Vestnik oftalmologii最新文献

{"title":"[Biosimilars of ranibizumab in retinal diseases: new possibilities in ophthalmology].","authors":"A A Voskresenskaya, M B Sarkizova, N S Khodzhaev, D A Kudlay, S A Kakunina, A Yu Borozinets, N A Pozdeyeva","doi":"10.17116/oftalma2025141021106","DOIUrl":"https://doi.org/10.17116/oftalma2025141021106","url":null,"abstract":"<p><p>The development of biological therapeutic agents has provided new opportunities for treating neovascular age-related macular degeneration (nAMD) using humanized monoclonal antibodies (mAbs) targeting vascular endothelial growth factor A (VEGF-A). The emergence of biosimilars of anti-VEGF agents can significantly improve treatment accessibility and its effectiveness by increasing patient adherence. The development of biosimilars involves comparative studies with the original drug to establish equivalence in physicochemical and biological properties, efficacy, and safety. Biosimilar development programs include extensive analytical and preclinical studies to compare structural and functional components with the original bioproduct, and clinical trials are conducted to prove bioequivalence and therapeutic equivalence. The process of development and registration of the biosimilars is strictly regulated and has no significant differences in Russia, the EU and the US. Currently, more than 10 biosimilars of ranibizumab have been approved worldwide, in Russia it is the drug Laxolan (AO GENERIUM). The introduction of a domestic biosimilar of ranibizumab into clinical practice allows reduction of the costs of retinal disease treatment while maintaining the efficacy and safety of antiangiogenic therapy.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 2","pages":"106-116"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Morphometric analysis of small retinoblastomas following combination chemotherapy].","authors":"E B Myakoshina, S V Saakyan, R A Tatskov, A Yu Tsygankov","doi":"10.17116/oftalma202514102138","DOIUrl":"https://doi.org/10.17116/oftalma202514102138","url":null,"abstract":"<p><p>To date, the nature of micro-level changes in retinoblastoma (RB) foci following combination chemotherapy (CT) remains poorly studied.</p><p><strong>Purpose: </strong>This study analyzed the morphometric characteristics of small RBs in children who underwent combination CT.</p><p><strong>Material and methods: </strong>The study included 31 patients - 17 girls and 14 boys (<i>n</i>=31) - who had undergone combination CT and transpupillary thermotherapy (TTT). The children's ages ranged from 1 to 20 months (mean 9.7±6.9 months). The average follow-up period was 60.8±4.6 months. Spectral-domain optical coherence tomography (SD-OCT) was performed for tumors located in the central parts of the ocular fundus and in the middle periphery.</p><p><strong>Results: </strong>The mean tumor height (prominence) was 2154±29 µm, and the mean basal diameter was 7998±122 µm. Microcalcifications (<i>n</i>=5; 16.1%) and confluent calcifications (<i>n</i>=26; 83.9%) were visualized in the tumor stroma, producing \"shadow track\" effects in these regions; confluent calcifications were observed in 83.9% (<i>n</i>=26) of cases, while microcalcifications were detected in 16.1% (<i>n</i>=5). All examined tumors were highly reflective. The incidence of endophytic and exophytic growth patterns was 65.6% and 34.4%, respectively. Detachment of the neuroepithelium above the tumor and in adjacent areas was diagnosed in 6.5% of cases. Additional morphometric characteristics of small RBs following combination CT included the formation of calcifications and hyperreflective changes in the inner, middle, and outer tumor layers, perifocal areas, and adjacent choroid in the area of neoplasms.</p><p><strong>Conclusion: </strong>This study is the first to investigate the morphometric changes in small RBs following combination CT. These findings may aid in selecting the optimal method, parameters, and timing of focal therapy for more effective destruction of tumor foci.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 2","pages":"38-43"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Iris melanoma: correlation of clinical, morphometric, pathomorphological features and infectious status].","authors":"E B Myakoshina, S V Saakyan, N V Balatskaya, G I Krichevskaya, E V Svetlova, I V Svirina","doi":"10.17116/oftalma202514101113","DOIUrl":"10.17116/oftalma202514101113","url":null,"abstract":"<p><p>Iris melanoma is a rare malignant tumor of melanocytic origin. Oncogenic viruses, whose invasion of the cell alters proliferation regulation mechanisms, play an important role in tumor development and progression.