Vestnik oftalmologii最新文献

{"title":"[Long-term outcomes of phakic intraocular lens implantation in high myopia].","authors":"Kh M Kamilov, N N Zaynutdinov","doi":"10.17116/oftalma202514101128","DOIUrl":"10.17116/oftalma202514101128","url":null,"abstract":"<p><p>Refractive anomalies are among the leading ocular conditions affecting the working-age population. One of them - high myopia - can cause severe and irreversible ocular changes, resulting in significant visual impairment or loss.</p><p><strong>Purpose: </strong>This study evaluated changes in vault height of phakic intraocular lenses (PIOL) and intraocular pressure (IOP) following the implantation of the ICL V5 (VICM5) lens in patients with high myopia.</p><p><strong>Material and method: </strong>The study included 60 patients. They were monitored for at least 24 months. Observation included measurement of clinical refraction, uncorrected visual acuity (UCVA), IOP, and the distance between the posterior surface of the optical part of the lens and the anterior surface of the crystalline lens (vault).</p><p><strong>Results: </strong>All surgeries were completed without complications. The safety and efficacy indices were 1.43 and 1.34, respectively. In 97 eyes (86%) with high myopia UCVA was equal to or better than preoperative values. The mean preoperative spherical equivalent was -10.59±3.4 D, which improved postoperatively to -0.5±0.75 D. Subsequently, the spherical equivalent remained within ±0.5 D in 89% of patients. The mean postoperative IOP was 15.86±3.30 mm Hg over the course of the 24-month follow-up. One month post-implantation, the vault height of the spherical lens ICL was 469.3±134.4 µm and 432.6±124.5 µm after 24 months (<i>p</i><0.001).</p><p><strong>Conclusion: </strong>Implantation of the Visian ICL V5 lens is a safe and effective alternative refractive surgery method for the correction of high myopia.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 1","pages":"28-31"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Predictive modeling of glaucomatous optic neuropathy progression rate in patients with newly diagnosed early primary open-angle glaucoma].","authors":"N I Kurysheva, S I Ponomareva, E V Maslova, V E Kim, O Ye Rodionova, A L Pomerantsev","doi":"10.17116/oftalma202514102122","DOIUrl":"https://doi.org/10.17116/oftalma202514102122","url":null,"abstract":"<p><p>Glaucoma, one of the leading causes of blindness, often develops asymptomatically, necessitating early diagnosis and prediction of the progression rate of glaucomatous optic neuropathy (GON).</p><p><strong>Purpose: </strong>To develop a classification model using machine learning methods for predicting the rate of GON progression, and to identify the most significant predictors of progression in patients with newly diagnosed early primary open-angle glaucoma (POAG).</p><p><strong>Material and methods: </strong>The study included 59 patients (59 eyes) with early POAG, categorized into three groups based on the expert assessment of GON progression rate over a 36-month follow-up using dynamic morphofunctional evaluation. A classification model incorporating 35 clinical parameters, including optical coherence tomography (OCT) and OCT-angiography (OCT-A) data, was developed using partial least squares discriminant analysis (PLS-DA).</p><p><strong>Results: </strong>Over the 36-month follow-up, slow GON progression was recorded in 21 patients, moderate in 18, and rapid in 20. The mean progression rates were -0.77±1.27%/year for visual field area, -1.21±1.48 µm/year for retinal nerve fiber layer (RNFL) thickness, and -1.23±1.77 µm/year for ganglion cell complex (GCC) thickness. The model demonstrated sensitivity of 90%, specificity of 95%, and efficiency of 92%. The most significant predictors of GON progression were mean vessel density in the deep vascular plexus of the macular region (wiVD_Deep), choriocapillaris dropout in the inferior-nasal peripapillary region, choroidal thickness in the fovea, and lamina cribrosa thickness.</p><p><strong>Conclusion: </strong>The developed model effectively classifies patients based on the predicted progression rate of GON, which is important for individualized approach to glaucoma treatment planning.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 2","pages":"22-29"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Correction of myopia with implantable collamer lenses].","authors":"S V Trufanov, X Jia, I A Riks, X Lu, Y Lu, Y Fu, G Liu","doi":"10.17116/oftalma20251410215","DOIUrl":"https://doi.org/10.17116/oftalma20251410215","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the effectiveness of the implantable collamer lens (ICL) V4c in the surgical treatment of myopia.</p><p><strong>Material and methods: </strong>The study analyzed the outcomes of ICL V4c implantation in 616 eyes with myopia. Visual acuity, refraction, intraocular pressure (IOP), anterior chamber angle (ACA), vault height, and corneal endothelial cell density (ECD) were evaluated. Patients were examined preoperatively and followed up for one year.