Veterinary journal最新文献_第9页

Urine pH as predictor of blood acid-base status in dairy cattle fed acidogenic diets 尿 pH 值可预测饲喂酸性日粮的奶牛的血液酸碱状态。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-06-26 DOI: 10.1016/j.tvjl.2024.106187

Pedro Melendez , Daniela Redrovan , Prasanth K. Chelikani

{"title":"Urine pH as predictor of blood acid-base status in dairy cattle fed acidogenic diets","authors":"Pedro Melendez , Daniela Redrovan , Prasanth K. Chelikani","doi":"10.1016/j.tvjl.2024.106187","DOIUrl":"10.1016/j.tvjl.2024.106187","url":null,"abstract":"<div><p>We determined the association between urine pH and blood acid-base indicators and assessed a urine pH cut-off value to predict severe metabolic acidosis under field conditions in cows fed acidogenic diets. Eighty-six cows were sampled for urine and blood. Urine pH was evaluated immediately after collection, and blood acid-base status was evaluated within 2 hours of collection using a portable blood analyzer. Twenty-five cows were classified as having severe metabolic acidosis (blood pH ≤ 7.4; bicarbonate < 24 mmol/L, base excess ≤ −0.5; PCO<sub>2</sub> low to normal concentrations and urine pH between 4.88 and 5.71. There was a positive linear association between urine pH and blood pH (r = 0.46), and between urine pH and base excess (r = 0.74). The area under the ROC curve was 0.91 (CI 95 %= 0.84–0.96; good-excellent test). The optimal cut-off value for urine pH to categorize a cow with severe metabolic acidosis was 5.5 (94 % specificity and 72 % sensitivity). For each 0.1 unit of decrease in urine pH below 5.5, cows were 1.6 times (95 % CI= 1.3–2.1) more likely to exhibit a severe metabolic acidosis. We conclude that a urine pH of 5.5 or less is indicative of more life-threatening metabolic acidosis in dairy cows.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"306 ","pages":"Article 106187"},"PeriodicalIF":2.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1090023324001266/pdfft?md5=a2fe7eacfa29a069bbc7f16ccd080c63&pid=1-s2.0-S1090023324001266-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a P30 protein-based indirect ELISA for detecting African swine fever antibodies utilizing the HEK293F expression system 利用 HEK293F 表达系统开发基于 P30 蛋白的间接 ELISA，用于检测非洲猪瘟抗体。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-06-25 DOI: 10.1016/j.tvjl.2024.106186

Huahan Chen , Junhai Zhu , Xuefeng Niu , Yuanyi Cheng , Weijun Jian , Fei Gao , Yongjie Sunkang , Wenbao Qi , Lihong Huang

{"title":"Development of a P30 protein-based indirect ELISA for detecting African swine fever antibodies utilizing the HEK293F expression system","authors":"Huahan Chen , Junhai Zhu , Xuefeng Niu , Yuanyi Cheng , Weijun Jian , Fei Gao , Yongjie Sunkang , Wenbao Qi , Lihong Huang","doi":"10.1016/j.tvjl.2024.106186","DOIUrl":"10.1016/j.tvjl.2024.106186","url":null,"abstract":"<div><p>African swine fever (ASF) is an acute, febrile, and highly lethal infectious disease in pigs caused by the African swine fever virus (ASFV). Effective detection methods and strict biosecurity measures are crucial for preventing and controlling ASF, especially since there are currently no commercially available vaccines or antiviral drugs to combat ASFV infection effectively. However, the emergence of low-virulence strains of ASFV in recent years has led to false-positive results, highlighting the importance of early-produced antibody detection methods. Therefore, detecting antibodies against ASFV produced early in the infection can facilitate the prompt identification of infected pigs. This study focused on the p30 protein, an early expressed protein during ASFV infection, to develop an indirect ELISA. This method was established using the HEK293F suspension cell expression system, which has the ability to produce large quantities of correctly folded proteins with normal functionality. In this study, we developed an indirect ELISA test utilizing the p30 recombinant protein produced by the HEK293F suspension cell expression system as the antigen coating. The concentration of the p30 protein obtained from the HEK293F suspension cell expression system was measured at 4.668 mg/mL, serving as the foundation for establishing the indirect ELISA. Our findings indicate that the indirect ELISA method exhibits a sensitivity of 1:12800. Furthermore, it demonstrates high specificity and excellent reproducibility. Comparing our results to those obtained from the commercial kit, we found a coincidence rate of 98.148 % for the indirect ELISA. In summary, we have developed a sensitive method for detecting ASFV, providing a valuable tool for monitoring ASFV infection in pig herds.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"306 ","pages":"Article 106186"},"PeriodicalIF":2.3,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating insulindysregulation in horses: A two-step insulin-tolerance test using porcine zinc insulin 评估马的胰岛素失调：使用猪锌胰岛素进行两步胰岛素耐受性测试。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-06-21 DOI: 10.1016/j.tvjl.2024.106172

