Value in Health最新文献

{"title":"The Functional Assessment of Cancer Therapy Eight Dimension (FACT-8D), a Multi-Attribute Utility Instrument Derived From the Cancer-Specific FACT-General (FACT-G) Quality of Life Questionnaire: Development and Australian Value Set","authors":"","doi":"10.1016/j.jval.2024.06.001","DOIUrl":"10.1016/j.jval.2024.06.001","url":null,"abstract":"","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":"28 8","pages":"Page 1302"},"PeriodicalIF":6.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Psychometric Performance of the EQ Health and Wellbeing in Caregivers of Persons Living With Dementia","authors":"Cate Bailey PhD ,&nbsp;Tessa Peasgood PhD ,&nbsp;Bernhard Michalowsky PhD ,&nbsp;Lidia Engel PhD","doi":"10.1016/j.jval.2025.04.2168","DOIUrl":"10.1016/j.jval.2025.04.2168","url":null,"abstract":"<div><h3>Objectives</h3><div>The EQ Health and Wellbeing (EQ-HWB) is a generic instrument recently developed for use in economic evaluations across public health and social care, including impacts on caregivers. Providing informal care to a person living with dementia can significantly affect the health and well-being of carers. However, it is unclear to what extent the EQ-HWB can capture such impacts. We aimed to investigate the psychometric properties of the EQ-HWB compared with other available instruments in caregivers of persons living with dementia.</div></div><div><h3>Methods</h3><div>An online survey included demographics, informal care-related questions, and quality-of-life measures suitable for caregivers (C-DEMQOL and CarerQol) and the 25-item EQ-HWB. We used the UK pilot value set for the index scores for the EQ-HWB-S (9-item short form). The psychometric properties of the EQ-HWB and EQ-HWB-S were assessed in terms of acceptability (missing data), response distribution, known-groups validity analysis using <em>t</em> tests and one-way ANOVAs (Cohen’s <em>d</em> and Eta squared for effect size), convergent validity (Spearman correlations), and an exploration of dimensionality using exploratory factor analysis.</div></div><div><h3>Results</h3><div>In known-group validity analysis, the EQ-HWB instruments performed similarly to the C-DEMQOL in terms of effect sizes across a range of variables and slightly better than the CarerQol on some variables. At the item level, 13 of the 25 items could discriminate respondents by caregiving time and 23 of 25 items by caregivers’ general self-reported health. Most hypothesized correlations in the convergent validity analysis were found to be above 0.3.</div></div><div><h3>Conclusions</h3><div>Our results suggest that the EQ-HWB instruments performed well in this population.</div></div>","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":"28 8","pages":"Pages 1221-1230"},"PeriodicalIF":6.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exemption System for Economic Evaluation Data Submission for Pharmaceuticals in South Korea: Achievements and Challenges","authors":"So-jung Hwang PhD ,&nbsp;Namhee Kim MPH ,&nbsp;Eunsol Seo MPH ,&nbsp;Yeji Kim MPH ,&nbsp;Tae-Jin Lee PhD","doi":"10.1016/j.jval.2025.04.2163","DOIUrl":"10.1016/j.jval.2025.04.2163","url":null,"abstract":"<div><h3>Objectives</h3><div>Since the implementation of the positive listing system in South Korea in 2007, new and improved drugs have been reimbursed based on economic evaluation. Nevertheless, concerns have arisen about reduced accessibility to some drugs. To address this, an Exemption system for Economic Evaluation data submission for pharmaceuticals (EEE) was introduced in 2015 to improve access to drugs with uncertainties in evidence generation. This study aims to assess the institutional and budgetary impact of EEE.</div></div><div><h3>Methods</h3><div>A descriptive analysis was conducted of the status of EEE-listed drugs. The institutional impact was assessed by evaluating changes in listing rates, time to listing, and cost-effectiveness assessment schemes. The budgetary impact was analyzed by comparing EEE-listed drugs with those listed under other schemes.