Vasa-european Journal of Vascular Medicine最新文献

{"title":"Management of dual antiplatelet therapy following covered femoropopliteal stenting - Why size matters.","authors":"Maria Elisabeth Leinweber, Suzanne Holewijn, Maxime Sibe, Tanja Böhme, Laurens van Walraven, Thomas Zeller, Michel M P J Reijnen, Amun Georg Hofmann","doi":"10.1024/0301-1526/a001227","DOIUrl":"https://doi.org/10.1024/0301-1526/a001227","url":null,"abstract":"<p><p><b></b> <i>Background:</i> Endovascular therapy has emerged as an effective minimally invasive approach for treating peripheral artery disease (PAD). Postprocedural dual antiplatelet therapy (DAPT) is commonly used to prevent adverse events, but optimal management remains uncertain. <i>Patients and methods:</i> This international, multicentre retrospective study synthesized data from three studies on covered stents (VIABAHN^® Endoprosthesis) in 437 PAD patients (2001-2015). A dimension index (total stent length/smallest diameter) was developed and externally validated in a second cohort (n=148). <i>Results:</i> Among 321 patients with DAPT, univariate analysis showed no association between the initiation of DAPT and reduced major adverse limb events (MALE). Longer total covered length (aHR: 1.02) and smoking (aHR: 1.43) were associated with increased MALE, while stent diameters of 7-8mm showed a protective effect (aHR: 0.30). Cox proportional hazards models repeatedly showed that both the duration of DAPT and the dimension index (total covered length/smallest stent-graft diameter) were significantly associated with MALE after adjusting for other confounders. However, in a sensitivity analyses, no significant impact of DAPT on MALE was observed in patients with a high dimension index. <i>Conclusions:</i> These findings suggest while longer DAPT strategies might be protective towards MALE, stent-graft properties might be at least as relevant if not more determining regarding impaired outcomes after femoropopliteal interventions. Individualizing DAPT duration based on stent proportions might offer further opportunities for optimized protocols by personalized pharmacological therapies.</p>","PeriodicalId":23528,"journal":{"name":"Vasa-european Journal of Vascular Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Needle INsitu Fenestration Aortic repair (NINFA) - Short term results of a multicentre registry.","authors":"Marco Virgilio Usai, Imam T P Ritonga, Tolga Atilla Sagban, Meera Gunaseelan, Yousef Khatatba, Martin Josef Austermann, Marwan Youssef","doi":"10.1024/0301-1526/a001235","DOIUrl":"https://doi.org/10.1024/0301-1526/a001235","url":null,"abstract":"<p><p><b></b> <i>Background:</i> Thoracic endovascular aortic repair (TEVAR) involving the left subclavian artery (Ishimaru zone 2) presents technical challenges. This multicentre study evaluates the Ankura thoracic stent graft with in-situ fenestration using a dedicated needle system (Lifetech, Shenzhen, China) for various thoracic aortic pathologies. <i>Patients and methods:</i> Between January 2020 and December 2025, 59 patients from three tertiary centres underwent in-situ fenestration TEVAR (if-TEVAR) for thoracoabdominal aortic pathologies. Clinical and imaging data were analysed, focusing on technical success, complications, and mid-term outcomes. <i>Results:</i> Demographics and comorbidities were comparable across pathologies. The SVS/AAVS age score was higher in TAAA and PAU patients (p=.005). Dissection cases required more grafts (p=.027), larger proximal diameters (p=.022), and showed less distal oversizing in TAAA (p=.031). Differences were noted in fenestration time (p=.049), stent type (p=.032), and adjunctive procedures (p<.001). Technical success was 93.2% (55/59), with no significant variation among groups. One patient died within 30 days (2% mortality). ICU/hospital stays and complications were similar. <i>Conclusions:</i> if-TEVAR with the Ankura graft in zone 2 is feasible with acceptable outcomes. Larger studies with extended follow-up are needed to confirm durability.