</p><p><strong>Results: </strong>Preoperative uncorrected and best-corrected visual acuity were 0.04±0.02 and 0.83±0.12, respectively, improving to 0.97±0.10 and 0.97±0.10 one year postoperatively. The efficacy index was 1.17±0.17, and the safety index was 1.18±0.18. The spherical equivalent (SE) decreased from a preoperative value of -8.79±2.62 to 0.20±0.58 D at one year (<i>p</i><0.0001). The ACA decreased from 39.46±4.97° preoperatively to 22.79±4.74° at one year. Vault height was 747±280 μm on the first postoperative day and 755±285 μm at one year (<i>p</i><0.72), with no tendency for reduction over time. ECD was 2784±244 cells/mm² preoperatively and 2755±254 cells/mm² at one year (<i>p</i><0.29).</p><p><p>No significant linear regression was found between IOP, vault, and ACA.</p><p><strong>Conclusion: </strong>In a large cohort of patients who underwent ICL V4c implantation using the standardized technique, the procedure was demonstrated to be a highly effective, safe, and predictable refractive surgery option for correction of myopia of various degrees, and helped achieve stable visual outcomes. The decrease in spatial relationships in the anterior chamber following standard ICL V4c implantation did not lead to increased IOP.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 2","pages":"5-15"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Angiographic parameters of the retina after various methods of membrane peeling in the treatment of diabetic maculopathy].","authors":"Yu Yusef, V M Filippov, D V Petrachkov, A L Sidamonidze","doi":"10.17116/oftalma202514101137","DOIUrl":"10.17116/oftalma202514101137","url":null,"abstract":"<p><p>The rising prevalence of diabetes mellitus increases the need for treatment of diabetic maculopathy (DM). Evaluation of surgical outcomes in DM, including postoperative microstructural changes in the retina and its vascular plexuses, remains a relevant challenge.</p><p><strong>Purpose: </strong>This article assesses changes in angiographic parameters of the retinal capillary plexuses after surgical treatment of DM using various methods of internal limiting membrane (ILM) peeling.</p><p><strong>Material and methods: </strong>Vitreoretinal surgery, including vitrectomy with membrane peeling, was performed in comparable groups of patients with proliferative diabetic retinopathy and DM. The surgical methods differed in the approach to retinal ILM peeling: in group 1 the ILM was completely removed; group 2 underwent dosed fovea-sparing peeling (DFSP) of the ILM; in group 3 the ILM was left intact. Postoperative outcomes were compared between groups using optical coherence tomography angiography (OCT-A).</p><p><strong>Results: </strong>Intergroup comparisons across all time points and parameters did not reveal statistically significant differences. The analysis showed no significant changes in angiographic parameters in groups 1 and 3. In group 2 significant changes were observed in the parameters of deep capillary plexus: increased vessel density, vessel skeleton density and vessel perimeter index, as well as reduced foveal avascular zone (FAZ) area. Correlation analysis revealed that high FAZ area values in the deep capillary plexus were predictors of the development of retinal atrophy in the long-term.</p><p><strong>Conclusion: </strong>The obtained results demonstrate the dynamics of changes following DFSP of the ILM in both the neuronal structures of the retina and its capillary plexuses, with these changes tending toward normalization of retinal structure.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 1","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[On correct clinical and pathogenetic OCT-based classification of vitreomacular interface pathologies].","authors":"S A Kovalev, Yu A Ivanishko, V V Miroshnikov","doi":"10.17116/oftalma202514102116","DOIUrl":"10.17116/oftalma202514102116","url":null,"abstract":"<p><p>Currently, there is no universally accepted classification of vitreomacular interface (VMI) pathology, which complicates professional communication and the choice of treatment strategies.</p><p><strong>Purpose: </strong>This article presents our perspective on a feasible and prognostically significant clinical and pathogenetic OCT-based classification of surgical VMI pathologies.</p><p><strong>Material and methods: </strong>In order to develop a classification approach to categorize the most common changes in VMI based on pathogenesis we summarized published literature and our own observations.</p><p><strong>Results: </strong>Based on pathogenesis, classification begins with vitreomacular adhesion. The formation of an epiretinal membrane (ERM) can result from the development of posterior vitreous detachment (PVD) along the path of vitreoschisis. The severity of retinal changes and the presence of ectopic internal foveal layers distinguish four stages of ERM. ERM can exhibit various contraction patterns. If proliferative tissue contracts with centripetal tension on the retina, it may result in ERM with a macular pseudohole. Centrifugal contraction may may lead to the formation of intraretinal cystic spaces, resulting in ERM with foveoschisis. If PVD occurs in the presence of strong local vitreomacular fixation, vitreomacular traction (VMT) may develop, which is also classified into four stages. VMT can resolve either asymptomatically or with the formation of a retinal tissue defect, leading to the development of a full-thickness macular hole (FTMH). In cases where tractional forces during PVD create a retinal defect without causing an FTMH, secondary processes may be initiated, leading to an OCT pattern of lamellar macular hole, which in rare instances may progress to FTMH.