</div></div><div><h3>Results</h3><div>The EEE system has positively influenced accessibility, as seen in increased listing rates. By September 2023, 33 ingredients had been listed under the EEE, including 23 for cancer and 6 for rare diseases, with 20 available controlled clinical data. The implementation of the EEE has significantly weakened the role of economic evaluations, especially for cancer and rare disease treatments. The cost per person for EEE-listed drugs was 2.13 to 8.52 times higher, and the number of patients treated with EEE follow-on drugs was substantially larger than those under other schemes.</div></div><div><h3>Conclusions</h3><div>Given the negative impact of the EEE on deriving appropriate drug values through economic evaluations, there is an imminent need for improved cost management. This can be achieved by implementing a reliable cost-effectiveness evaluation framework that addresses various uncertainties.</div></div>","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":"28 8","pages":"Pages 1185-1194"},"PeriodicalIF":6.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study of Health and Well-Being Measures in Ireland Using EQ Health and Wellbeing (EQ-HWB) and its Short Version, EQ-5D-5L, and ICEpop Capability Measure for Adults (ICECAP-A)","authors":"Irina Kinchin PhD ,&nbsp;Lidia Engel PhD ,&nbsp;Fanni Rencz PhD","doi":"10.1016/j.jval.2025.04.2160","DOIUrl":"10.1016/j.jval.2025.04.2160","url":null,"abstract":"<div><h3>Objectives</h3><div>The EQ Health and Wellbeing (EQ-HWB) is a new experimental measure of health and well-being, having been validated in an increasing number of countries and languages. This study aims to examine the psychometric properties of the EQ-HWB and its short version (EQ-HWB-S) in Ireland and compare them with the EQ-5D-5L and ICEpop Capability Measure for Adults (ICECAP-A).</div></div><div><h3>Methods</h3><div>A secondary analysis of cross-sectional data from a 2023 Irish general population survey (<em>n =</em> 1220). The survey included the EQ-HWB, EQ-5D-5L, ICECAP-A, and socioeconomic and health-related questions. EQ-HWB-S responses were derived from the EQ-HWB. The UK or Irish value sets were used for each measure to compute index values. Ceiling effects, convergent, divergent validity, and known-group validity were assessed and exploratory factor analysis was conducted.</div></div><div><h3>Results</h3><div>Mean index values were 0.755, 0.760 to 0.830, and 0.807 for the EQ-HWB-S, EQ-5D-5L, and ICECAP-A, respectively. Ceiling effects were 3%, 7%, 23%, and 15% for EQ-HWB, EQ-HWB-S, EQ-5D-5L, and ICECAP-A. EQ-HWB-S index values correlated strongly with EQ-5D-5L (r = 0.740-0.759) and ICECAP-A (r = 0.604) index values. All measures demonstrated good known-group validity for health-related variables, with EQ-5D-5L performing best overall. Factor analysis identified 5 factors: psychosocial health, pain and discomfort, sensory and physical functioning, capability well-being, and positive psychological states. Feeling settled and secure was the only ICECAP-A item that loaded onto the same factor (psychosocial health) as any of the EQ-HWB items.</div></div><div><h3>Conclusions</h3><div>To our knowledge, this is the first study to compare the measurement performance of EQ-HWB and EQ-HWB-S with ICECAP-A. The EQ-HWB and EQ-HWB-S showed good psychometric performance in an Irish population sample. Limited overlap was observed between EQ-HWB and ICECAP-A well-being concepts.</div></div>","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":"28 8","pages":"Pages 1268-1279"},"PeriodicalIF":6.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growing Evidence Base on Condition-Specific Patient-Reported Outcome Measures for Long COVID","authors":"Adam B. Smith PhD ,&nbsp;Darren Greenwood PhD ,&nbsp;Manoj Sivan MD","doi":"10.1016/j.jval.2024.12.011","DOIUrl":"10.1016/j.jval.2024.12.011","url":null,"abstract":"","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":"28 8","pages":"Pages 1300-1301"},"PeriodicalIF":6.