Vestnik oftalmologii最新文献

{"title":"[Results of the multicenter study \"Registry of patients with inherited retinal dystrophies caused by confirmed biallelic mutations in the RPE65 and RLBP1 genes in Russia (REGINA)\". Report 1. Molecular genetic characteristics of inherited retinal pathologies].","authors":"V V Kadyshev, A A Stepanova, K K Shefer, I V Kondrashina, O A Shchagina","doi":"10.17116/oftalma202614201170","DOIUrl":"10.17116/oftalma202614201170","url":null,"abstract":"<p><strong>Purpose: </strong>The primary objective of the study was to investigate and describe the molecular genetic characteristics of patients with inherited retinal dystrophies (IRDs) presenting with phenotypes of Leber congenital amaurosis (LCA) or retinitis pigmentosa (RP), taking into account clinical polymorphism.</p><p><strong>Material and methods: </strong>This noninterventional cohort study was conducted in Russia by collecting retrospective data from patients with LCA and RP phenotypes and annual prospective follow-up of patients with IRDs caused by biallelic mutations in the <i>RPE65</i> or <i>RLBP1</i> genes, entered into the registry between July 20, 2022 and March 3, 2025. Eligible participants were entered into the IRD database, followed by a two-stage genetic diagnostic algorithm to confirm the presence of biallelic mutations in <i>RPE65</i> or <i>RLBP1</i>. The data were entered into standardized electronic case report forms, verified, and analyzed using descriptive statistical methods.</p><p><strong>Results: </strong>The study cohort included 2425 patients with IRDs from 83 regions of the Russian Federation. The mean age was 23.22±16.74 years, with predominance of pediatric patients (51.34%) and males (52.99%).</p><p><p>Genetic testing was performed in two stages. At the first stage, mutations in <i>RPE65</i> and/or <i>RLBP1</i> were identified in 84 (3.52%) of 2388 examined patients. The second stage involving direct Sanger sequencing was conducted in 48 (2.01%) patients, it confirmed biallelic mutations in <i>RPE65</i> in 1.68% and in <i>RLBP1</i> in 0.04% of cases. In one case, mutations in both genes were verified. Among <i>RPE65</i> variants, 61 mutations were identified, including frequent pathogenic variants (c.304G>T, c.272G>A, c.370C>T); seven variants were detected in the <i>RLBP1</i> gene.</p><p><p>The frequency of biallelic <i>RPE65</i> mutations in the subgroup with LCA/RP phenotype was 1.68%, and 1.65% in the overall IRD cohort, which is consistent with published data from European populations.</p><p><strong>Conclusion: </strong>The study \"Registry of patients with inherited retinal dystrophies caused by confirmed biallelic mutations in the <i>RPE65</i> and <i>RLBP1</i> genes in Russia\" allowed characterization of the key molecular genetic features of a representative sample of patients with IRDs.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 1","pages":"70-78"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Endophthalmitis: pathogenesis, current methods of diagnosis and treatment].","authors":"S A Abakarov, O Sh A Ahmed, I A Loskutov","doi":"10.17116/oftalma2026142021115","DOIUrl":"10.17116/oftalma2026142021115","url":null,"abstract":"<p><p>This study is a systematic review of the literature on etiological structure, pathogenetic mechanisms, clinical manifestations, diagnostic approaches, and therapeutic strategies for endophthalmitis. The review discusses in detail the principal clinical forms of the disease (postoperative, post-traumatic and endogenous), their microbiological characteristics, and epidemiological features. Gram-positive cocci were shown to be the leading pathogens (85.1%), predominantly <i>Staphylococcus epidermidis</i> (30.3%), <i>Streptococcus viridans</i> (12.1%), and <i>Staphylococcus aureus</i> (11.1%). The article presents contemporary data on the incidence of endophthalmitis after various ophthalmic procedures, ranging from 0.046% after vitrectomy to 0.366% after secondary intraocular lens implantation. The review highlights key aspects of pathogenesis, including the role of microbial virulence, biofilm formation, and the host inflammatory response, and describes in detail the clinical manifestations of different forms of endophthalmitis, with emphasis on differential diagnostic criteria. The article also presents current algorithms for laboratory and instrumental confirmation of the diagnosis, including visual acuity testing, slit-lamp biomicroscopy, B-scan ultrasonography, microbiological, and molecular genetic methods, analyzes principles of antibacterial therapy (systemic, topical, and intravitreal), and substantiates the role of early vitrectomy in severe forms of the disease. This work emphasizes the importance of interdisciplinary collaboration, preventive measures, and timely recognition of endogenous forms, and notes prospects for further research, including the implementation of nanopore sequencing and optimization of antibacterial protocols based on local antimicrobial resistance data.