</p><p><strong>Purpose: </strong>To identify clinical, morphometric, and pathomorphological correlations with infectious status in patients with iris melanoma and to determine predictors of unfavorable prognosis.</p><p><strong>Material and methods: </strong>Sixteen patients with iris melanoma were examined. Anterior segment optical coherence tomography (AS-OCT) was performed using the RS-3000 Advance system (Nidek, Japan) with OCT-Angiography software. The specific humoral response to herpesviruses was assessed by detecting IgG and IgM antibodies in blood serum via enzyme-linked immunosorbent assay (ELISA) using an automated immunoassay analyzer LAZURITE (Dynex Technologies Inc., USA). Statistical analysis employed Spearman's rank correlation coefficient (<i>r</i>_s).</p><p><strong>Results: </strong>Iris melanoma was predominantly observed in female patients (<i>n</i>=11) of advanced age (<i>n</i>=8). Biomicroscopy revealed 10 pigmented, 1 hypopigmented, and 5 non-pigmented tumors. The mean prominence on OCT was 1461.7±740.5 μm, the basal diameter was 3409.6±1822.8 μm, and the volume was 4.7±3.7 mm³. Ciliary body involvement was detected in 10 patients. Iris melanomas were classified as epithelioid-cell (<i>n</i>=1), spindle-cell (<i>n</i>=12), and mixed-cell (<i>n</i>=3) types. Extrabulbar growth was noted in three patients. Serological markers of viral reactivation were identified: herpes simplex virus type 1 (<i>n</i>=11) and type 2 (<i>n</i>=5), and cytomegalovirus (<i>n</i>=3).</p><p><p>Direct correlations (<i>r</i>_s=0.5-0.8) were identified between the presence of serological markers of herpesvirus reactivation and unfavorable prognostic features, including advanced age, maximum tumor basal diameter, ciliary body involvement, dense pigmentation, and extrabulbar growth. The mean follow-up period was 18.5±2.97 months, and all patients were alive, with no evidence of recurrence.</p><p><strong>Conclusion: </strong>The findings of this study demonstrated a correlation between herpesvirus reactivation and unfavorable prognostic features of iris melanoma. Further research is needed to deepen the understanding of the role of herpesviruses in the pathogenesis of iris melanoma and to develop personalized approaches to prevention and treatment.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 1","pages":"13-20"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The results of fistulizing glaucoma surgeries in pseudophackic patients].","authors":"Yu G Kopchenova, M A Frolov, M P Tolstykh, A M Frolov, F T Dulani, L V Tebueva","doi":"10.17116/oftalma202514101145","DOIUrl":"10.17116/oftalma202514101145","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the hypotensive efficacy of resorbable, slowly resorbable, and non-resorbable implants in the surgical treatment of primary open-angle glaucoma (POAG) in pseudophakic patients.</p><p><strong>Material and methods: </strong>The study involved patients with pseudophakia and stage II-III POAG who underwent glaucoma surgeries using various types of implants. A total of 140 eyes were evaluated. Group 1 included patients with resorbable implants made of polylactide and polyethylene glycol (40 eyes, 28.3%); group 2 consisted of patients with partially resorbable hydrophilic collagen implants (40 eyes, 28.3%); group 3 comprised patients with non-resorbable collagen implants (40 eyes, 28.3%). The control group consisted of patients who underwent sinus trabeculectomy with basal iridectomy (STE+BI) without drainage implantation (20 eyes, 14.9%).</p><p><strong>Results: </strong>After two years, intraocular pressure (IOP) decreased from 29.4±7.8 to 18.29±3.67 mm Hg in group 1, from 29.8±7.5 to 18.6±2.15 mm Hg in group 2, from 29.6±3.12 to 18.3±0.47 mm Hg in group 3, and from 31.6±4.8 to 20.6±3.95 mm Hg in the control group. These results correlated with hydrodynamic indicators assessed by tonography and examination of surgically created aqueous outflow pathways using ultrasound biomicroscopy (UBM) of the anterior segment and optical coherence tomography (OCT).