VNU Journal of Science: Medical and Pharmaceutical Sciences最新文献

{"title":"Simultaneous Quantification of Kirenol, Daurutoside, and Darutigenol in Siegesbeckia orientalis L. by HLPC-DPA Method","authors":"Tran Thi Van Anh, P. D. Tuan, N. Khánh, Dao Viet Hung, N. Hai, N. Q. Tuan, N. Diep, Ngo Thi Xuan Thinh, Ha Thanh Hoa","doi":"10.25073/2588-1132/vnumps.4399","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4399","url":null,"abstract":"Kirenol (1), darutoside (2), and darutigenol (3), which are major active diterpenoids isolated from Herba Siegesbeckiae, are reported for analgesic activity and inflammatory effects. Currently, in Vietnamese Pharmacopoeia V, there is no requirement for the contents of active ingredients in this medicinal plant. In this study, a high-performance liquid chromatography (HPLC) method, which was developed with good repeatability and recovery, was used for simultaneous quantification of 1, 2, and 3 in Herba Siegesbeckiae. This method was successfully applied to quantify 1-3 in samples of Herba Siegesbeckiae collected from different locations. The results showed that the content of compound 1 accounted for 0 – 5.77 mg/g, compound 2 ranged from 0.82 to 5.48 mg/g, and compound 3 ranged from 0.37 to 3.18 mg/g. These results are considered a reference for upgrading the specification and quality control of Herba Siegesbeckiae. \u0000Keywords: \u0000Herba Siegesbeckiae; kirenol; darutoside; darutigenol; HPLC. \u0000  \u0000 ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80828597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Clinical and Magnetic Resonance, and Treatment Result for Anterior Cruciate Ligament Tear of the Knee Joint","authors":"Pham Thi Minh Ngoc, Nguyễn Văn Sơn","doi":"10.25073/2588-1132/vnumps.4407","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4407","url":null,"abstract":"Study on 41 patients with anterior cruciate ligament rupture diagnosed and treated at E Hospital from March 2021 to April 2022 showed: Mean age: 36.02, Male: 68.3%, female: 27.7%. Traffic accidents: 65.9%. Right foot: 53.7%, left foot: 44.3%. Timefrom injury to treatment > 3 weeks: 70.7%. Clinical: loose knee: 90.2%; pain: 87.8%; difficulty going up and down stairs: 65.9%; knee swelling: 51.2%; effusion: 68.3%; front drawer: 95.1%; Lachman: 92.7%; McMurray: 41.4%; average Lysholm score: 60.88. Magnetic resonance imaging (MRI): decompression/intermittent: complete: 52.7%, partial: 46.3%; contusion, edema: 41.5%; hematoma-hemorrhage: 87.7%; bone marrow edema: 34.1%; meniscus tear: 46.3%. Treatment results: pain relief upon discharge: 70.7%; incision: dry: 56.1% drainage: 43.9%, infection: 0, after follow-up: mean Lysholm score: 86.95, complications: numbness, burning behind the thigh: 2.44%.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81438201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Two Methods of Extracting Essential Oils from Citrus maxima","authors":"Dang Thi Thuy Ngan, Ha Thi Thanh Huong, Pham Thi Thu Thao, Nguyễn Thanh Hải, N. H. Hai Yen, Bùi Thị Thương, N. T. Hiền","doi":"10.25073/2588-1132/vnumps.4393","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4393","url":null,"abstract":"Essential oil from Citrus maxima was extracted by steam distillation and solvent extraction. The organic solvent extraction method achieved a 28.5% increase in efficiency compared with the steam distillation method. TD1 essential oil had a strong smell, mixed with water and other impurities (wax, resin...). In contrast, TD2 essential oil was fragrant due to its high essential oil content. The chemical composition of TD2 was more than TD1. The main components of essential oils such as pinene, limonene, phellandrene, ocimene, linalool, anethole, eugenol, zingiberene, nerolidol, etc. were kept intact, not denatured, without impurities. \u0000Keywords: \u0000Citrus maxima, Oil, steam distillation, solvent extraction, GC-MS.