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 2","pages":"115-120"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Selection of the method for additional correction of ametropia after previous femtosecond laser lenticule correction of myopia and myopic astigmatism using CLEAR technique].","authors":"T S Kuznetsova, V D Antonuk, S Yu Shchukin, R R Fayzrakhmanov, A A Golyakov","doi":"10.17116/oftalma202614204192","DOIUrl":"10.17116/oftalma202614204192","url":null,"abstract":"<p><strong>Objective: </strong>The study presents 3 options for additional correction of ametropia after previous femtosecond laser correction of myopia and myopic astigmatism using the corneal lenticule extraction for advance refractive correction (CLEAR) technique.</p><p><strong>Material and methods: </strong>The study included 3 patients (3 eyes). After CLEAR surgery, patient 1 had uncorrected visual acuity (UCVA) in the left eye (OS) of 0.8 with correction sph (+)0.25 cyl (+)1.0ax113=1.0; in patient 2 UCVA OS was 0.4 with correction sph (-)1.25 cyl (-)0.25ax134=1.0; in patient 3 UCVA OS was 0.4 with correction cyl (-)1.75-42=1.0. In the first case, the corneal flap was created mechanically, in the second case, a 3D corneal flap edge was created using the Femto Z8 femtosecond laser system, and in the third case, a 2D corneal flap edge was created using the same system. Excimer laser ablation of residual ametropia was then performed in all cases.</p><p><strong>Results: </strong>The surgeries were completed without complications. UCVA of 1.0 was achieved in all cases.</p><p><strong>Conclusion: </strong>Post-CLEAR ametropia correction is possible by shaping the edge of the corneal flap using a mechanical method, as well as using the Femto Z8 femtosecond laser system with the \"side-cut-only\" and \"border-cut-only\" programs.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 4","pages":"92-98"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Biological basis and clinical potential of wound healing modulators in glaucoma surgery].","authors":"S N Svetozarskiy, I G Smetankin","doi":"10.17116/oftalma202614205198","DOIUrl":"https://doi.org/10.17116/oftalma202614205198","url":null,"abstract":"<p><p>The purpose of this review is to analyze the molecular mechanisms of postoperative fibrosis of the filtering bleb and critically evaluate pharmacological approaches to modulating its key mediators as a basis for developing more effective and safer strategies to prolong the hypotensive effect of trabeculectomy. This review examines current approaches to the management of reparative processes in open-angle glaucoma surgery aimed at preventing excessive fibrosis of the outflow pathways and prolonging the hypotensive effect. Glaucoma continues to be the leading cause of irreversible blindness, and surgical reduction of intraocular pressure is the most effective treatment when medical therapy is insufficient. However, up to 50% of surgical procedures fail within 5 years because of subconjunctival and episcleral fibrosis. The review considers the key phases and molecular markers of wound healing (inflammation, proliferation, and remodeling) and the role of fibroblasts as effector cells. The article also analyzes the methods used in clinical practice to modulate wound healing, including steroids, mitomycin C, 5-fluorouracil, immunosuppressants, and angiogenesis inhibitors, from the standpoint of the benefit-risk ratio, and discusses various methods of drug delivery. Despite considerable progress, existing approaches do not fully meet the criteria of safety and effectiveness, highlighting the need for further experimental and clinical studies.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 5","pages":"98-109"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Changes in the mineral composition of orbital bones in thyroid disease].","authors":"N P Kiryushchenkova, M V Kravchik, I A Novikov, I K Dzamikhov, G V Zolotenkova, Yu I Pigolkin, N Yu Sviridenko, Y O Grusha","doi":"10.17116/oftalma202614205116","DOIUrl":"https://doi.org/10.17116/oftalma202614205116","url":null,"abstract":"<p><p>Thyroid diseases lead to significant systemic changes in bone tissue, but analysis and densitometric assessment in this pathology is usually limited to the lumbar vertebrae and the femoral and radial bones. At the same time, there are grounds to assume presence of significant changes in other bony structures, primarily the orbit. To date, no data are available on specific changes in the mineral composition of orbital bones in thyroid pathology.</p><p><strong>Objective: </strong>This study assessed the mineral composition of the bone tissue of the lateral orbital wall in thyroid eye disease (TED) using scanning electron microscopy with energy dispersive analysis.</p><p><strong>Material and methods: </strong>The study examined samples of the greater wing of the sphenoid bone (GWS) obtained during deep lateral orbital decompression in 33 patients with TED (30-59 years, group 1) and 25 cadaveric sphenoid bone samples from patients of a comparable age range (group 2). Based on the results of semiquantitative chemical microanalysis, we calculated the number of Na⁺, Ca2⁺, and Mg2⁺ cations per hydroxyapatite formula unit and assessed the overall mineralization of the samples.