[细胞技术是开发治疗泪腺疾病的再生原理的基础]。

Q3 Medicine
T N Safonova, G V Zaitseva
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引用次数: 0

摘要

泪腺(LG)是一种管状外分泌腺,由针状细胞、导管细胞和肌上皮细胞组成。针状小叶、导管和肌上皮细胞的三维分布是该器官有效运作的必要条件。LG 是眼表系统免疫监视的主要器官。腺体的胚胎发育受遗传机制、内部表观遗传(酶系统、激素)和外源因素的相互作用调节。毫无疑问,胚胎发育的复杂过程有一个明确的遗传程序。调节 LG 器官发生的机制启动了大量结构致癌基因、转录因子和生长因子等的工作。研究器官发育过程中调控基因的表达和选择性活动及其在不同细胞类型分化中的参与是当前临床遗传学、分子生物学、胚胎学和免疫细胞化学的发展趋势。由于人类 LG 的结构相对简单且容易获得,因此是再生医学潜在应用的合适对象。当务之急是开发一种通用方案,以获得能表达组织特异性标记的功能性分化 LG 分泌上皮。确定干细胞和祖细胞的性质和来源,就能在培养物中分离和繁殖这些细胞。在获得功能活跃的 LG 细胞培养物后,就有可能创建自身免疫性疾病的模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Cell technologies as a basis for the development of regenerative principles for the treatment of lacrimal gland diseases].

The lacrimal gland (LG) is a tubuloacinar exocrine gland composed of acinar, ductal, and myoepithelial cells. Three-dimensional distribution of acinar lobules, ducts, and myoepithelial cells is necessary for the effective functioning of the organ. LG is the main organ of immune surveillance of the ocular surface system. The embryogenesis of the gland is regulated by the interaction of genetic mechanisms, internal epigenetic (enzyme systems, hormones) and exogenous factors. There is no doubt that there is a clear genetic program for the implementation of the complex process of embryonic development. The mechanisms regulating LG organogenesis initiate the work of a huge number of structural oncogenes, transcription and growth factors, etc. Studying the expression and selective activity of regulatory genes during organ development, their participation in the differentiation of different cell types is a current trend at the nexus of clinical genetics, molecular biology, embryology and immunocytochemistry. Due to its relatively simple structure and accessibility, human LG is a suitable object for potential application in regenerative medicine. Development of a universal protocol for obtaining functional differentiated secretory epithelium of LG capable of expressing tissue-specific markers is an urgent task. Determining the nature and origin of stem cells and progenitor cells will allow the isolation and multiplication of these cells in culture. After obtaining a functionally active culture of LG cells, it is possible to create a model of autoimmune diseases.

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来源期刊
Vestnik oftalmologii
Vestnik oftalmologii Medicine-Ophthalmology
CiteScore
0.80
自引率
0.00%
发文量
129
期刊介绍: The journal publishes materials on the diagnosis and treatment of eye diseases, hygiene of vision, prevention of ophthalmic affections, history of Russian ophthalmology, organization of ophthalmological aid to the population, as well as the problems of special equipment. Original scientific articles and surveys on urgent problems of theory and practice of Russian and foreign ophthalmology are published. The journal contains book reviews on ophthalmology, information on the activities of ophthalmologists" scientific societies, chronicle of congresses and conferences.The journal is intended for ophthalmologists and scientific workers dealing with clinical problems of diseases of the eye and physiology of vision.
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