</p>","PeriodicalId":23528,"journal":{"name":"Vasa-european Journal of Vascular Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors and models for major adverse cardiovascular and limb events in patients with peripheral arterial disease.","authors":"Pan Song, Huarong Xiong, Xiaoyan Quan, Qin Chen, Dan Wang, Xiaoyu Liu, Meihong Shi","doi":"10.1024/0301-1526/a001228","DOIUrl":"https://doi.org/10.1024/0301-1526/a001228","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;&lt;/b&gt; &lt;i&gt;Background:&lt;/i&gt; Peripheral arterial disease (PAD) is associated with an increased risk of major adverse cardiovascular and limb events. However, the factors influencing major adverse cardiovascular events (MACE) and major adverse limb events (MALE) in patients with PAD remain unclear. Additionally, while some predictive models for MACE and MALE in patients with PAD have been developed, their performance is uncertain. This systematic review aims to identify the factors influencing MACE and MALE in patients with PAD and to systematically evaluate existing predictive models. &lt;i&gt;Materials and methods:&lt;/i&gt; We conducted a literature search in PubMed, Embase, and the Cochrane Library to identify studies exploring risk factors for MACE and MALE, as well as predictive models for these outcomes. Data extraction focused on study design, patient demographics, reported influencing factors (e.g., clinical, biochemical), and characteristics of predictive models (e.g., variables, validation methods, performance metrics). We specifically evaluated the methodological quality and risk of bias of the identified predictive models using established tools such as PROBAST (Prediction model Risk Of Bias ASsessment Tool). This study aimed to synthesize evidence on determinants of MACE and MALE and critically appraise existing prediction models to inform future research and clinical decision-making. &lt;i&gt;Results:&lt;/i&gt; One hundred and sixteen studies reported factors influencing MACE in patients with PAD. Six studies developed or validated predictive models. Three models were rated as having low risk of bias across all domains, while the other three had unclear or high risk of bias in at least one domain. A total of 118 influencing factors associated with MACE were identified. Common factors included: demographic characteristics (age, smoking); (2) comorbidities (diabetes mellitus (DM), coronary artery disease (CAD), prior stroke, heart failure); (3) clinical measures (body mass index (BMI), systolic blood pressure (SBP)); (4) diagnostic indicators (ankle-brachial index (ABI), estimated glomerular filtration rate (eGFR), C-reactive protein (CRP), serum creatinine); (5) medication use (statins); and (6) classification systems (Rutherford classification, Fontaine classification). Fifty-five studies reported factors influencing MALE in patients with PAD. Six studies developed or validated predictive models. Three models were rated as having low risk of bias across all domains, while the other three had unclear or high risk of bias in at least one domain. A total of 88 influencing factors were identified. Common factors across most studies included demographic characteristics (age, smoking, socioeconomic status), comorbid conditions (DM, chronic kidney disease, hypertension, cerebrovascular disease), clinical factors (degree of frailty, BMI), diagnostic indicators (hemoglobin, serum creatinine, serum albumin), medication use (statin), and other factors (Wound, Isc","PeriodicalId":23528,"journal":{"name":"Vasa-european Journal of Vascular Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new approach to pain management in Lipedema.","authors":"Erika Mendoza","doi":"10.1024/0301-1526/a001224","DOIUrl":"https://doi.org/10.1024/0301-1526/a001224","url":null,"abstract":"","PeriodicalId":23528,"journal":{"name":"Vasa-european Journal of Vascular Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages of implementing a hybrid operating room for endovascular aortic aneurysm repair at a new vascular surgery centre.","authors":"Apostolos G Pitoulias, Kapetanios Dimitrios, Gergana T Taneva, Konstantinos P Donas","doi":"10.1024/0301-1526/a001234","DOIUrl":"https://doi.org/10.1024/0301-1526/a001234","url":null,"abstract":"<p><p><b></b> <i>Background:</i> Endovascular aortic aneurysm repair (EVAR) has evolved into a widely established alternative to traditional open surgical repair. For EVAR procedures, both mobile (standard operating room (SOR)) and fixed C-arm (hybrid operating room (HOR) systems are available. The aim of our study was to evaluate the advantages of implementing a HOR for endovascular aortic aneurysm repair at a new vascular surgery centre. <i>Materials and methods:</i> Between April 2020 and December 2024, data of 140 patients who treated endovascularly for aortic aneurysms (AAs) were retrospectively evaluated. In