Veterinary journal最新文献

{"title":"The effects of general anaesthesia on body temperature of dogs subjected to ovariohysterectomy or orchiectomy performed by veterinary students in a teaching hospital","authors":"N. Wenham ,&nbsp;L.C.P. Santos","doi":"10.1016/j.tvjl.2024.106252","DOIUrl":"10.1016/j.tvjl.2024.106252","url":null,"abstract":"<div><div>Hypothermia during anaesthesia is a significant concern in veterinary practice, as it can lead to various complications, making it essential to understand the factors that contribute to temperature regulation in animals undergoing surgical procedures. This retrospective study aimed to evaluate the change in body temperature over the course of anaesthesia in dogs undergoing elective ovariohysterectomy and orchiectomy, and determine the effect of gender, dose of premedication, weight, age and duration of anaesthesia of the change of body temperature over time. One-hundred and ten dogs (n=110) that underwent elective ovariohysterectomy (n=75) and orchiectomy (n=35) surgery performed by veterinary students at the University of Adelaide were enrolled in this study. Dogs’ anaesthesia records were evaluated for change in body temperature over the course of anaesthesia, and correlated with gender, two premedication doses of acepromazine (mg/kg), body weight (kg), age (months) and anaesthesia times (minutes). The analyses were performed at TPm (temperature at premedication), T0 (induction), T15, T30, T60, T90, T120 and TRec (recovery) minutes. Statistical analysis was performed using the GenStat software and included repeated measures analysis and ANOVA. Significance was considered when p &lt; 0.05. The data showed a significant time-by-gender interaction with female dogs experienced a greater degree of heat loss than male dogs at T60 (p&lt;0.01), T90 (p&lt;0.01) and T120 (p&lt;0.01). At recovery, female average temperature was higher than in males (p&lt;0.01). There was no significant difference in body temperature when other covariates were used in the analysis. The core body temperature of female dogs decreased significantly over time compared to males, with the most pronounced differenced during the intraoperative period. However, the study’s retrospective nature and limited sample size may influence the generalizability of these findings.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106252"},"PeriodicalIF":2.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental factors of equine osteochondrosis and fetlock osteochondral fragments: A scoping review – Part 1","authors":"B. Van Mol ,&nbsp;M. Oosterlinck ,&nbsp;S. Janssens ,&nbsp;N. Buys ,&nbsp;F. Pille","doi":"10.1016/j.tvjl.2024.106249","DOIUrl":"10.1016/j.tvjl.2024.106249","url":null,"abstract":"<div><div>Various environmental and genetic risk factors are linked to the pathogenesis of equine osteochondrosis and osteochondral fragments in the fetlock joint. Therefore, a scoping review was conducted to describe current evidence linking genetic factors and environmental factors of these osteochondral disorders. This article constitutes the first part of this scoping review and focuses on environmental factors, with the second part addressing genetic factors. To identify potentially relevant papers online bibliographical databases PubMed and Web of Science were utilised, supplemented with articles listed on the OMIA website (OMIA:000750–9796). After entry collection, removing duplicates, screening titles, abstracts, and full-text documents for eligibility, and manually searching reference lists of the remaining articles, a total of 212 studies was identified for this scoping review. First, an overview of the current understanding of the etiopathogenesis of equine osteochondrosis and osteochondral fragments in the fetlock joint is given. Subsequently, the article delves into the environmental factors associated with the prevalence of these disorders, which are categorized into foetal programming, biomechanical trauma and exercise, growth, anatomic conformation, nutrition, weaning, hormonal factors, bacterial infection, sex, date of birth, and other environmental factors. In conclusion, future research should adopt a multidisciplinary approach, emphasizing longitudinal studies and precise phenotype definitions. This strategy will help elucidate the complex relationships between environmental factors and OC, DOF, and POF, considering the dynamic nature, varying phenotypes, and scarcity of research in some domains of these osteochondral disorders. This approach will be crucial in developing effective management strategies aimed at improving equine orthopaedic health.