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Risk factors associated with tail damage in New Zealand dairy cattle. 新西兰奶牛尾部损伤的相关风险因素。
IF 3.1 2区 农林科学
Veterinary journal Pub Date : 2025-09-16 DOI: 10.1016/j.tvjl.2025.106439
E L Cuttance, W A Mason, M A Bryan, R A Laven
{"title":"Risk factors associated with tail damage in New Zealand dairy cattle.","authors":"E L Cuttance, W A Mason, M A Bryan, R A Laven","doi":"10.1016/j.tvjl.2025.106439","DOIUrl":"https://doi.org/10.1016/j.tvjl.2025.106439","url":null,"abstract":"<p><p>Tail damage in dairy cattle is an increasingly recognised cause of poor welfare. However, there have been very few studies of the risk factors associated with the prevalence of tail damage. This analysis combined a 200-farm study of the prevalence of tail damage in New Zealand with a survey of farm management and handling practice with the aim of identifying the risk factors associated with tail damage (defined as either a deviated tail or one with evidence of other injury). Across the farms, the median herd level prevalence of tail damage was 11.5%. The survey included 42 variables which were analysed at the univariable level. Factors which were identified as being potentially associated based on these univariable analyses included region, parlour type, milking frequency, use of automatic cup removers, use of coaxing to get cows to move and farmer's opinion of how many cows with tail damage they had. The final multivariable model had region, milking frequency (odds of tail damage 1.18 times higher for farms which always milked cows twice daily than for those which did not) and the use of coaxing (i.e. gentle persuasion) (odds of tail damage on farms which used coaxing was 0.83 times that on farms which did not). These results support the hypothesis that poor handling and/or interaction with infrastructure are important causes of tail damage on New Zealand dairy farms. More studies in more countries are needed to better understand the cause of tail damage in dairy cows. In addition, we need to standardise and optimise the repeatability of tail scoring.</p>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":" ","pages":"106439"},"PeriodicalIF":3.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of use of respiratory physiotherapy in treatment of dogs with pneumonia 呼吸物理疗法在犬肺炎治疗中的应用评价。
IF 3.1 2区 农林科学
Veterinary journal Pub Date : 2025-09-15 DOI: 10.1016/j.tvjl.2025.106440
H.S. Rossi , M.M. Rajamäki , J.J.T. Junnila , H.K. Hyytiäinen
{"title":"Evaluation of use of respiratory physiotherapy in treatment of dogs with pneumonia","authors":"H.S. Rossi ,&nbsp;M.M. Rajamäki ,&nbsp;J.J.T. Junnila ,&nbsp;H.K. Hyytiäinen","doi":"10.1016/j.tvjl.2025.106440","DOIUrl":"10.1016/j.tvjl.2025.106440","url":null,"abstract":"<div><div>Pneumonia frequently affects dogs, leading to the buildup of inflammatory secretions in their airways. While respiratory physiotherapy is often used to treat pneumonia in humans, its efficacy in dogs remains largely unexplored. This study assessed the safety and efficacy of respiratory physiotherapy as a supplementary treatment for canine pneumonia. Fifty-four dogs with pneumonia were included. The intervention group (<em>n</em> = 16) received daily physiotherapy and was compared with a historical control group (<em>n</em> = 38) treated for pneumonia without physiotherapy. Physiotherapy included manual techniques such as chest wall percussion, vibration, and postural drainage. Key outcomes measured before and after the interventions included oxygenation via pulse oximetry and arterial blood samples, respiratory rate, breathing sounds, respiratory type, and assessment of potential adverse effects. Most importantly, respiratory physiotherapy was shown to be safe and feasible as a supplementary treatment in dogs with pneumonia. Respiratory physiotherapy significantly increased PaO<sub>2</sub> of dogs with pneumonia compared with their admission levels long-term (estimated change of 9.3 mmHg, 95 % CI 2.4; 16.2), a change not observed in the control group. However, there was no significant difference between groups, making the clinical significance of this finding uncertain. Oxygen saturation increased transiently after the physiotherapy intervention relative to saturation before the procedure (estimated difference of 1.1 %, 95 % CI 0.3; 1.9, <em>P</em> = 0.006), but this significant increase was not observed in PaO<sub>2</sub>, thereby limiting the interpretive value of the result. Mortality rate, oxygen supplementation length, or clinical parameters were not consistently affected. Findings suggest that respiratory physiotherapy could represent a safe supplementary approach to improving oxygenation in dogs with pneumonia, but its potential benefits remain to be validated in larger, controlled trials.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"314 ","pages":"Article 106440"},"PeriodicalIF":3.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic prediction accuracy in Korean Holstein population: A comprehensive study of milk production traits 韩国荷斯坦奶牛种群的基因组预测准确性:产奶量性状的综合研究。
IF 3.1 2区 农林科学
Veterinary journal Pub Date : 2025-09-13 DOI: 10.1016/j.tvjl.2025.106436
Md Azizul Haque , You-Sam Kim , Chang-Gwon Dang , Yun-Mi Lee , Jong-Joo Kim
{"title":"Genomic prediction accuracy in Korean Holstein population: A comprehensive study of milk production traits","authors":"Md Azizul Haque ,&nbsp;You-Sam Kim ,&nbsp;Chang-Gwon Dang ,&nbsp;Yun-Mi Lee ,&nbsp;Jong-Joo Kim","doi":"10.1016/j.tvjl.2025.106436","DOIUrl":"10.1016/j.tvjl.2025.106436","url":null,"abstract":"<div><div>This study evaluated methods to improve genomic prediction in Korean Holstein cows by comparing pedigree-based BLUP (PBLUP), genome-based BLUP (GBLUP), and single-step genomic BLUP (ssGBLUP). Phenotypic data were obtained from 14,377 Korean Holstein cows, provided by the National Agricultural Cooperative Federation and Korean Livestock Improvement Association. These records included first and second lactation data for 305-day total milk yield (Milk305), milk fat yield (Fat305), and milk protein yield (Prot305). Genotypic data for 2016 cows were obtained using the Illumina Bovine 50 K SNP BeadChip. Heritability estimates for Milk305, Fat305, and Prot305 were consistently the highest when using PBLUP for both lactations, whereas GBLUP yielded lower estimates and ssGBLUP provided intermediate values. The average accuracies for Milk305 were 0.424, 0.411, and 0.528 for PBLUP, GBLUP, and ssGBLUP, respectively, during the first lactation and 0.385, 0.375, and 0.486 for the second lactation. For Fat305, the accuracies were 0.403, 0.457, and 0.529 for the first lactation and 0.381, 0.304, and 0.487 for the second lactation. For Prot305, the accuracies were 0.409, 0.374, and 0.523 for the first lactation period, and 0.388, 0.371, and 0.496 for the second lactation period. The results show that ssGBLUP consistently outperforms traditional PBLUP and GBLUP in prediction accuracy. This study highlights the potential of advanced breeding techniques and strategic genomic integration to improve the efficiency and sustainability of dairy production in South Korea and beyond.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"314 ","pages":"Article 106436"},"PeriodicalIF":3.1,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An e-survey study on the practice of recruitment manoeuvres in dogs among board-certified veterinary anaesthesia and analgesia specialists 一项关于在委员会认证的兽医麻醉和镇痛专家中招募狗的实践电子调查研究
IF 3.1 2区 农林科学
Veterinary journal Pub Date : 2025-09-12 DOI: 10.1016/j.tvjl.2025.106438
Fergus Fox, Chiara Adami