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Costs and Outcomes After Primary and Revision Hip Replacements by Implant Bearing Materials: Analysis of 550 760 linked Patient Records from English Routinely Collected Databases","authors":"Patricia Navvuga MSc ,&nbsp;Erik Lenguerrand PhD ,&nbsp;Rita Patel PhD ,&nbsp;Jonathan M. French BMBS ,&nbsp;Ashley W. Blom PhD ,&nbsp;Michael R. Whitehouse PhD ,&nbsp;Elsa M.R. Marques PhD","doi":"10.1016/j.jval.2025.04.2170","DOIUrl":"10.1016/j.jval.2025.04.2170","url":null,"abstract":"<div><h3>Objectives</h3><div>We investigated 10-year revision risks, hospital admission costs, and quality of life for patients in the year after elective primary and revision total hip replacement (THR), overall and by implant bearing materials and fixation combination.</div></div><div><h3>Methods</h3><div>We analyzed linked National Joint Registry, Hospital Episode Statistics, and Patient Reported Outcome Measure databases for adults undergoing elective primary THR in England (2009-2018). Implants were classified by bearing material combinations (cobalt chrome and stainless steel, delta or alumina ceramics, and highly or nonhighly crosslinked polyethylene [HCLPE]) and fixation (cemented, uncemented, and hybrid). We estimated hazard ratios with flexible parametric survival models, and generalized linear models for costs and quality of life. Missing quality-of-life data were imputed using multiple imputation.</div></div><div><h3>Results</h3><div>We analyzed 550 760 elective primary (mean age = 69, SD = 10.7) and 9590 subsequent revision THRs. On average, a primary THR costed, £10 365 (95% CI £10 350-£10 381); quality of life after primary was 0.786 (95% CI 0.785- 0.786), and 10-year revision risk was 2.4% (95% CI 2.08%-2.78%). First and second revisions costed, on average, £20 387 and £24 290, with mean quality-of-life scores of 0.609 and 0.502, respectively. Compared with cemented cobalt chrome and stainless steel on HCLPE, cemented delta-on-HCLPE, uncemented delta-on-HCLPE, and hybrid delta-on-HCLPE, alumina-on-HCLPE, delta-on-delta and alumina-on-alumina were associated with lower 1-year costs, improved quality of life, and lower 10-year revision risks.</div></div><div><h3>Conclusions</h3><div>Revision surgery costs double than that of an elective primary with drastically lower quality of life. Bearing materials and fixation were associated with varying 1-year costs, quality-of-life scores and revision risks. Although observational data may be affected by unmeasured confounding, our findings could help guide procurement decisions given changing trends in implant choice.</div></div>","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":"28 8","pages":"Pages 1176-1184"},"PeriodicalIF":6.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis of Health-State Utility Values for Infectious Diseases With Pandemic Potential and Associated Vaccine Adverse Reactions","authors":"Taito Kitano MD, DrPH ,&nbsp;Daniel A. Salmon PhD ,&nbsp;Matthew Z. Dudley PhD ,&nbsp;Ian J. Saldanha PhD ,&nbsp;David A. Thompson DNSc ,&nbsp;Lilly Engineer DrPH","doi":"10.1016/j.jval.2025.02.007","DOIUrl":"10.1016/j.jval.2025.02.007","url":null,"abstract":"<div><h3>Objectives</h3><div>The COVID-19 pandemic and its vaccine deployment have illustrated the importance of estimating the disease burden of the pandemic and vaccine adverse reactions in a comparable fashion. The objective was to evaluate health-state utility value (HSUV) scores for infectious diseases with pandemic potential and associated vaccine adverse reactions.</div></div><div><h3>Methods</h3><div>We included studies from which we could extract a single HSUV associated with priority infectious diseases with pandemic potential or associated vaccine adverse reactions. We assessed risk of bias using the criteria recommended by National Institute for Health and Care Excellence. We conducted random-effects meta-analyses.</div></div><div><h3>Results</h3><div>We included 39 studies, and data synthesis was conducted for COVID-19, influenza, and dengue for infectious diseases and myocarditis and narcolepsy for vaccine adverse reactions. Response rates varied (2%-98%), whereas follow-up rates ranged from 68% to 100%. Twenty-four studies did not report how they handled missing data. Compared with control groups, COVID-19 (acute phase) and influenza (acute phase) had reduced EQ-5D scores: −0.11 (95% CI −0.14, −0.07) in COVID-19 and −0.50 (95% CI −0.60, −0.41) in influenza. For associated vaccine adverse reactions, the mean EQ-5D score for myocarditis and PedsQL score for narcolepsy were 0.88 (95% CI 0.76, 1.00) and 64.0 (95% CI 59.4, 68.7), respectively. No apparent asymmetry was observed in funnel plots.