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106249"},"PeriodicalIF":2.3,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of maternal bromoform supplementation in late gestation on blood parameters of cows and their progeny","authors":"M. Dasari ,&nbsp;C.J. Keller ,&nbsp;B.R. Costa Alves ,&nbsp;K.M. Wenham ,&nbsp;C.L. Trengove ,&nbsp;S.J. Lee ,&nbsp;W.S. Pitchford ,&nbsp;N.W. Tomkins ,&nbsp;M. Caetano","doi":"10.1016/j.tvjl.2024.106248","DOIUrl":"10.1016/j.tvjl.2024.106248","url":null,"abstract":"<div><div>Bromoform supplementation has been successful in reducing enteric methanogenesis in ruminants; however, the impacts on the health of these animals are still limited. The current study evaluates the impact of maternal bromoform supplementation on the health of late-gestation cows and their progeny. Pregnant Angus cows (<em>n</em> = 42) were allocated into a control or bromoform group (<em>n</em> = 21 cows per treatment). Bromoform extracted from <em>Asparagopsis armata</em> (7,372 mg/kg) was supplemented once daily. Blood samples were collected from cows before supplementation (baseline). Within 24 h of parturition, blood and colostrum samples were collected from each cow and blood from neonates. Colostrum brix was measured to indicate immunoglobulin content. All data was analysed using the MIXED procedure in SAS.</div><div>Supplementation of cows with bromoform resulted in increased blood urea to creatinine ratio (<em>P</em> = 0.048), base excess (<em>P</em> = 0.049), total carbon dioxide (TCO₂; <em>P</em> = 0.048) and a decrease in blood glutamate dehydrogenase (GLDH; <em>P</em> = 0.031) compared to the control group. For cows in the bromoform group, a trend was observed for higher levels of partial pressure of carbon dioxide (pCO₂; <em>P</em> = 0.070) and bicarbonate (HCO₃^-; <em>P</em> = 0.052), and lower levels of partial pressure of oxygen (pO₂; <em>P</em> = 0.058) compared to the control group. Blood gamma-glutamyl transferase (GGT) was elevated in offspring of cows fed bromoform (<em>P</em> = 0.050). The lower blood pO₂ of pregnant cows fed bromoform and elevated blood GGT levels in offspring are not well understood and highlight the need for further investigation. Additionally, the low-dose bromoform supplementation affected various blood gas parameters of cows and calves, demonstrating the importance of monitoring these parameters when using different doses of halogenated compounds in livestock.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106248"},"PeriodicalIF":2.3,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetics and tissue residues of colistin following intravenous, and single and repeated oral dosing in domestic geese (Anser anser domesticus)","authors":"Krzysztof Bourdo ,&nbsp;Charbel Fadel ,&nbsp;Mario Giorgi ,&nbsp;Anna Gajda ,&nbsp;Magdalena Bilecka ,&nbsp;Amnart Poapolathep ,&nbsp;Beata Łebkowska-Wieruszewska","doi":"10.1016/j.tvjl.2024.106245","DOIUrl":"10.1016/j.tvjl.2024.106245","url":null,"abstract":"<div><div>Colistin, also known as polymyxin E, is a member of the polymyxin group of antibiotics. It is approved in Europe to treat enteric infections caused by Gram-negative bacteria, such as <em>Escherichia coli,</em> in poultry, although the similarity of infections between species make it likely used off-label in geese as well.This study investigated the pharmacokinetics and tissue residues of colistin in geese through <em>in vivo</em> experiments. The study involved longitudinal open studies on 16 healthy adult male geese, divided into three phases separated by one-month washout period. Geese were administered colistin via intravenous (IV, 1 mg/kg), single oral (PO, 30 mg/kg), and multiple oral (SID, 2.5 mg/kg for five consecutive days) routes, with blood samples drawn at specific intervals. Tissue samples were also collected at pre-assigned times for subsequent analysis. Colistin levels in geese plasma were quantified using a fully validated UHPLC-MS/MS method.</div><div>Plasma concentrations could be quantified up to 24 h for the single PO (n= 2) and IV (n= 4) routes, and up to 10 h (n= 6) from the last dose administered for the multiple PO route (n=6). The bioavailability was significantly low, averaging 3 %. The terminal half-life in geese was 2.18 h following IV administration, similar to values found in other avian species. Following IV administration, clearance and volume of distribution values were 0.11 mL⋅h⁻¹⋅g⁻¹ and 0.41 mL⋅g⁻¹, respectively. The body extraction ratio was low at 0.2 %, indicating minimal hepatic and renal elimination of colistin. Multiple oral doses showed no plasma accumulation, and tissue levels consistently remained below the maximum residue limit (MRL) set for food-producing animals. This study highlights the minimal systemic bioavailability and tissue penetration of colistin in geese, consistent with findings in other poultry and mammals. Future research should focus on intestinal colistin content in geese to optimize dosing strategies and minimize anti-microbial resistance.