VNU Journal of Science: Medical and Pharmaceutical Sciences最新文献_第9页

A Simplified Method for Simultaneous Extraction and Purification of Stevioside and Rebaudioside A from Stevia Rebaudiana Bert. Applying in Pharmaceutical 同时提取纯化甜菊糖苷和甜菊糖苷A的简化方法研究。医药应用

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-09-23 DOI: 10.25073/2588-1132/vnumps.4383

Tra Trong Bien, Nguyen Van Han

引用次数: 0

The Susceptibility to Antibiotics of Isolated Bacteria and the Suitability of Antibiotic Regimens to Drugs Susceptibility Test for Patients with Community-acquired Pneumonia at National Hospital 74 74 .国立医院社区获得性肺炎分离菌对抗生素的敏感性及抗生素方案对药敏试验的适宜性

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-09-23 DOI: 10.25073/2588-1132/vnumps.4410

Trang Thanh Trung, Vu Khanh Linh, Bui Son Nhat, Le Thi Luyen

{"title":"The Susceptibility to Antibiotics of Isolated Bacteria and the Suitability of Antibiotic Regimens to Drugs Susceptibility Test for Patients with Community-acquired Pneumonia at National Hospital 74","authors":"Trang Thanh Trung, Vu Khanh Linh, Bui Son Nhat, Le Thi Luyen","doi":"10.25073/2588-1132/vnumps.4410","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4410","url":null,"abstract":"Abstract: Community-acquired pneumonia (CAP) is a common infectious disease in clinical practice. The objective of the study was to describe the susceptibility to antibiotics of isolated bacteria and to analyze the suitability of antibiotics regimens for treatment after having a drugs susceptibility test (DST) to bacteria in CAP patients. A retrospective study was conducted at National Hospital 74, after screening the medical records of CAP patients hospitalized in the first 6 months of 2021, 32 patients with isolated pathogenic bacteria were included in the study. The results revealed that the percentage of CAP patients who isolated pathogenic bacteria was low. There were 9 isolations of isolated bacteria, in addition to the common bacteria in CAP, also including isolations of bacteria that commonly cause hospital-acquired pneumonia such as P. aeruginosa and S. aureus. Different strains were tested with different antibiotics and had different antibiotic susceptibility despite the same isolations of bacteria. Some physicians have not noticed the role of DST results in the choice of antibiotics for treatment, such as treatment regimens are not suitable for the results of DST, accounting for a high percentage. \u0000Keywords: Community-acquired pneumonia, drugs susceptibility test. \u0000 ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"111 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80721887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Associated Factors for the Development of Alcohol Withdrawal Delirium 酒精戒断性谵妄发生的相关因素

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-09-23 DOI: 10.25073/2588-1132/vnumps.4356

Nguyen Huu Chien, Le Thi Thuy An, Nguyen Viet Chung

{"title":"Associated Factors for the Development of Alcohol Withdrawal Delirium","authors":"Nguyen Huu Chien, Le Thi Thuy An, Nguyen Viet Chung","doi":"10.25073/2588-1132/vnumps.4356","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4356","url":null,"abstract":"Abstract: This study was conducted to evaluate some associated factors predicting the development of alcohol withdrawal delirium; 56 patients in E hospital were divided into two groups including group 1 of 28 patients diagnosing mental and behavioral disorders due to use of alcohol, withdrawal state with delirium (F10.4) and group 2 of 28 patients diagnosing mental and behavioral disorders due to use of alcohol, withdrawal state (F10.3) according to ICD-10 criteria; Method: cross-sectional study; Result showed that clinical features are sweating and seizure; laboratory tests are GGT, total bilirubin, direct bilirubin, platelet emerged as associated factors of alcohol withdrawal delirium. The level of direct bilirubin over 13 μmol/L is the strongest associated factor with OR(95%CI) 6(1.648-21.840). These risk factors about alcohol dependence featured can be easily evaluated in a clinical setting for physicians to identify patients at risk for developing alcohol withdrawal delirium to make intensive therapy plans for them. \u0000Keywords: Alcohol withdrawal delirium, risk factor, clinical feature, laboratory test.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"98 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84969352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of EGFR Mutation Prevalence in Advanced and Metastatic Lung Squamous Cell Carcinoma in Vietnam 越南晚期和转移性肺鳞状细胞癌中EGFR突变发生率的测定