</div></div><div><h3>Conclusions</h3><div>This study provided HSUV scores for some infectious diseases with pandemic potential and associated vaccine adverse reactions. These results can be used as HSUV indicators for future health technology and cost-effectiveness assessments.</div></div>","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":"28 8","pages":"Pages 1280-1287"},"PeriodicalIF":6.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Budget Impact Analysis of Artificial Intelligence to Support the Review of Radiographic Examinations for Suspected Fractures in National Health Service Emergency Departments","authors":"Lucy Gregory MSc ,&nbsp;Trishal Boodhna PhD ,&nbsp;Mathew Storey MbChB ,&nbsp;Susan Shelmerdine PhD ,&nbsp;Alex Novak MBChB ,&nbsp;David Lowe MD ,&nbsp;Hugh Harvey MD","doi":"10.1016/j.jval.2025.04.2165","DOIUrl":"10.1016/j.jval.2025.04.2165","url":null,"abstract":"<div><h3>Objectives</h3><div>To develop an early budget impact analysis of and inform future research on the national adoption of a commercially available artificial intelligence (AI) application to support clinicians reviewing radiographs for suspected fractures across National Health Service (NHS) emergency departments (ED) in England.</div></div><div><h3>Methods</h3><div>A decision tree framework was coded to assess a change in outcomes for suspected fractures in adults when AI fracture detection was integrated into the clinical workflow over a 1-year time horizon. Standard of care was the comparator scenario, and the ground truth reference cases were characterized by radiology report findings. The effect of AI on assisting ED clinicians when detecting fractures was sourced from US literature. Data on resource use conditioned on the correct identification of a fracture in the ED were extracted from a London NHS trust. Sensitivity analysis was conducted to account for the influence of parameter uncertainty on results.</div></div><div><h3>Results</h3><div>In 1 year, an estimated 658 564 radiographs were performed in the EDs across England for suspected wrist, ankle, or hip fractures. The number of patients returning to the ED with a missed fracture was reduced by 21 674 cases, and a reduction of 20 916 unnecessary referrals to fracture clinics was also noted. The cost of the current practice was estimated at £66 646 542 and £63 012 150 with the integration of AI. Overall, a return on investment of £3 634 392 to the NHS was generated.</div></div><div><h3>Conclusions</h3><div>The adoption of AI in EDs across England has the potential to generate cost savings. Nevertheless, additional evidence on radiograph review accuracy and subsequent resource use is required to further signify this.</div></div>","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":"28 8","pages":"Pages 1161-1168"},"PeriodicalIF":6.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergizing Needs Assessments and Patient Preference Studies for Enhanced Patient-Centered Decision Making in Healthcare","authors":"Elise Schoefs MSc ,&nbsp;Alice Vanneste MSc ,&nbsp;Alessandra Blonda MSc ,&nbsp;Zilke Claessens MSc ,&nbsp;Khadidja Abdallah PhD ,&nbsp;Fábio Cardoso Borges MPharm ,&nbsp;Jolien Broekmans MSc ,&nbsp;Thomas Desmet MSc ,&nbsp;Teodora Lalova-Spinks PhD ,&nbsp;Phaedra Locquet MSc ,&nbsp;Janos Meszaros PhD ,&nbsp;Lauren Michiels MPharm ,&nbsp;Charlotte Verbeke MSc ,&nbsp;Io Wens MSc ,&nbsp;Isabelle Huys PhD","doi":"10.1016/j.jval.2025.04.2169","DOIUrl":"10.1016/j.jval.2025.04.2169","url":null,"abstract":"<div><h3>Objectives</h3><div>Over the past decades, criticism has grown regarding the supply-driven approach of medicinal product development. In response, patient-centered methods have been developed to inform decision making. This perspective article aims to reflect on two of these methods, which are needs assessments and patient preference studies (PPSs).</div></div><div><h3>Methods</h3><div>A reflection was conducted based on existing literature and our collaborative experiences, proposing a conceptual framework that synergistically combines needs assessments and PPSs.