Vestnik oftalmologii最新文献

{"title":"[Thresholds and variability of retinal light sensitivity in each point of the examined visual field].","authors":"A A Vitkov, A A Antonov, I I Asinovskova, I V Kozlova, E D Semenov","doi":"10.17116/oftalma2024140022116","DOIUrl":"https://doi.org/10.17116/oftalma2024140022116","url":null,"abstract":"<p><strong>Purpose: </strong>This study assesses the light sensitivity and its variability in each point of the visual field in patients without glaucoma and with different stages of glaucoma.</p><p><strong>Material and methods: </strong>The data of a prospective analytical case-control study involving 500 patients were analyzed. The initial examination of all patients was performed using basic ophthalmological methods, including static perimetry. Retinal light sensitivity and its variability were assessed in 54 points corresponding to the Humphrey 24-2 program. Mean deviation and pattern standard deviation of light sensitivity were calculated for each point.</p><p><strong>Results: </strong>The lowest light sensitivity values in patients with moderate glaucoma were found in the periphery of the nasal sector, at point No. 27 - 14.4 dB, and at points No. 24-26 along the horizontal axis from the nasal side - from 17.7 to 22.7 dB. The maximum variability of light sensitivity was found in the nasal sector on both sides of the horizontal line - from 10.7 to 11.5 dB. The average light sensitivity above the horizontal axis in patients with advanced glaucoma was 10.8 dB, which is 2 dB higher than in the lower half of the visual field - 8.8 dB. The highest light sensitivity values were found at points No. 24 - 17.7 dB and No. 31 - 16.78 dB, the lowest - at point No. 32 - 4.5 dB. The average variability values of light sensitivity in the upper half of the visual field were 9.6 dB, which is 1 dB less than in the lower half of the visual field - 10.6 dB.</p><p><strong>Conclusion: </strong>According to our data, points No. 32 and No. 40 are of particular interest in the diagnostic plan. In these loci, the highest light sensitivity values were determined in early and moderate glaucoma. However, the values in these points decrease significantly in advanced glaucoma. It can be assumed that changes in light sensitivity in these loci at the early stages of glaucoma may be a predictor of glaucoma progression.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"140 2. Vyp. 2","pages":"116-122"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Anatomical structure and morphometric parameters of the distal segment of the lacrimal drainage system].","authors":"E L Atkova, V D Yartsev, M A Ekaterinchev","doi":"10.17116/oftalma2024140022143","DOIUrl":"10.17116/oftalma2024140022143","url":null,"abstract":"<p><p>The article analyzes the literature data concerning the anatomical structure of the tear ducts with a focus on morphometric studies of individual structures. It is noted that, despite the high information content of cadaveric studies, most of the information to date has been obtained with the use of intravital radiation visualization methods. It is shown that the lacrimal drainage system has age, gender, and racial characteristics. Most studies focus on features of the bone nasolacrimal canal, while there is a relative shortage of research devoted to soft-tissue nasolacrimal duct. The analysis showed that most of the studies are devoted to particular morphometric indicators, which makes it difficult to obtain a complete objective picture of the size of the tear duct. Information about its volume can be found only in a couple of studies. The numerical values of the obtained data vary, which can be explained by a different approach to the selection of research subjects, sample sizes, anatomical criteria and the calculation method of morphometric parameters. There are only a few studies on morphometric parameters of the nasolacrimal duct in healthy humans, which is extremely important for determining the pathogenesis of disorders of the patency of the lacrimal drainage system.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"140 2. Vyp. 2","pages":"143-149"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Alternative methods of surgical treatment of keratoconus].","authors":"A V Tereshchenko, I G Trifanenkova, S K Demianchenko, Yu D Erina, Yu Yu Golubeva, A N Pashtaev, K I Katmakov, A R Bulatov, A M Gelyastanov","doi":"10.17116/oftalma202414002185","DOIUrl":"10.17116/oftalma202414002185","url":null,"abstract":"<p><p>The introduction of early diagnostic methods for keratoconus into clinical practice has become the basis for the development of surgical treatment techniques for this pathology, such as corneal collagen crosslinking and interlamellar keratoplasty with implantation of intrastromal segments. The article analyzes the results of research by Russian and foreign specialists in these areas and presents the data on the combination of SMILE surgery and corneal crosslinking, the Rome protocol of corneal crosslinking, modifications of interlamellar keratoplasty, the use of femtosecond laser technologies, and some pilot studies. Modern requirements for ophthalmological care require a personalized approach to each patient, and therefore the surgeon should have a wide range of surgical methods of treatment applicable to different patient cohorts. The described methods of treatment, according to the authors, are the most promising.