VNU Journal of Science: Medical and Pharmaceutical Sciences最新文献_第7页

Evaluation of Protein Kinase C Inhibition of some Benzofuro[3,2-d]pyrimidine Derivatives 一些苯并呋喃[3,2-d]嘧啶衍生物对蛋白激酶C抑制作用的评价

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2023-03-25 DOI: 10.25073/2588-1132/vnumps.4493

Tran Thi Van Anh, Ha Thanh Hoa, Pham Quoc Tuan, Ngo Thi Sau, Doan Thi Mai Huong, Nguyen Van Thang, Tran Van Thao, Nguyen Thi Thanh Hai, Dao Viet Hung

{"title":"Evaluation of Protein Kinase C Inhibition of some Benzofuro[3,2-d]pyrimidine Derivatives","authors":"Tran Thi Van Anh, Ha Thanh Hoa, Pham Quoc Tuan, Ngo Thi Sau, Doan Thi Mai Huong, Nguyen Van Thang, Tran Van Thao, Nguyen Thi Thanh Hai, Dao Viet Hung","doi":"10.25073/2588-1132/vnumps.4493","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4493","url":null,"abstract":"Abstract: Treatment of fungal infections is very difficult because of the limited therapeutic arsenal and the emergence of resistance to the two major antifungal classes: azoles and echinocandins. Consequently, finding new targets and new therapeutic strategies is a priority. The protein kinase Pkc1 of Candida albicans (CaPkc1), one of the key proteins involved in MAPK pathways, is described as a regulator of cell wall integrity during growth, morphogenesis, and response to cell wall stress. Therefore, the discovery of CaPkc1 inhibitory molecules can open up new and promising prospects in the development of new antifungal drugs that inhibit CaPkc1. In this study, we evaluated the CaPkc1 inhibitory activity of three benzofuro[3,2-d]pyrimidine derivatives at three different concentrations of 50 µM, 100 µM, and 150 µM. A concentration of 100 μM was optimal for CaPkc1 inhibitory activity with all three benzofuro[3,2-d]pyrimidine derivatives. \u0000Keywords: Benzofuro[3,2-d]pyrimidine, CaPkc1, Candida albicans, antifungal activity. \u0000 \u0000 ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80326577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards Developing Quantitative Structure-activity Relationship Models for the Design of Novel Influenza A Inhibitors Targeting Neuraminidase 为设计新型靶向神经氨酸酶的甲型流感抑制剂建立定量构效关系模型

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2023-03-25 DOI: 10.25073/2588-1132/vnumps.4412

Ly Cong Thanh

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The Clinical Characteristics of Acute Otitis Media at Several Hospitals in Hanoi from 2019 to 2020 2019 - 2020年河内市多家医院急性中耳炎临床特点分析

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-12-19 DOI: 10.25073/2588-1132/vnumps.4373

Nguyen Nhu Dua, Doan Thi Hong Hoa, Nguyen Tuan Son, Nguyen Le Hoa

{"title":"The Clinical Characteristics of Acute Otitis Media at Several Hospitals in Hanoi from 2019 to 2020","authors":"Nguyen Nhu Dua, Doan Thi Hong Hoa, Nguyen Tuan Son, Nguyen Le Hoa","doi":"10.25073/2588-1132/vnumps.4373","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4373","url":null,"abstract":"Acute otitis media (AOM) is an infection and accumulation of fluid in the middle ear. The disease usually begins suddenly in a short duration and manifests with the symptoms of ear pain, tinnitus, ear discharge, or hearing loss. Clinical characteristics of acute otitis media in children at several hospitals in Hanoi were described from 2019 to 2020. A cross-sectional descriptive study included 40 patients under 16 years old, diagnosed with AOM, and treated at the Department of Otolaryngology at several hospitals in Hanoi from September 2019 to April 2020. The results indicated that the clinical characteristics of AOM included mild fever (37.5%), moderate fever (20%), high fever (22.5%), unilateral otalgia (57.5%), bilateral otalgia (7.5%), no ear discharge (77.5%), and ear discharge (22.5%). In addition, symptoms accompanied by cough, excessive crying, and digestive disorders accounted for 82.5%, 65%, and 30%, respectively. The main symptoms of AOM are fever and otalgia, accompanied by some co-symptoms such as cough, excessive crying, and digestive disorders. \u0000 ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86139836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Large-scale Deletions and Copy Numbers of Mitochondrial DNA in Gout Patients Treated with Allopurinol 别嘌呤醇治疗痛风患者线粒体DNA的大规模缺失和拷贝数

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-12-19 DOI: 10.25073/2588-1132/vnumps.4397

Le Lan Phuong, Tran Le Huyen Linh, Le Thi Thanh Nhan, Bui Phuong Thao, Tran Thi Huyen Trang, Nguyen Van Hung, Nguyen Thi Van Anh, Trinh Hong Thai