detail, between April 2020 and March 2023, in 43 consecutive cases a mobile C-arm device was used, compared to the second period from April 2023 up to December 2024 when 97 consecutive patients with AAs were treated in a HOR. Primary endpoints of the study were procedural duration, radiation exposure time, and radiation dose. <i>Results:</i> Radiation exposure was significantly lower in the HOR group, with median radiation time of 15.3 vs. 23.1 minutes and median dose of 7.9 vs. 13.5 Gy·cm² (p<.001). The EVAR radiation time (14.1 vs. 20.6 minutes) and dose (6.6 vs. 11.4 Gy·cm²) remained significantly lower in the HOR group (p<.001). The implementation of the HOR was associated with a 125% increase of treated cases, resulting in a nearly four-fold rise of the total monthly case volume compared to the first period with the mobile C-arm. <i>Discussion:</i> The results of our study highlight the advantages of the HOR, such as reduced radiation, improved workflow efficiency and greater procedural capacity. <i>Conclusions:</i> Newly founded vascular centres should consider incorporating a HOR at the earliest opportunity.</p>","PeriodicalId":23528,"journal":{"name":"Vasa-european Journal of Vascular Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"54. Jahrestagung der Deutschen Gesellschaft für Angiologie - Gesellschaft für Gefäßmedizin e.V. und 9. DGA-Interventionskongress.","authors":"","doi":"10.1024/0301-1526/a001222","DOIUrl":"https://doi.org/10.1024/0301-1526/a001222","url":null,"abstract":"","PeriodicalId":23528,"journal":{"name":"Vasa-european Journal of Vascular Medicine","volume":"54 S114","pages":"1-45"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular endothelial cell biopsy - a systematic review.","authors":"Charles Piercy, John Adam, James N Harrison, Christian Heiss, Paola Campagnolo, Ben Creagh-Brown","doi":"10.1024/0301-1526/a001207","DOIUrl":"10.1024/0301-1526/a001207","url":null,"abstract":"<p><p><i>Background:</i> Endovascular endothelial cell biopsy (ECBx) allows direct sampling of endothelial cells (ECs) and subsequent assessment of EC function in patients. Our systematic review aims to summarise the current literature describing protocols to obtain and analyse EC and obtain pooled estimates of success rate and EC numbers obtained with different techniques in different populations. <i>Materials and methods:</i> Studies were identified on Medline using the terms 'endothelial cell' AND 'biopsy' AND 'humans'. All primary research involving EC biopsy was included, while animal studies or non-primary research studies were excluded from the review. The data was integrated into a narrative review and the study was registered with PROSPERO (CRD42022278551). <i>Results:</i> Of all journal articles identified (n=784), 51 articles were included in this review. Most studies (n=46) used a J wire for EC sampling from blood vessels in the arm (superficial arm veins [n=30], brachial artery [n=3], radial artery [n=4]). The pooled success rate was 91±15%. The average yield was 1,058±893 cells per biopsy, with variability depending on procedural factors such as wire placement, depth and technique. No significant complications were reported. Several analytical techniques were used to evaluate the isolated ECs with the most common technique being immunofluorescence (n=36). Risk of bias assessment and statistical analysis not performed due to heterogeneity of data and variability in reporting. <i>Conclusions:</i> Endothelial cells can be obtained with a variety of techniques with a high success rate and minimal complications. This review highlights novel research opportunities provided by ECBx.</p>","PeriodicalId":23528,"journal":{"name":"Vasa-european Journal of Vascular Medicine","volume":" ","pages":"305-313"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular manifestations of thalidomide embryopathy.","authors":"Peter Franz Klein-Weigel, Christina Ding-Greiner","doi":"10.1024/0301-1526/a001208","DOIUrl":"10.1024/0301-1526/a001208","url":null,"abstract":"<p><p><b></b> More than 60 years after withdrawal of ConterganR (thalidomide) from the market, the issue is more relevant than ever for physicians specialised in vascular medicine and cardiology due to the age-related increased use of appropriate health services by those affected. We describe cardiovascular abnormalities of thalidomide embryopathy and point out clinically relevant features that may have a profound influence on the disease management. We also describe and discuss whether arteriosclerotic diseases and complications occur more frequently in those affected by thalidomide embryopathy than in the general population.