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106245"},"PeriodicalIF":2.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1090023324001849/pdfft?md5=6bb1cf743b0c93a273e3074699585960&pid=1-s2.0-S1090023324001849-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose titration of intravenously administered gamma-hydroxybutyric acid for sedation in Holstein-Friesian calves","authors":"C. Cuypers ,&nbsp;B. Alonso ,&nbsp;M. Devreese ,&nbsp;S. Schauvliege","doi":"10.1016/j.tvjl.2024.106246","DOIUrl":"10.1016/j.tvjl.2024.106246","url":null,"abstract":"<div><p>Gamma-hydroxybutyric acid (GHB) is a short-chain fatty acid that can potentially provide safe, prolonged sedation with minimal cardiorespiratory effects. This preliminary trial, performed in 10 three-week-old male Holstein-Friesian calves, investigated the effects of GHB administered intravenously over 5 min at a dose of 100 (G100, <em>n</em>=2), 150 (G150, <em>n</em>=4) or 200 mg/kg (G200, <em>n</em>=4). Once lateral recumbency was achieved, scores for sedation depth (range: 0 = no sedation to 3 = marked) and response to noxious stimulation (range: 0 = strong to 3 = absent), heart rate (HR), respiratory rate (RR), mean arterial pressure (MAP) and arterial blood gases were monitored every 15 min until sternal recumbency. Times from end of administration to lateral recumbency and return to sternal/standing positions were recorded. Dose G100 resulted in mild sedation and ataxia without decubitus. Doses G150 and G200 respectively resulted in time to lateral recumbency 8 ± 2 and 9 ± 3 min, lasting 189 ± 41 and 283 ± 29 min, while overall median (range) scores for sedation were 3 (1−3) and 3 (2−3) respectively and response to noxious stimulation 0 (0−3) and 0 (0−3) respectively. The mean ± SD for HR was 110 ± 10 and 106 ± 11 bpm respectively; for MAP 87±9 and 94±5 mmHg respectively; and for RR 28 ± 5 and 26 ± 5 bpm respectively. The mean ± SD for arterial partial pressure of oxygen (PaO2) at these two dose rates was 74 ± 6 and 74 ± 2 mmHg respectively, while the arterial partial pressure of carbon dioxide oxygen (PaCO₂) was 53 ± 3 and 47 ± 0.8 mmHg respectively. Based on these preliminary results we conclude that GHB has the potential to be used as a long-acting sedative in calves. Further studies are needed to confirm this.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106246"},"PeriodicalIF":2.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles in kidney disease – A veterinary perspective","authors":"Jack S. Lawson ,&nbsp;Timothy L. Williams","doi":"10.1016/j.tvjl.2024.106247","DOIUrl":"10.1016/j.tvjl.2024.106247","url":null,"abstract":"<div><div>Extracellular vesicles (EVs) are membrane bound vesicles secreted from cells into the extracellular space which have an emerging role in both normal kidney physiology and the pathophysiology of kidney injury, predominantly as mediators of intercellular communication. EVs contain proteins and RNA cargo which reflect their cell of origin and can be isolated from the urine of cats and dogs. The majority of urinary EVs (uEVs) originate from the kidney, and both the uEV proteome and transcriptome have been investigated as sources of biomarkers of kidney disease. In addition to their possible diagnostic role, EVs may also have therapeutic potential, and veterinary species have been used as models to demonstrate the efficacy of exogenous EVs derived from mesenchymal stromal cells in the treatment of acute kidney injury. Furthermore, bioengineered EVs may represent a novel vehicle for the administration of drugs or therapeutic nucleic acids in kidney disease. This article reviews the biological functions of EVs within the kidney, techniques for their isolation, and their potential use as biomarkers and therapeutic agents, with particular focus on the potential significance to veterinary patients.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106247"},"PeriodicalIF":2.