{"title":"An e-survey study on the practice of recruitment manoeuvres in dogs among board-certified veterinary anaesthesia and analgesia specialists","authors":"Fergus Fox,&nbsp;Chiara Adami","doi":"10.1016/j.tvjl.2025.106438","DOIUrl":"10.1016/j.tvjl.2025.106438","url":null,"abstract":"<div><div>Recruitment maneuvers (RMs) are used to treat alveolar collapse and improve lung volumes and ventilatory mechanics. The primary aim of this study was to describe current practice pertaining to the use of three types of RMs - sustained inflation (SI), incremental positive end-expiratory pressure increases (Inc-PEEP) and extended sigh (ES) in dogs, among veterinary anaesthesiologists. Based on the Checklist for Reporting Results of Internet E-Surveys (CHERRIES), a questionnaire composed of 33 questions was developed by the authors and distributed via email to approximately 600 potential participants. Measures were applied to ensure data quality and prevent duplicate entries. Data from 92 anonymous participants were analysed with descriptive statistics and analysis of proportions. The most commonly used RMs were SI and Inc-PEEP. For SI, most participants reportedly set inspiratory time below 20 s, and factors associated with conservative ventilation parameters setting were chronic lung disease (P = 0.001), BOAS (P = 0.002), and acute lung disease (P &lt; 0.001). For Inc-PEEP, regardless of patient factors, most participants reportedly increased PEEP values at 10–15 breaths intervals, with incremental increases in PEEP of 2–3 cmH<sub>2</sub>O. For ES, factors associated with setting of conservative pressure values were chronic lung disease (P = 0.025) and open chest surgery (P = 0.034). This study indicates that RMs are performed by veterinary anaesthesiologists, particularly the SI and Inc-PEEP techniques, with a tendency toward more conservative settings in the presence of underlying lung disease. However, unanimous consensus on parameters setting is lacking at date.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"314 ","pages":"Article 106438"},"PeriodicalIF":3.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emergence and rapid propagation of ST4 Mycoplasma bovis subtype in France and Belgium ST4牛支原体亚型在法国和比利时的出现和快速繁殖。
IF 3.1 2区 农林科学
Veterinary journal Pub Date : 2025-09-10 DOI: 10.1016/j.tvjl.2025.106437
Maxime Bruto , Maryne Jaÿ , Stéphanie Lefebvre , Florine Dieu , Marc Saulmont , Nathalie Jarrige , Florence Tardy , Fabien Labroussaa , Claire A.M. Becker , Chloé Ambroset
{"title":"Emergence and rapid propagation of ST4 Mycoplasma bovis subtype in France and Belgium","authors":"Maxime Bruto ,&nbsp;Maryne Jaÿ ,&nbsp;Stéphanie Lefebvre ,&nbsp;Florine Dieu ,&nbsp;Marc Saulmont ,&nbsp;Nathalie Jarrige ,&nbsp;Florence Tardy ,&nbsp;Fabien Labroussaa ,&nbsp;Claire A.M. Becker ,&nbsp;Chloé Ambroset","doi":"10.1016/j.tvjl.2025.106437","DOIUrl":"10.1016/j.tvjl.2025.106437","url":null,"abstract":"<div><div><em>Mycoplasma (M.) bovis</em> is a major pathogen worldwide involved in bovine respiratory disease with significant economic and welfare impacts. Since the 2000s, the laboratory-based surveillance network Vigimyc has integrated molecular typing of an annual subset of <em>M. bovis</em> isolates collected in France, and more recently in Belgium. This study aimed to characterize the epidemiological situation and evolution of <em>M. bovis</em> in both countries over the 2018–2024 period. A total of 498 <em>M. bovis</em> isolates were characterized using a routine monitoring approach based on <em>polC</em> subtyping. We observed the apparent re-emergence and the rapid spread of <em>polC</em> st1 isolates since 2019 in France and 2020 in Belgium, accompanied by a concurrent and marked decline of the previously dominant <em>polC</em> st2 genotype. To investigate this phenomenon, we performed whole-genome sequencing on 45 <em>polC</em> st1 isolates to explore their genetic diversity and evolutionary relationships between strains. Genome-based analyses highlighted that this population was phylogenetically distinct from the older <em>polC</em> st1 isolates collected before 2000 and belonged to the ST4 according to the updated PubMLST database. The genetic diversity within these isolates was extremely low in comparison to that observed in the other subtypes, thus highlighting the recent and clonal emergence of this new lineage. In the absence of apparent AMR switch associated with this expansion, as previously observed for the emergence of <em>polC</em> st2 population, we identified putative genetic patterns specific to this lineage that may contribute to the fitness and epidemiological success of recent <em>polC</em> st1 isolates.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"314 ","pages":"Article 106437"},"PeriodicalIF":3.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial use practices among companion animal veterinarians in Hong Kong 香港宠物兽医使用抗微生物药物的情况。