A.J. Grob , J. Delarocque , K. Feige , T. Warnken

{"title":"Evaluating insulindysregulation in horses: A two-step insulin-tolerance test using porcine zinc insulin","authors":"A.J. Grob , J. Delarocque , K. Feige , T. Warnken","doi":"10.1016/j.tvjl.2024.106172","DOIUrl":"10.1016/j.tvjl.2024.106172","url":null,"abstract":"<div><p>In insulin dysregulation, hyperinsulinemia (HI) can be accompanied by peripheral insulin resistance (IR) in horses, which can be diagnosed with an insulin-tolerance test (ITT). The administration of 0.1 IU/kg body weight of recombinant regular human insulin (RHI) should elicit a 50 % reduction of the initial blood glucose concentration at 30 min after insulin administration in insulin sensitive horses. Compared to RHI, porcine zinc insulin (PZI) is veterinary-approved and therefore easier accessible for many practitioners. The aim of this study was to compare the insulin and glucose dynamics during a standard ITT with RHI to an ITT performed with PZI. Twelve Icelandic horses were subjected to an ITT with RHI (ITT-RHI) and with PZI (ITT-PZI) at same dosages in a randomised crossover design. The insulin and glucose dynamics that resulted from these tests were compared, and the consistency of classification into insulin-sensitive and IR categories was evaluated. No complications were observed with the use of either RHI or PZI in ITT. A good correlation of the test results was observed (<em>r</em> = 0.88; <em>P</em> < 0.001). The blood glucose concentrations and the percentage reduction in glucose concentration did not differ significantly between the two tests (<em>P</em> = 0.053), but four out of twelve horses were classified as IR in the ITT-RHI whereas with the ITT-PZI seven out of twelve horses were classified as IR with the 50 % glucose reduction from baseline. Based on the Youden index, when using the ITT-PZI, an adjusted cut-off value for blood glucose reduction of 40 % at 30 min resulted in better test performance. With consideration for the seemingly weaker effect of PZI and the adjusted cut-off value, PZI can be an appropriate substitute to RHI in an ITT.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"306 ","pages":"Article 106172"},"PeriodicalIF":2.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1090023324001114/pdfft?md5=36c394fe3129420d19ce6d8ceeeb0030&pid=1-s2.0-S1090023324001114-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential role of peste des petits ruminants virus in small ruminant abortions 小反刍兽疫病毒在小反刍兽流产中的潜在作用

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-06-20 DOI: 10.1016/j.tvjl.2024.106185