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1090023324001862/pdfft?md5=e94c4ce82bdba93d2e93aba0e67e774b&pid=1-s2.0-S1090023324001862-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salmonella pathogenesis-based In-silico design and immunoinformatic analysis of multi-epitope vaccine constructs in broiler veterinary medicine","authors":"Yuliana I. Mora-Ochoa,&nbsp;Lenin J. Ramirez-Cando","doi":"10.1016/j.tvjl.2024.106240","DOIUrl":"10.1016/j.tvjl.2024.106240","url":null,"abstract":"<div><p>Salmonellosis, a zoonotic gastrointestinal disease, presents a significant global health burden with a high incidence rate. Transmission primarily occurs through the consumption of contaminated poultry products, although water and contact with asymptomatic animals are also vectors. The disease’s pervasiveness has prompted international health organizations to advocate for robust prevention and control strategies. This study focuses on the <em>in-silico</em> design of a multi-epitope vaccine targeting Salmonella enterica serovar Typhimurium’s fimH protein, a fimbriae component crucial for bacterial adhesion and pathogenicity. The vaccine construct was developed by identifying and synthesizing non-allergenic, antigenic, and non-toxic epitopes for both Cytotoxic T Lymphocytes and Helper T Lymphocytes. Adjuvants were incorporated to enhance immunogenicity, and the vaccine’s structure was modeled using advanced bioinformatics tools. The proposed vaccine demonstrated promising antigenicity and immunogenicity profiles, with a favorable physical-chemical property analysis. The vaccine’s structures, designed by computational analysis, suggests high likelihood to native protein configurations. Antigenicity and allergenicity assessments validate the vaccine’s immunogenic potential and hypoallergenic nature. Physicochemical evaluations indicate favorable stability and solubility profiles, essential for vaccine efficacy. This comprehensive approach to vaccine design expressed in <em>Chlorella vulgaris</em> holds promises for effective salmonellosis control. The multi-epitope vaccine, designed through meticulous <em>in-silico</em> methods, emerges as a promising candidate for controlling salmonellosis. Its strategic construction based on the fimH protein epitopes offers a targeted approach to elicit a robust immune response, potentially curbing the spread of this disease in poultry.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106240"},"PeriodicalIF":2.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benchmarking claw health across three dairy cow breeds in 508 dairy farms using numerical claw health indicators","authors":"J. Kofler ,&nbsp;P. Berger ,&nbsp;C. Egger-Danner ,&nbsp;B. Fuerst-Waltl","doi":"10.1016/j.tvjl.2024.106242","DOIUrl":"10.1016/j.tvjl.2024.106242","url":null,"abstract":"<div><p>Currently, prevalence and incidence of claw lesions are used as parameters for benchmarking claw health. The aims of this study were to create a benchmarking system for claw health utilizing the claw health indicators Farm-Claw-Score (FCS) for the herd and Cow-Claw-Score (CCS) for the individual animal, and to benchmark claw health of the three predominant dairy cattle breeds in Austria. Claw health data from 17,642 cows from 508 Austrian dairy farms were analyzed. The CCS and FCS were calculated based on recorded claw lesions and their three severity levels using geometrically weighted scoring. The FCS of each of the dairy farms was classified into five percentile thresholds (P10, P25, P50, P75, P90), with the FCS calculated using the median value of CCS in each herd. Furthermore, claw health was benchmarked for three breeds (Fleckvieh, Holstein, Brown Swiss cows), using claw lesion prevalences and CCS values.</p><p>When the median FCS was calculated, dairy farms in P50 and below had an FCS of 20.0, indicating very good claw health. However, P90 farms showed an FCS-MEDIAN of 67.5. Evaluation of the prevalences of the 14 claw lesions considered and the CCS values revealed that Fleckvieh cows (CCS-MEDIAN: 24.0), followed closely by Holstein cows (CCS-MEDIAN: 22.7) had significantly poorer claw health (<em>P</em> &lt; 0.0001) compared to Brown Swiss cows (CCS-MEDIAN: 12.0). The use of CCS and FCS as primary claw health indicators allowed for a quick assessment of the current state of an individual cow and a dairy herd in a benchmarking system. Detailed information on the claw health of each animal and the dairy herd can be easily reviewed by examining diagnosis lists that display prevalences, particularly those related to lameness, in the respective electronic documentation systems.