IF 3.1 2区 农林科学
Veterinary journal Pub Date : 2025-09-09 DOI: 10.1016/j.tvjl.2025.106433
Esa Karalliu , Sum Yuet Lorraine Ngan , Paweł M. Bęczkowski , Vanessa R. Barrs , Stefan Hobi , Brett MacKinnon , Howard Wong , Owen Swan , Myriam Baranger-Ete , Jane Gray , Fiona Woodhouse , Ka Chun Ng , Ibrahim Elsohaby , Omid Nekouei
{"title":"Antimicrobial use practices among companion animal veterinarians in Hong Kong","authors":"Esa Karalliu ,&nbsp;Sum Yuet Lorraine Ngan ,&nbsp;Paweł M. Bęczkowski ,&nbsp;Vanessa R. Barrs ,&nbsp;Stefan Hobi ,&nbsp;Brett MacKinnon ,&nbsp;Howard Wong ,&nbsp;Owen Swan ,&nbsp;Myriam Baranger-Ete ,&nbsp;Jane Gray ,&nbsp;Fiona Woodhouse ,&nbsp;Ka Chun Ng ,&nbsp;Ibrahim Elsohaby ,&nbsp;Omid Nekouei","doi":"10.1016/j.tvjl.2025.106433","DOIUrl":"10.1016/j.tvjl.2025.106433","url":null,"abstract":"<div><div>Adopting international guidelines on the prudent use of antimicrobials in companion animal practices has been debated in Hong Kong. This study was conducted to assess antimicrobial use (AMU) practices among companion animal veterinarians in Hong Kong and highlight the areas for targeted interventions. Data on demographics, antimicrobial prescribing behaviors, and administered antibiotic classes were collected using an online questionnaire targeting all registered companion animal veterinarians in Hong Kong (estimated at 800–900). Of all invited veterinarians, 112 submitted the survey and 74 finished the questionnaire. Most respondents worked in primary care practices (76.4 %) and were women (67.4 %); 85 % reported the absence of a formal, written AMU policy in their clinics. Veterinary drug handbooks were the main source of information used for AMU (76 %), followed by courses or workshops (64.6 %) and clinicians’ professional experience and judgment (59.5 %). Owner compliance issues regarding the dosage and duration of AMU were never-rarely observed by 63 %, and 21.5 % reported they never-rarely requested culture and antimicrobial susceptibility testing to guide their AMU. The majority (71 %) prescribed antimicrobials empirically in &gt; 30 % of cases. Most frequent barriers to ordering and conducting the susceptibility test were the financial burden on animal owners (82 %), delay in starting treatments (56 %), and time constraints (24 %). Most respondents never or rarely used preoperative (81 %) or postoperative (86 %) antimicrobials in clean surgical procedures. We highlighted key gaps in antimicrobial stewardship which can be addressed through locally tailored guidelines informed by our findings, education for veterinarians and pet owners, and improved enforcement of antimicrobial regulations.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"314 ","pages":"Article 106433"},"PeriodicalIF":3.1,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Population pharmacokinetics of intravenous ampicillin in awake and anesthetised dogs 清醒和麻醉犬静脉注射氨苄西林的群体药代动力学。
IF 3.1 2区 农林科学
Veterinary journal Pub Date : 2025-09-08 DOI: 10.1016/j.tvjl.2025.106435
Claire Pressiat , Claire Audrac , Stéphanie Marotto , Patrick Verwaerde , Christelle Maurey , Anne Hulin , Matthias Kohlhauer
