Vestnik oftalmologii最新文献

{"title":"[Terrien's marginal degeneration: clinical manifestations, diagnosis, and treatment].","authors":"D A Krakhmaleva, P N Ilina","doi":"10.17116/oftalma2026142021100","DOIUrl":"10.17116/oftalma2026142021100","url":null,"abstract":"<p><p>Terrien's marginal degeneration is a rare idiopathic condition characterized by minimally symptomatic, typically bilateral peripheral corneal thinning without ulceration, accompanied by superficial neovascularization and lipid deposition. The absence of pathognomonic diagnostic criteria, along with the diversity of clinical manifestations and potential complications, can make establishing the diagnosis more difficult. This review summarizes current knowledge regarding the etiopathogenesis, clinical course, and diagnostic features of Terrien's marginal degeneration. It also discusses contemporary classifications and current approaches to differential diagnosis and treatment of the disease.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 2","pages":"100-106"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Dry eye disease in university students].","authors":"S V Yanchenko, E A Kharibova, A V Malyshev, Sh Zh Teshaev, M Yu Odilov, Sh Sh Ramazonova","doi":"10.17116/oftalma202614204151","DOIUrl":"https://doi.org/10.17116/oftalma202614204151","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to assess the prevalence of dry eye disease (DED) in university students, identify significant risk factors, and determine possible directions for therapeutic management.</p><p><strong>Material and methods: </strong>The study included 88 students from Bukhara State Medical Institute named after Abu Ali ibn Sino aged 18-28 years. During stage 1 (online screening), the prevalence of symptomatic DED was determined (criterion: OSDI>12), and the significance of risk factors was assessed. During stage 2, students with OSDI>12 underwent the Norn test, Schirmer I test, Korb compression test, and meibography for diagnosis of meibomian gland dysfunction (MGD); clinical signs of infestation (CSI) by <i>D. folliculorum</i> and allergic conjunctivitis (AC) were identified, and the prevalence of DED was determined according to the DEWS III criteria (OSDI>12 and tear film breakup time <10 s). Statistics: <i>χ</i>² test, calculation of the normalized Pearson`s contingency coefficient (C').</p><p><strong>Results: </strong>The prevalence of symptomatic DED was 72.7%. Significant associations were found with female sex (C'=0.413), screen time >6 h per day (C'=0.332), eyeliner use (C'=0.555), and mascara use (C'=0.404). According to the DEWS III criteria, DED was diagnosed in 52.3% of students, with predominance of the evaporative form. Among the risk factors, the most significant were MGD (C'=0.579), AC (C'=0.371), and CSI (C'=0.347).</p><p><strong>Conclusions: </strong>According to the DEWS III criteria, DED was detected in 52.3% of students, evaporative DES predominated, and MGD was the most significant factor and may be considered a pathogenetic component of the disease. The findings support eyelid hygiene, including the use of Blepharogel Ochischenie cleansing gel, Blepharolosion lotion, Blepharosalfetka wipes, Blepharogel-1, Blepharogel-2, and Blepharogel Forte, as one of the potential components of comprehensive DED therapy in university students.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 4","pages":"51-61"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Use of recombinant nerve growth factor in the treatment of neurotrophic keratitis associated with ichthyosis follicularis, atrichia, and photophobia (IFAP syndrome)].","authors":"A V Sergeeva, E L Sorokin","doi":"10.17116/oftalma202614204169","DOIUrl":"10.17116/oftalma202614204169","url":null,"abstract":"<p><p>Treatment of neurotrophic keratitis (NTK) remains one of the challenges in ophthalmology. This article presents a case of successful use of recombinant nerve growth factor in the treatment of NK in a child with ichthyosis follicularis, atrichia, and photophobia (IFAP syndrome), type 2. The child had blepharospasm and extensive corneal epithelial defects with superficial vascularization in both eyes since birth. Despite local trophic therapy, the erosions persisted. The child was diagnosed with the systemic condition «ichthyosis follicularis, atrichia, and photophobia (IFAP syndrome), type 2». Despite long-term trophic therapy, corneal epithelial defects in both eyes persisted. Due to the ineffectiveness of standard treatment, the patient was prescribed cenegermin drug. Complete epithelialization of the epithelial defects was observed by day 34 of specific neurotrophic therapy, and a reliable corneal pain response appeared during the cotton wisp test. Complete restoration of the epithelial layer and corneal sensitivity persisted two months after completion of the treatment course. The use of the drug cenegermin effectively restored the epithelium and corneal sensitivity in long-persisting corneal erosions in a child with ichthyosis follicularis, atrichia, and photophobia (IFAP syndrome).