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"140 2","pages":"85-90"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140915666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pharmacoeconomic analysis of anti-angiogenic drugs for diabetic macular edema].","authors":"I S Krysanov, D L Klabukova, V S Krysanova, V Yu Ermakova","doi":"10.17116/oftalma2024140021112","DOIUrl":"10.17116/oftalma2024140021112","url":null,"abstract":"<p><p>Diabetic macular edema (DME) is a degenerative disease of the macular area in diabetes mellitus and can lead to vision loss, disability, and significantly reduced quality of life. Faricimab is the only bispecific antibody for DME therapy that targets two pathogenic pathways (Ang-2 and VEGF-A).</p><p><strong>Purpose: </strong>This study comparatively evaluates the clinical and economic feasibility of faricimab and other angiogenesis inhibitors in patients with DME.</p><p><strong>Material and methods: </strong>This article analyzed literature on the efficacy and safety of intravitreal injections (IVI) of ranibizumab 0.5 mg, aflibercept 2 mg, and faricimab 6 mg. A model of medical care was developed for patients with DME receiving anti-angiogenic therapy. Pharmacoeconomic analysis was performed using cost minimization and budget impact analysis (BIA) methods. Modeling time horizon was 2 years. The research was performed from the perspective of the healthcare system of the Russian Federation.</p><p><strong>Results: </strong>The efficacy and safety of faricimab in a personalized regimen (up to one IVI in 16 weeks) are comparable to those of aflibercept and ranibizumab, administered in various regimens. The use of faricimab is associated with the lowest number of IVIs. Over 2 years, the maximum costs of drug therapy were associated with the use of ranibizumab (about 914 thousand rubles), while the minimum costs were associated with the use of faricimab (614 thousand rubles). The reduction in inpatient care costs with faricimab therapy was 36% compared to aflibercept (216 and 201 thousand rubles in inpatient and day hospitals, respectively) and 82% compared to ranibizumab (486 and 451 thousand rubles in inpatient and day hospitals, respectively). BIA demonstrated that the use of faricimab will reduce the economic burden on the healthcare system by 11.3 billion rubles (9.8%) over 2 years.</p><p><strong>Conclusion: </strong>The use of faricimab is a cost-effective approach to treatment of adult patients with DME in Russia.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"140 2","pages":"112-120"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140916324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Polymorphism and modern diagnostic approaches for Leber congenital amaurosis].","authors":"I E Khatsenko, E I Brodnitskaya, S V Kuznetsova","doi":"10.17116/oftalma202414005156","DOIUrl":"https://doi.org/10.17116/oftalma202414005156","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the prevalence and morphofunctional characteristics of the retina in the diagnosis of various types of Leber congenital amaurosis (LCA) among patients from Moscow and the Moscow region, based on the data from the Consultative and Diagnostic Center of the Morozov Children's City Clinical Hospital.</p><p><strong>Material and methods: </strong>In order to analyze the polymorphism and prevalence of LCA, the study examined a total of 226 patients suspected of having hereditary retinal dystrophies, genetic diagnosis of Leber amaurosis was confirmed in 24 patients. All 24 patients underwent electrophysiological tests, including visual evoked potentials (VEP) from the sensory retina to the visual centers, and electroretinography (ERG) of the posterior pole of the retina. In children over 5 years old, additional methods were used: optical coherence tomography (OCT), fundus photography, and fundus autofluorescence (FAF) using a fundus camera.</p><p><strong>Results: </strong>According to the molecular genetic analysis, the most frequent type was LCA type 10 (37%), followed by LCA type 2 (16%). The most common clinical manifestations among patients were nystagmus, impaired night vision, waxy optic disc pallor, narrowed arteries, and changes on the ERG. OCT revealed changes in the outer retinal layers in all patients. ERG showed abnormalities in 100% of the patients, with the maximal ERG either not being recorded or significantly reduced. During VEP, most patients exhibited configuration disturbances, increased latency, and a sharp decrease in the amplitude of the P100 component.</p><p><strong>Conclusion: </strong>The analysis of patients with genetically confirmed Leber amaurosis revealed that LCA type 10 caused by mutations in the <i>CEP290</i> gene was the most common (37%), followed by LCA type 2 (16%) caused by mutations in the <i>RPE65</i> gene.