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-09-23 DOI: 10.25073/2588-1132/vnumps.4401

Mai Trong Khoa, Nguyen Son Lam, Pham Cam Phuong, Nguyen Thuan Loi, Vo Thi Thuy Quynh, Pham Van Thai, Pham Van Tuyen, Vu Binh Thu, Vu Thi Thu Hien, Hoang Quoc Binh, Le Thi Bich Ngoc

引用次数: 0

Study on the Chemical Composition of Millettia Speciosa Roots 木粟根化学成分的研究

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-09-23 DOI: 10.25073/2588-1132/vnumps.4425

Vu Duc Loi, Nguyen Thi Hien, Tran Thi Hong Nhung, Nguyen Minh Thai, Nguyen Thi Mai, Pham Thi Minh Hai

引用次数: 0

Result of the 2016 Oxford Classification Apply in Children with Nephritis Caused by Henoch Schonlein Purpura 2016年牛津分类在过敏性紫癜肾炎患儿中的应用结果

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-09-23 DOI: 10.25073/2588-1132/vnumps.4379

Pho Hong Diep, Trinh Tuan Dung, Hoang Ngoc Thanh, Pham Van Dem, Nguyen Thu Huong

{"title":"Result of the 2016 Oxford Classification Apply in Children with Nephritis Caused by Henoch Schonlein Purpura","authors":"Pho Hong Diep, Trinh Tuan Dung, Hoang Ngoc Thanh, Pham Van Dem, Nguyen Thu Huong","doi":"10.25073/2588-1132/vnumps.4379","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4379","url":null,"abstract":"Abstract: Henoch Schonlein purpura (Henoch Schonlein purpura-HSP) is a systemic inflammatory vasculitis with IgA deposition causing damage to multiple organ systems in which kidney damage can progress to end-stage renal disease. A retrospective study in 70 children with HSP nephritis ≤ 15 years old who had kidney biopsy at the National Children's Hospital for 5 years (2016-2020) and classified according to the updated 2016 Oxford classification criteria. The result showed that the rates of mesangial hypercellularity (M1), endocapillary proliferation (E1), segmental glomerulosclerosis/adhesion (S1), tubular atrophy/interstitial fibrosis (T1, T2) and crescent (C1, C2) were 34 (48.6%), 32 (45.7%), 43 (61.4%), 3 (4.3% and 0%) and 47 (51.4% and 15.7%). The Oxford classification applied to the histopathological diagnosis of HSP nephritis helps to comprehensively assess the glomerular injury scores (M, E, S, C) and tubules, interstitial tissue (T), thereby treatment orientation and disease prognosis. \u0000Keywords: Henoch-Schonlein purpura, HSP nephritis in children, Oxford classification criteria.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84354357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Situation of primary health care activities in non-communicable diseases for people in Dap Thanh commune, Ba Che district, Quang Ninh province in 2019 2019年广宁省巴彻县Dap Thanh公社非传染性疾病人群初级卫生保健活动情况

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-06-24 DOI: 10.25073/2588-1132/vnumps.4339

Nguyen Vu Ban, Le Anh Tuan, Dang Duc Nhu, Vu Duc Loi, Vu Thi Ngoc Ha, Mac Dang Tuan, Nguyen Thanh Trung