</p><p><strong>Results: </strong>In patients with TED aged 30-44 years, the content of Mg2⁺ cations in the hydroxyapatite of the GWS was significantly lower than in the control group (<i>p</i><0.05) (0.16 vs 0.19 f.u.). At the same time, in both groups, the content of Mg2⁺ cations in bone tissue hydroxyapatite increased with age (<i>p</i><0.05; <i>r</i>=0.37 and <i>r</i>=0.43 for groups 1 and 2, respectively), whereas overall mineralization decreased, which is consistent with the general concepts of age-related changes in bone mineral.</p><p><strong>Conclusion: </strong>The identified differences indicate two mechanisms of bone tissue changes: hypermagnesemic (age-related) and hypomagnesemic (associated with thyroid hyperfunction). This concept may provide a basis for personalized strategies to correct mineral metabolism based on the patient's somatic status.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 5","pages":"16-23"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Experimental study of a new anti-glaucoma intrascleral implant].","authors":"K I Slastina, G V Sorokoletov, I G Trifanenkova, M A Plakhotniy, E V Erokhina, D G Uzunyan","doi":"10.17116/oftalma202614202116","DOIUrl":"10.17116/oftalma202614202116","url":null,"abstract":"<p><strong>Purpose: </strong>This study consisted of an <i>in vivo</i> experiment with the goal of performing instrumental evaluation of the position of a novel anti-glaucoma intrascleral implant.</p><p><strong>Material and methods: </strong>This <i>in vivo</i> study was conducted on 5 Chinchilla rabbits (<i>n</i>=5). The main group included 5 right eyes that underwent glaucoma surgery with implantation of the device. The comparison group consisted of 5 left eyes that underwent glaucoma surgery without implant placement. Animals in both groups were followed up for 3 months with biomicroscopy, ultrasound biomicroscopy, and optical coherence tomography (OCT) of the surgery area. At the end of the observation period, the rabbits were removed from the experiment for further research.</p><p><strong>Results: </strong>The developed intrascleral implant maintained correct position and was clearly visualized within the scleral tissue in animals of the main group throughout the entire observation period (up to 3 months).</p><p><strong>Conclusion: </strong>The new anti-glaucoma intrascleral implant made of polymethylmethacrylate is promising for further research.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 2","pages":"16-20"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Characteristics and features of ocular diseases in children born from consanguineous marriages].","authors":"R M Hasanova","doi":"10.17116/oftalma202614202129","DOIUrl":"10.17116/oftalma202614202129","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated features of ocular diseases in children born from consanguineous marriages.</p><p><strong>Material and methods: </strong>The study analyzed outpatient records of 560 patients under 15 years of age with vision-threatening ocular pathology leading to disability, who presented to the National Ophthalmology Center in 2019-2023. Every second child was selected by random sampling from a cohort of 1120 patients with congenital cataract, glaucoma, retinal dystrophies, optic nerve pathology, and developmental eye anomalies. Two groups were formed: group 1 - children born from consanguineous marriages (409 subjects), group 2 - children of non-related parents (151 subjects). Light perception, visual acuity, binocular vision, and visual fields were assessed. Effectiveness of treatment (conservative and surgical) was evaluated according to improvement in visual function: outcomes were considered satisfactory in the presence of positive changes and unsatisfactory in their absence.</p><p><strong>Results: </strong>In group 1, bilateral lesions in girls were detected 28.4 times more often, and in boys 65.7 times more often, than unilateral involvement. In group 2, these differences were less pronounced: 1.2 times in girls and 2.3 times in boys. Satisfactory treatment outcomes in group 1 were observed in 13 (8.8%) girls and 24 (9.2%) boys, whereas in group 2, treatment success was more than three times higher - 20 (32.8%) girls and 29 (32.2%) boys. Overall, treatment effectiveness in children born from consanguineous marriages was significantly lower compared with that in the control group.</p><p><strong>Conclusion: </strong>Children born from consanguineous marriages demonstrate a high prevalence of congenital and hereditary ocular diseases, predominantly of dystrophic and developmental origin. These disorders tend to have a more severe course and are characterized by lower treatment efficacy. The findings underscore the importance of genetic counseling and early ophthalmological screening to prevent severe visual impairment.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 2","pages":"29-33"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[MicroRNA deregulation as a method for assessing the effectiveness of brachytherapy for choroidal melanoma].","authors":"A F Brovkina, K B Mirzaev, L A Kabardikova","doi":"10.17116/oftalma202614201121","DOIUrl":"10.17116/oftalma202614201121","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the plasma expression levels of microRNA-223, microRNA-27b, and microRNA-155 in patients with choroidal melanoma (CM) T_1-2N₀M₀ before and after brachytherapy (BT).