</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 4","pages":"69-76"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Next-generation pharmaceutically acceptable vehicles for eye drops (preliminary report)].","authors":"M V Kravchik, I A Novikov, S V Kuznetsov, A M Subbot, G A Osipyan, O A Pak, A I Novikova, L S Pateyuk, A I Bilyalov, O A Gusev, S E Avetisov, Yu Yusef","doi":"10.17116/oftalma202614201145","DOIUrl":"10.17116/oftalma202614201145","url":null,"abstract":"<p><p>Efficient delivery of instilled drugs into the corneal stroma and intraocular tissues remains a major challenge in ophthalmic pharmacology. Existing enhancers of transmucosal and transepithelial permeability are often toxic and fail to overcome ocular surface barriers effectively. Dynamic modulation of ocular surface acidity during drug instillation represents a promising approach for gentle \"opening\" of these barriers and enhancing the bioavailability of certain classes of drugs.</p><p><strong>Purpose: </strong>This study aimed to develop a pharmaceutically acceptable eye drop vehicle based on an overloaded pH buffer capable of dynamically regulating ocular surface acidity and thereby ensuring effective and safe transmucosal and transepithelial delivery of substances.</p><p><strong>Material and methods: </strong>This pilot study included six rabbits (four groups). The permeability of copper (Cu²⁺) and neodymium (Nd³⁺) ions was investigated; these ions were selected as models due to their high affinity for mucins and the epithelium. The ions were delivered into the corneal stroma using a vehicle based on an overloaded pH buffer and phosphate-buffered saline (PBS). Stromal concentrations were assessed as follows: Cu - by atomic absorption spectrometry, Nd - by energy-dispersive spectrometry. The absence of toxic reactions was confirmed by biomicroscopy.</p><p><strong>Results: </strong>The eye drop vehicle based on an overloaded pH buffer increased the stromal copper concentration by 1.6-fold compared to PBS (0.54 vs 0.33 mg/kg). The new vehicle enabled significant accumulation of Nd in the corneal stroma at 0.39 wt% [0.36-0.43 wt.%], whereas with PBS the stromal Nd level was measured at 0.07 wt.% [0.07-0.08 wt.%] (below the detection threshold of <i>p</i><0.001).</p><p><strong>Conclusions: </strong>The eye drop vehicle based on an overloaded pH buffer provides a physiological and significant enhancement of transmucosal and transepithelial transport of cationic substances without inducing ocular tissue damage. This approach may increase drug bioavailability, reduce the required initial dose of active components in dosage forms, decrease toxic burden, and eliminate the need for toxic permeability enhancers in ophthalmic formulations.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 1","pages":"45-53"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Risk factors of unfavorable clinical outcome in orbital granulomatosis with polyangiitis].","authors":"D S Ismailova, P I Novikov, I V Zhitareva","doi":"10.17116/oftalma202614201154","DOIUrl":"10.17116/oftalma202614201154","url":null,"abstract":"<p><strong>Purpose: </strong>This study analyzed outcomes of orbital inflammation in granulomatosis with polyangiitis (GPA) and identified risk factors for unfavorable outcomes.</p><p><strong>Material and methods: </strong>The study included 107 patients with orbital GPA. A systemic form of the disease was identified in 37 (34.6%) patients, while a localized form of GPA was observed in 70 (65.4%) patients.</p><p><strong>Results: </strong>Visual acuity of 0.7 or higher was recorded in 69 (64.5%) patients, visual acuity below 0.7 was noted in 30 (28%) patients, blindness was detected in 3 (2.8%) cases, and anophthalmos in 5 (4.7%) patients. Oculomotor disorders were observed in the outcome in 44 (41.1%) patients. In 25 (23.4%) individuals, ocular motility was limited in one or more directions, with or without diplopia in those gaze positions, but in primary gaze there were no eye deviation or diplopia. Severe oculomotor impairment was characterized by the presence of strabismus and/or binocular diplopia in primary gaze position and was identified in 19 (17.7%) patients of the study gorup. Unfavorable prognostic factors included positive antineutrophil cytoplasmic antibodies (ANCA), a systemic form of the disease, diffuse orbital inflammation, and the presence of optic neuropathy and peripheral ulcerative keratitis (PUK) during the active phase of orbital inflammation.</p><p><strong>Conclusion: </strong>In a large clinical cohort (107 patients), a favorable outcome of orbital inflammation in GPA was observed in 62.6% of cases, whereas an unfavorable outcome occurred in 27.4% of patients. Risk factors of an unfavorable outcome were identified for the first time, and a formula for predicting clinical outcome was proposed.