Ş. Murat

{"title":"Potential role of peste des petits ruminants virus in small ruminant abortions","authors":"Ş. Murat","doi":"10.1016/j.tvjl.2024.106185","DOIUrl":"https://doi.org/10.1016/j.tvjl.2024.106185","url":null,"abstract":"<div><p>The aim of the present study was to investigate the frequency, genetic variability, and phylogeny of the peste des petits ruminants virus (PPRV) in ovine and caprine fetuses. During 2014 and 2017, a total of 1054 embryos/fetuses were collected in Turkey. A real-time RT-PCR assay was used for the detection of the PPRV RNA. Genetic characterization and phylogenetic analysis of the PPRV field isolates were conducted by sequencing fusion (F) protein and nucleoprotein (N) gene segments. Samples were also collected from ewes (n = 83) and nanny goats (n = 3) that had aborted and whose embryos/fetuses were found to be PPRV positive. PPRV positive embryos/fetuses were also tested for the presence of <em>Listeria monocytogenes</em>, <em>Campylobacter</em> spp., <em>Coxiella burnetii</em>, <em>Chlamydophila abortus</em>, <em>Brucella</em> spp., akabane virus, aino virus, bluetongue virus, border disease virus, bovine viral diarrhea virus, Cache Valley virus, and Schmallenberg virus. PPRV RNA was detected in 123 (11.7 %) of the 1054 embryos/fetuses, 78 of the 83 (94 %) ewes and 3 (100 %) nanny goats. Border disease virus RNA and <em>Chlamydophila abortus</em> DNA were detected in 7 and 12 PPRV positive sheep fetuses, respectively, while other bacterial and viral agents were not detected. Phylogenetically, the field isolates in this study belong to lineage IV, and compared to other strains of lineage IV considered in this study, they showed 1 and 5 new amino acid substitutions in the F and N gene sequences, respectively. The results of the study suggest that PPRV plays an important role in abortion. Therefore, PPRV needs to be taken into consideration in sheep and goats abortions.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"306 ","pages":"Article 106185"},"PeriodicalIF":2.3,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141438804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research priorities in veterinary palliative care 兽医姑息治疗的研究重点。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-06-20 DOI: 10.1016/j.tvjl.2024.106184

J. Maria da Costa , Teresa Guerra Barroso , Joana Correia Prata

引用次数: 0

Thoracolumbar hydrated nucleus pulposus extrusion and intervertebral disc extrusion in dogs: Comparison of clinical presentation and magnetic resonance imaging findings 狗的胸腰椎水合髓核挤压和椎间盘挤压：临床表现与磁共振成像结果的比较。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-06-19 DOI: 10.1016/j.tvjl.2024.106178

E. Alcoverro , I. Schofield , S. Spinillo , A. Tauro , M. Ruggeri , M. Lowrie , S.A. Gomes

{"title":"Thoracolumbar hydrated nucleus pulposus extrusion and intervertebral disc extrusion in dogs: Comparison of clinical presentation and magnetic resonance imaging findings","authors":"E. Alcoverro , I. Schofield , S. Spinillo , A. Tauro , M. Ruggeri , M. Lowrie , S.A. Gomes","doi":"10.1016/j.tvjl.2024.106178","DOIUrl":"10.1016/j.tvjl.2024.106178","url":null,"abstract":"<div><p>Thoracolumbar hydrated nucleus pulposus extrusion (TL-HNPE) is an increasingly recognised pathology with a substantial lack of literature describing its features. The aim of this retrospective case-control study was to analyse the clinical and magnetic resonance imaging (MRI) features of dogs with TL-HNPE compared to dogs affected with thoracolumbar intervertebral disc extrusion (TL-IVDE). Data from dogs diagnosed with TL-HNPE and TL-IVDE via MRI at two referral hospitals, were retrospectively collected and compared in terms of clinical signs and MRI features. Cases diagnosed with TL-IVDE were deemed controls. The MRI features of the affected IVD space, herniated IVD material, affected overlying spinal cord and local epaxial musculature were evaluated for each group. Fifty-one cases with TL-HNPE and 105 randomly selected cases of TL-IVDE were included. Several signalment and neurological signs were identified as statistically distinct between groups in univariate analysis. Multivariate analysis identified that dogs affected with TL-HNPE were typically older, less likely to be chondrodystrophic (62.2 % vs. 91 %), more frequently experiencing a peracute onset (90.2 % vs. 61.9 %) often attributed to a suspected trauma linked with exercise (37.3 % vs. 10.5 %), being less frequently progressive (41.2 % vs. 86.5 %) and with herniated disc material less frequently lateralised (72.6 % vs. 89.5 %) than cases with TL-IVDE. MRI-identifiable intervertebral disc degeneration was found in every TL-IVDE case but only in 60 % of TL-HNPE cases. TL-HNPEs were associated to significantly less spinal cord compression and less hyperalgesia than TL-IVDE.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"306 ","pages":"Article 106178"},"PeriodicalIF":2.3,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141437615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Detection of Sub-clinical Mastitis in Murrah Buffaloes through Udder Thermogram Analysis during the Natural Progression of Infection 在感染的自然发展过程中，通过乳房热图分析及早发现穆拉水牛的亚临床乳腺炎。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-06-18 DOI: 10.1016/j.tvjl.2024.106176

