Value in Health最新文献

{"title":"Validity, Reliability, and Responsiveness of the EQ-5D in Hematological Cancers: A Systematic Review of Measurement Properties","authors":"Aleksandra Dudzisz MSc,&nbsp;Grzegorz W. Basak MD,&nbsp;Emilian Snarski MD,&nbsp;Dominik Golicki MD","doi":"10.1016/j.jval.2026.03.2239","DOIUrl":"10.1016/j.jval.2026.03.2239","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to conduct a systematic review of the published evidence regarding the measurement properties of the EuroQoL 5-Dimension (EQ-5D) (3 level [EQ-5D-3L] and 5 level [EQ-5D-5L]) in adult patients with hematological cancers.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was carried out utilizing the MEDLINE, EMBASE, and Web of Science (up to October 2025). Full-text English articles focusing on original research concerning the measurement properties of the EQ-5D, including construct validity, test-retest reliability, or responsiveness, were included. Studies involving experimental versions of the EQ-5D were excluded. The quality assessment utilized the COSMIN Risk of Bias checklist, and data synthesis followed the COSMIN methodology.</div></div><div><h3>Results</h3><div>A total of 16 studies from 31 countries, presenting 996 individual tests (96% met results) of the EQ-5D measurement properties were included. Sufficient construct validity for EQ-5D-5L index, EQ-5D-5L dimensions, EQ-5D-3L index, EQ-5D-3L dimensions, and EQ visual analog scale (VAS) was supported by high certainty. Evidence regarding test-retest reliability was limited to EQ-5D-5L index and EQ VAS, had moderate and low certainty, and indicated sufficient overall rating of measurement properties. Responsiveness was assessed in 104 tests (100 for EQ-5D-5L index, 2 for EQ-5D-3L index, 2 for EQ VAS). Most tests demonstrated the expected directional change (97%; 101/104).</div></div><div><h3>Conclusion</h3><div>This systematic review provides an overview of the measurement properties of the EQ-5D as a health-related quality-of-life measure in hematological cancers. The available evidence suggests that both EQ-5D-3L and EQ-5D-5L have sufficient construct validity and may be used to assess health-related quality of life in this patient population. Evidence for reliability and responsiveness remains limited and warrants further investigation.</div></div>","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":"29 9","pages":"Pages 1653-1662"},"PeriodicalIF":6.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the agreement between self- and proxy-reported responses for measuring health-related quality of life in people with dementia using the Alzheimer's Disease Five Dimensions instrument.","authors":"Jinwen Sima, Jiaqi Wu, Zewen Zhao, Leqi Du, Junli Zhang","doi":"10.1016/j.jval.2026.06.028","DOIUrl":"https://doi.org/10.1016/j.jval.2026.06.028","url":null,"abstract":"","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporating Equity Considerations Related to Financial Protection Through Extended Cost-Effectiveness Analysis: A Systematic Review.","authors":"Sarayuth Khuntha, Sitaporn Youngkong, Ukrit Sitthiboot, Montarat Thavorncharoensap, Usa Chaikledkaew, Ammarin Thakkinstian","doi":"10.1016/j.jval.2026.08.003","DOIUrl":"10.1016/j.jval.2026.08.003","url":null,"abstract":"<p><strong>Objectives: </strong>Extended cost-effectiveness analysis (ECEA) incorporates financial risk protection (FRP) and distributional outcomes across socioeconomic groups. This study assessed FRP outcomes and synthesized the landscape of ECEA applications.</p><p><strong>Methods: </strong>A systematic literature search was conducted in PubMed, Scopus, International Network of Agencies for Health Technology Assessment (INAHTA) Database, and Tufts Medical Center's Cost-Effectiveness Analysis Registry from January 1, 2010, to June 1, 2025. Studies were included if they report FRP outcomes, such as out-of-pocket expenditure, cases of catastrophic health expenditure, cases of poverty, value of insurance, or indirect costs. Study quality was appraised using the Economic Evaluation Bias Assessment (ECOBIAS) checklist. The distribution of FRP outcomes across socioeconomic groups was assessed to determine whether benefits were propoor or prorich.</p><p><strong>Results: </strong>Thirty-nine studies were included from 5212 records screened. Most studies evaluated out-of-pocket expenditure (n = 31), followed by catastrophic health expenditure cases (n = 22), poverty cases (n = 16), value of insurance (n = 9), and indirect costs (n = 3). Propoor FRP impacts were consistently reported for tobacco taxation, immunization, and other infectious disease interventions. In contrast, some interventions, such as alcohol pricing and unhealthy diet policies, showed mixed effects depending on the FRP metric applied and the income setting. Overall, study quality was generally high, although methodological approaches and outcome definitions varied across studies.