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 1","pages":"54-59"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effectiveness of the \"sliding eight\" technique for the treatment of upper eyelid ptosis].","authors":"M G Kataev, F M Khulamkhanova, M A Zakharova, I Yu Trofimova","doi":"10.17116/oftalma202614205132","DOIUrl":"https://doi.org/10.17116/oftalma202614205132","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated the effectiveness and reliability of suspension surgery using the \"sliding eight\" technique with a polypropylene thread in patients with severe upper eyelid ptosis over a long-term follow-up period.</p><p><strong>Material and methods: </strong>The study included 107 patients (149 eyelids) with unilateral or bilateral congenital or acquired upper eyelid ptosis with poor or absent levator function (up to 5 mm). All patients underwent surgery using the \"sliding eight\" technique with a polypropylene thread. Postoperative assessment included MRD1, palpebral folds height, symmetry of these parameters between the two eyes, and the degree of lagophthalmos.</p><p><strong>Results: </strong>Perfect symmetry of upper eyelid position in both eyes was achieved in 73 (68.2%) patients. In 34 (31.8%) patients, a difference in eyelid position was observed, averaging 1 mm. Asymmetry in the prominence of the palpebral folds was observed in 3 patients with bilateral ptosis. Repeat surgery was required in 11 (10.3%) patients. The mean follow-up period was 23 months.</p><p><strong>Conclusion: </strong>The \"sliding eight\" technique provides long-term, stable, and cosmetically favorable outcomes in the treatment of upper eyelid ptosis with poor levator function. The technique leaves virtually no visible traces and preserves eyelid softness throughout the follow-up period, while its atraumatic nature makes it possible to perform repeat surgery without damaging the surrounding tissues.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 5","pages":"32-37"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of a combined physiotherapeutic approach on changes in functional parameters after endovitreal surgery of rhegmatogenous retinal detachment with a favorable anatomical outcome].","authors":"V M Sheludchenko, A G Matyushchenko, L Alharki, K V Baryshev, S Sh Balkar, M A Makarova, M M Alenov, Yu Al Harki","doi":"10.17116/oftalma202614203129","DOIUrl":"https://doi.org/10.17116/oftalma202614203129","url":null,"abstract":"<p><strong>Objective: </strong>The study evaluated the effect of combined physiotherapeutic treatment (CPT) on changes in functional retinal parameters after endovitreal surgery of rhegmatogenous retinal detachment (RRD) with a favorable anatomical outcome.</p><p><strong>Material and methods: </strong>The study included 42 patients (42 eyes) diagnosed with primary macula-off RRD with the duration of up to 30 days. After surgical treatment, which included vitrectomy with silicone oil tamponade, the patients were divided into two groups. Group 1 included 23 patients who received a course of CPT on day 5 after surgery; the course comprised respiratory heliox therapy by inhalation of the helium-oxygen mixture Heliox 21, containing 21% O₂ and 79% He. After 15 min, endonasal electrophoresis was performed with application of a 1% Semax solution for 10 min once daily; the course consisted of 8 procedures. Group 2 included 19 patients who received nasal instillations of 0.1% Semax drops starting on day 5 after surgery. The follow-up period was 12 months, with control examinations on day 7 and at 1, 3, 6, and 12 months. The functional effectiveness of the treatment was analyzed by data of best-corrected visual acuity (BCVA) and macular light sensitivity, as well as by changes in central retinal thickness and ganglion cell complex.</p><p><strong>Results: </strong>Patients in group 1 showed a higher level of recovery of functional BCVA and fundus microperimetry parameters compared with patients in group 2 by month 6 of the follow-up.</p><p><strong>Conclusion: </strong>The proposed combination of methods is effective and promising for the rehabilitation of patients after endovitreal surgical treatment of RRD, as it promotes more effective recovery of visual function and reduces the risk of complications.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 3","pages":"29-37"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prospects for the use of depot drug formulations in dacryology].","authors":"V D Yartsev, E L Atkova, M A Efremenko","doi":"10.17116/oftalma202614203163","DOIUrl":"https://doi.org/10.17116/oftalma202614203163","url":null,"abstract":"<p><p>This literature review analyzes the prospects for the use of depot drug formulations in dacryology. The limited bioavailability of conventional topical agents and the inability to maintain a stable drug concentration on the ocular surface stimulate the development of local controlled-release systems. Punctal plugs and intracanalicular implants, which use hydrogels and biodegradable polymers for prolonged delivery of anti-inflammatory and immunosuppressive drugs, have been studied extensively. Experimental designs include customizable drug-delivery constructs based on photopolymerizable and composite materials, expanding the possibilities of targeted therapy. Despite the obtained results, the potential of depot systems in the treatment of lacrimal drainage system diseases, including dacryostenosis, requires further investigation in clinical studies.