</div></div><div><h3>Results</h3><div>Needs assessments identify unmet health-related needs from the patient and/or societal perspective, whereas PPSs determine the trade-offs patients make among treatment options. Although both methods produce patient-based evidence, their differing scopes and purposes offer complementary benefits and limitations. Combining needs assessments with PPSs can result in significant advantages by providing a holistic and in-depth understanding of patients’ needs and preferences. In their conceptual framework, the authors advocate for a sequential approach: conducting a needs assessment to identify a broad spectrum of unmet health-related needs, followed by a PPS to capture nuanced preferences guiding patients’ priorities. Although this approach enhances accuracy and relevance, practical constraints and contextual considerations may hamper its application, necessitating careful consideration of the most suitable approach based on the specific research context.</div></div><div><h3>Conclusions</h3><div>This perspective article provides clarity on the effective use of both methods in navigating patient-centered research in healthcare. It emphasizes the need for well-designed, unbiased studies applying this conceptual framework to shift from a supply-driven to a needs- and preference-driven healthcare system, ensuring that innovations align more closely with patients’ true needs and preferences.</div></div>","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":"28 8","pages":"Pages 1253-1258"},"PeriodicalIF":6.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Transition Between Age-Specific Measures of Health-Related Quality of Life: Evidence on the Relationship Between and Comparative Performance of the EQ-5D-Y-5L and EQ-5D-5L","authors":"Nicole Reyes MPH ,&nbsp;Tianxin Pan PhD ,&nbsp;Renee Jones MPH ,&nbsp;Kim Dalziel PhD ,&nbsp;Nancy Devlin PhD ,&nbsp;Quality Of Life in Kids: Key evidence to strengthen decisions in Australia (QUOKKA) project team","doi":"10.1016/j.jval.2025.04.2161","DOIUrl":"10.1016/j.jval.2025.04.2161","url":null,"abstract":"<div><h3>Objectives</h3><div>The EQ-5D-5L is widely used to measure adults’ health-related quality of life (HRQoL). The EQ-5D-Y-5L is a corresponding measure adapted for children/adolescents, in principle allowing HRQoL to be measured consistently from childhood to adulthood. However, little is known about how their measurement properties compare. This study investigated the relationship between EQ-5D-Y-5L and EQ-5D-5L in adolescents and compared their psychometric performance.</div></div><div><h3>Methods</h3><div>The Australian Pediatric Multi-Instrument Comparison Study includes a sample of 591 adolescents (aged 12-18) who completed both EQ-5D-5L and EQ-5D-Y-5L. Responses were compared descriptively and HRQoL summarized using the level sum score. Acceptability, feasibility, ceiling effects, convergence, test-retest reliability, and known-group validity were assessed overall and in subgroups defined by special healthcare needs (SHCN), mental health concerns (MHC), and age (12-13, 14-16, and 17-18 years).</div></div><div><h3>Results</h3><div>Ceiling effects were lower for EQ-5D-Y-5L than EQ-5D-5L. The EQ-5D-Y-5L better differentiated between adolescents with and without SHCN and MHC than EQ-5D-5L, whereas EQ-5D-5L showed better test-retest reliability in adolescents with SHCN and MHC. We found strong correlations between dimensions anticipated to be correlated. EQ-5D-Y-5L identified a higher incidence of self-reported HRQoL problems than EQ-5D-5L both overall and particularly in mental health.</div></div><div><h3>Conclusions</h3><div>Although both instruments are valid for measuring HRQoL in adolescents aged 12 to 18 years, EQ-5D-Y-5L had some psychometric advantages. The instruments are closely related, but differences in their descriptive systems produce differences in self-reported HRQoL. Results highlight potential discontinuities in HRQoL measured using age-specific instruments, which may be important for their use in economic models that involve transitions between age groups.</div></div>","PeriodicalId":23508,"journal":{"name":"Value in Health","volume":"28 8","pages":"Pages 1231-1240"},"PeriodicalIF":6.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}