Veterinary journal最新文献

{"title":"Phosphocalcic metabolism and its potential association with biomarkers of kidney disease in dogs with spontaneous hyperadrenocorticism","authors":"F. Da Riz ,&nbsp;D. Pichard ,&nbsp;C. Maurey ,&nbsp;M. Kurtz ,&nbsp;M. Canonne ,&nbsp;R. Lavoué ,&nbsp;C. Trumel ,&nbsp;T. Buronfosse ,&nbsp;L. Desquilbet ,&nbsp;G. Benchekroun","doi":"10.1016/j.tvjl.2024.106146","DOIUrl":"10.1016/j.tvjl.2024.106146","url":null,"abstract":"<div><p>The pathogenesis of increased serum phosphate concentration and proteinuria in dogs with spontaneous hyperadrenocorticism (HAC) is unclear. A potential link between proteinuria and calcium/phosphate metabolism has never been studied in dogs with HAC. The aims of the study were: (1) To evaluate calcium/phosphate metabolism in dogs with spontaneous HAC and compare to healthy dogs as well as to dogs with non-HAC illness; (2) to look for associations between markers of calcium/phosphate metabolism and biomarkers of kidney disease in dogs with HAC. Fifty-four dogs were included in the study, classified as HAC (<em>n</em>=27), non-HAC disease (<em>n</em>=17), and healthy (<em>n</em>=10). Serum calcium, phosphate, 25(OH)Vitamin D, 1,25(OH)₂Vitamin D, plasma intact parathyroid hormone conce<em>n</em>tration (iPTH), FGF23, a<em>n</em>d urinary fractio<em>n</em>al excretion of calcium and phosphate were evaluated in all dogs at diagnosis and compared between each group. The correlation between these variables and urine protein-to-creatinine ratio (UPC) and urinary N-acetylglucosaminidase-to-creatinine ratio (uNAG/C) was evaluated in the HAC group. Medians [range] of serum phosphate concentration, urinary fractional excretion of calcium (FE(Ca)), and iPTH were significantly higher in dogs with HAC than in dogs with non-HAC illness (<em>P</em>&lt;0.01) and healthy dogs (<em>P</em>&lt;0.01). Increased 1,25(OH)₂Vitamin D/25(OH)Vitamin D was also observed (P&lt;0.001). In HAC group, UPC was significantly negatively correlated with 25(OH)Vitamin D (r(s): -0.54; <em>P</em>&lt;0.01). Urinary NAG/C was significantly positively correlated with serum phosphate (r(s): 0.46; <em>P</em>=0.019). Increased serum phosphate, urinary excretion of calcium, and hyperparathyroidism were observed in dogs with HAC. Vitamin D metabolism may be shifted towards increased 1-alpha hydroxylation.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"305 ","pages":"Article 106146"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1090023324000856/pdfft?md5=76eace49e015fcf896218031fc39baef&pid=1-s2.0-S1090023324000856-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial resistance patterns of Staphylococcus spp. isolated from clinical specimens of companion animals in Northern Portugal, 2021–2023","authors":"D. Araújo ,&nbsp;R. Oliveira ,&nbsp;B.L. Silva ,&nbsp;J. Castro ,&nbsp;C. Ramos ,&nbsp;F. Matos ,&nbsp;C. Almeida ,&nbsp;S. Silva","doi":"10.1016/j.tvjl.2024.106153","DOIUrl":"10.1016/j.tvjl.2024.106153","url":null,"abstract":"<div><p><em>Staphylococcus</em> spp. are growing pathogens in humans and companion animals. The emergence of multidrug-resistant bacterial infections, such as methicillin-resistant <em>Staphylococcus</em>-associated infections, due to zoonotic transmission, is a major public health concern. Domestic animals, such as dogs and cats, are possible reservoirs of multi-resistant bacterial species, which makes it relevant to monitor them due to their proximity to humans. However, there is a lack of information on the real scenario in Europe, especially in Portugal, particularly for animal infections caused by <em>Staphylococcus</em> spp. Therefore, this study aimed to investigate the antimicrobial resistance profile of <em>Staphylococcus</em> spp. isolated from cats and dogs diagnosed with infection in Northern Portugal.</p><p>During 2021–2023, 96 <em>Staphylococcus</em> isolates from dogs and cats with symptoms of bacterial infection, including animals being treated in veterinary clinics/hospitals and cadavers submitted for necropsy at INIAV were included in the study collection. Of the 96 isolates, 63 were from dogs and 33 were <em>Staphylococcus</em> spp. from cats, most of which were isolated from ear (57% and 18%, respectively), skin (19 % and 27 %, respectively) and respiratory tract infections (6 % and 27 %, respectively). Among all the isolates, 12 different <em>Staphylococcus</em> spp. were identified, with <em>Staphylococcus pseudintermedius</em> being the most identified (61 % from dogs and 30 % from cats). It is noteworthy that 36 % of the isolates were multi-drug resistant and 25 % of the isolates showed a methicillin-resistant phenotype, with the <em>mecA</em> gene having been identified in all these isolates. This study highlights a high occurrence of multidrug-resistant <em>Staphylococcus</em> spp. in companion animals in Northern Portugal. This underlines the potential for cats and dogs to act as reservoirs of antimicrobial resistance, that can be transmitted to humans, posing a serious threat to public health.