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91374076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging Characteristics and Value of Multislice Computed Tomography in the Diagnosis of Acute Appendicitis","authors":"D. Ngoc, Le My Hanh, Pham Quang Huy, Phung Hai Nam","doi":"10.25073/2588-1132/vnumps.4384","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4384","url":null,"abstract":"Objectives: This study was done to describe the imaging characteristics of acute appendicitis on multislice computed tomography (MSCT) and the value of MSCT scan in the diagnosis of acute appendicitis. Methods: The study used retrospective and cross-sectional methods to analyze the results of 117 patients who were taken photos of CT at E Hospital from February 2021 to November 2021. Results: The most common age was over 50 years old, and the average age was 40.1±20.8. The ratio of male/female was 1/1.25. Locations of appendix: right iliac fossa 69.2%, posterior cecum 16.2%, pelvis 12%, subhepatic 0.9%, 1.7% in other places in the abdomen. The diameter of appendicitis was 10.48±2.5mm (the min was 5mm, the max was 18mm). The increase of diameter over 7mm accounted for 95.7%, appendiceal wall thickness ≥ 3mm had 83.8% of patients, and fat infiltration was seen in 88% of cases studied. Other signs: fecal stones 35%, fluid around appendix 7.7%, Douglas fluid 3.4%, right iliac fossa fluid 3.4%, mesenteric lymphadenopathy 25.7%. The rate of appendix rupture diagnosed by CT accounted was 4.3%. The sensitivity, accuracy, and positive diagnostic value of multislice CT in the diagnosis of acute appendicitis were 97.4%, 96.6%, and 99.1%, respectively. Conclusion: Multislice CT has a high value in the diagnosis of acute appendicitis.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86357670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal Extracts: Importance, Classification, Quality Characteristics, and Control","authors":"Tran Trong Bien, Tran Mai Thi Tuyet, Bui Thi Lan Phuong, Pham Thai Ha Van","doi":"10.25073/2588-1132/vnumps.4374","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4374","url":null,"abstract":"Herbal extracts are one of the herbal preparations obtained by the extraction method. There has been an increasing trend of application of herbal extracts to replace traditional medicinal herbs in using and manufacturing of drug dosage forms. The quality characteristics of herbal extracts roots from their multi-components nature, leading to multiple targets and mechanisms of action. Thus hindering the development of quality assessment systems and also the application of pharmaceutical technologies in the development of modern dosage forms, leading to a decrease in therapeutic efficacy in clinical practice. This review systematizes some information related to herbal extracts: the position and importance of herbal extracts in drug research and development, classification, characteristics, and quality control strategies. The purpose of this review is to consolidate and expand the general understanding of the “pharmaceutical nature” of herbal extracts and to provide some quality control strategies using markers and reference materials \u0000Keywords \u0000Herbal extracts, quality characteristics, classification, quality control, pharmaceutical nature.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81481591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Whole Exome Sequencing in Mutational Analysis of Patients with Ohtahara Syndrome","authors":"Nguyen Thi Quynh Mai, Nguyen Le Trung Hieu, Le Thi Khanh Van, Nguyen Thuy Minh Thu, Le Tran Anh Ngan, Huynh Thi Dieu Hien, Do Thi Thu Hang","doi":"10.25073/2588-1132/vnumps.4347","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4347","url":null,"abstract":"Ohtahara syndrome is one of the earliest and most severe forms of developmental and epileptic encephalopathy. Over the last decade, the rapid advances in molecular techniques, especially in high-throughput sequencing (HTS), have revealed that a majority of Ohtahara patients have genetic etiology. About 20 genes have been found to be related to this syndrome so far, and Next Generation Sequencing (NGS) technique is now an important genetic test for this syndrome. This study was conducted on 4 patients with Ohtahara syndrome referred to Children’s Hospital 2, Ho Chi Minh City. Whole-exome sequencing (WES) following targeted analysis on 283 epileptic encephalopathy–related genes was performed to identify disease-causing variants of the patients. Following multi-step bioinformatics analysis, trio-based Sanger sequencing confirmation, and variant classification according to standards of The American