</p><p><strong>Conclusions: </strong>In the late postoperative period (24 months post-surgery), the complete success rate of the surgeries showed a decreasing trend. All groups eventually required the reintroduction of hypotensive therapy. The most sustained success was observed in groups with resorbable and non-resorbable implants. Further dynamic monitoring will determine which implant type is the most favorable for surgical treatment of glaucoma.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 1","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pharmacological correction of burning eye syndrome].","authors":"T N Safonova, E S Medvedeva","doi":"10.17116/oftalma202514102151","DOIUrl":"10.17116/oftalma202514102151","url":null,"abstract":"<p><p>Burning eye syndrome (BES) is a subtype of dry eye syndrome (DES) characterized by neuropathic pain that is resistant to conventional DES therapy aimed at restoring tear film stability. The lack of impact on the corneal neural pathways is the reason for ineffectiveness of such treatment.</p><p><strong>Purpose: </strong>This study evaluated the effectiveness of a novel treatment regimen for BES.</p><p><strong>Material and methods: </strong>The study included patients aged 18-45 years diagnosed with BES. The criterion for exclusion from the study was the presence of clinical signs of blepharitis, meibomian gland dysfunction, as well as existing rheumatologic or oncologic diseases. The follow-up period was 12 months. All patients underwent standard and specialized ophthalmic examinations. They were randomly assigned to two groups: group 1 received gabapentin combined with neuroprotective therapy (thioctic acid, ipidacrine, and B vitamins) and topical 0.4% hyaluronic acid (HA) four times daily, while group 2 received only tear substitution therapy with 0.4% HA four times daily. Treatment efficacy was assessed using subjective (the Russian version of the Central Sensitization Inventory (CSI-20) and Visual Analog Scale (VAS)) and objective (laser corneal confocal microscopy and tearscopy) evaluation methods. Therapeutic effectiveness was assessed at 3, 6, and 12 months.</p><p><strong>Results: </strong>By the third month, patients in group 1 reported subjective improvement based on CSI-20 and VAS scores, while objective findings demonstrated decreased tear osmolarity, increased anisotropy coefficient of nerve fiber orientation, and an increase in nerve fiber length. No significant changes were observed in group 2 over the same period.</p><p><strong>Conclusion: </strong>The proposed treatment regimen, incorporating gabapentin along with neuroprotective therapy (thioctic acid, ipidacrine, and B vitamins) and topical 0.4% HA, proved more effective in alleviating neuropathic pain in BES compared to isolated topical therapy.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 2","pages":"51-58"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cytomegalovirus chorioretinitis in human immunodeficiency virus (case study)].","authors":"I Yu Razumova, I V Andreeva, A S Stoyukhina, S A Smolin","doi":"10.17116/oftalma202514101162","DOIUrl":"10.17116/oftalma202514101162","url":null,"abstract":"<p><p>Cytomegalovirus retinitis affecting the posterior pole of the eye is the most common opportunistic infection in acquired immunodeficiency syndrome (AIDS). It typically develops at CD₄ lymphocyte levels below 50-100 cells/μL and, if untreated, leads to blindness. Much less frequently, cytomegalovirus infection results in choroiditis, followed by secondary retinal changes. This article presents a clinical case of cytomegalovirus chorioretinitis in a human immunodeficiency virus-infected patient.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 1","pages":"62-68"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Primary angle closure suspects: application of machine learning method for substantiation of close monitoring].","authors":"N I Kurysheva, O Ye Rodionova, A L Pomerantsev, G A Sharova","doi":"10.17116/oftalma202514102167","DOIUrl":"https://doi.org/10.17116/oftalma202514102167","url":null,"abstract":"<p><p>One of the priority areas in healthcare is the concept of predictive, preventive and personalized medicine, which is based on an individualized approach to the patient, including before the onset of diseases such as glaucoma.</p><p><strong>Purpose: </strong>This study was conducted to substantiate the necessity of close monitoring of primary angle closure suspects (PACs) by comparing their clinical and anatomical parameters with those in normal eyes and in primary angle closure (PAC) before and after lens extraction (LE) or laser peripheral iridotomy (LPI).