{"title":"Population pharmacokinetics of intravenous ampicillin in awake and anesthetised dogs","authors":"Claire Pressiat ,&nbsp;Claire Audrac ,&nbsp;Stéphanie Marotto ,&nbsp;Patrick Verwaerde ,&nbsp;Christelle Maurey ,&nbsp;Anne Hulin ,&nbsp;Matthias Kohlhauer","doi":"10.1016/j.tvjl.2025.106435","DOIUrl":"10.1016/j.tvjl.2025.106435","url":null,"abstract":"<div><div>The aim of this study is to describe a population pharmacokinetic model for intravenous ampicillin-sulbactam in awake and anaesthetized dogs in these two treatment scenarios and to compute PK/PD cut-offs (PK/PD<sub>CO</sub>).</div><div>This was a prospective clinical trial in 20 client-owned dogs, either treated by ampicillin after post-surgical infection, or in the context of surgical antimicrobial prophylaxis. All animals received 20 mg/kg of ampicillin by slow iv route. During anesthesia ampicillin administration was repeated every 90 min according to standard recommendations, whereas in awake animals, ampicillin administration was every 8 h. A bi-compartmental model best described the data. Anesthesia and creatinine plasma concentration at the administration correlated with ampicillin clearance, which was 318 ± 36 ml/kg/h in awake animals and 186 ± 12 ml/kg/h in anesthetized animals. Monte-Carlo simulation showed that 20 mg/kg every 8 h in awake dogs led to PK/PD<sub>CO</sub> of 0.5 mg/L using a target of 40 %fT&gt;MIC and 0.25 mg/L with 50 % fT&gt;MIC. Administration of ampicillin by prolonged infusion (4 h) every 8 h allowed to achieve a PK/PD<sub>CO</sub> of 4 mg/L and 2 mg/L with the 40 % and 50 % targets, respectively. In anesthetized animals, repetition of the 20 mg/kg of ampicillin every 90 min allowed to remain above 4 mg/L during 100 % of the time.</div><div>Plasma clearance of ampicillin inversely correlates with creatinine plasma concentration in client-owned dogs and is reduced of about 40 % during anesthesia. In awake dogs, the standard regimen of 20 mg/kg every 8 h by intravenous route is probably insufficient to treat soft tissues infections caused by gram-negative bacteria. Using prolonged infusion could help to increase ampicillin efficacy against specific pathogens.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"314 ","pages":"Article 106435"},"PeriodicalIF":3.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel lytic Seuratvirus phage CABI-SEA 2301 with broad host range against multidrug-resistant avian pathogenic Escherichia coli 一种新的具有广泛宿主范围的抗多重耐药禽致病性大肠杆菌的溶性天然病毒噬菌体CABI-SEA 2301。
IF 3.1 2区 农林科学
Veterinary journal Pub Date : 2025-09-02 DOI: 10.1016/j.tvjl.2025.106426
Siwaporn Bilhman , Sakkarin Lethongkam , Anis Waeoh , Arithat Limsatanun , Jiranan Pattano , Rosesathorn Soontarach , Supayang Piyawan Voravuthikunchai , Supakit Paosen
{"title":"A novel lytic Seuratvirus phage CABI-SEA 2301 with broad host range against multidrug-resistant avian pathogenic Escherichia coli","authors":"Siwaporn Bilhman ,&nbsp;Sakkarin Lethongkam ,&nbsp;Anis Waeoh ,&nbsp;Arithat Limsatanun ,&nbsp;Jiranan Pattano ,&nbsp;Rosesathorn Soontarach ,&nbsp;Supayang Piyawan Voravuthikunchai ,&nbsp;Supakit Paosen","doi":"10.1016/j.tvjl.2025.106426","DOIUrl":"10.1016/j.tvjl.2025.106426","url":null,"abstract":"<div><div>Multidrug-resistant avian pathogenic <em>Escherichia coli</em> (MDR-APEC) causes high mortality in newborn chickens, leading to significant economic losses for poultry industry worldwide. The present study proposes an effective alternative strategy to control APEC infections by using bacteriophage specific to MDR-APEC. Lytic phage CABI-SEA 2301 isolated from a chicken faecal sample collected at a commercial poultry farm using the double layer agar overlay technique was classified as a novel species in the genus <em>Seuratvirus</em>, subfamily Queuovirinae. Genome sequencing unveiled that the selected phage consisted of a double-stranded DNA molecule with 61,452 base pairs and a GC content of 38 %, with no toxins, virulence, and antimicrobial resistance. Phage CABI-SEA 2301 demonstrated a broad host range, lysing 68 % of 50 MDR-APEC clinical isolates obtained from <em>E. coli</em> lesions at poultry farms. A high adsorption rate to the host was exhibited with 77 % within 10 min. One-step growth analysis showed that phage CABI-SEA 2301 had a latent