</p><p><strong>Conclusion: </strong>The proposed classification scheme encompasses the full spectrum of primary surgical VMI pathologies, is based on modern pathogenetic concepts, and relies on clear OCT-defined criteria for each nosological entity. The scheme relies on specific morphological criteria and delineates the stages of pathological processes, facilitating research standardization and streamlining treatment decision-making.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 2","pages":"16-21"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Surgical treatment of central corneal opacities in Salzmann's degeneration].","authors":"S V Trufanov, I A Riks","doi":"10.17116/oftalma202514102175","DOIUrl":"https://doi.org/10.17116/oftalma202514102175","url":null,"abstract":"<p><p>Salzmann's nodular degeneration (SND) is a condition characterized by superficial subepithelial fibrosis of the cornea. Surgical treatment of SND usually consists of manual keratectomy of fibrotic nodules. When stromal layers of the optical zone are involved in the pathologic process, more technically complicated approaches may be preferred.</p><p><strong>Purpose: </strong>This study evaluated the effectiveness of surgical treatment of central corneal opacities in SND.</p><p><strong>Material and methods: </strong>The study analyzed surgical treatment outcomes of 61 eyes in 46 patients following the removal of centrally located fibrous nodules in the anterior stromal layers. Patients were divided into two groups based on the depth of stromal involvement. Patients of group 1 had stromal lesion depth up to 70 μm and underwent either phototherapeutic keratectomy (PTK) (subgroup 1a - 22 eyes) or automated microkeratome-assisted keratectomy (subgroup 1b - 13 eyes). Group 2 included patients with the depth of stromal layers lesion more than 70 μm, they underwent automated anterior lamellar keratoplasty (ALK) using a microkeratome head of either 130 μm (subgroup 2a - 14 eyes) or 200 μm (subgroup 2b - 12 eyes).</p><p><strong>Results: </strong>In group 1, both methods of keratectomy significantly improved visual acuity. Postoperative sphere-equivalent (SE), astigmatism and keratometry values showed no significant differences between PTK and automated keratectomy. Rate of epithelialization was significantly higher after PTK. In group 2, postoperative visual acuity, SE, astigmatism and keratometry readings had no statistically significant differences between the subgroups. ALK performed using a 200 μm head with graft fixation by continuous suture resulted in a smaller variation of astigmatism values.</p><p><p>All patients were prescribed Stillavit or Stillavit Intensiv, which promoted rapid recovery of corneal epithelium.</p><p><strong>Conclusion: </strong>Both keratectomy techniques can be effectively used in clinical practice depending on equipment availability. Although ALK with a 200-μm microkeratome head demonstrated more predictable outcomes, further improvement of thin-flap techniques will be beneficial.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 2","pages":"75-84"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The role of meibum proteins in the pathogenesis of meibomian gland dysfunction].","authors":"T N Safonova, G V Zaitseva","doi":"10.17116/oftalma202514101170","DOIUrl":"10.17116/oftalma202514101170","url":null,"abstract":"<p><p>Proteins and lipids in the meibum help maintain the balanced chemical composition of the tear film. However, the secretion of the meibomian glands contains various protein fractions, the function and effects of which on the lipid profile remain incompletely understood. This literature review provides a description of the main proteins of the meibum and their roles in the pathogenesis of meibomian gland dysfunction associated with age-related changes and metabolic disorders that lead to impaired tear film functionality. The article also analyzes modern methods for studying meibomian gland secretion.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 1","pages":"70-75"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between integrity of foveal photoreceptors and ultimate visual outcome in neovascular age-related macular degeneration].","authors":"A Jatoi","doi":"10.17116/oftalma202514101132","DOIUrl":"10.17116/oftalma202514101132","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates the clinical features and outcome dimensions of neovascular age-related macular degeneration (nAMD).</p><p><strong>Material and methods: </strong>This retrospective study analyzed 80 subjects diagnosed with nAMD. The patients received successful treatment through intravitreal administration of anti-vascular endothelial growth factor (anti-VEGF) agents. The subjects were classified into three groups based on the final integrity of their inner segment/outer segment (IS/OS) layer of the retina, assessed using spectral-domain optical coherence tomography (SD-OCT). This classification helped to understand the extent of retinal damage and the progression of nAMD. The primary evaluation was to examine the association between final IS/OS integrity and final visual acuity in the groups. The study also evaluated foveal microstructures (choroidal neovascularization size, external limiting membrane, outer nuclear layer thickness, and central macular thickness) at the initial and final visits, and their relationships with final IS/OS integrity.