College of Medical Genetics and Genomics – 2015, we have identified 2 pathogenic mutations in 2 patients: OH3 (KCNQ2, c.868G>A, p.G290S) and OH4 (SCN2A, c.788C>T, p.A263V). The results of this study contribute to verifying the role of genetic factors in Ohtahara syndrome in Vietnamese patients. This study also confirms that NGS in general and WES, in particular, are reliable and useful in detecting genetic causes of Ohtahara syndrome, thereby, assisting in diagnosis and treatment of this syndrome. \u0000 \u0000  \u0000 \u0000 \u0000  \u0000","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89876495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Situation and some Factors Related to Injury of Children Under 5 Years Old in 3 Communes of Hoai Duc District, Hanoi City in 2020","authors":"Nguyen Thi Kim Dung, Chu Van Thang","doi":"10.25073/2588-1132/vnumps.4348","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4348","url":null,"abstract":"Research objective: describe the current situation and some factors related to injury accidents of children under 5 years old in 3 communes of Hoai Duc district, Hanoi city 2020. Objects and research methods: A cross-sectional descriptive study on 901 families with children under 5 years old in 3 communes of Hoai Duc district, Hanoi city in 2020. Research results: About the situation: The rate of accidents and injuries is 14.77%. Most of the injuries in 2-year-olds accounted for 40.53%. The leading causes are: Fall/fall (41.05%); sharp objects (14.74%) and burns (12.63%). The most common time for children to have accidents and injuries is from 6 am to 12 am (45.79%) and 12 to 18 pm (34.74%). Accidents and injuries are unintentionally caused by children themselves, accounting for 62.11%. 97.4% of children received first aid within 30 minutes of the accident. Regarding the relationship: Male caregivers are 1.46 times more likely to cause injury to children than female caregivers. Caregivers of children who have completed university/college/secondary education are 8.85 times less likely to cause their children to suffer from an accident than people who do not attend school (OR: 8.85, 95%CI: 1.92) – 40.88). Male children have 1.47 times higher risk of having a stroke than girls (OR: 1.47, 95% CI: 1.08 – 2.00), the relationship is statistically significant with p < 0.05. Conclusion: The rate of accidents and injuries is still quite high at 14.77%, most of the children have self-inflicted injuries at a time when there are few caregivers at home. Education level, caregiver's gender, and child's gender are related to the risk of injury.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84548595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of the Cost-effectiveness of Perampanel in the Treatment of Epilepsy","authors":"Nguyen Doan Duy Linh, Pham Huy Tuan Kiet, Dang Thi Hon, Tran Tien Dat, Nguyen Xuan Bach","doi":"10.25073/2588-1132/vnumps.4377","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4377","url":null,"abstract":" Objective: Epilepsy is a chronic non-communicable disease that can affect all ages, genders, races, and social classes with large treatment costs that vary widely between countries and regions. Perampanel is a new generation of antiepileptic drugs (AEDs), but cost-effectiveness reports are inconsistent in several countries that have conducted pharmacoeconomic evaluations. Study with the objective of systematically summarizing the evidence on the cost-effectiveness of Perampanel for the treatment of epilepsy. Methods: An exhaustive search was performed in four publication databases. Evaluation of the reporting quality of the studies using the CHEERS checklist. Results: Findings: Costs were lower in the Perampanel group than in the Lacosamide group (Perampanel 8mg/day vs. Lacosamide 400mg/day - Total cost: $2390 (12.89%), but higher than in the antiepilepsy drugs group without perampanel (Total Direct Cost: 5475 Euro and Total Indirect Cost: -5288 Euro, Total Cost: 188 Euro) and the group with recent add-on regime such as Brivaracetam (3188 Euro in total). When compared with the Lacosamide group, the Perampanel group showed increased outcomes in all three outcomes (convulsions, LY, and QALY). Similarly, the Perampanel group showed increased outcomes in all