{"title":"Situation of primary health care activities in non-communicable diseases for people in Dap Thanh commune, Ba Che district, Quang Ninh province in 2019","authors":"Nguyen Vu Ban, Le Anh Tuan, Dang Duc Nhu, Vu Duc Loi, Vu Thi Ngoc Ha, Mac Dang Tuan, Nguyen Thanh Trung","doi":"10.25073/2588-1132/vnumps.4339","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4339","url":null,"abstract":"Objectives: Describe the current status of village health care workers (VHWs) in non-communicable diseases (NCDs) with people in Dap Thanh commune, Ba Che district, Quang Ninh province in 2019. Subjects and methods: Direct interview with people in Dap Thanh commune, Ba Che district, Quang Ninh province: 151 people aged 18 and over. Information related to exposure to messages about NCD risk factors and primary health care activities of VHWs. Results: Most of the respondents heard about NCD risk factors messages in the past 30 days, from 56.3% (messages in physical inactivity), and 59.6% (notifications). on diet), 75.5% (messages on alcohol use) to 79.5% (messages for smoking). Radio / television is the most popular source of messages (between 91.8% and 95.8%) and the majority of people hear these messages from one source (from 77.1% to 80.9%). Most of the respondents said that there is no local village health worker (53.6%). Among localities with village health workers, the most common services provided were health communication and education (54.3%), while only 30% received NCD management services. These services are rated effective and moderate (6.6 - 7.7 points). Farmers who smoke and have diabetes are more likely to hear health messages than the rest of the population. Conclusion: The results show that the primary health care activities for non-communicable diseases of the people in the Dap Thanh commune are not really effective, the role of health workers as an official source of information has not yet promoted their tasks mine. VHWs are not fully involved in primary health care activities of the people. Efforts should be made to improve the capacity and participation of VHWs in health care activities, especially those NCDs managed by local VHWs.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75155022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Survey of Antibiotic Usage Characteristics in Treatment of Acute Exacerbation of COPD Patients in National Hospital 74 国立医院慢性阻塞性肺病急性加重期抗菌药物使用特点调查

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-06-24 DOI: 10.25073/2588-1132/vnumps.4408

Tran Xuan Bach, Trang Thanh Trung, Bui Son Nhat, L. Luyen

{"title":"A Survey of Antibiotic Usage Characteristics in Treatment of Acute Exacerbation of COPD Patients in National Hospital 74","authors":"Tran Xuan Bach, Trang Thanh Trung, Bui Son Nhat, L. Luyen","doi":"10.25073/2588-1132/vnumps.4408","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4408","url":null,"abstract":"Acute exacerbation of COPD (AECOPD) represents a pivotal point in the progression of COPD, which is a major cause of physician visits, hospitalization, and death in COPD patients. Bacterial respiratory infections have long been considered the main cause of exacerbations. This study was conducted with the aim of surveying the antibiotic usage characteristics in AECOPD of hospitalized patients at National Hospital 74. Data were collected from 265 patients hospitalized from January 1st, 2021 to March 31st, 2021. Most of the patients in the study were male (82.3%) and had comorbidities (74.7%). The most isolated bacteria were Haemophilus influenzae, Moraxella catarrhalis, and Pseudomonas aeruginosa. The majority of patients did not change their antibiotic regimen during treatment (61.5%). Alternative regimens in patients having regimen changes tended to be more focused on Pseudomonas aeruginosa than the first regimens. In the antibiotic-containing regimens tested antibiograms of 38 patients with isolated bacteria, most of the regimens had at least 1 antibiotic sensitive to the isolated bacteria (38.5%). The results of this study provide reliable information for making recommendations to contribute to improving the effectiveness of antibiotic usage in the AECOPD treatment at National Hospital 74, reducing the medical burden for patients and society.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82169367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical, Subclinical Characteristics and Classify Urinary Tract Malformation in Children with Urinary Tract Infections at the National Children’s Hospital 国立儿童医院尿路感染患儿的临床、亚临床特征及分类

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-06-24 DOI: 10.25073/2588-1132/vnumps.4363