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106242"},"PeriodicalIF":2.3,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1090023324001813/pdfft?md5=d8a618cb8f0f869934c7d7acfc070c20&pid=1-s2.0-S1090023324001813-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory study of cervical disc degeneration model and mechanism of acupuncture therapy in rabbits","authors":"Wei Liu ,&nbsp;Qianyu Jia ,&nbsp;Haidong Pang ,&nbsp;Bo Kang ,&nbsp;Jiahao Lin","doi":"10.1016/j.tvjl.2024.106244","DOIUrl":"10.1016/j.tvjl.2024.106244","url":null,"abstract":"<div><p>Acupuncture is an important therapy method in traditional Chinese medicine for treating intervertebral disc degeneration (IVDD), offering a wide range of applications. It is based on the theory of Chinese veterinary medicine and combines the stage of the disease course and individual differences for syndrome differentiation and treatment. However, there are few studies on the acupuncture treatment of cervical disc degeneration (CDD) in rabbits. Treatment based on syndrome differentiation is the basic principle of Chinese veterinary treatment. The selection of acupoints for external treatment should be based on individual etiology and pathogenesis. Nevertheless, most current studies do not follow this guideline. In this study, we established the CDD model and explored the mechanism of acupuncture treatment in alleviating CDD in rabbits by selecting a group of main acupoints including cervical Jiaji, Fengchi, Tianzhu, Naohu, Dazhui, and Houxi acupoints, combined with Western medicine's understanding of the pathogenesis of cervical spondylosis, from the anti-inflammatory, analgesic, and tissue-repairing perspectives. Magnetic resonance imaging (MRI) confirmed the successful establishment of the rabbit CDD model. Acupuncture stimulation reduced the increase of average and maximum neck temperature due to CDD in rabbits. The acupuncture treatment relieved the spinal disc damage in the neck of the rabbit, which also decreased the expression level of pro-apoptotic factor Bax and increased the expression level of anti-apoptotic factor Bcl-2. In addition, it can alleviate the abnormal apoptosis of rabbit intervertebral disc, decrease the expression level of inflammatory factors such as TNF-α, IL-1β, IL-2, and PGE2α, and alleviate the intense inflammation and pain response caused by CDD in rabbits. In conclusion, Acupuncture treatment can slow down the CDD of rabbits by regulating the inflammatory response and abnormal apoptosis of intervertebral disc tissue.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106244"},"PeriodicalIF":2.3,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Owner expectations regarding antimicrobial prescription for canine acute diarrhea: A prospective observational study from the capital of Denmark","authors":"A.S. Gravgaard ,&nbsp;L.R. Jessen ,&nbsp;C.R. Bjørnvad ,&nbsp;P.L. Heidemann ,&nbsp;K.J. Christensen ,&nbsp;E.K.S. Kristensen ,&nbsp;N. Dupont","doi":"10.1016/j.tvjl.2024.106243","DOIUrl":"10.1016/j.tvjl.2024.106243","url":null,"abstract":"<div><p>Acute diarrhea is a common condition in dogs. Most cases are mild and self-limiting and according to guidelines, antimicrobial treatment is only indicated in dogs with severe systemic disease. However, antimicrobials are still prescribed in 50–65 % of mild cases. Multiple factors have been shown to influence the antimicrobial prescription decision, including perceived pressure from pet owners. This study aimed to investigate dog owners’ expectations regarding antimicrobial prescription for dogs with acute diarrhea and the attending veterinarians’ perceived owner expectation. To investigate this, a structured telephone interview with owners and a post-consultation questionnaire for the attending veterinarians were conducted. Ninety-nine unique dog-consultations were included with a 91 % owner response rate (n = 90), in these cases 63 % of veterinarians responded (n = 57). Only 6/90 (7 %) owners expressed an expectation of antimicrobial prescription. Of these, two expressed dissatisfaction that antimicrobials were withheld. In 5/57 cases, the attending veterinarian perceived an expectation to prescribe antimicrobials. Three cases aligned with an actual owner expectation, the latter two were pure perception. Eighty percent of owners expressed satisfaction with the consultation in general (n = 72/90), while 16 % (14/90) and 4 % (4/90) expressed minor or major dissatisfaction with non-treatment related issues, respectively. In this study, very few dog owners expressed an expectation of antimicrobials for treatment of acute diarrhea. Likewise, the veterinarians perceived an expectation in only a minority of cases, however, the actual and perceived expectation did not always align. In conclusion, this study suggests that an overall high owner satisfaction is feasible despite a non-antimicrobial approach.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"308 ","pages":"Article 106243"},"PeriodicalIF":2.3,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1090023324001825/pdfft?md5=8e04c153f14989efb918665147b069b7&pid=1-s2.0-S1090023324001825-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}