{"title":"The Large-scale Deletions and Copy Numbers of Mitochondrial DNA in Gout Patients Treated with Allopurinol","authors":"Le Lan Phuong, Tran Le Huyen Linh, Le Thi Thanh Nhan, Bui Phuong Thao, Tran Thi Huyen Trang, Nguyen Van Hung, Nguyen Thi Van Anh, Trinh Hong Thai","doi":"10.25073/2588-1132/vnumps.4397","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4397","url":null,"abstract":"Allopurinol is now the first-line treatment for managing gout and its increasing usage has brought more gout patients at risk of developing allopurinol-induced hypersensitive reactions. Up to now, our attempts to identify the biomarkers for hypersensitivity to allopurinol are still finite. Besides, the association between drug-induced hypersensitive reactions and some mitochondrial DNA (mtDNA) alterations has been proved but remains unclear in gout patients. In this study, 41 blood samples of gout patients prescribed with allopurinol including 22 hypersensitive and 29 tolerant ones were used to analyze their mtDNA large-scale deletions through PCR and determine the mtDNA deletion level and the copy number by quantitative PCR. The results indicated that the mtDNA large-scale deletions and mtDNA copy number of the hypersensitive group were lower than that of the tolerant one (p < 0.05). However, no association was found between the mtDNA deletion level and the appearance of hypersensitive reactions in gout patients. In addition, the study showed that the mtDNA deletion level and copy number were negatively correlated with the copy numbers of mitochondrial DNA in gout patients (R = -0.3495; p = 0.0119) and allopurinol hypersensitive group (R = -0.6744; p = 0.0005). Thus, a decrease in mtDNA copy number might serve as a potential biomarker for further investigation to assess the risk of hypersensitive reactions to allopurinol in gout patients. \u0000 ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86351065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Ultrasound in the Diagnosis of Gallstones and Assessment of Gallbladder Function 超声在胆结石诊断及胆囊功能评价中的作用

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-12-19 DOI: 10.25073/2588-1132/vnumps.4357

Doan Van Ngoc, Hoang Dinh Au

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Anti-peptic Ulcer of the N-hexane Fraction from Sanchezia nobilis Hook.F. Leaves and its Isolated Compounds 三叶草正己烷部位抗消化性溃疡的研究。叶及其分离化合物

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-12-18 DOI: 10.25073/2588-1132/vnumps.4424

Bui Thi Xuan, Tran Minh Ngoc, Tran Thi Thanh Hoa

引用次数: 0

An Initiative Research of the Physicochemical Properties and Fatty Acid Composition of the Crescentia Cujete L. Seed Oil 月牙菜理化性质及脂肪酸组成的初步研究。籽油

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-12-18 DOI: 10.25073/2588-1132/vnumps.4376

Nguyen Thi Hai Yen, Nguyen Thi Thanh Thuy, Nguyen Thi Thanh Hai, Nguyen Cong Bang

{"title":"An Initiative Research of the Physicochemical Properties and Fatty Acid Composition of the Crescentia Cujete L. Seed Oil","authors":"Nguyen Thi Hai Yen, Nguyen Thi Thanh Thuy, Nguyen Thi Thanh Hai, Nguyen Cong Bang","doi":"10.25073/2588-1132/vnumps.4376","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4376","url":null,"abstract":"Objectives: To establish the quality standard of the Crescentia cujete L. seed oil. Material and methods: The Crescentia cujete L. seed oil was extracted by Soxhlet system with n-hexane solvent; the acid, peroxide, and iodine values were determined by the methods described in the Vietnamese pharmacopoeia V; GC/MS method was used to determine the composition and the major components of the seed oil. Results and conclusion: The chemical composition and characteristics of Crescentia cujete L. seed oil have been determined. The result showed that seeds have a high oil content (16.44%). The acid, peroxide, and iodine values were 4.02, 9.6, and 92, respectively. A total of 7 fatty acids were identified in the Crescentia cujete L. seed oil (palmitic acid C16:0 – 19.56%, acid stearic C18:0 – 3.85%, nonadecanoic acid C19:0 – 1.20%, eicosanoic acid C20:0 – 0.54%, octadecadienoic acid C18:2 – 73.75%, palmitoleic acid C16:1 – 0.31%, 11-eicosenoic acid C19:1 – 0.15%). These results will be further used in the development of regulatory documents (draft monograph for the Pharmacopoeia) on the Crescentia cujete L. oil. \u0000 ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88273309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Preparation and Valuation of Capsules Containing Quercetin Phytosome for Hepatoprotective Activity 槲皮素光敏体保肝胶囊的制备及评价

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-12-18 DOI: 10.25073/2588-1132/vnumps.4443