</p><p><strong>Conclusion: </strong>ECEA has expanded in scope and application, demonstrating its value in identifying interventions that reduce financial hardship. FRP benefits represent a critical dimension for promoting equity. Policymakers should incorporate ECEA to ensure that financial protection is evaluated alongside other values.</p>","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Harmonization to Clinically Accountable Implementation: Refining Health Technology Assessment for Digital Health Technologies.","authors":"Yuhan Lin, Xinyang Zuo, Yuanyue Song","doi":"10.1016/j.jval.2026.07.014","DOIUrl":"10.1016/j.jval.2026.07.014","url":null,"abstract":"","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Integration or Physical Premium? A Review of Caregiver Preferences in Early Neurodevelopmental Screening.","authors":"Muhammad Liaquat Raza, Asma Perveen","doi":"10.1016/j.jval.2026.06.027","DOIUrl":"10.1016/j.jval.2026.06.027","url":null,"abstract":"","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148832794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Long Should We Wait? The Impact of Immature Data on Colorectal Cancer Decision Modeling.","authors":"Jaemin Sim, Gyeongseon Shin, Donghwan Lee, Gyeyoung Choi, SeungJin Bae","doi":"10.1016/j.jval.2026.08.002","DOIUrl":"10.1016/j.jval.2026.08.002","url":null,"abstract":"<p><strong>Objectives: </strong>To identify a practical data maturity threshold at which model-based long-term survival projections become sufficiently reliable to inform health technology assessment.</p><p><strong>Methods: </strong>This retrospective modeling study used real-world, patient-level data from the Korea Clinical Data Utilization Network for Research Excellence registry. Patients with KRAS wild-type advanced colorectal cancer receiving first-line cetuximab- or bevacizumab-based chemotherapy between 2013 and 2021 (N = 1208) were included. Hypothetical immature data sets were created by right censoring at 30%, 50%, and 70% maturity (30%, 50%, and 70% of deaths observed). Partitioned survival analysis (PartSA) and state-transition model (STM) were developed for each maturity level and validated against observed 6-year overall survival and life expectancy using absolute prediction error and coverage within observed 95% confidence intervals.</p><p><strong>Results: </strong>With highly immature data at 30% maturity, 6-year survival prediction errors ranged from 2.4% to 11.1% (PartSA) and 4.5% to 16.3% (STM). Prediction stability improved substantially at 50% maturity (PartSA 0.4%-5.8%, STM 0.04%-7.7%), with only modest gains at 70% maturity (PartSA 0.2%-3.9%, STM 0.3%-6.1%). Life-expectancy deviations showed a similar pattern, narrowing from up to 0.4 years (PartSA) and 0.8 years (STM) at 30% maturity to within ±0.3 years at 50% and ±0.2 years at 70% maturity, regardless of modeling framework.</p><p><strong>Conclusions: </strong>In this first-line advanced colorectal cancer case study, prediction stability improved substantially once 50% maturity was reached. This threshold may provide a practical benchmark for planning reassessment or evidence-updating strategies in health technology assessment; however, its applicability to other cancers, treatment settings, and data structures requires further evaluation.</p>","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Age is Appropriate for Self-Reporting EQ-5D-Y-3L? Chinese Insights From a Sample of Children Aged 6 to 11 Years.","authors":"Yukun Wei, Beibei Yan, Yushan Li, Yeyi Feng, Yuankai Huang, Ennan Wang, Shitong Xie, Xiaoyu Xi","doi":"10.1016/j.jval.2026.08.001","DOIUrl":"10.1016/j.jval.2026.08.001","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to explore the minimum age threshold for children to self-complete the EuroQol 5-Dimension Youth version, 3-Level (EQ-5D-Y-3L) in China through mixed-methods, providing evidence on the self-report validity from the perspective of respondents.</p><p><strong>Methods: </strong>A consecutive sample of children aged 6-11 years was recruited from 4 schools in Ningxia province, China. Participants completed EQ-5D-Y-3L and were invited to participated in cognitive interview. Mixed-methods, including both qualitative and quantitative methods we used. Qualitative data were systematically derived from coding analysis of cognitive interview outcomes and subsequently transformed into quantitative data based on Tourangeau's 4-stage response model. Quantitative analyses included chi-square test for age-response problem associations, Cochran-Armitage trend test, and logistic regression for trend analysis.