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"305 ","pages":"Article 106153"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population pharmacokinetic meta-analysis of five beta-lactams antibiotics to support dosing regimens in dogs for surgical antimicrobial prophylaxis","authors":"L. Pelligand ,&nbsp;T. Møller Sørensen ,&nbsp;P. Cagnardi ,&nbsp;P.-L. Toutain ,&nbsp;F. Allerton","doi":"10.1016/j.tvjl.2024.106136","DOIUrl":"10.1016/j.tvjl.2024.106136","url":null,"abstract":"<div><p>The Pharmacokinetic/Pharmacodynamic (PK/PD) relationship of antimicrobial drugs (AMD) for surgical prophylaxis has been poorly studied, hampering evidence-based decision making around AMD dosing and timing. Our objective is to use PK/PD principles to inform (1) the timing of administration and (2) the interval for re-administration of AMD used peri-operatively in dogs. Raw plasma concentrations of cefazolin, cefuroxime, cefalexin, amoxicillin and ampicillin were retrieved from original intravenous studies performed in dogs. <em>E. coli</em> and methicillin-susceptible staphylococci were identified as possible intraoperative contaminants and their epidemiological cut-offs (ECOFF) were retrieved from the EUCAST database. Individual PK data were refitted with non-linear mixed effect models (Phoenix®). We performed Monte Carlo simulation to compute i) the 95^th percentile of time of peak concentration in the peripheral compartment (informing timing between administration and first incision) and ii) the duration for which at least 90% of dogs maintain a free plasma concentration above ECOFF (informing timing of re-administration: 1.5–4 h). Cefazolin (22–25 mg/kg), cefuroxime (20 mg/kg), cefalexin (15 mg/kg) and amoxicillin (16.7 mg/kg) reached peak peripheral concentrations within 30 min, but ampicillin (20 mg/kg) required 82 min, respectively. For methicillin-susceptible staphylococci, cefazolin and cefuroxime require re-administration every 2 h, whereas cefalexin and both amoxicillin and ampicillin can be readministered every 3 and 4 h, respectively. For <em>E. coli,</em> only cefazolin provided adequate perioperative coverage with 2-hourly administration, where cefuroxime and cefalexin failed uniformly. Alternatively, ampicillin and amoxicillin (critically ill dogs) may cover <em>E. coli</em> contaminations, but only if readministered every 1.5 h. These PK-derived conclusions provide a rationale for perioperative AMD administration timing.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"305 ","pages":"Article 106136"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1090023324000753/pdfft?md5=b6ec81d7951795ab374e1bd63641bcca&pid=1-s2.0-S1090023324000753-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141057967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of coagulation profile in dogs with ACTH-dependent hyperadrenocorticism compared to healthy dogs by rotational thromboelastometry (ROTEM)","authors":"F.G. Romão ,&nbsp;B. dos Santos ,&nbsp;S.E.V. Mora ,&nbsp;D.S. Gonçalves ,&nbsp;V. de Marco ,&nbsp;P.A. Lopes ,&nbsp;M.H. Tsunemi ,&nbsp;R.K. Takahira","doi":"10.1016/j.tvjl.2024.106141","DOIUrl":"10.1016/j.tvjl.2024.106141","url":null,"abstract":"<div><p>Despite their low morbidity, thromboembolic events in hyperadrenocorticism are associated with high mortality. Identifying the main hemostatic abnormalities will improve the prophylactic approach of these canine patients. The aim of this study was to evaluate hemostatic alterations related with ACTH-dependent HAC and its association with hypercoagulable state. For this purpose, 25 dogs diagnosed with ACTH-dependent HAC were compared with 28 healthy dogs as a control group. The hemostatic variables included platelet count, antithrombin, fibrinogen, D-dimer, PT, aPTT, rotational thromboelastometry (ROTEM) and platelet aggregation. Results showed a hypercoagulable state in 32% (8/25) dogs by ROTEM, which had at least 2 of the next features: decreased coagulation time (CT) or clot formation time (CFT) on INTEM (5/25) or EXTEM (4/25); increased maximum clot firmness (MCF) on INTEM (9/25), EXTEM (6/25) and FIBTEM (9/25). These same variables had a significant difference (P≤ 0.05) compared with the control group, as well as the parameters of α-angle and CT. Median fibrinogen levels (310 vs.178 mg/dL), mean platelet aggregation (11.1 vs. 7.9 Ohms), median platelet count (360 vs. 225 ×10³/µL) and mean antithrombin activity (140 vs. 119%) were increased in ACTH-dependent HAC dogs compared to control group. PT (7.1 vs. 8.0 seconds) and aPTT (11.6 vs. 15.2 seconds) were also shortened in ACTH-dependent HAC dogs. Our findings confirm the presence of a hypercoagulable tendency in dogs with HAC. Although multifactorial, fibrinogen concentration and MCF FIBTEM showed the relevance of this protein for hypercoagulability in HAC.