however, most M. pachydermatis isolates exhibited MBEC values >20,000 μg/mL. Triz/EDTA at the highest concentration tested (3,025/19,520 μg/mL) did not demonstrate antibiofilm activity against most COE pathogens except for S. canis (94.5/610 μg/mL).</p><p><strong>Conclusions and clinical relevance: </strong>PHMB-EDTA had intrinsic antibiofilm activity at low concentrations against all COE pathogens. Therefore, it is likely to be a very effective adjuvant when used in conjunction with other antimicrobials for the treatment of COE caused by biofilm-producing pathogens.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"148-158"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of oclacitinib maleate and prednisolone combined therapy for the control of atopic dermatitis in dogs: A controlled clinical trial.","authors":"Tássia Sell Ferreira, Wendy Roldán Villalobos, Vanessa Cunningham Gmyterco, Diogo Simões Fonseca, Marconi Rodrigues de Farias","doi":"10.1111/vde.13327","DOIUrl":"10.1111/vde.13327","url":null,"abstract":"<p><strong>Background: </strong>Canine atopic dermatitis (cAD) is a chronic inflammatory and pruritic dermatopathy requiring a multimodal therapeutic approach.</p><p><strong>Objective: </strong>To assess the effectiveness, safety and cost of oclacitinib and prednisolone treatment in dogs with AD.</p><p><strong>Animals: </strong>Twenty-three client-owned dogs with cAD.</p><p><strong>Materials and methods: </strong>Dogs were randomly assigned to one of two groups: Group 1 received prednisolone (0.5 mg/kg every 24 h) for 7 days, then oclacitinib (0.5 mg/kg) and prednisolone (0.5 mg/kg), were administered alternately with a 1 day pause between each drug, for 7 additional weeks. Group 2 received oclacitinib (0.5 mg/kg every 12 h for 14 days, then every 24 h) for 8 weeks. Assessments included the Canine Atopic Dermatitis Extent and Severity Index, 4th iteration (CADESI-04) and pruritus Visual Analog Scale (PVAS) on Day (D)0, D7, D14, D30, D45 and D60.</p><p><strong>Results: </strong>Both groups showed significant CADESI and PVAS reductions on D7 (p < 0.001). From D14 to D60, mean scores remained stable compared to D7, with no significant differences between groups. Adverse events included two dogs with polyuria and polydipsia, and three with polyphagia in Group 1, all of which resolved by D14. In Group 2, one dog experienced polyphagia, and two had self-limiting vomiting. Three dogs in Group 1 and one dog in Group 2 had mild increases in liver enzyme concentrations.</p><p><strong>Conclusions and clinical relevance: </strong>The combined protocol was effective and safe for managing itch and inflammation over a 60 day period. It had a 73.3% lower cost compared to oclacitinib alone.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"177-185"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localised apolipoprotein A-I amyloidosis arising in a fibroadnexal hamartoma in a dog.","authors":"Tomoaki Murakami, Kenta Owaku, Natsumi Kobayashi, Yoshiyuki Itoh, Miki Hisada, Linden E Craig","doi":"10.1111/vde.13316","DOIUrl":"10.1111/vde.13316","url":null,"abstract":"<p><p>Canine apolipoprotein A-I (ApoA-I) amyloidosis has only been reported as an age-related pulmonary vascular condition. In this report, the authors identified cutaneous ApoA-I amyloidosis within a fibroadnexal hamartoma in a dog. Based on proteomic analysis using mass spectrometry, the mechanism of ApoA-I amyloidogenesis is discussed.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"222-226"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of a commercial formula containing natural antimicrobials versus oral cephalexin or topical chlorhexidine-miconazole therapies for treating superficial pyoderma in dogs.","authors":"Vanessa Cunningham Gmyterco, Fernando Bittencourt Luciano, Lucas André Ludwig, Alberto Gonçalves Evangelista, Tássia Sell Ferreira, Fernanda Borek, Marconi Rodrigues de Farias","doi":"10.1111/vde.13323","DOIUrl":"10.1111/vde.13323","url":null,"abstract":"<p><strong>Background: </strong>Chronic and recurrent pyoderma in dogs is driving a growing interest in natural antimicrobial products that offer minimal adverse effects and avoid antibiotic resistance.</p><p><strong>Objectives: </strong>Evaluate the safety and efficacy of dermatological products with antimicrobial peptides and plant extracts, comparing them to chlorhexidine + miconazole and cephalexin therapy for superficial pyoderma in dogs.</p><p><strong>Materials and methods: </strong>Forty-five dogs with superficial pyoderma underwent clinical, cytopathological and microbiological diagnosis, and were randomly assigned to Group 1 (G1) treated with shampoo (two weekly baths) and lotion (twice daily on the affected areas) containing natural antimicrobials; Group 2 (G2) treated with two weekly baths using a therapeutic shampoo containing 2% chlorhexidine and 2.5% miconazole; or Group 3 (G3) treated with oral cephalexin 30 mg/kg twice daily. Staphylococcus spp. strains were identified using matrix-assisted laser desorption ionisation-time of flight mass spectrometry and pruritus Visual Analog Scale (PVAS)/lesion scores were evaluated on Day (D)0, D7, D14, D21 and D28.</p><p><strong>Results: </strong>Statistical differences (p < 0.05) were noted between D0 and D28 in PVAS values and lesion scores for all groups. G1 had lower PVAS scores than other groups on D7 and D14 (p < 0.05) and lower lesion scores than G3 on D7. By D28, G1 and G3 had lower lesion scores than G2. Notably, G1 and G2 had no adverse effects, while 26% of G3 patients experienced gastrointestinal issues during therapy.</p><p><strong>Conclusions and clinical relevance: </strong>This preliminary investigation of the new product (G1) suggests that it is effective, safe and a promising topical treatment for managing superficial pyoderma in dogs, offering an alternative to systemic antibiotics and topical antiseptic treatments.</p>","PeriodicalId":23599,"journal":{"name":"Veterinary dermatology","volume":" ","pages":"137-147"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}