</p><p><strong>Results: </strong>A total of 906 children completed the survey (mean age 8.5 years, 52.1% male), with 650 completing cognitive interviews. Systematic health conceptualization mapping with EQ-5D-Y-3L constructs emerged at children aged 9 years or older, with higher consensus in item-health relevance judgment attribution. A significant association was observed between age and response issues (P < .001), with the prevalence of response problems having a statistically significant decreasing trend as age increased (Z = -5.37, P < .001). Each year of age reduced response problem risk by 26% (odds ratio = 0.740, 95% CI [0.662, 0.828], P < .001).</p><p><strong>Conclusion: </strong>Children under 9 years demonstrated an underdeveloped health framework and complex cognitive deviations in item-health relevance assessment, necessitating cautious interpretation of self-reported EQ-5D-Y-3L. Although self-report validity becomes generally acceptable from 9 years old, age-specific response variations persist, requiring context-specific applicability evaluation.</p>","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How National Volume-Based Procurement Reshapes Drug Prices and Public Spending in China.","authors":"Chenglong Lin, Mingyue Zhao, Amna Saeed, Yu Fang","doi":"10.1016/j.jval.2026.07.013","DOIUrl":"https://doi.org/10.1016/j.jval.2026.07.013","url":null,"abstract":"<p><strong>Objectives: </strong>China's National Volume-Based Procurement (NVBP) program centrally tenders selected off-patent molecules. Winning products are purchased under contracted volumes at discounted prices, while non-winning products may remain available outside the contracted volume. We assessed how NVBP tender waves 2-5 affected procurement prices and first-year public procurement spending.</p><p><strong>Methods: </strong>We used monthly hospital procurement records from 29 mainland provincial-level regions during 2019-2022, measured at the product-province-month level, for five therapeutic areas. Prices were measured as defined daily cost (DDC) in Chinese yuan. We estimated log-price effects using dynamic difference-in-differences models for staggered treatment timing across molecules. We then mapped estimated price changes onto one-year public procurement spending under fixed-share and realized-reallocation scenarios.</p><p><strong>Results: </strong>DDC fell by 58% for winning products and by 10% for non-winning products. Baseline spending was CNY 2.82 trillion. Estimated savings were CNY 779.9 billion (27.7%) under the fixed-share scenario and CNY 1,038.1 billion (36.9%) under the realized-reallocation scenario.</p><p><strong>Conclusions: </strong>NVBP was associated with large direct price reductions and smaller spillover reductions, yielding substantial procurement savings.</p>","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Simple Inequality of Opportunity Model for Guiding Resource Allocation in Health.","authors":"Namal N Balasooriya, Tianjiao Wang, Joshua Byrnes, Kim-Huong Nguyen, Nicholas Rohde","doi":"10.1016/j.jval.2026.07.012","DOIUrl":"10.1016/j.jval.2026.07.012","url":null,"abstract":"<p><strong>Objectives: </strong>The allocation of healthcare resources involves making implicit value judgments related to welfare and inequality. This paper develops a simple approach for addressing distributional issues by merging a Social Welfare Function with a Roemerian Inequality of Opportunity model.</p><p><strong>Methods: </strong>Social Welfare Functions are used to measure the desirability of distributions of health outcomes, and we calculate the derivative of aggregate social welfare with respect to each individual's health. We then use regression models to identify subsets of the population for which the derivative is the largest. An application using Australian data estimates the social welfare benefits of a unit improvement in health as a function of race, class, and gender.</p><p><strong>Results: </strong>In the baseline physical health model, when the inequality aversion parameter was set to γ = 1, a marginal improvement in the health of a non-White, lower-socioeconomic-status woman yields approximately 23% more social welfare in health than an analogous improvement in the health of a White, higher-socioeconomic-status man. The corresponding difference for mental health was approximately 6.6%, driven primarily by gender and socioeconomic background.</p><p><strong>Conclusion: </strong>The marginal social benefit of improvements in the distribution of health varies significantly over race, class, and gender, with social class at birth being the most important determinant.</p>","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Reply.","authors":"Marcela M Suazo Guevara, Juanita A Haagsma, Dorthe O Klein, Sander M J van Kuijk","doi":"10.1016/j.jval.2026.05.018","DOIUrl":"10.1016/j.jval.2026.05.018","url":null,"abstract":"","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}