Vu Thi Thu Giang, P. Huệ, Nguyen Hong Trang

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Preparation of Berberine Chloride Nanoparticles by Ball Milling Method 球磨法制备氯化小檗碱纳米颗粒

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-12-18 DOI: 10.25073/2588-1132/vnumps.4437

Tran Thi Van Anh, Dao Viet Hung, Pham Quoc Tuan, Ha Thanh Hoa, Nguyen Thi Minh Diep, Nguyen Van Thang, Ngo Thi Sau, Trinh Thi Duyen, Nguyen Thi Thanh Hai, N. Van Khanh

{"title":"Preparation of Berberine Chloride Nanoparticles by Ball Milling Method","authors":"Tran Thi Van Anh, Dao Viet Hung, Pham Quoc Tuan, Ha Thanh Hoa, Nguyen Thi Minh Diep, Nguyen Van Thang, Ngo Thi Sau, Trinh Thi Duyen, Nguyen Thi Thanh Hai, N. Van Khanh","doi":"10.25073/2588-1132/vnumps.4437","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4437","url":null,"abstract":"Berberine is a quaternary benzylisoquinoline alkaloid that has been used for the local treatment of gastrointestinal tract diseases. Recently, several pharmacological effects of berberine have been reported, which include anti-hypertension, antitumor, anti-hypercholesterolemia, and neuroprotective effects. However, berberine has exhibited poor aqueous solubility and low oral bioavailability. To overcome these limitations, this study aims to develop and investigate nano berberine. Nano berberine fabricated by ball milling method is a simple process and easily applied in the production scale. The characterization of nano berberine was evaluated, including appearance, particle size, potential zeta, dissolution in vitro in a phosphate buffer media (pH 6.8), differential scanning calorimetry (DSC) analysis, fourier transformed infrared spectroscopy (FTIR), and X-ray diffraction analysis (XRD). Results from this study showed that spray-dried nano berberine powder was almost uniform in size, particle size average of 570.7 nm, and potential zeta of -28.6 mV. The dissolution in vitro study revealed that nano berberine was about 2 times more soluble than raw berberine for 60 minutes. No incompatibility between drug and excipients can be observed through FTIR and DSC analysis. XRD analysis suggested that raw berberine and nano berberine might exist in a crystal form. Thus, findings from this study indicate that the physicochemical properties of spray-dried nano berberine may increase the bioavailability of oral berberine. \u0000 ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77757456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Hepatoprotective Activity of the Wood of Heliciopsis lobata (Merr.) Sleumer 海参木(Merr.)的保肝活性评价Sleumer

VNU Journal of Science: Medical and Pharmaceutical Sciences Pub Date : 2022-12-18 DOI: 10.25073/2588-1132/vnumps.4448

B. V. Trung, Nguyen Thu Hang, Duong Hong Anh, Pham Hung Viet

{"title":"Evaluation of the Hepatoprotective Activity of the Wood of Heliciopsis lobata (Merr.) Sleumer","authors":"B. V. Trung, Nguyen Thu Hang, Duong Hong Anh, Pham Hung Viet","doi":"10.25073/2588-1132/vnumps.4448","DOIUrl":"https://doi.org/10.25073/2588-1132/vnumps.4448","url":null,"abstract":"Heliciopsis lobata (Merr.) Sleumer is a popular herbal material in the North-West territories of Vietnam. The wood of this plant is still used for the treatment of some liver diseases, although there is no scientific evidence for evaluating these activities and the safety of this herbal material. Our study focused on accessing acute toxicity and hepatoprotective activity of water extract from the wood of Heliciopsis lobata. Among experimental groups of mice induced by high dosage of paracetamol, mice were treated with extract at dosages of 0.56 g/kg, 1.15 g/kg and 2.30 g/kg could be against liver damage with different levels. Water extract at dosages of 0.56 g/kg and 1.15 g/kg could maintain the original situation of livers; significantly reduced the increase of ALT and AST enzymes at levels of about 80% and 87% respectively; significantly reduced 70% the increase of AST, and against most of the peroxidation process in liver tissue. A dosage of 2.30 g/kg expressed lower hepatoprotective activities in comparison with the former dosages and which may increase liver toxicity when used with high dosages of paracetamol. The highest experimental dosage at 32.60 g/kg did not show acute toxicity by independent oral administration. It could be concluded that water extract of the wood of Heliciopsis lobata exposed hepatoprotective ability with dosage from 0.56 g/kg to 1.15 g/kg, equivalent to dosages from 60 g to 120 g for humans per day. \u0000Keywords: Hepatoprotective, ALT, AST, TBARs, Heliciopsis lobata, acute toxicity. \u0000 \u0000 \u0000 ","PeriodicalId":23520,"journal":{"name":"VNU Journal of Science: Medical and Pharmaceutical Sciences","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81479519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0