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"305 ","pages":"Article 106141"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global status of gene edited animals for agricultural applications","authors":"Alba V. Ledesma,&nbsp;Alison L. Van Eenennaam","doi":"10.1016/j.tvjl.2024.106142","DOIUrl":"10.1016/j.tvjl.2024.106142","url":null,"abstract":"<div><p>Gene editing (GnEd) involves using a site-directed nuclease to introduce a double-strand break (DSB) at a targeted location in the genome. A literature search was performed on the use of GnEd in animals for agricultural applications. Data was extracted from 212 peer-reviewed articles that described the production of at least one living animal employing GnEd technologies for agricultural purposes. The most common GnEd system reported was CRISPR/Cas9, and the most frequent type of edit was the unguided insertion or deletion resulting from the repair of the targeted DSB leading to a knock-out (KO) mutation. Animal groups included in the reviewed papers were ruminants (cattle, sheep, goats, <em>n</em>=63); monogastrics (pigs and rabbits, <em>n</em>=60); avian (chicken, duck, quail, <em>n</em>=17); aquatic (many species, <em>n</em>=65), and insects (honeybee, silkworm, <em>n</em>=7). Yield (32%), followed by reproduction (21%) and disease resistance (17%) were the most commonly targeted traits. Over half of the reviewed papers had Chinese first-authorship. Several countries, including Argentina, Australia, Brazil, Colombia and Japan, have adopted a regulatory policy that considers KO mutations introduced following GnEd DSB repair as akin to natural genetic variation, and therefore treat these GnEd animals analogously to those produced using conventional breeding. This approach has resulted in a non-GMO determination for a small number of GnEd food animal applications, including three species of GnEd KO fast-growing fish, (red sea bream, olive flounder and tiger pufferfish in Japan), KO fish and cattle in Argentina and Brazil, and porcine reproductive and respiratory syndrome (PRRS) virus disease-resistant KO pigs in Colombia.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"305 ","pages":"Article 106142"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1090023324000819/pdfft?md5=594ec0cc585e243d47341cea8b2e7f27&pid=1-s2.0-S1090023324000819-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of serum concentrations of pregnancy-associated glycoproteins and estrone sulphate during pregnancy in eutocia and dystocia beef cattle","authors":"T. Maeda ,&nbsp;G. Kitahara ,&nbsp;T. Osawa","doi":"10.1016/j.tvjl.2024.106147","DOIUrl":"10.1016/j.tvjl.2024.106147","url":null,"abstract":"<div><p>Preventing dystocia can stabilise beef cattle management. This study aimed to investigate the relationship between serum pregnancy-associated glycoproteins (PAGs) S-N values and estrone sulphate (E₁S) concentrations during pregnancy and the calf birth weight in beef cattle and to evaluate their usefulness as new predictive parameters for dystocia due to foetal overgrowth. Thirty-eight pregnant Japanese Black cattle were used. Blood samples were collected at 40, 70, 100, 150, 200, 250, 280, and 285 days after artificial insemination (AI), and birth weight of the offspring was measured. Serum PAGs S-N values and E₁S concentrations were measured, and the area under the curve (AUC) and the ratio of change based on 70 days after AI were calculated, followed by calculation of the correlation coefficient with the birth weight of the offspring and comparison between the eutocia (n = 32) and dystocia (n = 6) groups. The birth weight of the offspring was moderately positively correlated with the AUC of serum PAGs S-N values and E₁S concentrations in the second (r = 0.425, P &lt; 0.01) and third (r = 0.595, P &lt; 0.01) trimesters, respectively. The ratio of change in serum E₁S concentrations between 70 and 280 days after AI was greater (P &lt; 0.05) in the dystocia group (1276.6 ± 229.1 %) than in the eutocia group (852.6 ± 69.6 %). These results suggest that blood PAGs S-N values at mid-pregnancy (100–199 days after AI) and the ratio of changes in blood E₁S concentrations between 70 and 280 days after AI may be new parameters for predicting dystocia.