Pham Van Dem, Vu Thi Ngoc Bich, Luong Thi Phuong, Nguyen Thu Huong

{"title":"Clinical, Subclinical Characteristics and Classify Urinary Tract Malformation in Children with Urinary Tract Infections at the National Children’s Hospital","authors":"Pham Van Dem, Vu Thi Ngoc Bich, Luong Thi Phuong, Nguyen Thu Huong","doi":"10.25073/2588-1132/vnumps.4363","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4363","url":null,"abstract":"Aim: To describe clinical, subclinical characteristics and classify urinary tract malformation in children with urinary tract infections at the National Children’s Hospital. Subjects and research methods: A cross-sectional descriptive study on 100 children with urinary tract infections and urinary tract malformations treated at the Department of Nephrology and Dialysis of National Children’s Hospital from June 2019 to June 2021. Results: The rate of malformed urinary tract infections in children accounted for 2.1% of the total urinary tract infections. The male/female ratio was 1.22/1. The most common age was from 3 months to 3 years old (78%). The most common clinical manifestations were fever (89%) and urination disorder (52%). Symptoms of other organs included the digestive system 45%, respiratory system 24%, and nervous system 17%. Children with white blood cell count ≥15 G/L and CRP ≥ 20 mg/L accounted for 60% and 77% respectively. Kidney failure was 11% of children. There was a strong correlation between nitrite-positive and children with positive urine culture (OR: 4.7, Cl95% [1.2-15.2]). Vesicoureteral reflux was the highest observed of urinary malformation of the kidney (78%), followed by the duplex kidney (16%) and ureteropelvic junction narrowing (14%). The rates of recurrence and complications were 59% and 11%, respectively. The rate of recurrent urinary tract infections increased with the severity of reflux. Conclusion: The clinical and subclinical characteristics of urinary tract infections in urinary tract malformations children are most commonly fever, urination disorder, and vesicoureteral reflux get the highest rate.","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87320079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study the EGFR and HER2 Receptors Inhibitory Effect of Compounds in Siegesbeckia orientalis L. for Supporting Cancer Treatment 紫穗槐中化合物对肿瘤辅助治疗的EGFR和HER2受体抑制作用

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-06-24 DOI: 10.25073/2588-1132/vnumps.4398

Do Thi Hang, Tran Hoang Mai, Le Thi Huong, Do Thi Hong Khanh, Nguyễn Thi Thuy, Nguyen Van Khoi, Nguyen Thi Thanh Binh, Bui Thanh Tung

{"title":"Study the EGFR and HER2 Receptors Inhibitory Effect of Compounds in Siegesbeckia orientalis L. for Supporting Cancer Treatment","authors":"Do Thi Hang, Tran Hoang Mai, Le Thi Huong, Do Thi Hong Khanh, Nguyễn Thi Thuy, Nguyen Van Khoi, Nguyen Thi Thanh Binh, Bui Thanh Tung","doi":"10.25073/2588-1132/vnumps.4398","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4398","url":null,"abstract":" Epidermal growth factor receptor (EGFR) and Human epithelium receptor 2 (HER2) are important targets in cancer treatment such as lung cancer, breast cancer. Siegesbeckia orientalis L. is a medicinal plant that has the ability to inhibit the proliferation of cancer cells. In this study, we evaluated the ability to inhibit EGFR and HER2 receptors of compounds from the Siegesbeckia orientalis L. by molecular docking method. Based on the published phytochemicals of Siegesbeckia orientalis L., we have collected 50 isolated compounds. Molecular docking results showed that the ability to inhibit EGFR was higher than erlotinib with 34 compounds, higher than icotinib with 7 compounds, higher than almonertinib with 21 compounds, and higher than olmutinib with 3 compounds; 4 compounds with higher ability to inhibit HER2 than neratinib, and 4 compounds may inhibit both EGFR and HER2 receptors simultaneously. Analysis of Lipinski's rule of five and predicting pharmacokinetic - toxicological parameters, we obtained two compounds that have drug-like properties. Therefore, these two compounds have the potential to be drugs that inhibit EGFR and HER2 receptors for cancer treatment and need to be studied further. \u0000Keywords \u0000EGFR, HER2, Molecular docking, Siegesbeckia orientalis L. ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89118526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0