</p><p><strong>Material and methods: </strong>A total of 41 patients with choroidal melanoma T_1-2N₀M₀ were examined. The mean age was 59.8±15.26 years (ranged 25-81). All patients underwent standard ophthalmologic examination and CT/MRI to exclude metastases. Blood plasma expression levels of microRNA-223, -27b, and -155 were determined using real-time PCR before and after ruthenium-106 brachytherapy at follow-up intervals ranging from 3 to 49 months. In 15 patients, repeat testing was performed at 32-49 months (mean 37.78±5.67 months). Results were expressed as percentages relative to controls (taken as 100%). The control group consisted of volunteers without oncological or inflammatory diseases.</p><p><strong>Results: </strong>Patients were divided into three groups according to tumor size: small, medium, and large CM. Before treatment, expression levels of microRNA-223 and microRNA-27b increased with tumor growth (<i>p</i><0.05). No significant differences in microRNA-155 expression were observed between groups. Three months after BT, patients with small CM demonstrated a reduction in the expression of all three microRNAs, which became more pronounced at 12.9±1.3 months (<i>p</i><0.05). In 10 patients examined 32-49 months after treatment, microRNA expression levels were lower than those in the control group. In one patient with small CM, metastases were detected 48 months after BT; 16 months prior to this, no microRNA deregulation or metastatic signs on CT/MRI had been identified. In patients with medium-sized CM, the decrease in microRNA expression occurred more slowly. In one case, a liver metastasis was detected 5 months after BT; after exclusion of this patient from the analysis, a trend toward decreasing microRNA levels was confirmed in the remaining group. In patients with large CM, no decrease in microRNA expression was observed. Regardless of the degree of tumor regression (complete or partial), the expression levels of microRNA-223, -27b, and -155 remained elevated throughout the follow-up period, which may reflect a persistently high risk of occult metastasis.</p><p><strong>Conclusion: </strong>Analysis of microRNA expression levels in the blood plasma of CM patients can be used to assess the effectiveness of brachytherapy and to monitor patients within the framework of lifelong follow-up.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 1","pages":"21-26"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Friction: the effect on the ocular surface].","authors":"N V Sheludchenko, S E Avetisov, A P Vasilyeva, S Yusef, V M Sheludchenko, M A Makarova","doi":"10.17116/oftalma202614203156","DOIUrl":"https://doi.org/10.17116/oftalma202614203156","url":null,"abstract":"<p><p>The adverse consequences of friction in biological structures include wear and discomfort. The tribological model of the eye comprises two rubbing surfaces and lubrication provided by the complex composition of the tear film. Eyelid movement corresponds to the hydrodynamic regime of the Stribeck curve. This review considers various components of the tribological system of the visual organ, including the \"lid wiper\", the structure of the \"brushes\", the role of the glycocalyx, and tear film components relevant to friction. The study separately analyzes the patterns and mechanisms of friction under dry eye conditions, and presents in detail the effects of contact lenses on the tribological components of the ocular surface. The review identifies a number of conditions and diseases that affect ocular surface wear and microtrauma, and outlines possible directions for the development of tribological analysis in clinical practice and approaches to reducing friction between ocular surfaces.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 3","pages":"56-62"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Differential assessment of diagnostic signs of primary open-angle glaucoma and high myopia].","authors":"A N Samoylov, E V Kozina, M B Aliev, A I Kacharov, V A Utenkova","doi":"10.17116/oftalma202614203186","DOIUrl":"https://doi.org/10.17116/oftalma202614203186","url":null,"abstract":"<p><p>The prevalence of high myopia and primary open-angle glaucoma is rapidly increasing, complicating differential diagnosis because of overlapping morphological changes in the optic nerve head and lamina cribrosa. Both pathologies are accompanied by changes in the optic nerve head and lamina cribrosa, which makes interpretation of optical coherence tomography findings challenging. Analysis of literature sources shows that the most significant criteria include lamina cribrosa parameters (thickness, curvature, deformation index), features of peripapillary atrophy, the pattern of retinal nerve fiber layer thinning, and biomechanical parameters, including corneal hysteresis. Comparison of these signs helps differentiate myopic and glaucomatous changes and improves the accuracy of differential diagnosis between high myopia and primary open-angle glaucoma.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 3","pages":"86-90"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}