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"140 5","pages":"56-62"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Aberrometry in the diagnosis and treatment of keratoconus].","authors":"S I Anisimov, S Micovic, N S Anisimova","doi":"10.17116/oftalma2024140051162","DOIUrl":"https://doi.org/10.17116/oftalma2024140051162","url":null,"abstract":"<p><p>Keratoconus (KC) is a bilateral progressive disease that often begins in young adulthood. Advanced KC significantly impairs patients' quality of life, making early detection of the condition a critical goal for specialists. Early identification of KC greatly influences both the treatment strategy and the outcomes. This review focuses on the ocular wavefront in KC, which is of interest from the perspective of early diagnosis. The article outlines the nature of optical aberrations in the eye, particularly in KC, and the principles of wavefront aberration analysis. An increase in higher-order aberrations is one of the earliest signs of incipient KC and a key contributor to reduced visual quality. Some of the widely used KC treatment methods, such as corneal cross-linking and the implantation of intracorneal segments, has been established to positively impact many aspects of KC pathogenesis, including reduction in higher-order aberrations, which in turn improves visual quality. Monitoring of the outcomes of treatment or optical correction in KC using higher-order aberrations is a delicate approach, as vision improvements following treatment are often unexplained by routine eye examination methods. However, the choice of the optimal method of visual rehabilitation for KC patients remains unresolved. Efforts to find new treatment methods, primarily through combinations and modifications of existing techniques, are ongoing. The article discusses this promising approach of using wavefront as an additional criterion for assessing the performance of the optical system in the diagnosis, treatment, and optical correction of KC.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"140 5","pages":"162-168"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of the effectiveness of cataract surgery in neovascular age-related macular degeneration].","authors":"A Zh Fursova, E I Dmitrieva, M A Vasilieva, A S Derbeneva, Yu A Karlash, A A Atamanenko, I F Nikulich, M S Tarasov","doi":"10.17116/oftalma20241400617","DOIUrl":"https://doi.org/10.17116/oftalma20241400617","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the impact of phacoemulsification cataract surgery (PE) on anatomical and functional parameters, as well as the regimen and frequency of anti-VEGF injections in patients with neovascular age-related macular degeneration (nAMD) over a long-term period (up to 3 years).</p><p><strong>Material and methods: </strong>The study included 117 patients (117 eyes) diagnosed with nAMD and cataract, graded by LOCS: LOCS I (<i>n</i>=56; 47.9%), LOCS II (<i>n</i>=57; 48.7%), LOCS III (<i>n</i>=4; 3.4%); the average age of the patients was 76.2±5.7 years. All patients received anti-VEGF therapy (aflibercept 2 mg) following the treat-and-extend protocol. PE was performed only with disease activity under control. The observation period included 12 months before PE and 36 months after, with eight checkpoints for standard ophthalmological examination.</p><p><strong>Results: </strong>The average number of injections before PE was 6.85±1.78. In the first year after PE, the injection frequency increased to 7.85±0.83, then decreased to 7.04±1.50 in the second year and 3.85±1.22 in the third, with intervals between injections lengthening (to 13.35±1.84 weeks by the third year). All eyes (100%) demonstrated significant improvement in best-corrected visual acuity (BCVA), with an absolute increase of 0.28 from pre-PE baseline (from 0.22±0.17 to 0.50±0.18 by study end). There was a positive trend in reduction of central retinal thickness (by 138.5 μm or 36.5%) compared to baseline at the start of treatment, as well as reduction in neuroretinal and retinal pigment epithelial detachment over the observation period. Statistically significant correlations were found between BCVA, injection frequency, injection interval, and morphological biomarkers of nAMD activity over time.</p><p><strong>Conclusion: </strong>Initiation of antiangiogenic therapy in nAMD patients and the continuation of individualized monitoring and treatment after PE is associated with effective suppression of nAMD activity, improvement in functional and anatomical parameters, and a reduction in the number of intravitreal injections both in the short term and the long term.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"140 6","pages":"7-14"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Selective assessment of biomechanical properties of the lens capsule].","authors":"S E Avetisov, A V Shitikova, K S Avetisov, T E Borisenko, L S Pateyuk, A E Aslamazova, P S Timashev, Yu M Efremov","doi":"10.17116/oftalma202414006115","DOIUrl":"https://doi.org/10.17116/oftalma202414006115","url":null,"abstract":"<p><p>The scientific and practical interest in studying the biomechanical characteristics of the lens capsule, on the one hand, is associated with its anatomical significance in modern microinvasive phaco surgery, and on the other hand, with investigation of the mechanisms of lens curvature changes during accommodation. Selective study of the biomechanical properties of the lens capsule aims to identify characteristics of various regions and surfaces of the capsule.</p><p><strong>Purpose: </strong>This study is a comparative analysis of age-related changes in the biomechanical properties of the anterior (AC) and posterior (PC) lens capsules in humans.