</p><p><strong>Material and methods: </strong>This prospective study included 30 PACs patients. The comparison group consisted of 60 patients with PAC: 30 patients underwent LE with intraocular lens implantation, and 30 patients underwent LPI. Control group - 30 eyes without ophthalmic pathology. All subjects underwent swept-source optical coherence tomography (SS-OCT), including analysis of choroidal thickness in the macula, lens vault (LV), iris thickness and curvature (ICurv), and anterior chamber angle (ACA) profile. Machine learning methods were used, including data driven soft independent modelling of class analogies (DD-SIMCA).</p><p><strong>Results: </strong>The parameters of PACs eyes occupied an intermediate position between those of PAC before treatment (according to DD-SIMCA classification) and normal eyes, but remained distinct from PAC eyes after treatment, falling outside the \"safety zone\" relative to normal values. Compared with the PAC group after LE, the PACs group had a shallower anterior chamber (2.60±0.13 mm vs. 3.63±0.199 mm, <i>p</i>=0.00), a narrower ACA profile (all <i>p</i>=0.00), a steeper iris (all <i>p</i>=0.00), lower uncorrected visual acuity (0.50±0.24 vs. 0.95±0.08, <i>p</i>=0.00), and a higher spherical equivalent (SE). Compared with PAC eyes after PLI, the PACs had greater LV (0.84±0.11 mm vs. 0.58±0.07 mm, <i>p</i>=0.00), higher intraocular pressure (19.7±0.8 mm Hg vs. 16.9±2.0 mm Hg, <i>p</i>=0.00), greater ICurv (all <i>p</i><0.05), higher SE, and a narrower ACA profile.</p><p><strong>Conclusion: </strong>Untreated PACs have significantly worse clinical and anatomical parameters, both in comparison with the norm and with PAC patients after treatment. This substantiates the need for closer monitoring of PACs.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 2","pages":"67-74"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Features of treatment of acute postoperative endophthalmitis].","authors":"I A Frolychev, N A Pozdeyeva","doi":"10.17116/oftalma202514102159","DOIUrl":"https://doi.org/10.17116/oftalma202514102159","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to analyze the outcomes of treatment of acute postoperative endophthalmitis and verify its main causative agents.</p><p><strong>Material and methods: </strong>The study included 49 patients (49 eyes) with acute postoperative endophthalmitis that developed following surgical interventions in various clinics. At the onset of endophthalmitis, 3 patients (6.1%) retained object vision with visual acuity ranging from 0.05 to 0.20, while 7 patients (14.3%) had visual acuity between 0.01 and 0.05. Visual acuity deteriorated to finger counting near face in 15 patients (30.6%), to 1/∞ pr.l.certa in 21 patients (42.9%), and to 1/∞ pr.l.incerta in 3 patients (6.1%).</p><p><p>All patients were treated using a new technique we developed, which involved short-term tamponade of the vitreous cavity with perfluorodecalin and intravitreal administration of antibiotics. Before treatment start, biological material was collected for bacteriological examination.</p><p><strong>Results: </strong>Visual function was preserved in 46 patients (93.9%). Clinically significant improvement in visual acuity (0.3-0.4) was observed in 36 patients (73.5%), while 6 patients (12.2%) achieved visual acuity greater than 0.5. No cases of recurrent inflammation were recorded; however, laser tyndallometry indicated a persistent disruption of the blood-ocular barrier for up to 6 months post-treatment, with a protein flow value of 14.6 (8.4; 19.2) ph/ms (<i>p</i>=0.002).</p><p><p>The most informative method for identifying the etiological cause of endophthalmitis was vitreous sampling (81.6% effectiveness), compared to anterior chamber sampling (38.8% effectiveness).</p><p><strong>Conclusion: </strong>The best functional outcomes were achieved in patients with endophthalmitis caused by <i>S. epidermidis</i> and <i>S. aureus</i>. Endophthalmitis caused by gram-negative bacteria had a poor visual prognosis.