S.L. Gayathri, M. Bhakat , T.K. Mohanty

{"title":"Early Detection of Sub-clinical Mastitis in Murrah Buffaloes through Udder Thermogram Analysis during the Natural Progression of Infection","authors":"S.L. Gayathri, M. Bhakat , T.K. Mohanty","doi":"10.1016/j.tvjl.2024.106176","DOIUrl":"10.1016/j.tvjl.2024.106176","url":null,"abstract":"<div><p>Mastitis is a global production disease that needs an intelligent solution to tackle effectively. Infrared Thermography (IRT) is a non-invasive technology that could be incorporated into routine day-to-day farm activities to monitor the health status of the animals. In this study, the udder health status was routinely monitored for 30 days among 41 Murrah buffaloes via IRT and the California Mastitis Test (CMT). Further, somatic cell count (SCC), microbial identification, and milk quality parameters were also estimated for representative samples. The thermal imaging data obtained was tabulated and back propagated from the 0th day to the −10th day and front propagated from the 0th day to +10th day for all the udder quarters. Results revealed that on the 0th day, the mean of udder skin surface temperature (USST) and teat skin surface temperature (TSST) showed a difference (p < 0.05) in the sub-clinical mastitis (SCM) and clinical mastitis (CM) affected quarters to the healthy quarters, and their degree of difference was the highest. The indication of infection was signaled during the −9th to −5th day to <sup>th</sup>e 0th day in SCM and CM cases. There was a steep increment in the temperature from −2nd and −1st day to the 0th day of infection. Sometimes, some quarters show an increment in temperature due to mastitis during morning hours but recover by evening milking due to the animal's innate immune system. Thus, the initiation period in which the udder gets assaulted is crucial in the early assessment of SCM by monitoring temperature change using IRT.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"306 ","pages":"Article 106176"},"PeriodicalIF":2.3,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into the gut-kidney axis and implications for chronic kidney disease management in cats and dogs 洞察肠道-肾轴及其对猫狗慢性肾病管理的影响。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-06-17 DOI: 10.1016/j.tvjl.2024.106181

Stacie Summers , Jessica Quimby

{"title":"Insights into the gut-kidney axis and implications for chronic kidney disease management in cats and dogs","authors":"Stacie Summers , Jessica Quimby","doi":"10.1016/j.tvjl.2024.106181","DOIUrl":"10.1016/j.tvjl.2024.106181","url":null,"abstract":"<div><p>Chronic kidney disease (CKD) in cats and dogs presents significant clinical challenges, with emerging research highlighting the pivotal role of the gut-kidney axis in its pathogenesis and management. Gut dysbiosis, characterized by alterations in the gut microbiome composition and function, contributes to microbial dysmetabolism of key nutrients causing uremic toxin accumulation and disruptions in amino acid, bile acid and fatty acid profiles. These disturbances in turn exacerbate renal dysfunction and systemic inflammation. Recent research in veterinary medicine, particularly in cats, supports the gut microbiome and microbial-derived metabolites as novel therapeutic targets. Potential therapeutic strategies targeting the gut microbiome and microbial dysmetabolism, including dietary management, probiotics, adsorbents, and addressing constipation, offer promising avenues for intervention to restore metabolic balance and preserve renal function. This review highlights the microbial influence on renal health and focuses on potential therapeutic strategies available to veterinarians to optimize the management of CKD in cats and dogs.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"306 ","pages":"Article 106181"},"PeriodicalIF":2.3,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1090023324001205/pdfft?md5=74f4d843441c9455edb38e169d8460fb&pid=1-s2.0-S1090023324001205-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of systemic virus-specific T lymphocyte responses in pigs supplemented with algae-derived β-glucan 增强补充藻源β-葡聚糖的猪的全身病毒特异性T淋巴细胞反应。

IF 2.2 2区农林科学

Veterinary journal Pub Date : 2024-06-17 DOI: 10.1016/j.tvjl.2024.106182

SH.B. Chuaychu , C. Sirisereewan , N. Techakriengkrai , P. Tummaruk , R. Thanawongnuwech , T. Nedumpun

