VNU Journal of Science: Medical and Pharmaceutical Sciences最新文献

{"title":"Flos Lonicerae: A Review of Chemical Structures and Biological Activities of Phenolic Derivatives","authors":"P. D. Tuan, Tran Thi Van Anh, N. Hai, Ha Quang Loi, Dao Viet Hung, Ha Thanh Hoa, N. Diep, Ngo Thi Xuan Thinh","doi":"10.25073/2588-1132/vnumps.4429","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4429","url":null,"abstract":"Flos Lonicerae, a widely used Vietnamese medicinal material, is the dried buds or flowers of Lonicera japonica Thunb., and several other species of genus Lonicera such as Lonicera dasystyla Rehd., Lonicera confusa DC., Lonicera cambodiana Pierre ex Danguy, belonging to the family Caprifoliaceae. This material has been used for a long time in traditional medicine for clearing heat, removing toxins, and dispersing wind heat. According to a variety of recent phytochemistry and biological studies that we systematically summarized, Flos Lonicerae contains 129 phenolic derivatives including 48 flavonoids, 13 lignans and neolignans, 55 phenolic acid derivatives, and 13 other phenolic compounds. These phenolic compounds have remarkable biological effects such as antibacterial, antiviral, antioxidant, anti-inflammatory, anti-cancer, hepatoprotective, anti-endotoxin, anti-allergic, anti-diabetic, cardioprotective, anti-allergic activities, etc. In particular, chlorogenic acid, a prominent component with significant biological activities, is utilized as a marker compound to evaluate the quality of Flos Lonicerae in the Vietnamese and Chinese Pharmacopoeia. \u0000  \u0000  \u0000 ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79149991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Berberine: A Perspective Compound in the Development of New Medicines","authors":"Thu Thi Duong, Tran Thi Hai Yen, Nguyen Thi Thanh Hai, J. Heinämäki, Pham Thi Minh Hue","doi":"10.25073/2588-1132/vnumps.4452","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4452","url":null,"abstract":"Berberine (BBR) is a plant-origin alkaloid with a long history, commonly used for treating infectious diarrhea. In recent years, BBR has been found with many pharmacological effects such as lowering blood glucose, anti-hyperlipidemia, liver protection, kidney protection, anti-atherosclerosis, antioxidants, etc. However, several studies revealed that the oral bioavailability of BBR was very low. Therefore, drug delivery systems have been studied to improve the absorption of BBR through an intestinal epithelial barrier such as liposomes, proliposomes, phytosomes, and nano lipids. The finding of new drug delivery systems has great potential in developing new medicines with a traditional active substance – BBR. \u0000Besides, BBR is also an important lead compound with different pharmacological effects, promising to form many new drug discovery programs with high feasibility. \u0000 ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85671630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Therapeutic Drug Monitoring and Model-Informed Precision Dosing in Personalized Medicine","authors":"Bui Son Nhat, Le Thi Luyen","doi":"10.25073/2588-1132/vnumps.4378","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4378","url":null,"abstract":"Therapeutic drug monitoring (TDM) and model-informed precision dosing (MIPD) have become effective methods in determining and adjusting dose regimens of various drugs in clinical practice. With the latest development in technology, particularly in computer science, drug individualization has evolved to be more flexible and precise. However, these methods still have certain drawbacks and have not been applied on a grand scale. This review shall present the most basic concept of TDM and MIPD as well as current issues in their application. \u0000  \u0000  \u0000  \u0000 ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89856388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of Treatment of the GEU at the Infundibulum of Fallopian Tube by Endoscopic Surgery at National Hospital of Obstetrics and Gynecology","authors":"Vu Van Du, Nguyen Thi Ngoc Quyen, Nguyen Duong Truyen, Mac Dang Tuan","doi":"10.25073/2588-1132/vnumps.4349","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4349","url":null,"abstract":"Abstract: Objective: To evaluate the results of laparoscopic management of tubal cystectomy at the National Hospital of Obstetrics and Gynecology. Subjects and research methods: A retrospective descriptive study of medical records of patients with tubal cystectomy at the National Hospital of Obstetrics and Gynecology from November 1, 2020, to the end of December 31, 2020. Results: The most common age group for tubal pregnancy is 25-34 years old (59.1%), and the least common is under 20 years old (1.1%). 57% of patients had less than two children. The size of the gestational mass at surgery ≤ 3cm accounted for the highest percentage (86%), and the group of patients with gestational mass ≥ 5cm accounted for only 1.1%. Morphology of the gestational mass before surgery: most of the gestational masses were unbroken, accounting for 69.9%, and 5.9% had ruptured gestational masses. Mainly during surgery, the amount of blood in the abdomen is from 100-500 ml (54.8%), and blood volume >500 ml only accounts for 8.1%. There were 7.5% of patients who had laparoscopic tubal conservation, and the remaining 92.5% had a laparoscopic tubal resection. The group of patients who had never had children and had only one child had the highest rate of tubal preservation, in which the rate of tubal preservation in the group of patients without children was up to 17.6%. Total treatment time after laparoscopic surgery is usually less than 4 days, an average of 2.6±1.2 days. Out of 186 patients studied, only one patient required a blood transfusion. There were no cases of complications after laparoscopic surgery. Conclusions: The most common age group to get pregnant is women of reproductive age. Most of the patients come to the hospital in the early stage, the pregnancy mass has not broken, and the size is small. Patients without children had the highest rate of tubal preservation. The proportion of patients requiring blood transfusion was not significant, and there were no cases of complications after laparoscopic surgery. \u0000Keywords: results of treatment, GEU at the infundibulum of fallopian tube, endoscopic surgery.