</p><p><strong>Material and methods: </strong>The study analyzed 73 pairs of central fragments of the AC and PC of the lens, obtained from donor (cadaver) eyes and through anterior and posterior capsulorhexis during microinvasive phaco surgery (38 and 35 paired samples, respectively). Planned biomechanical testing followed a previously developed protocol for examining the anterior capsule, including determination of the Young's modulus using atomic force microscopy.</p><p><strong>Results: </strong>Comparing the Young's modulus of lens capsule samples from donor eyes and microinvasive phaco surgery revealed no significant differences in mean values, indirectly indicating minimal postmortem impact on the biomechanical properties of the capsule. General biomechanical patterns observed in the human lens capsule show the Young's modulus (stiffness) is higher in the AC than the PC, and higher on the inner than the outer surface for both the AC and PC. Age-related changes are associated with an increase in stiffness on the outer surface and its decrease on the inner surface, more pronounced in the AC.</p><p><strong>Conclusion: </strong>The obtained results indicate the need for further investigation into the role of capsule biomechanics in age-related accommodative disorders.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"140 6","pages":"15-23"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Isolated primary vitreoretinal lymphoma (case report)].","authors":"A S Stoyukhina, E N Korobov, S A Smolin","doi":"10.17116/oftalma202414002294","DOIUrl":"10.17116/oftalma202414002294","url":null,"abstract":"<p><p>This case report presents the diagnostic features of isolated primary intraocular lymphoma, which was initially misdiagnosed as neovascular age-related macular degeneration. A comprehensive examination using ultrasound, optical coherence tomography, and fundus autofluorescence revealed changes characteristic of vitreoretinal lymphoma. Molecular genetic analysis of the vitreous body showed the presence of a MYD88 gene mutation and B-cell clonality by immunoglobulin heavy chain (IGH) gene rearrangement tests, which confirmed the diagnosis.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"140 2. Vyp. 2","pages":"94-101"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The role of mitochondrial dysfunction in the stabilization of the glaucomatous process].","authors":"A S Vlasova, T N Malishevskaya, S A Petrov, D G Gubin, S Yu Petrov, Yu E Filippova","doi":"10.17116/oftalma202414004149","DOIUrl":"https://doi.org/10.17116/oftalma202414004149","url":null,"abstract":"<p><p>Many key aspects of retinal ganglion cell (RGC) neurodegeneration in glaucoma are associated with mitochondrial dysfunction. Understanding the mechanisms and relationships between structural and functional changes in mitochondria would be beneficial for developing mitochondria-targeted therapeutic strategies to protect RGCs from glaucomatous neurodegeneration.</p><p><strong>Purpose: </strong>This study determines the extent of mitochondrial dysfunction in patients with primary open-angle glaucoma (POAG) and evaluates the potential for stabilizing the glaucomatous process by improving mitochondrial functional activity and energy production by therapy with Mexidol and Mexidol FORTE 250.</p><p><strong>Material and methods: </strong>The study included 80 patients with moderate POAG with compensated intraocular pressure and 20 healthy volunteers. The extent of mitochondrial dysfunction was assessed by measuring the activity levels of mitochondrial enzymes: succinate dehydrogenase (SDH) and α-glycerophosphate dehydrogenase (α-GPDH) in peripheral blood lymphocytes using cytochemical analysis and cytometric morphology and density analysis (cytomorphodensitometry). Patients in the main group received sequential therapy with Mexidol as follows: Mexidol solution for intravenous and intramuscular administration at 50 mg/ml, 300 mg daily intramuscularly for 14 days, followed by Mexidol FORTE 250 tablets, one tablet three times daily for 56 days. Stabilization of glaucomatous optic neuropathy during treatment was evaluated using a comprehensive set of perimetric, electrophysiological, and structural-topographical methods at 14, 56, and 90 days.</p><p><strong>Results: </strong>Sequential therapy in the main group resulted in a significant increase in mitochondrial enzyme activity at 14 and 56 days compared to baseline, with a gradual regression by the end of the observation period (90 days). This was accompanied by an increase in the number of mitochondria and an increase in their optical density as measured by cytomorphodensitometry. The improvement in mitochondrial enzyme activity at 14 and 56 days was associated with positive changes in the structural and functional parameters of the retina, as evidenced by static perimetry, optical coherence tomography, and a series of electrophysiological tests.</p><p><strong>Conclusion: </strong>The obtained data can be used to optimize POAG therapy by reducing mitochondrial dysfunction and stabilizing glaucomatous optic neuropathy.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"140 4","pages":"49-58"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}