three outcomes (convulsions, LY, and QALY) compared with groups without Perampanel. Meanwhile, QALY in the Perampanel group was lower than in the Brivaracetam group (total of 0.059 QALY). Conclusions: Perampanel as an adjunct therapy for antiepilepsy drugs may be a cost-effective treatment option in the management of epilepsy. \u0000Keywords: Fycompa, perampanel, seizure, epilepsy, systematic review, cost-effective. \u0000References \u0000[1] R. S. Fisher, C. Acevedo, A. Arzimanoglou, A. Bogacz, J. H. Cross, C. E. Elger et al., ILAE Official Report: a Practical Clinical Definition of Epilepsy. Epilepsia, Vol. 55, No. 4, 2014, pp. 475-482.[2] K. M. Fiest, K. M. Sauro, S. Wiebe, S. B. Patten, C. S. Kwon, J. Dykeman, et al., Prevalence and Incidence of Epilepsy: A Systematic Review and Meta-analysis of International Studies, Neurology, Vol. 88, No. 3, 2017, pp. 296-303.[3] A. C. Meyer, T. Dua, J. Ma, S. Saxena, G. Birbeck, Global Disparities in The epilepsy Treatment Gap: a Systematic Review, Bull World Health Organ, Vol. 88, No. 4, 2010, pp. 260-266.[4] GBD, Neurology Collaborators, Global, Regional, and National Burden of Neurological Disorders, 1990-2016: a Systematic Analysis for the Global Burden of Disease Study 2016, Lancet Neurol, Vol. 18, No. 5, 2019, pp. 459-480.[5] S. Y. Chen, N. Wu, L. Boulanger, P. Sacco, Antiepileptic Drug Treatment Patterns and Economic Burden of Commercially-insured Patients with Refractory Epilepsy with Partial Onset Seizures in the United States, J Med Econ, Vol. 16, No. 2, 2013, pp. 240-248.[6] J. A. Cramer, Z. J. Wang, E. Chang, A. Powers, R. Copher, D. Cherepanov et al., Healthcare Utilization and Costs in Adults with Stable and Uncontrolled Epilepsy, Epilepsy Behav, Vol. 31,","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78514234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RNA Drugs","authors":"Nguyen Hue Linh, P. Huệ, Nguyen Thi Thanh Binh, Bui Thanh Tung, V. Loi, Ng Yen, N. Hai","doi":"10.25073/2588-1132/vnumps.4388","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4388","url":null,"abstract":"RNA drugs are a new group of drugs that delivers RNAs or similar structures inside the body to achieve the therapeutic effect. This is a promising direction in drug development to treat serious and rare genetic diseases more specifically and effectively. In reality, the genetic systems and protein synthesis processes of living organisms are extremely complex, so the development of RNA drugs faces many difficulties. To achieve success, many different studies have been carried out to address issues such as finding suitable RNAs, synthesizing similar RNA structures, stabilizing RNA structures, and introducing drugs into targeted cells. Since the first RNA drug was officially approved by the FDA (2004), 10 RNA drugs in total have been approved to date. Among them, two vaccines, appearing at the time when much needed support to cope with the new SARS-CoV-2 variants, were developed using mRNA technology. With these achievements, scientists can have more confidence in the possibilities of evolving a new drug group that is more specific and effective, which is RNA drugs. This review briefly introduces the group of drugs that use RNAs, RNA structural analogs, and RNA biomarkers to develop novel drugs for application in the diagnosis, prevention, and treatment of disease. \u0000Keywords: \u0000RNA drugs; mRNA; the protein; vaccines; RNA diagnostics; small molecule drugs; RNA target. \u0000References \u0000[1] U. Sahin, K. Karikó, Ö. Türeci, Mrna-Based Therapeutics-Developing A New Class of Drugs, Nature Reviews Drug Discovery, Vol. 13, No. 10, 2014, pp. 759-780.[2] T. H. Nguyen, T. M. H. Pham, M. K. Tu, Pharmacogenetics: Prospects and Issues. Journal of Pharmacy, No. 54, Vol. 456, 2014, pp. 2-6.[3] A. M. Yu, Y. H. Choi, M. J. Tu, Rna Drugs and Rna Targets for Small Molecules: Principles, Progress, and Challenges, Pharmacological Reviews, Vol. 72, No. 4, 2020, pp. 862-898.[4] M. A. Hendaus, F. A. Jomha, Mrna Vaccines for Covid-19: A Simple Explanation, Qatar Medical Journal, Vol. 2021, No. 1, 2021, pp. 1-5.[5] A. Banerji, P. G. Wickner, R. Saff, C. A. Stone Jr, L. B. Robinson, A. A. Long et al., Mrna Vaccines to Prevent Covid-19 Disease and Reported Allergic Reactions: Current Evidence and Suggested Approach, the Journal of Allergy and Clinical Immunology: in Practice, Vol. 9, No. 4, 2021, pp. 1423-1437.