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79947910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of Ultrasound in the Diagnosis of Cholecystitis","authors":"D. Ngoc, Tran Quyet Thang, Tran Cong Hoan, Nguyen Van Sang","doi":"10.25073/2588-1132/vnumps.4345","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4345","url":null,"abstract":"Abstract: This study was carried out on 64 patients with a preoperative diagnosis of cholecystitis and preoperative ultrasound at E hospital. Results: mean age was 57.4 ± 16.1; male/female = 1/1.3; 95.3% cholecystitis with gallstones; 100% of chronic cholecystitis had gallstones, gallstones stuck in gallbladder neck accounted for 18.7%; gallbladder wall thickening accounts for 67.2%, in acute cholecystitis, this rate accounts for 90%; Sono-Murphy (+) accounted for 67.2%; in the group of patients with acute cholecystitis, this sign accounts for 95%. Peri-gall bladder fluid accounts for 60% of acute cholecystitis. Value of ultrasound in diagnosis: gallstones Se 100%; Acc 96.9%; PPV 96.7%; stones stuck in gallbladder neck: Se 42.8%; Sp 88%; Acc 78.1%; PPV 50%; NPV 84.6%; gallbladder wall thickness: Se 88.9%; Sp 60.7%, Acc 76.6%; PPV 74.4%, NPV 80.9%; fluid around the gallbladder: Se 82.1%; Sp 94.4%; Acc 89.1%; PPV 92.0%; NPV 87.2%; fat infiltration around the gallbladder: Se 35.7%; Sp 100%; Acc 71.9%; PPV 100%; NPV 66.7%; cholecystitis: Se 70.3%, Acc 70.3%; PPV 70.3%. Conclusion: Ultrasonography is reliable enough in the diagnosis of cholecystitis. \u0000Keywords: Cholecystitis, gallstones, ultrasound. \u0000  \u0000  \u0000 ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72789712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein Drugs","authors":"Nguyen Hue Linh, P. Huệ, Nguyen Thi Thanh Binh, Bui Thanh Tung, Ng Yen, Nguyễn Thanh Hải","doi":"10.25073/2588-1132/vnumps.4436","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4436","url":null,"abstract":"Abstract: To serve health care, up to now, sciences have successfully developed many drugs with different effects. In general, in terms of chemical structure and effect characteristics, medicine can be classified into groups including inorganic drugs, small-molecule organic drugs, protein drugs (macromolecules), and recently a new group of drugs has been formed, separate from the protein drug class, which is the RNA drugs. In terms of pharmacological effects, in general, the mechanisms of protein drugs and small-molecule organic drugs do not differ too much because they all act at a particular stage related to pathological manifestations. \u0000Protein drugs in the process of development have gone through many different stages, with different origins, from extraction and isolation from living tissues at an early stage to biosynthesis by recombinant technology and other modern biotechnology methods. To date, most of the proteins used in medicine have been produced through recombinant pathways, possibly through different semisynthetic steps to give the molecules more superior drug properties. Therefore, the group of protein drugs has an additional new name, biopharmaceuticals, to indicate their synthetic origin by biological methods. \u0000The research, development, and application of protein drugs into clinical practice are of great significance, helping to enhance the ability of medicine to control and treat many difficult-to-treat diseases today, bringing many opportunities to have good health for people. \u0000Keywords: Protein drugs, RNA drugs, Biopharmaceuticals, Inorganic drugs, Small-molecule organic drugs, Drug development, Cytokine, Enzyme, Hormone peptide, Stem cell, Recombinant technology, Biosimilar. *","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81770103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyze the Influencing Factors and Predictability of Metabolic Syndrome in Schizophrenic Patients Treated with Olanzapine through Decision Tree Model","authors":"Kieu Mai Anh, Nguyen Thi Thanh Tuyen, Nguyen Huu Chien, Nguyen Xuan Bach, Pham Thu Huong, Nguyen Chi Thanh, Nguyen Thi Thanh Hai","doi":"10.25073/2588-1132/vnumps.4411","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4411","url":null,"abstract":"Abstract: Olanzapine is a typical antipsychotic that has demonstrated efficacy for the treatment of schizophrenia, but the patients treated with olanzapine usually appear it’s specific adverse events such as metabolism. It shows some factors that may affect metabolism such as age, BMI, high-dose antipsychotics, etc. Up to now the main predictors for metabolism in a patient with schizophrenia have not been comprehensively evaluated. Subjects and research methods: In this prospective cohort study, a total of 202 inpatients with schizophrenia at Vietnamese National Psychiatric Hospital No1 were included. The univariate regression and decision tree model were applied to find out the statistically significant factors. Results: The factors influencing metabolism were: baseline waist, baseline triglyceride, baseline HDL, age, baseline BMI, baseline metabolism, cholesterol ≥6.2 history, and schizophrenia duration. The final decision tree model included 3 important nodes: baseline waist < 89 cm, baseline triglyceride <3.1 mmol/l, age <36. The predictive accuracy and other parameters were good to be able to apply for predictive purposes: accuracy 0.88, precision 0.90, recall 0.69, f1-score 0.78. Conclusion: The final model was good to predict no metabolism (0 code). In contrast, it is necessary to verify the metabolism status and have appropriate routine monitoring. \u0000Keywords: Metabolism, schizophrenia, olanzapine, predictive model, decision tree model.