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 3","pages":"63-69"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Mucoperiosteal graft in the correction of paralytic lagophthalmos].","authors":"Y O Grusha, E I Fettser, K V Presnyakova, O V Eksarenko, E A Chizhonkova","doi":"10.17116/oftalma20261420315","DOIUrl":"https://doi.org/10.17116/oftalma20261420315","url":null,"abstract":"<p><p>Various spacers are used to achieve a higher position for the lower eyelid and reduce the degree of lagophthalmos in chronic facial palsy (CFP). Most authors consider a hard palate mucoperiosteal graft (HPG) to have major advantages over other spacers, particularly minimal shrinkage in the postoperative period. However, only a few publications report possible HPG shrinkage, and their findings are based on subjective assessments.</p><p><strong>Objective: </strong>The study aimed to perform clinical and echographic assessment of the lower eyelid tissues after the use of HPG for the correction of paralytic lagophthalmos (PL).</p><p><strong>Material and methods: </strong>The study included 30 patients (30 eyelids) with CFP and PL. The work involved measurement of biometric parameters of the palpebral fissure and ultrasound examination of the lower eyelid (high-resolution grayscale B-scan ultrasonography, color Doppler mapping with 3D mode, echodensitometry, and ultrasound biomicroscopy) at 6 and 12 months after HPG placement.</p><p><strong>Results: </strong>We observed significant changes in palpebral fissure parameters and improvement in the state of the cornea. The distance from the corneal light reflex to the lower eyelid margin (MRD2) decreased from 7.0±1.2 to 5.7±0.8 mm (<i>p</i><0.001) after surgery, and the degree of lagophthalmos decreased from 2.75 [0.5; 6.0] to 1.0 [0.0; 3.0] mm (<i>p</i><0.001). At 6 and 12 months, HPG thickness changed from 2.89±0.65 to 2.82±0.69 mm (<i>p</i>=0.68), height from 6.01±0.47 to 5.84±0.54 mm (<i>p</i>=0.449), and volume from 0.56±0.05 to 0.52±0.74 cm³ (<i>p</i>=0.398); these changes were not statistically significant. We identified features of HPG vascularization up to 12 months after HPG placement. The study also describes the complications of HPG placement.</p><p><strong>Conclusion: </strong>The use of HPG for the correction of PL showed high effectiveness and safety. There was no graft shrinkage during the 12-month follow-up period. The study demonstrates the capabilities of ultrasound methods for assessing the dimensions and biointegration features of HPG.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 3","pages":"5-12"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Frequency and nature of complications of deep anterior lamellar keratoplasty].","authors":"G A Osipyan, N V Fisenko, E A Budnikova, A K Dzamikhova","doi":"10.17116/oftalma202614204184","DOIUrl":"https://doi.org/10.17116/oftalma202614204184","url":null,"abstract":"<p><strong>Objective: </strong>The study analyzed intraoperative and postoperative complications of deep anterior lamellar keratoplasty (DALK) performed in 2008-2023 at the Krasnov Research Institute of Eye Diseases.</p><p><strong>Material and methods: </strong>This retrospective study included 523 patients (548 eyes) with corneal pathology: keratoconus, post-refractive keratectasia, pellucid marginal degeneration, stromal dystrophies, and opacities due to keratitis or trauma. All patients underwent DALK using the big-bubble technique. The maximum follow-up period was 15 years; follow-up exceeded 5 years in 373 cases, and 10 years in 175 cases.</p><p><strong>Results: </strong>Type 1 Descemet membrane (DM) detachment was recorded in 434 cases, type 2 - in 51 cases, and type 3 - in 8 cases. In 55 eyes, DM detachment using the big-bubble technique was not possible, in these cases DM was separated from the stroma with a dissector. The main intraoperative complications were DM damage during needle insertion into the stroma (2.2%), during stromectomy (0.5%), or during corneal suture placement (2.7%). Early postoperative complications included a false chamber between the graft and the patient's DM (0.9%), delayed graft epithelialization (20.4%), and acute graft rejection (2.2%). Late postoperative complications included acute graft rejection (1.1%), chronic graft rejection (1.1%), suture cut-through or loosening (1.6%), suture-related infiltrates (0.5%), ocular hypertension (3.1%), and posterior capsular cataract (2.9%).</p><p><strong>Conclusion: </strong>DALK offers the advantage of a relatively low risk of damage to intraocular structures and tissue incompatibility reactions. When intraoperative and postoperative complications of DALK occur, additional surgical interventions or adjustment of drug therapy are required.</p>","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"142 4","pages":"84-91"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}