{"title":"Enhancement of systemic virus-specific T lymphocyte responses in pigs supplemented with algae-derived β-glucan","authors":"SH.B. Chuaychu , C. Sirisereewan , N. Techakriengkrai , P. Tummaruk , R. Thanawongnuwech , T. Nedumpun","doi":"10.1016/j.tvjl.2024.106182","DOIUrl":"10.1016/j.tvjl.2024.106182","url":null,"abstract":"<div><p>Algae-derived β-glucan has been widely used as a feed additive in the swine industry. The supplementation of β-glucan aims to improve growth performance and modulate the immunity of pigs. However, the potential effects of supplementing β-glucan from algae on immune responses in pigs—specifically antigen-specific immunity—must be determined. In this study, the effects of algae-derived β-glucan supplementation on growth performance, virus neutralising antibody and virus-specific T lymphocytes responses were investigated in pigs. Piglets (n=112 per treatment) were assigned to three treatments including non-supplemented group (control), β-glucan 100 g/ton supplemented group (BG100), and β-glucan 200 g/ton supplemented group (BG200).</p><p>In this study, production performance of pigs was not found to be different between the experimental groups. Pigs supplemented with β-glucan exhibited high levels of classical swine fever virus (CSFV)-specific producing T lymphocytes and neutralising antibody titer, compared to the control group. Interestingly, supplementation of β-glucan significantly enhanced porcine reproductive and respiratory syndrome virus (PRRSV)-specific interferon-gamma (IFN-γ) producing T lymphocytes, including CD4<sup>+</sup>, CD8<sup>+</sup>, and CD4<sup>+</sup>CD8<sup>+</sup> T lymphocyte subpopulations. Moreover, PRRS modified live vaccine (MLV) viremia was reduced in earlier for β-glucan-supplemented pigs compared to the control group. The findings indicate that the algae-derived β-glucan possesses biological potential as an immunomodulatory substance to enhance antiviral immunity, which may contribute to disease resistance in pigs.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"306 ","pages":"Article 106182"},"PeriodicalIF":2.2,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measuring hoof horn haemorrhage in heifers: A history 测量小母牛的蹄角出血：一段历史。

IF 2.3 2区农林科学

Veterinary journal Pub Date : 2024-06-17 DOI: 10.1016/j.tvjl.2024.106183

Richard Laven, Linda Laven

{"title":"Measuring hoof horn haemorrhage in heifers: A history","authors":"Richard Laven, Linda Laven","doi":"10.1016/j.tvjl.2024.106183","DOIUrl":"10.1016/j.tvjl.2024.106183","url":null,"abstract":"<div><p>Understanding the aetiology and pathogenesis of claw-horn disease (CHD) is essential for developing prevention/treatment programmes. Haemorrhages in the hoof horn (i.e. white line/sole haemorrhages) are an important part of the pathogenesis of CHD, being precursors to and predictors of lesions such as white-line disease and sole ulcer. Understanding haemorrhage development can provide useful information about the aetiology and pathogenesis of CHD. The development of hoof horn haemorrhages is best studied in cattle without previous claw-horn damage, as previous history of damage can markedly alter the hoof’s response to stressors. Since the early 1990s, many prospective studies of the risk factors associated with CHD have been undertaken in late pregnant and early lactation heifers, which have a low risk of having had CHD but which are exposed to the same risk factors as lactating cows. Those studies have used a range of methods to assess hoof horn haemorrhages, with the principal focus, particularly initially (but also more recently), being on measuring lesion severity. However, as the science developed it became clear that measuring lesion extent was also important and that combining severity and extent in a single measure was the best approach to assess hoof horn haemorrhages. Studies of hoof horn haemorrhage in heifers have significantly increased our understanding of CHD, demonstrating the importance of housing and the relative lack of importance of post-calving nutrition. Most importantly, they have shown the importance of parturition as a risk factor for CHD, and how parturition interacts with other risk factors to accentuate their effect. The use of such studies has decreased in recent years, despite recent research showing that we still have much to learn from prospective studies of hoof horn haemorrhages in heifers.</p></div>","PeriodicalId":23505,"journal":{"name":"Veterinary journal","volume":"306 ","pages":"Article 106183"},"PeriodicalIF":2.3,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1090023324001229/pdfft?md5=1066ce0166bfbc8849d73e5f3d441334&pid=1-s2.0-S1090023324001229-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0