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 2","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Heavy metals and derangement in carbohydrate metabolism in eye diseases: a systematic review].","authors":"G J Udom, B Oritsemuelebi, C Frazzoli, B Bocca, F Ruggieri, O E Orisakwe","doi":"10.17116/oftalma202514102189","DOIUrl":"https://doi.org/10.17116/oftalma202514102189","url":null,"abstract":"<p><strong>Purpose: </strong>To uncover the negative impacts of heavy metals on carbohydrate metabolism, their mechanisms and contributory factors, as well as their role on the etiopathogenesis, pathophysiology, and progression of eye diseases.</p><p><strong>Material and methods: </strong>Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), various databases were searched (e.g., Scopus, PubMed, etc.) to collect evidence on the link and role of heavy metals in carbohydrate metabolism and pathogenesis of eye diseases. Included studies were appraised for quality using the Critical Appraisal Skills Programme checklists and extracted data were analyzed using the narrative synthesis method.</p><p><strong>Results: </strong>Of the 128 papers retrieved, 24 papers met the inclusion criteria. Heavy metals are associated with the onset and progression of diabetes and eye diseases secondary to diabetes (age-related macular degeneration, cataract, and diabetic retinopathy) majorly via toxic interference (induction, inhibition and/or deactivation) of glucose metabolizing enzymes and oxidative stress. The etiology of DR is intricate and includes the simultaneous disruption of several metabolic and signaling mechanisms within the retinal neurovascular unit. The retina is more susceptible to metal-induced toxicities due to the high affinity of heavy metals to melanin content of the retinal epithelium.</p><p><strong>Conclusion: </strong>This study emphasizes the harmful effects of chronic and intermittent exposure to heavy metals, suggesting no safe exposure levels. To prevent eye diseases secondary to heavy metals-induced altered carbohydrate metabolism, metal chelators, low glycemic diets, and lifestyle modifications should be exploited among vulnerable populations.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 2","pages":"89-100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The role of iridotrabecular contact in the pathogenesis of primary angle closure disease].","authors":"N I Kurysheva, G A Sharova, L R Kalimullina","doi":"10.17116/oftalma202514101121","DOIUrl":"10.17116/oftalma202514101121","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the correlation between iridotrabecular contact (ITC) and clinical-anatomical parameters in patients with primary angle closure disease (PACD) based on anterior segment imaging data obtained via swept-source optical coherence tomography (SS-OCT).</p><p><strong>Material and methods: </strong>The study analyzed data from 92 patients aged 32-89 years, including 56 patients with PACD (43 phakic and 13 pseudophakic) and 36 control group participants (21 phakic and 15 pseudophakic). All participants underwent SS-OCT imaging of the anterior segment, including measurements of the ITC index and ITC area.</p><p><strong>Results: </strong>The study revealed that in phakic PACD patients, ITC parameters (ITC Index and ITC Area) were significantly correlated with anterior chamber depth (ACD; <i>r</i>=-0.42, <i>p</i>=0.01 and <i>r</i>=-0.43, <i>p</i>=0.00, respectively), lens vault (LV; <i>r</i>=0.35, <i>p</i>=0.02 and <i>r</i>=0.36, <i>p</i>=0.02, respectively), lens thickness (LT; <i>r</i>=0.47, <i>p</i>=0.01 and <i>r</i>=0.44, <i>p</i>=0.01, respectively), all anterior chamber angle (ACA) parameters (all <i>p</i>=0.00), and the number of hypotensive medications used (<i>r</i>=0.63, <i>p</i>=0.01 and <i>r</i>=0.68, <i>p</i>=0.01, respectively). In pseudophakic PACD patients, ITC Index and ITC Area were associated with the number of hypotensive medications (<i>r</i>=0.71, <i>p</i>=0.02 and <i>r</i>=0.72, <i>p</i>=0.02, respectively) and the iridotrabecular space area in the nasal sector (<i>r</i>=0.62, <i>p</i>=0.02). No significant correlations were observed in the control group, regardless of lens status.</p><p><strong>Conclusion: </strong>ITC parameters in phakic PACD patients demonstrated the highest number of correlations compared to pseudophakic patients. The persistence of a direct relationship between ITC parameters and the number of hypotensive medications in primary angle-closure glaucoma following lens extraction supports the rationale for early surgical intervention.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 1","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}