</p><p><strong>Results: </strong>The study found a significant association (P<0.001) between final visual acuity and IS/OS integrity. The V group had the best visual acuity (0.12±0.09) compared to the P group (0.39±0.45) and I group (0.92±0.42). Improved visual acuity was strongly correlated with less disrupted IS/OS and ELM. Intact photoreceptor integrity was linked to preserved IS/OS and ELM, thinner CMT, and shorter CNV height before treatment. However, photoreceptor integrity was not significantly correlated with CMT, RPE regularity, or ONL thickness at the final examination, suggesting it may be independently affected by nAMD.</p><p><strong>Conclusion: </strong>Final visual acuity in nAMD patients post-treatment was strongly linked to foveal photoreceptor integrity. Photoreceptor integrity correlated with initial visual acuity, CMT, ELM integrity, CNV height, and IS/OS layer integrity. These factors can predict visual outcomes after resolution of exudaiton.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 1","pages":"32-36"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of neural networks for improving the methods of assessment of corneal nerve fibers (preliminary report)].","authors":"S E Avetisov, Z V Surnina, S Georgiev","doi":"10.17116/oftalma2025141021117","DOIUrl":"https://doi.org/10.17116/oftalma2025141021117","url":null,"abstract":"<p><p>Processing large datasets using artificial intelligence is a promising approach in disease diagnosis and monitoring that focuses on improving research algorithms for existing technologies. Interest in studying corneal nerve fibers (CNFs) arises not only from the need to understand the pathogenesis and progression of various ocular diseases but also from the potential for thin, unmyelinated corneal nerves to be used as biomarkers for systemic polyneuropathies.</p><p><strong>Purpose: </strong>This study evaluates the preliminary results of using a neural network-based algorithm for analysis of confocal images of CNFs.</p><p><strong>Material and methods: </strong>The comparative study of CNFs was conducted in a group of 50 healthy volunteers (100 eyes) aged 25 to 55 years without concomitant ocular or systemic diseases. Confocal microscopy of the central cornea was performed to assess the state of CNFs. Image analysis and nerve recognition were carried out using special software (Liner calculate, Liner 1.2S) and a newly developed neural network-based algorithm.</p><p><strong>Results: </strong>The study considered suitable encoders for image processing, including ResNet_50, VGG_16, and InceptionResNetV2. Among these, images processed with the VGG_16 encoder in Imagenet mode demonstrated the highest quality. Quantitative CNF parameters (length and density of the main trunks, macrophage count, anisotropy and symmetry coefficients) were comparable between the regular software and the neural network-based algorithm.</p><p><strong>Conclusion: </strong>The results indicate the potential of using neural networks, particularly the VGG_16 encoder family, for structural assessment of the CNFs. Key advantages of the proposed algorithm include improved quality of image interpretation and reduced time required for analysis.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 2","pages":"117-122"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Biosimilars of ranibizumab in retinal diseases: new possibilities in ophthalmology].","authors":"A A Voskresenskaya, M B Sarkizova, N S Khodzhaev, D A Kudlay, S A Kakunina, A Yu Borozinets, N A Pozdeyeva","doi":"10.17116/oftalma2025141021106","DOIUrl":"https://doi.org/10.17116/oftalma2025141021106","url":null,"abstract":"<p><p>The development of biological therapeutic agents has provided new opportunities for treating neovascular age-related macular degeneration (nAMD) using humanized monoclonal antibodies (mAbs) targeting vascular endothelial growth factor A (VEGF-A). The emergence of biosimilars of anti-VEGF agents can significantly improve treatment accessibility and its effectiveness by increasing patient adherence. The development of biosimilars involves comparative studies with the original drug to establish equivalence in physicochemical and biological properties, efficacy, and safety. Biosimilar development programs include extensive analytical and preclinical studies to compare structural and functional components with the original bioproduct, and clinical trials are conducted to prove bioequivalence and therapeutic equivalence. The process of development and registration of the biosimilars is strictly regulated and has no significant differences in Russia, the EU and the US. Currently, more than 10 biosimilars of ranibizumab have been approved worldwide, in Russia it is the drug Laxolan (AO GENERIUM). The introduction of a domestic biosimilar of ranibizumab into clinical practice allows reduction of the costs of retinal disease treatment while maintaining the efficacy and safety of antiangiogenic therapy.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"141 2","pages":"106-116"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}