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"305 ","pages":"Article 106147"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1090023324000868/pdfft?md5=cb5ae1eb2613eba09947a027831dceae&pid=1-s2.0-S1090023324000868-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of limb and cuff positioning on measurement of arterial blood pressure with an oscillometry device (PetMAP) in anaesthetized cats","authors":"G. Franchino,&nbsp;P. Fordyce,&nbsp;C. Adami","doi":"10.1016/j.tvjl.2024.106137","DOIUrl":"10.1016/j.tvjl.2024.106137","url":null,"abstract":"<div><p>Arterial blood pressure (ABP) is often measured with oscillometry during anaesthesia. Changing the height of the measuring cuff with respect to the level of the heart is known to affect oscillometry accuracy in some species; however, this effect has not been investigated in cats. The objective of this study was to determine the effects of raising and lowering the measuring cuff from standard position (level of the heart) on ABP, measured with PetMAP, in anaesthetised cats. ABP readings were obtained from 29 cats with the cuff at standard position (baseline), and 5 cm above and below the heart. The end-tidal isoflurane concentrations were maintained constant during data acquisition. There were no differences between baseline values and those measured below the heart, while ABP measured above the heart was consistently lower than baseline for both the thoracic and pelvic limbs (P &lt; 0.001), with absolute differences of 8.2 (2.5 – 14) mmHg and 6.5 (3.0 – 15.0) mmHg, respectively. Systolic ABP readings at the pelvic limb were consistently higher than those at the thoracic limb at standard position (112 ± 26 versus 103 ± 21 mmHg, p = 0.010), above (106 ± 22 versus 95 ± 20 mmHg, p = 0.003), and below the heart (116 ± 26 versus 107 ± 22 mmHg, p = 0.011). This study shows that raising the cuff by 5 cm above the heart, which may become necessary during procedural positioning, results in clinically significant underestimation of ABP measured with PetMAP.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"305 ","pages":"Article 106137"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1090023324000765/pdfft?md5=97ce54f9f8377b1dced7c1c60fa801bf&pid=1-s2.0-S1090023324000765-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141038483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative pharmacokinetics of intravenous and subcutaneous pantoprazole in sheep and goats","authors":"Charbel Fadel ,&nbsp;Beata Łebkowska-Wieruszewskac ,&nbsp;Firas Serih ,&nbsp;Andrew Lisowski ,&nbsp;Amnart Poapolathep ,&nbsp;Mario Giorgi","doi":"10.1016/j.tvjl.2024.106138","DOIUrl":"10.1016/j.tvjl.2024.106138","url":null,"abstract":"<div><p>Abomasal ulcers are a significant concern in intensive animal farming due to their impact on animal health and productivity. While proton pump inhibitors (PPIs) such as pantoprazole (PTZ) show promise in treating these ulcers, data on PTZ's pharmacokinetics (PK) in adult goats and sheep are limited. This study aims to fill this gap by investigating and comparing PTZ's PK in these species following single intravenous (IV) and subcutaneous (SC) administrations. Five healthy male goats and sheep were included in the study. PTZ concentrations in plasma samples were determined using a validated analytical method. Non-compartmental analysis was conducted, and statistical comparisons were made between IV and SC administrations and between species. Sheep and goats showed similar systemic exposure levels regardless of the administration route. However, sheep had a shorter t1/2 due to a higher V_d compared to goats. Cl values were comparable in both species, with low extraction ratio values. There were no significant differences in C_max and T_max between the two species with regards to SC administration, and complete bioavailability was observed. The MAT exceeded the t1/2 in both species, indicating a potential flip-flop phenomenon. Considering the AUC as a predictor for drug efficacy, and observing no significant differences in systemic exposure between sheep and goats for any route of administration, dosage adjustment between the two species may not be necessary. In field settings, SC administration proves more practical, providing not only complete bioavailability but also a longer half-life compared to IV. Further studies are warranted to explore the PK/PD of PTZ in small ruminants with abomasal ulcers, to fully comprehend its therapeutic efficacy in such scenarios.