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88250448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Characteristics, Disease Knowledge of COVID-19 Patients in Dong Thap","authors":"Dao Duy Anh, Nguyen Tuan Son, Le Thi Nhung","doi":"10.25073/2588-1132/vnumps.4392","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4392","url":null,"abstract":"Abstract: A cross-sectional descriptive study was conducted from August 2021 to September 2021 to describe the epidemiological characteristics of COVID-19 patients at the field hospital in Dong Thap Community College. The study collected epidemiological data from 240 subjects. The results show that the male/female ratio is 1.2/1; the mean age was 29.2±15.1(1-65) years old; the proportion of subjects having contact with the pandemic area is 90%. The percentage of patients who caught Covid-19 from their family is the highest (62.1%), followed by the number of patients with an unknown source of infection (24.6%) and the number of patients who caught Covid-19 from community transmission (13.3%). The mean time between infection to hospitalization was 4.8 days. The percentage of subjects having 1st dose of vaccine is 12.5%. Most patients acknowledge the COVID-19 pandemic and know the modes of transmission of the SARS-CoV-2 virus. Most of the sick people practiced adequately or inadequately 5K measures in the community and did not practice disease prevention measures at home. The goals of this study are: i) Contributing to a general assessment of epidemiological factors and the accumulated understanding of the disease of COVID-19 patients in general, and COVID-19 subjects at the field hospital of Dong Thap Community College in particular; and ii) Contributing to the development of better disease prevention measures. \u0000Keywords: COVID-19, SARS-CoV-2, epidemiological characteristics.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86867225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of N-acetyltransferase 2 Phenotype Status and Pharmacokinetic Parameters of Vietnam Pulmonary Tuberculosis Patients","authors":"Le Anh Tuan, Bui Son Nhat, Le Thi Luyen, Vu Duong Anh Minh, Le Ba Hai, Tran Thi Thu Trang, Nguyen Thi Lien Huong","doi":"10.25073/2588-1132/vnumps.4440","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4440","url":null,"abstract":"Abstract: We conducted this research to determine the NAT2 gene-phenotype characteristics and pharmacokinetics (PK) parameters of isoniazid among patients with non-MDR pulmonary tuberculosis. Data were collected from 132 patients diagnosed with newly acquired or relapsed tuberculosis and treated at 03 hospitals: Hanoi Lung Hospital, Central Lung Hospital, and National K74 Hospital. PK samples were collected one day from the 10th – 14th day after commencing treatment. The average age of the recruited patients was 45.43 ± 15.76 years; the majority were male (74.24%). The slow and medium acetylator types, as indicated by NAT2 phenotypes, were the two major types (37.88% and 35.6%, respectively). 61.12% of the patients had their Bayesian isoniazid-acetyl isoniazid population PK modeling - determined Cmax value within the therapeutic range of 3 – 6 µg/mL. Acelytator type showed a statistically significant correlation with Cmax. \u0000Keywords: Isoniazid, pharmacokinetics, Cmax, tuberculosis.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85552123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening in silico Alkaloid Compounds Inhibiting Estrogen-α Receptors Against Breast Cancer","authors":"Bui Phuc Loc, Vu Manh Hung, Nguyễn Thi Thuy, Tran Hoang Mai, Le Thi Huong, Do Thi Hong Khanh, Bui Thanh Tung","doi":"10.25073/2588-1132/vnumps.4426","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4426","url":null,"abstract":"Abstract: The estrogen-α (ER-α) receptor is an important target in breast cancer therapy. Alkaloids are a class of plant extracts that have the potential to inhibit ER-α receptors. In this study, we evaluated the ability of alkaloids to inhibit ER-α receptors by molecular docking method. Based on previous publications, we collected 52 alkaloid compounds. The results showed that there were 4 compounds with stronger inhibitory effects on ER-α receptors than positive controls, which are co-crystallized ligands with 4-hydroxytamoxifen. Conducting analysis according to Lipinski's 5-criteria rule and predicting pharmacokinetic-toxicological parameters, we obtained one compound with drug-like properties is Pityriacitrin B. Therefore, this compound has the potential to develop into drugs that inhibit ER-α receptors for breast cancer treatment. \u0000Keywords: Breast cancer, ER-α, molecular docking, alkaloid, Pityriacitrin B.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86072276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}