period of 30 min with a burst size of 522 PFU/cell. Phage-infected MDR-APEC isolate CABI-SEA 2349 at the lowest multiplicity of infection of 0.01 showed a significant decrease in the bacterial growth after 4 h post-infection. Scanning electron microscopy further confirmed abnormal cellular morphology after treatment. Moreover, phage CABI-SEA 2301 could effectively inhibit the bacterial biofilm formation. Interestingly, the phage survived in mimic simulated chicken gastrointestinal conditions (96.67 ± 4.71 %) and revealed good stability under temperature between −80–50 ˚C and pH 4–12. The findings highlight the potential of the phage CABI-SEA 2301 as a biocontrol agent against MDR-APEC in the commercial farms.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"314 ","pages":"Article 106426"},"PeriodicalIF":3.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The predictive ability of blood-based biomarkers to detect bacteremia in hospitalized neonatal foals 基于血液的生物标志物检测住院新生马驹菌血症的预测能力
IF 3.1 2区 农林科学
Veterinary journal Pub Date : 2025-09-02 DOI: 10.1016/j.tvjl.2025.106427
Amanda N. Samuels , Niamh M. Collins , Kelly Hanlon , Celine Bartish , Payton Kelly , Ahmed M. Kamr , Ramiro E. Toribio
{"title":"The predictive ability of blood-based biomarkers to detect bacteremia in hospitalized neonatal foals","authors":"Amanda N. Samuels ,&nbsp;Niamh M. Collins ,&nbsp;Kelly Hanlon ,&nbsp;Celine Bartish ,&nbsp;Payton Kelly ,&nbsp;Ahmed M. Kamr ,&nbsp;Ramiro E. Toribio","doi":"10.1016/j.tvjl.2025.106427","DOIUrl":"10.1016/j.tvjl.2025.106427","url":null,"abstract":"<div><div>Early and accurate identification of septicemia in neonatal foals improves survival. In human medicine, the neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-monocyte ratio (NMR), monocyte-to-lymphocyte ratio (MLR), and plasma cell-free DNA (cfDNA) aid in early bacteremia detection. This study evaluated the diagnostic utility of these markers in conjunction with other clinical and hematological parameters in hospitalized foals &lt; 5 days old to predict positive blood culture at admission and to distinguish between Gram-positive, Gram-negative, or polymicrobial bacteremia. A total of 391 foals with a complete blood count and aseptically obtained blood culture at admission were included. Physical exam and hematologic parameters, including white blood cell count (WBC) and immunoglobulin G (IgG), were incorporated into logistic regression models, with the area under the curve (AUC) used to assess predictive performance. Plasma cfDNA was measured via fluorometry. We found that plasma cfDNA, IgG, NLR, and WBC were independent predictors of bacteremia, and a composite model demonstrated excellent discriminatory ability to identify foals with a positive blood culture (AUC = 0.806). Additionally, plasma cfDNA, IgG, and neutrophil counts were independent predictors of Gram-negative bacteremia, and a composite model demonstrated excellent discrimination (AUC = 0.807), and monocyte count and age predicted Gram-positive bacteremia with a composite model that demonstrated fair discriminatory ability (AUC = 0.67). Our findings demonstrate that NLR and plasma cfDNA are significantly altered in bacteremic foals. whereas the NMR and MLR do not differ significantly between groups. Combining these markers with other clinicopathologic variables may enable early identification and timely intervention in affected foals.</div></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"314 ","pages":"Article 106427"},"PeriodicalIF":3.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reference intervals for blood biochemical parameters in growing male water buffaloes (Bubalus bubalis) 生长雄性水牛血液生化参数的参考区间。
IF 3.1 2区 农林科学
Veterinary journal Pub Date : 2025-09-02 DOI: 10.1016/j.tvjl.2025.106425
Camila Sabino de Oliveira , Caroline de Lima Francisco , Daiane Cristina Marques da Silva , André Michel de Castilhos , Eunice Oba , André Mendes Jorge
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