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"305 ","pages":"Article 106138"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1090023324000777/pdfft?md5=71548125ccf30e1b8cea5b7b9037a7a0&pid=1-s2.0-S1090023324000777-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141055816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International renal interest society best practice consensus guidelines for intermittent hemodialysis in dogs and cats","authors":"Gilad Segev ,&nbsp;Jonathan D. Foster ,&nbsp;Thierry Francey ,&nbsp;Catherine Langston ,&nbsp;Ariane Schweighauser ,&nbsp;Larry D. Cowgill","doi":"10.1016/j.tvjl.2024.106092","DOIUrl":"10.1016/j.tvjl.2024.106092","url":null,"abstract":"<div><p>Intermittent hemodialysis (IHD) is an advanced adjunctive standard of care for severe acute kidney injury (AKI) and other indications. Most animals with AKI are managed medically, however, when the disease is severe, medical management may not control the consequences of the disease, and animals with a potential for renal recovery may die from the consequences of uremia before recovery has occurred. Extracorporeal therapies aid the management of AKI by expanding the window of opportunity for recovery of sufficient kidney function to become dialysis independent. Intermittent hemodialysis (IHD) was introduced into veterinary medicine over 50 years ago, however, updated guidelines for the delivery of IHD have not been published for several decades. To that end, the International Renal Interest Society (IRIS) constituted a Working Group to establish best practice guidelines for the safe and effective delivery of IHD to animals with indications for dialytic intervention. The IRIS Working Group generated 60 consensus statements and supporting rational for a spectrum of prescription and management categories required for delivery of IHD on designated intermittent dialysis platforms (i.e., AKI, chronic hemodialysis and intoxications). A formal consensus method was used to validate the recommendations by a blinded jury of 12 veterinarians considered experts in extracorporeal therapies and actively performing IHD. Each vote provided a level of agreement for each recommendation proposed by the Working Group. To achieve a consensus, a minimum of 75% of the voting participants had to “strongly agree” or “agree” with the recommendation.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"305 ","pages":"Article 106092"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1090023324000315/pdfft?md5=588d458130c53233aadecc03ca2caf90&pid=1-s2.0-S1090023324000315-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiome in cancer: A comparative analysis between humans and dogs","authors":"Dell’Anno Filippo ,&nbsp;Lisa Guardone ,&nbsp;Valeria Listorti ,&nbsp;Razzuoli Elisabetta","doi":"10.1016/j.tvjl.2024.106145","DOIUrl":"10.1016/j.tvjl.2024.106145","url":null,"abstract":"<div><p>Cancer is a major cause of death in humans and animals worldwide. While cancer survival rates have increased over recent decades, further research to identify risk factors for the onset and progression of disease, and safe and highly efficacious treatments, is needed. Spontaneous tumours in pets represent an excellent model for neoplastic disease in humans. In this regard, dogs are an interesting species, as the divergence between the dog and human genome is low, humans and dogs have important similarities in the development and functioning of the immune system, and both species often share the same physical environment. There is also <strong>a higher</strong> homology between the canine and human microbiome <strong>than murine model</strong>. This review aims to describe and organize recently published information on canine microbiome assemblages and their relationship with the onset and progression of colorectal cancer, breast cancer and lymphoma, and to compare this with human disease. In both species, dysbiosis can induce variations in the gut microbiota that strongly influence shifts in status between health and disease. This can produce an inflammatory state, potentially leading to neoplasia, especially in the intestine, thus supporting canine studies in comparative oncology. Intestinal dysbiosis can also alter the efficacy and side effects of cancer treatments. Fewer published studies are available on changes in the relevant microbiomes in canine lymphoma and mammary cancer, and further research in this area could improve our understanding of the role of microbiota in the development of these cancers.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"305 ","pages":"Article 106145"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1090023324000844/pdfft?md5=8597fcb9dfed3d9729ef301b72016647&pid=1-s2.0-S1090023324000844-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}