</p>","PeriodicalId":23528,"journal":{"name":"Vasa-european Journal of Vascular Medicine","volume":" ","pages":"299-304"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiR-21, miR-126 and miR-181b expression in Thromboangiitis obliterans.","authors":"Breno Pinheiro Rossoni, Juliana Lima Toledo Rossoni, Carlos Augusto Schreiner, Elisa Helena Subtil Zampieri, Daniela Pretti da Cunha Tirapelli, Edwaldo Edner Joviliano","doi":"10.1024/0301-1526/a001194","DOIUrl":"10.1024/0301-1526/a001194","url":null,"abstract":"<p><p><b></b> <i>Background:</i> Several studies have demonstrated the participation of by-products of the NF-kB pathway in thromboangiitis obliterans, however, the involvement of microRNAs 21, 126 and 181b that are related to this pathway in TAO activation is unknown. <i>Patients and methods:</i> We analyzed the serum levels of miR-21, miR-126 and miR-181b in TAO patients at two times separated by 6 months (TAO-1 and TAO-2 groups) and compared them with three healthy control groups with smokers (SC), former smokers (FSC) and never smokers (NSC). <i>Results:</i> Three patients activated the disease between periods TAO-1 and TAO-2, with elevation of the studied microRNAs. We identified an overexpression of miR-21 in TAO-2 compared to NSC (CI 5.37-21.45; p<0.01); FSC (CI 1.46-18.14; p=0.02) and SC (CI 0.97-16.13; p=0.03). MiR-126 showed overexpression in TAO-2 relative to NSC (CI 3.36-30.95. p=0.02). MiR-181b showed overexpression relative to NSC (CI 0.27-14.18. p=0.04). The groups with a history of smoking had higher means of the microRNAs studied, but without statistical difference. <i>Conclusions:</i> Serum levels of microRNAs 21, 126 and 181b appears to be upregulated in TAO patients and to correlate with periods of greater disease activity, but further studies with a larger number of patients are needed to validate an eventual process of using them as biomarkers of disease activity.</p>","PeriodicalId":23528,"journal":{"name":"Vasa-european Journal of Vascular Medicine","volume":" ","pages":"347-353"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of lower limb peripheral artery disease in urban areas of the Estuaire Province, Gabon.","authors":"Marie Jocelyne Kouna Oumoyi Doumbeneny, Euloge Ibinga, Jean Leonard Mbini Junior, Edgard Brice Ngoungou, Jean Raymond Nzenze, Victor Aboyans","doi":"10.1024/0301-1526/a001200","DOIUrl":"10.1024/0301-1526/a001200","url":null,"abstract":"<p><p><b></b> <i>Background:</i> Lower limb peripheral artery disease (PAD) is a common manifestation of atherosclerosis, ranging from subclinical to severe stages including critical ischemia and amputation. Data on epidemiology of PAD in Africa are scarce. This study aimed to determine the prevalence of PAD and identify associated cardiovascular risk factors in Gabon's general population. <i>Patients and methods:</i> Our cross-sectional study utilized quota sampling in three municipalities of the Estuaire province in Gabon. We selected 1502 urban residents aged 18 years and older. Sociodemographic and behavioural data were collected using a questionnaire, along with the Edinburgh Claudication Questionnaire. Ankle-brachial index (ABI) was measured using Doppler examination. PAD was defined as an ABI ≤ 0.90. <i>Results:</i> The average age of the population was 45.2±16.23 years, with 55.7% being females. Among participants, 299 (25.7%) had PAD (95% CI: 23.2-28.3). The prevalence of PAD was 26.2% (95% CI: 22.3-30.2) among men and 25.3% (95% CI: 22.0-28.7) among women. Among the PAD cases, 35 subjects (11.7%) were symptomatic. In the multivariate analysis, factors significantly associated with PAD were sedentary lifestyle (OR = 1.4; 95% CI: 1.0-1.8), hypertension (OR=1.3; 1.0-1.7) and being overweight (OR = 1.8; 95% CI: 1.1-3.1), grade 1 obesity (OR = 1.7; 95% CI: 1.0-2.9), and grade 2 obesity (OR = 1.9; 95% CI: 1.1-3.2) <i>Conclusions:</i> The prevalence of lower limb PAD in Gabon's urban population is important. This highlights the need for greater awareness among those with high cardiovascular risk and mandatory screening in health facilities.</p>","PeriodicalId":23528,"journal":{"name":"Vasa-european Journal of Vascular Medicine","volume":" ","pages":"354-360"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}