[6] https://www.Fda.Gov/Emergency-Preparedness-and-Response/Coronavirus-Disease-2019-Covid-19/Covid-19-Vaccines (accessed on: December 15th, 2021).[7] E. H. Aarntzen, G. Schreibelt, K. Bol, W. J. Lesterhuis, A. J. Croockewit, J .H. De Wilt et al., Vaccination with Mrna-Electroporated Dendritic Cells Induces Robust Tumor Antigen-Specific Cd4+ and Cd8+ T Cells Responses in Stage Iii and Iv Melanoma Patients, Clinical Cancer Research, Vol. 18, No. 19, 2012, pp. 5460-5470.[8] H. M. Phan, K. L. Vu, T. H. Nguyen, T. T. Bui, A Comprehensive Review of Vaccines Against Covid-19, VNU Journal of Science: Medical and Pharmaceutical Sciences, Vol. 37, No. 3, 2021, pp. 1-19 (in Vietnamese).[","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73430225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of Clinical and Magnetic Resonance Imaging of Lumbar Disc Herniation","authors":"D. Ngoc, Ho Thi Nhung, Tran Cong Hoan","doi":"10.25073/2588-1132/vnumps.4341","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4341","url":null,"abstract":"A study of 55 patients with lumbar disc herniation who were taken MRI and surgery at hospital E from January 2019 to December 2019. Results: The mean age was 58.96 ± 16.4, the female/male ratio was 1.12/1. People doing heavy work had a higher risk of disc herniation than those doing light work (63.7%). Common symptoms: lumbar pain (100%), sciatica pain, pain with mechanical properties (85.45%), limited spinal movement (90.91%), Lasègue sign (+) (74.55%), bell sign (+) (54.55%); signs of nerve root damage: sensory disturbances 72.73%, movement disorders 50.91%. Clinical lesions were common in L5 (65.45%) and S1 (45.45%) roots. Hernias were common at L4/5 (81.8%) and L5/S1 (70.9%). The degree of hernia was mainly bulge and hernia, accounting for 60% and 52.73%, respectively. 98.18% herniated to the back, central hernia accounted for the highest rate (41.82%). The rate of nerve root compression detected on MR is 90.91%. Evaluation of nerve root damage in clinical and magnetic resonance had high concordance in L5 and S1 roots (98.17% and 100%, respectively). Conclusion: MRI helps in early, accurate diagnosis and treatment orientation of lumbar disc herniation. \u0000Keywords: Disc herniation, MRI lumbar spine, lumbar pain.  \u0000References \u0000[1] R. J. Gardocki, A. L. Park, Lower Back Pain and Disorders of Intervertebral Discs, Campbell's Operative Orthopaedics, 12th ed, Elsevier Mosby, 2013:chap 42.[2] N. V. Chuong et al., Research on Lumbar Disc Herniation at Department - Department of Internal Neurology, Hospital 103 - Military Medical Academy, Journal of Military Medicine, Vol. 3, 2015, pp. 5 - 16 (in Vietnamese).[3] S. Lee, J. H. Kang, U. Srikantha et al., Extral Foraminal Compression of the L5 Nerve Root at the Lumbosacral Junction: Clinical Analysis, Decompression Technique, and Outcome, Journal Neurosurgery Spine, Vol. 24, No. 1, 2014, pp. 1-9, https://doi.org/10.3171/2013.12.spine12629.[4] S. Eicker, S. Rhee, H. Steiger et al., Transtubular Microsurgical Approach to Treating Extra Foraminal Lumbar Disc Herniations, Neurosurgery Focus, Vol. 35, No. 2E1, 2013, pp. 1-6, https://doi.org/10.3171/2013.4.focus13126. \u0000[5] H. M. Cuong, Research on the Diagnosis and Surgical Treatment of Disc Herniation in the Lumbar Spine and Side Deviation by Bone Window Opening Method, Master's Thesis of Medicine, Hanoi Medical University, 2010 \u0000(in Vietnamese).[6] J. D. Lurie, T. D. Tosteson, A. N. Tostenson et al., Surgical Versus Non-operative Treatment for Lumbar Disc Herniation: Eight-year Results for the Spine Patient Outcomes Research Trial, Spine, Vol. 39, No. 1, 2014, pp. 3-16, https://dx.doi.org/10.1097%2FBRS.0000000000000088.[7] M. R. Konieczny, R. Jeremia, M. Post et al., Signal Intensity of Lumbar Disc Herniations: Correlation With Age of Herniation for Extrusion, Protrusion, and Sequestration, Int J Spine Surg. Vol. 14, No. 1, 2020, pp. 102–107, https://doi.org/10.14444/7014.[8] M. H. Daghighi, M. Pouriesa, M. Maleki et al., Migration Patterns of Herniated Disc ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74255973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}